LOCUS       NM_010192               6834 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus fem 1 homolog a (Fem1a), mRNA.
ACCESSION   NM_010192
VERSION     NM_010192.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6834)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6834)
  AUTHORS   Higuchi,S., Fujikawa,R., Nakatsuji,M., Yasui,M., Ikedo,T.,
            Nagata,M., Mishima,K., Irie,K., Matsumoto,M., Yokode,M. and
            Minami,M.
  TITLE     EP4 receptor-associated protein regulates gluconeogenesis in the
            liver and is associated with hyperglycemia in diabetic mice
  JOURNAL   Am J Physiol Endocrinol Metab 316 (3), E410-E417 (2019)
   PUBMED   30562059
REFERENCE   3  (bases 1 to 6834)
  AUTHORS   Fujikawa,R., Higuchi,S., Nakatsuji,M., Yasui,M., Ikedo,T.,
            Nagata,M., Hayashi,K., Yokode,M. and Minami,M.
  TITLE     Deficiency in EP4 Receptor-Associated Protein Ameliorates Abnormal
            Anxiety-Like Behavior and Brain Inflammation in a Mouse Model of
            Alzheimer Disease
  JOURNAL   Am J Pathol 187 (8), 1848-1854 (2017)
   PUBMED   28624505
REFERENCE   4  (bases 1 to 6834)
  AUTHORS   Fujikawa,R., Higuchi,S., Ikedo,T., Nagata,M., Hayashi,K., Yang,T.,
            Miyata,T., Yokode,M. and Minami,M.
  TITLE     Behavioral abnormalities and reduced norepinephrine in EP4
            receptor-associated protein (EPRAP)-deficient mice
  JOURNAL   Biochem Biophys Res Commun 486 (2), 584-588 (2017)
   PUBMED   28336432
REFERENCE   5  (bases 1 to 6834)
  AUTHORS   Higuchi,S., Fujikawa,R., Ikedo,T., Hayashi,K., Yasui,M., Nagata,M.,
            Nakatsuji,M., Yokode,M. and Minami,M.
  TITLE     EP4 Receptor-Associated Protein in Macrophages Protects against
            Bleomycin-Induced Pulmonary Inflammation in Mice
  JOURNAL   J Immunol 197 (11), 4436-4443 (2016)
   PUBMED   27799315
  REMARK    GeneRIF: Immunoprecipitation analyses demonstrated that EPRAP
            associated with PP2A in both MEFs and alveolar macrophages from
            BLM-treated mice.
REFERENCE   6  (bases 1 to 6834)
  AUTHORS   Yoshikawa,T., Piao,Y., Zhong,J., Matoba,R., Carter,M.G., Wang,Y.,
            Goldberg,I. and Ko,M.S.
  TITLE     High-throughput screen for genes predominantly expressed in the ICM
            of mouse blastocysts by whole mount in situ hybridization
  JOURNAL   Gene Expr Patterns 6 (2), 213-224 (2006)
   PUBMED   16325481
REFERENCE   7  (bases 1 to 6834)
  AUTHORS   Ventura-Holman,T., Hahn,H., Subauste,J.S. and Maher,J.F.
  TITLE     The Fem1a gene is downregulated in Rhabdomyosarcoma
  JOURNAL   Tumour Biol 26 (6), 294-299 (2005)
   PUBMED   16254458
  REMARK    GeneRIF: Fem1a downregulation may be involved in, and/or a marker
            of, an early cell fate defect fundamental to rhabdomyosarcoma
            pathogenesis
REFERENCE   8  (bases 1 to 6834)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   9  (bases 1 to 6834)
  AUTHORS   Krakow,D., Sebald,E., King,L.M. and Cohn,D.H.
  TITLE     Identification of human FEM1A, the ortholog of a C. elegans
            sex-differentiation gene
  JOURNAL   Gene 279 (2), 213-219 (2001)
   PUBMED   11733146
REFERENCE   10 (bases 1 to 6834)
  AUTHORS   Ventura-Holman,T., Seldin,M.F., Li,W. and Maher,J.F.
