LOCUS       NM_001039824             807 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus ferredoxin 2 (Fdx2), transcript variant 1, mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001039824 XM_908908 XM_990431
VERSION     NM_001039824.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 807)
  AUTHORS   Zhang,J., Zhang,Y., Mohibi,S., Perng,V., Bustamante,M., Shi,Y.,
            Nakajima,K., Chen,M. and Chen,X.
  TITLE     Ferredoxin 2 Is Critical for Tumor Suppression and Lipid
            Homeostasis but Dispensable for Embryonic Development
  JOURNAL   Am J Pathol (2024) In press
   PUBMED   39732391
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 807)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 807)
  AUTHORS   Boniecki,M.T., Freibert,S.A., Muhlenhoff,U., Lill,R. and Cygler,M.
  TITLE     Structure and functional dynamics of the mitochondrial Fe/S cluster
            synthesis complex
  JOURNAL   Nat Commun 8 (1), 1287 (2017)
   PUBMED   29097656
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 807)
  AUTHORS   Gakh,O., Ranatunga,W., Smith,D.Y. 4th, Ahlgren,E.C.,
            Al-Karadaghi,S., Thompson,J.R. and Isaya,G.
  TITLE     Architecture of the Human Mitochondrial Iron-Sulfur Cluster
            Assembly Machinery
  JOURNAL   J Biol Chem 291 (40), 21296-21321 (2016)
   PUBMED   27519411
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC061189.1, AK020979.1 and BF318146.1.
            
            On Jun 20, 2018 this sequence version replaced NM_001039824.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK020979.1, AK008401.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BC061189.1         1-17
            18-799              AK020979.1         5-786
            800-807             BF318146.1         2-9                 c
FEATURES             Location/Qualifiers
     source          1..807
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.7 cM"
     gene            1..807
                     /gene="Fdx2"
                     /gene_synonym="B230118G17Rik; Fdx1l"
                     /note="ferredoxin 2"
                     /db_xref="GeneID:68165"
                     /db_xref="MGI:MGI:1915415"
     exon            1..143
                     /gene="Fdx2"
                     /gene_synonym="B230118G17Rik; Fdx1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..550
                     /gene="Fdx2"
                     /gene_synonym="B230118G17Rik; Fdx1l"
                     /note="adrenodoxin-like protein, mitochondrial;
                     ferredoxin-1-like protein; ferredoxin-2, mitochondrial;
                     ferredoxin 1-like"
                     /codon_start=1
                     /product="ferredoxin-2, mitochondrial precursor"
                     /protein_id="NP_001034913.1"
                     /db_xref="CCDS:CCDS22892.1"
                     /db_xref="GeneID:68165"
                     /db_xref="MGI:MGI:1915415"
                     /translation="MAASMARGVSARVLLRAAGGSWGPRAGHAAVTSRTFGTTGERRA
                     GEEAADSPELPRDVVNVVFVDRSGKRIPVRGKVGDNVLYLAQRHGVDLEGACEASLAC
                     STCHVYVSEAHLDLLPPPEEREDDMLDMAPLLQENSRLGCQIVLTPELEGVEFALPKI
                     TRNFYVDGHIPKPH"
     exon            144..198
                     /gene="Fdx2"
                     /gene_synonym="B230118G17Rik; Fdx1l"
                     /inference="alignment:Splign:2.1.0"
     exon            199..305
                     /gene="Fdx2"
                     /gene_synonym="B230118G17Rik; Fdx1l"
                     /inference="alignment:Splign:2.1.0"
     exon            306..393
                     /gene="Fdx2"
                     /gene_synonym="B230118G17Rik; Fdx1l"
                     /inference="alignment:Splign:2.1.0"
     exon            394..807
                     /gene="Fdx2"
                     /gene_synonym="B230118G17Rik; Fdx1l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      783..788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fdx2"
                     /gene_synonym="B230118G17Rik; Fdx1l"
                     /note="hexamer: AATAAA"
     polyA_site      800
                     /gene="Fdx2"
                     /gene_synonym="B230118G17Rik; Fdx1l"
                     /note="major polyA site"
ORIGIN      
        1 aggtcttccg gtcacgtggc ctatcatggc cgcctccatg gcccggggcg tgagcgcccg
       61 ggtcctgtta cgggcggccg ggggatcttg gggacccagg gccgggcacg cggcggtaac
      121 atctaggacg ttcgggacta caggcgagcg gcgtgctggc gaggaggcgg cggacagccc
      181 ggagctgccc cgggacgtgg tcaacgtggt gttcgtggac cgctctggca agcggatccc
      241 ggtgaggggc aaagtcgggg acaatgttct atacctggcc cagcgccacg gggtggacct
      301 ggaaggggcc tgcgaagcat ccctggcctg ttccacctgt catgtgtatg tgagtgaggc
      361 ccacctggat ctcctgcctc ctcctgagga gagggaggac gacatgttgg acatggctcc
      421 actgctccaa gagaactcaa gactgggctg ccagattgtg ctgacccctg agctagaggg
      481 agttgaattt gctcttccca agatcaccag gaacttctat gtggacggcc acatccccaa
      541 gccccactga catgaggcca ctggacagac caggccatgg aactgaaaag aaaagccacg
      601 cttcctactc cagaggacgg actgcccagg aaagagaagt tggacccaca gtgtgagacc
      661 agagctgcca ctggggacag ccagtgtctg agccctgagg gggatgggtc tccatcttgg
      721 gtgtgtcagt ccaccaggga gaatcgaact ataaattaag gatggactct aaccagagct
      781 gcaataaaaa gtcacacaca tctccga
//
