LOCUS       NM_007996               1227 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus ferredoxin 1 (Fdx1), transcript variant 1, mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_007996
VERSION     NM_007996.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1227)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
REFERENCE   2  (bases 1 to 1227)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1227)
  AUTHORS   Mohibi,S., Zhang,Y., Perng,V., Chen,M., Zhang,J. and Chen,X.
  TITLE     Ferredoxin 1 is essential for embryonic development and lipid
            homeostasis
  JOURNAL   Elife 13, e91656 (2024)
   PUBMED   38251655
  REMARK    GeneRIF: Ferredoxin 1 is essential for embryonic development and
            lipid homeostasis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1227)
  AUTHORS   Li,L., Pei,Z., Wu,R., Zhang,Y., Pang,Y., Hu,H., Hu,W., Geng,Z.,
            Feng,T., Niu,Y., Hao,G. and Zhang,R.
  TITLE     FDX1 regulates leydig cell ferroptosis mediates PM2.5-induced
            testicular dysfunction of mice
  JOURNAL   Ecotoxicol Environ Saf 263, 115309 (2023)
   PUBMED   37517308
  REMARK    GeneRIF: FDX1 regulates leydig cell ferroptosis mediates
            PM2.5-induced testicular dysfunction of mice.
REFERENCE   5  (bases 1 to 1227)
  AUTHORS   Lu,J., Ling,X., Sun,Y., Liu,L., Liu,L., Wang,X., Lu,C., Ren,C.,
            Han,X. and Yu,Z.
  TITLE     FDX1 enhances endometriosis cell cuproptosis via G6PD-mediated
            redox homeostasis
  JOURNAL   Apoptosis 28 (7-8), 1128-1140 (2023)
   PUBMED   37119432
  REMARK    GeneRIF: FDX1 enhances endometriosis cell cuproptosis via
            G6PD-mediated redox homeostasis.
REFERENCE   6  (bases 1 to 1227)
  AUTHORS   Itoh,S., Iemura,O., Yamada,E., Yoshimura,T., Tsujikawa,K.,
            Kohama,Y. and Mimura,T.
  TITLE     cDNA cloning of mouse ferredoxin reductase from kidney
  JOURNAL   Biochim Biophys Acta 1264 (2), 159-162 (1995)
   PUBMED   7495857
REFERENCE   7  (bases 1 to 1227)
  AUTHORS   Keeney,D.S., Jenkins,C.M. and Waterman,M.R.
  TITLE     Developmentally regulated expression of adrenal 17
            alpha-hydroxylase cytochrome P450 in the mouse embryo
  JOURNAL   Endocrinology 136 (11), 4872-4879 (1995)
   PUBMED   7588219
REFERENCE   8  (bases 1 to 1227)
  AUTHORS   Itoh,S., Iemura,O., Yamada,E., Yoshimura,T., Tsujikawa,K.,
            Kohama,Y. and Mimura,T.
  TITLE     Mouse cytochrome P-450 linked ferredoxin: its cDNA cloning and
            inducibility by dibutyryladenosine 3',5'-cyclic monophosphate and
            forskolin
  JOURNAL   Biochim Biophys Acta 1263 (2), 173-175 (1995)
   PUBMED   7640310
REFERENCE   9  (bases 1 to 1227)
  AUTHORS   Keeney,D.S., Ikeda,Y., Waterman,M.R. and Parker,K.L.
  TITLE     Cholesterol side-chain cleavage cytochrome P450 gene expression in
            the primitive gut of the mouse embryo does not require
            steroidogenic factor 1
  JOURNAL   Mol Endocrinol 9 (8), 1091-1098 (1995)
   PUBMED   7476982
REFERENCE   10 (bases 1 to 1227)
  AUTHORS   Stromstedt,M. and Waterman,M.R.
  TITLE     A full-length cDNA encoding mouse adrenodoxin
  JOURNAL   Biochim Biophys Acta 1261 (1), 126-128 (1995)
   PUBMED   7893748
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BB578768.1, D43689.1 and
            AI050584.1.
            
            On Sep 11, 2014 this sequence version replaced NM_007996.1.