  TITLE     The murine fem1 gene family: homologs of the Caenorhabditis elegans
            sex-determination protein FEM-1
  JOURNAL   Genomics 54 (2), 221-230 (1998)
   PUBMED   9828124
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY343573.1, BC054382.1, AK080978.1, AI021455.1, CO426831.1,
            AK042461.1 and BP757418.1.
            
            On Apr 18, 2009 this sequence version replaced NM_010192.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BY343573.1         1-29
            30-3330             BC054382.1         1-3301
            3331-3818           AK080978.1         3304-3791
            3819-4108           AI021455.1         49-338
            4109-4522           CO426831.1         287-700
            4523-6656           AK042461.1         79-2212
            6657-6834           BP757418.1         1-178               c
FEATURES             Location/Qualifiers
     source          1..6834
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.24 cM"
     gene            1..6834
                     /gene="Fem1a"
                     /gene_synonym="Eprap; Fem1aa"
                     /note="fem 1 homolog a"
                     /db_xref="GeneID:14154"
                     /db_xref="MGI:MGI:1335089"
     exon            1..6816
                     /gene="Fem1a"
                     /gene_synonym="Eprap; Fem1aa"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..2081
                     /gene="Fem1a"
                     /gene_synonym="Eprap; Fem1aa"
                     /note="FEM1a-A; FEM1-alpha-A; feminization 1 homolog a;
                     prostaglandin E receptor 4-associated protein"
                     /codon_start=1
                     /product="protein fem-1 homolog A-A"
                     /protein_id="NP_034322.3"
                     /db_xref="CCDS:CCDS28899.1"
                     /db_xref="GeneID:14154"
                     /db_xref="MGI:MGI:1335089"
                     /translation="MDLHTAVYNAAHDGKLPLLQKLLAGRGREELEELLGEVAGGGTP
                     LLIAARRGHLDVVEYLVDHCGASVEASGSVHFDGETIEGAPPLWAASAAGHLAVVRSL
                     LRRGASVNRTTRTNSTPLRAACFDGHLDVVRYLVGEHKADLEVANRHGHTCLMISCYK
                     GHREIARYLLERGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCHARMERDGYGMTP
                     LLAASVTGHTNIVEYLIQEQPGHEQLSGTELPGEGSSQVAGNHCSTPEEAEPYESCCP
                     TSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGGGYLPKPEPQQLVLAYD
                     YSREVTTPQELEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFE
                     RCIRLWKYALDMQQNNLEPLSPMTASSFLSFAELFSYVLQDRSAKGNLGMQLGFADLM
                     GVLSKGVREVERALQLPKEPGDSAQFTKAIAIILHLLYLLEKVECTPSQEHLKHQTVY
                     RLLKCAPRGKNGFTPLHMAVDKETTNVGRYRVGVFPSLQVVKVLLDCGADPDSRDFDN
                     NTPLHIAAQNNCPAIMDALIEAGAHMDATNAFKKTAYELLDSKLLAKSTVQPFNYVTL
                     QCLAARALDRNKVPYKGFIPEELEAFIQLH"
     regulatory      3310..3315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fem1a"
