LOCUS       NM_007997               1866 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ferredoxin reductase (Fdxr), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_007997 XM_991496
VERSION     NM_007997.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1866)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1866)
  AUTHORS   Mohibi,S., Zhang,Y., Perng,V., Chen,M., Zhang,J. and Chen,X.
  TITLE     Ferredoxin 1 is essential for embryonic development and lipid
            homeostasis
  JOURNAL   Elife 13, e91656 (2024)
   PUBMED   38251655
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1866)
  AUTHORS   Feng,S., Wen,H., Liu,K., Xiong,M., Li,J., Gui,Y., Lv,C., Zhang,J.,
            Ma,X., Wang,X. and Yuan,S.
  TITLE     hnRNPH1 establishes Sertoli-germ cell crosstalk through cooperation
            with PTBP1 and AR, and is essential for male fertility in mice
  JOURNAL   Development 150 (3) (2023)
   PUBMED   36718792
  REMARK    GeneRIF: hnRNPH1 establishes Sertoli-germ cell crosstalk through
            cooperation with PTBP1 and AR, and is essential for male fertility
            in mice.
REFERENCE   4  (bases 1 to 1866)
  AUTHORS   Zhang,Y., Mohibi,S., Vasilatis,D.M., Chen,M., Zhang,J. and Chen,X.
  TITLE     Ferredoxin reductase and p53 are necessary for lipid homeostasis
            and tumor suppression through the ABCA1-SREBP pathway
  JOURNAL   Oncogene 41 (12), 1718-1726 (2022)
   PUBMED   35121827
REFERENCE   5  (bases 1 to 1866)
  AUTHORS   Slone,J.D., Yang,L., Peng,Y., Queme,L.F., Harris,B., Rizzo,S.J.S.,
            Green,T., Ryan,J.L., Jankowski,M.P., Reinholdt,L.G. and Huang,T.
  TITLE     Integrated analysis of the molecular pathogenesis of
            FDXR-associated disease
  JOURNAL   Cell Death Dis 11 (6), 423 (2020)
   PUBMED   32499495
  REMARK    GeneRIF: Integrated analysis of the molecular pathogenesis of
            FDXR-associated disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1866)
  AUTHORS   Fairfield,H., Srivastava,A., Ananda,G., Liu,R., Kircher,M.,
            Lakshminarayana,A., Harris,B.S., Karst,S.Y., Dionne,L.A.,
            Kane,C.C., Curtain,M., Berry,M.L., Ward-Bailey,P.F., Greenstein,I.,
            Byers,C., Czechanski,A., Sharp,J., Palmer,K., Gudis,P., Martin,W.,
            Tadenev,A., Bogdanik,L., Pratt,C.H., Chang,B., Schroeder,D.G.,
            Cox,G.A., Cliften,P., Milbrandt,J., Murray,S., Burgess,R.,
            Bergstrom,D.E., Donahue,L.R., Hamamy,H., Masri,A., Santoni,F.A.,
            Makrythanasis,P., Antonarakis,S.E., Shendure,J. and Reinholdt,L.G.
  TITLE     Exome sequencing reveals pathogenic mutations in 91 strains of mice
            with Mendelian disorders
  JOURNAL   Genome Res 25 (7), 948-957 (2015)
   PUBMED   25917818
REFERENCE   7  (bases 1 to 1866)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 1866)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   9  (bases 1 to 1866)
  AUTHORS   Furukawa,A., Okuyama,E., Sumi,T. and Ichikawa,Y.
  TITLE     Molecular cloning of sheep and goat ferredoxin reductase messenger
            ribonucleic acids, and identification of an alternatively spliced
            form of sheep ferredoxin reductase
  JOURNAL   Biol Reprod 56 (5), 1336-1342 (1997)
   PUBMED   9160736
REFERENCE   10 (bases 1 to 1866)
  AUTHORS   Itoh,S., Iemura,O., Yamada,E., Yoshimura,T., Tsujikawa,K.,
            Kohama,Y. and Mimura,T.
  TITLE     cDNA cloning of mouse ferredoxin reductase from kidney
  JOURNAL   Biochim Biophys Acta 1264 (2), 159-162 (1995)
   PUBMED   7495857
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D49920.1.
            
            [WARNING] On Jun 18, 2024 this sequence was replaced by
            NM_007997.2.