                     /gene_synonym="Eprap; Fem1aa"
                     /note="hexamer: ATTAAA"
     polyA_site      3330
                     /gene="Fem1a"
                     /gene_synonym="Eprap; Fem1aa"
                     /note="major polyA site"
ORIGIN      
        1 ttcgcggcgg ccattttatt cctcccggag acccgctaag atgacagccc gggagaaggt
       61 gaaggttgtc tctggcgacc ggcggcccgg ctagatccag cagcgaggct tccagcatgg
      121 atctgcacac agcggtgtac aatgcggcgc acgacggcaa gctgccgctg ctgcagaagc
      181 tgctggccgg ccgtgggcgt gaggagctgg aggagctgct gggtgaggtg gccggcggtg
      241 gcacgccact gctaatcgca gcgcgccgtg gacacctaga cgtggtggag tatctggtgg
      301 accactgcgg cgccagcgtg gaggcgagcg gctccgtgca cttcgatggc gagaccatcg
      361 agggcgcgcc gccgctctgg gcagcgtcgg ccgcgggtca cctggccgtg gtgcgtagcc
      421 ttctgcgccg aggcgcctcg gtcaaccgca ccacgcgcac caactccacg ccgctgcgcg
      481 ccgcctgctt cgacggccac ctggacgtgg tacgctacct ggtgggcgag cacaaggcgg
      541 acctggaggt ggccaatcgc cacggccaca cgtgccttat gatctcctgc tacaagggcc
      601 accgcgagat cgcgcgctac ctgctggagc gcggcgcaca ggtgaaccgg cgcagcgcca
      661 agggcaacac cgccctgcac gactgtgcag aatctggcag cctggagatc ctacagctgc
      721 tgctgggctg ccacgcgcgc atggagcgcg acggctatgg catgaccccg ctgctggccg
      781 ccagcgtcac cgggcacacc aacatcgtgg agtacctcat ccaggaacag ccgggccacg
      841 agcagctctc agggacagag cttcccgggg aaggctcctc ccaggtggca ggaaaccact
      901 gctccacccc agaagaagca gaaccgtatg agagctgctg ccctaccagc cgggaagcag
      961 ctgtggaagc tttggagctg ctgggtgcca cctacgtgga taagaaaagg gatctgcttg
     1021 gagccctgaa gcactggaga agggcgatgg aactccgtca ccagggtgga ggctacctcc
     1081 ctaagccgga gccccagcaa ctggttctgg cctatgacta ttccagggag gtgactacac
     1141 cccaagagtt ggaagccctc attacagatc ctgatgaaat gcggatgcag gcgctgctga
     1201 tacgggagag aatcttgggc ccctcacatc ctgacacttc atactacata cggtaccggg
     1261 gtgctgtcta tgcggactcc gggaatttcg agcgctgtat ccgtctgtgg aagtatgcct
     1321 tggacatgca acaaaacaac ttggagcccc tgagccccat gaccgccagc agcttcctgt
     1381 cgtttgcaga gctcttctcc tacgtgctgc aggaccgctc ggccaagggc aacctgggca
     1441 tgcagcttgg ctttgccgac ctcatgggtg tgctcagcaa aggggttcgg gaagtggagc
     1501 gggctctgca gttgcccaag gaaccgggtg actccgcaca gttcaccaaa gccattgcca
     1561 tcatcctcca ccttctgtac ctattggaga aggtggagtg cacccccagc caggaacacc
     1621 tcaagcacca gacagtctac cgcctgctca agtgtgcccc tcgcggtaaa aacggcttca
     1681 ccccactaca catggcggtg gacaaggaga ccaccaacgt gggccggtat cgtgtgggcg
     1741 tcttcccatc gctgcaggtg gtcaaggtgc tgttggactg cggagcagac cctgacagca
     1801 gggatttcga caacaacacc ccactgcaca tcgctgccca gaataattgc ccggccatca
     1861 tggatgctct catcgaagct ggggcccaca tggacgccac caatgccttc aaaaagactg
     1921 cctacgagct gctggactcg aagctgttgg ctaagagcac cgtgcagcct ttcaattatg
     1981 tgacactgca gtgcctagct gcccgtgccc tggacaggaa caaggtccct tataagggct
     2041 tcatcccaga ggagctggag gccttcatcc agttgcattg agcctagccc agctgttggt
     2101 gcccacttgg gccttactcc tccaagcaga agcatccagg ccctatggcc tgctggagtg
     2161 aacccagctg ctgattctag aagccttcag ggtcacatgg taggaagacg gtcttttttt
     2221 ctgtggaagt gcaaaaacaa aaacccggat gcctgagcct ccccagtggc atgcttctgt
     2281 ctgggtctgg aggcctctgc actgtcctag agtcctgcag tgagcaaagc tgtctccttc
     2341 ctgtggtggg cactgaccac ctagatgttt gcatttggtt tttccttttc taagcagatg
     2401 ggcagcagcc tggagcccat gttgtgaggg tttttctgtc tgttttcact ggtttctgtt
     2461 tgttggactt agtaatgact gagttgagag ttgccagtat tttgcagtgg ccacagctga
     2521 gaacagcatg aactgtgtgt gcagatctgt gaccaagatc ctgggaagcc tcctcagttc
     2581 tgtgctgatt agagagagga ctatctccca agaaagccca gagccagttg caagagccac
     2641 agccaggcag acactggtgc cttctgtccc gccctctgga tggacagaca gttcccaacc
     2701 ttgggacaca gctggaactg ccaggcagat ggtgaccagg ccacctggcc accaggttca
     2761 catctgtgcc acacttgtca cactgtcacc ttcatcgctg aggacctgac ccctcttttg
     2821 ttgaggagtc cccggtatcc caataacttc tggggatggg cttctaacca agatagggga
     2881 aggtgggggg ctgccagcca gggtagcgat ggacccatgt ggtactagct tggcccacgt
     2941 gagaccctgt gtgcagcccc agaaccacaa aaagttactg aacagctgcc tatgactcca
     3001 ccagctctcg attccatcat atgtggtgag tggttcaccc tggattaggc caaagcagga
     3061 ggtactcatc cccggccgta gaagccagct acatggatag gaagtcatgt gtagaggggc
     3121 cagtccctcc ctcagccatt taagccacat aaactgtccc ttgaggaccg tcagtgtgtg
     3181 attgcagtgc taggtagatt ctctgtataa gcaaacttta ggccttactg ggcagggtct
     3241 cgctgctcca ccctgccaaa gctcagggca aacatgaacc cctttgagtc ttggcactga
     3301 tatttatgga ttaaaatgca ggtatgtgaa gatgtctgcc tagctgttat ttaatgtagc
     3361 taggtagagc gggagccagg tgagtgcctg tcaagcatgc gtggtggcac acacccaaca
     3421 tcttagcact tccagggctg aggcaggagg atcataagtt ggaggccacg ggagtagaca
     3481 gtaagttcaa gaatagcctg ggggtattgt aataagagta ttttaagact ccctaccctc
     3541 tcaaaactgt ctcctatgaa gtgtagcact agtgagcatt tactgagtcc ctgctgcacc
     3601 ccacgtgctc aaatgtacca cctggttcac agcagctgcc ttctgatgga accagtacca
     3661 ttcaggtatc tcaggtggag caagttcaga gaggttacac taatggtgtg cctggggagg
     3721 gacacagagc acatgagaaa atatcagact caaaccctct gtctcagtgg ctgacatgtt
     3781 tagatccact cccctacctc agcaccttga acatatatct catgggtcct tccataacca
     3841 ctgacttccg acctcaaatt taagaggaac aattgtttga accccatgtt cttcatgctg
     3901 tcagaattag gaaatttgac ctggggcctg aacattcttc tgggagggtt aatacagcgg
     3961 gtcccagagg ctgcctccag ccaggttctt cctaggtgga acagcaggat caaagaacag
     4021 attcctgcca agccaccaca gggcccaccc agccttaact ctatgctacc tgtaattgaa
     4081 caggcctgtg tcacctgtgt actctttagc caattacagt agcctgtgaa tgggctgcag
     4141 tgattttaaa gactaaagca gggtattgtg ggtgtgttct agaggcagag gcaggtgact
     4201 ctttctgagt ttaaggtcat cttggtctac gtagttctag gataggtata actacttaga
     4261 ctcccccctc accctccccc cccaaaaaac aaaaagatta gtgcaggaga gacggctcag
     4321 tggtaagtgc ctgtgagact ccagtttaac ccctcaatac catagcaagt gggcagatta
     4381 gactgggagc aagggcggga gacatgcccc taaccagctc tggctggttc tctggtctct
     4441 attcatgtag atagcacagc ccgttcctgt ggtgccacat ggctgtacca gtgtctggta