            
            On May 4, 2006 this sequence version replaced XM_991496.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D49920.1, BC071268.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1866
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.84 cM"
     gene            1..1866
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /note="ferredoxin reductase"
                     /db_xref="GeneID:14149"
                     /db_xref="MGI:MGI:104724"
     exon            1..161
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1567
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /EC_number="1.18.1.6"
                     /note="NADPH:adrenodoxin oxidoreductase, mitochondrial;
                     adrenodoxin reductase; ferredoxin--NADP(+) reductase"
                     /codon_start=1
                     /product="NADPH:adrenodoxin oxidoreductase, mitochondrial
                     precursor"
                     /protein_id="NP_032023.1"
                     /db_xref="CCDS:CCDS25625.1"
                     /db_xref="GeneID:14149"
                     /db_xref="MGI:MGI:104724"
                     /translation="MAPRCWHWWRWSAWSGLRPSPSRSTPTPGFCQKFSTQEKTPQIC
                     VVGSGPAGFYTAQHLLKHHTHAHVDIYEKQLVPFGLVRFGVAPDHPEVKNVINTFTQT
                     ARSDRCAFQGNVVVGRDVSVPELREAYHAVVLSYGAEDHQPLGIPGEELPGVVSARAF
                     VGWYNGLPENQELAPDLSCDTAVILGQGNVALDVARILLTPPEHLEKTDITEAALGAL
                     RQSRVKTVWIVGRRGPLQVAFTIKELREMIQLPGTRPILDPSDFLGLQDRIKDVPRPR
                     RRLTELLLRTATEKPGVEEAARQALASRAWGLRFFRSPQQVLPTPDGQRVAGIRLAVT
                     SLEGVGESTRAVPTGDVEDLPCGLLLSSVGYKSRPIDPSVPFDPKLGVIPNTEGRVVN
                     VPGLYCSGWVKRGPTGVITTTMTDSFLTSQALLEDLKAGLLPSGPRPGYVAIQALLSN
                     RGVRPVSFSDWEKLDAEEVSRGQGTGKPREKLVDRREMLRLLGH"
     exon            162..265
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /inference="alignment:Splign:2.1.0"
     exon            266..361
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /inference="alignment:Splign:2.1.0"
     exon            362..484
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /inference="alignment:Splign:2.1.0"
     exon            485..598
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /inference="alignment:Splign:2.1.0"
     exon            599..700
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /inference="alignment:Splign:2.1.0"
     exon            701..808
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /inference="alignment:Splign:2.1.0"
     exon            809..893
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1093
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1265
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1436
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1866
                     /gene="Fdxr"
                     /gene_synonym="AR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgtcctcgg cgggctgctg gacctgcgct cagcactaga gtcattgcta gctcttccgc
       61 ttgctggttg cacttctcag ccatggctcc tcgctgctgg cactggtggc gctggtccgc
      121 gtggtctggg cttcggccgt ctccctccag gagcactccg accccaggct tctgccagaa
      181 gttctccaca caggagaaga cccctcagat ctgtgtggtc ggcagtggcc cagctggctt
      241 ctacacagcc caacacttgt taaagcacca cacccatgcc cacgtagaca tctacgagaa
      301 gcagctcgtg ccattcggcc tggtgcgctt tggtgtggca cctgaccatc ctgaagtaaa
      361 gaatgttatc aacacattta cacagacagc ccgctcagac cgctgtgcct tccagggcaa
      421 tgtggtggtg ggcagggacg tgtcggttcc agagcttcgg gaagcctacc atgctgtggt
      481 gctgagttat ggagcagagg accaccaacc cctgggaatt cctggcgagg agctgcctgg
      541 agtggtctca gcccgggcct ttgtgggctg gtacaatgga cttcccgaga accaggagct
      601 ggcgccagat ctgagctgtg acacggctgt aattctggga caggggaatg tggctctgga
      661 tgtggcccgg atcctgctga ccccacctga gcacctggag aaaacagaca tcacagaggc
      721 tgcattgggg gccctgaggc agagtcgggt gaagactgtg tggatagtgg gccggcgtgg
      781 gcccttgcaa gtagcgttca ccattaagga gcttcgggag atgattcagt tgccaggaac
      841 ccggcccatt ttggatcctt cggatttctt gggcctccag gacagaatta aggatgtccc
      901 ccgtccaagg aggcggctaa cagaactgct gcttcggaca gccacggaga agccaggagt
      961 ggaagaggct gcccgccagg cactggcctc ccgggcctgg ggtctccgct ttttccgaag
     1021 cccccagcag gtgctcccta ccccagatgg ccaacgggta gcaggcatcc gcctggcagt
     1081 tactagtcta gagggtgttg gggagtccac tcgggcagtg cccacaggag acgtggagga
     1141 cctcccttgt ggactgctgc tgagcagcgt tgggtataag agccgcccca tcgaccccag
     1201 cgtgcccttt gaccccaagc ttggagtcat ccccaacaca gagggccggg ttgtgaatgt
     1261 cccaggcctc tactgcagtg gctgggtgaa gaggggaccc acaggtgtca tcaccacaac
     1321 catgacagac agcttcctca ccagccaggc gctgctggag gacctgaagg cggggctgct
     1381 gccctccggc cccagacccg gctatgtggc cattcaagcc ctgctcagca atcgaggagt
     1441 ccggccagtg tctttctcag actgggagaa gctggatgct gaggaagtct ctcgaggcca
     1501 aggtactggg aaaccaaggg agaagctggt ggatcgaaga gagatgctgc ggctgctggg
     1561 ccactgaacc tgggccccag cccctaccgt gcaagacaag agccggacag tctgggttgg
     1621 actcttctct cgttcattat gttattgacg gccctggctt agacgccgaa ccgtgccctt
     1681 tccaggggcc tctgagctct gccttctgca agctgacctc ccagtgtggc ttgaggccaa
     1741 ggagggaacc tgaagctagg gatggatgga gatacagact gaccctaccc gtcctgcttc
     1801 ctttctgatg gaccttggag ggcctctaga acggaacaca gtggaaataa aacagatgtg
     1861 cctaag
//