     4501 tttctaagta gggagtgtcc tgaccccagg ttaaacatag cccagcacag aaccacctca
     4561 cttggcactc agtcagatct acagagggcc cagcaggatg aaagacagca cagcaggtgt
     4621 ggggcagagt ctggcctgca cttgcaaggc tgcagaggag aacgtgggcc tggctctgca
     4681 catttgagat gccaccctag gggctcccca ccctcagccc tcatgacttg ttaaatcctg
     4741 tcaagaagca agcttgaacc agatgtgctg tctgtcacac accgtcagtc cctgagctcg
     4801 agaggcagat ggacaaaaac aagcaacaaa taccaagtga gcttgattga ctctgacctg
     4861 cagaagcctt cctagatcat gaactgcctc cccagggtgc ttccctcaca gccaattgct
     4921 tgtttgcttt taaaattatg tgtgtgtgcc agatgtgatg gtacatgcct cgggcagagg
     4981 caggtgggtc tctataagtt ctaggccagc ctggtctaca gagagttcca ggacagccag
     5041 gacaagccct gtcttgaccc tgccccccaa aaatgtgtat gtgatggggt gtgtgcattt
     5101 gagcgcaggg cctgcagagg ccgcgtaggt ccgtctccct ggagctggag ttatagtgga
     5161 cgtgagccac ctgatgtggg ttctgggaat ctgggctaac tgctgagcca tctcaccagc
     5221 cctttgctct taatctcttt aggcagagtt tcatgttgtc caagctggtc ttgaactgcc
     5281 tcctggctga gatcactgcc atgtgacagc gtgctcagtt tataaaactg accgtgttca
     5341 catctataga tcagtggttt ttagagtatc ctcagagctg tacaatcatt gccatttcca
     5401 gaggtccccc cagaagttta tttcaggcct ggggtgcagt cagcagtaaa cattggtgag
     5461 catggagccc tggggtctac cccaagccct gggaaaaata ctttttaaaa acagtaaagt
     5521 ttgcttatag aaaaaaaaaa tctcagtagt ggcagatgac tgggatgagt gaggctggat
     5581 caccagcaat aaaattatga gactacaaaa gtcagaatgt gagagctaca gagcagtgga
     5641 cacggggctg gccagcattc cagcctgaca agtgggcatt gaccagccca catctggtga
     5701 aggatctgag aacccctggg gcaagagtgg tggacctaag tcttcaggaa gaagaaaacc
     5761 cctttcactt ccctgggagt ctgattgcct tcctagactg cttaagtgcc tggtccacag
     5821 gacaggctaa aaataaaagc cccaccctgg catctggcag gagactaccc tctttgggca
     5881 ccaactccag gcataacagt gacattcagt ttcaccttat aatcttggag actgactcta
     5941 ccctctctgc ctcagttttc ctgcctgcaa gatgtggaag gggcattatg cccctcagga
     6001 atgctagctg agtgacagct gttgctatct ttgtcccagg gctggaattc tcaccagaca
     6061 ggcagggagt gctcatgagc tcaggctgct gcccatggtg cctcctgatg gaaaagtctt
     6121 cattgcccag ctaccttggc atcccccagc acttcccaca cccctcaaca tgtcatgatc
     6181 ggcacgaagc ccaggttgaa ctcaaactca ctgtgtagct gtagctgaag ttgaccttga
     6241 atcttggatc aactgagagt ggagtctggg gtttcatgtc tgacagctga gatcagctcg
     6301 ttggcctagt gtgtgctccc cctccatgct atagaaacat tggcttccct gggtctctga
     6361 gaggctccat gcttacttcc caggctctgc tctccctccg tcttccagga tgcccctcta
     6421 ggagctgccc cagaggacct aggatgccca cctcctcagc atccccacct caggtgagta
     6481 aagctctgag ctcacaaagg tacaagcagg aaccacagaa ggcatctttg gcatacagta
     6541 gatgctgaac acacttgagt ccatcatgag ggggtaataa gtctcaccag caggaagaga
     6601 acagcggcca agatgatcag aaatccaagt taaacatcag ttgaaagtca aatgttaaaa
     6661 aaaaaagtca aatgtttatt gtgggagctg aatgactgga gcatatggag ttctggttgg
     6721 ttggttggtt gttgtggatg tttctgtttt ttggaaatag ggtctcactg tgtatcccag
     6781 gctggcctgg cataaatttt agggtttttg tttgttaaaa aaaaaaaaaa aaaa
//