            
            Summary: Ferrodoxins are iron-sulfur proteins that facilitate
            monooxygenase reactions catalyzed by P450 enzymes. The protein
            encoded by this gene is present in the mitochondrial matrix and
            transfers electrons from ferredoxin reductase to steroidogenic
            mitochondrial cytochrome P450 proteins. Alternative splicing
            results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD768318.1, L29123.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                BB578768.1         2-70
            70-930              D43689.1           1-861
            931-1227            AI050584.1         1-297               c
FEATURES             Location/Qualifiers
     source          1..1227
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 28.62 cM"
     gene            1..1227
                     /gene="Fdx1"
                     /note="ferredoxin 1"
                     /db_xref="GeneID:14148"
                     /db_xref="MGI:MGI:103224"
     exon            1..332
                     /gene="Fdx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..702
                     /gene="Fdx1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; adrenodoxin, mitochondrial; adrenal ferredoxin"
                     /codon_start=1
                     /product="adrenodoxin, mitochondrial isoform 1 precursor"
                     /protein_id="NP_032022.1"
                     /db_xref="CCDS:CCDS23178.1"
                     /db_xref="GeneID:14148"
                     /db_xref="MGI:MGI:103224"
                     /translation="MAAAPGARLLRAACASVPFRGLDRCRLLVCGTGAGTAISPWTPS
                     PRLHAEAGPGRPLSVSARARSSSEDKITVHFKNRDGETLTTKGKIGDSLLDVVIENNL
                     DIDGFGACEGTLACSTCHLIFEDHIYEKLDAITDEENDMLDLAFGLTDRSRLGCQVCL
                     TKAMDNMTVRVPEAVADVRQSVDMSKNS"
     exon            333..457
                     /gene="Fdx1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..587
                     /gene="Fdx1"
                     /inference="alignment:Splign:2.1.0"
     exon            588..1214
                     /gene="Fdx1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      727..732
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fdx1"
                     /note="hexamer: ATTAAA"
     polyA_site      732
                     /gene="Fdx1"
                     /note="major polyA site"
     regulatory      910..915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fdx1"
                     /note="hexamer: AATAAA"
     polyA_site      931
                     /gene="Fdx1"
                     /note="major polyA site"
     regulatory      955..960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fdx1"
                     /note="hexamer: AGTAAA"
     polyA_site      974
                     /gene="Fdx1"
     regulatory      1191..1196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fdx1"
                     /note="hexamer: AATAAA"
     polyA_site      1214
                     /gene="Fdx1"
ORIGIN      
        1 ggggcgcagc cgcgggttat aggacacgca gggcgctcgc gggagtgtag ccctctcgca
       61 gccggacacg cgggacctac ccgaccctca gcactgcgca ggactccgcg ggacccggaa
      121 ccttccgaca gggttatggc ggccgctccg ggcgcccgac tcctgcgcgc ggcctgcgcc
      181 tccgtccctt tccgcggcct tgaccgctgt cggctgctgg tctgcgggac cggagcggga
      241 actgccatct ctccgtggac cccgagtccc cgcctgcatg cagaggccgg gcccggccgg
      301 ccgctgagcg tgtctgcgcg cgcgcggagc agctcagaag ataagataac agtccacttc
      361 aagaaccgag atggcgagac gctaacgacc aaggggaaaa ttggcgactc tctgctagat
      421 gttgtgattg agaacaactt agatatcgat gggtttggtg cgtgtgaggg aacgttggct
      481 tgctctactt gtcatcttat ctttgaggat cacatctatg agaagttaga tgccattact
      541 gatgaagaga atgacatgct tgacctggct tttggactaa cagacaggtc aaggttgggc
      601 tgccaagttt gtctgaccaa ggctatggac aatatgactg tgcgtgtgcc tgaagcagtg
      661 gcggatgtcc gacagtctgt tgacatgagc aagaattcct aagctacaat aaaaagaaat
      721 attttcatta aatttttacc tatttttata attatttctt agtataatta agtgattata
      781 tgacagaata tatatcttag tgtgagtagc tgtgctgtct tagttcagtt ctgtagaact
      841 gaaactttgc agtttttatt ttgattaaat tattaaaaca tcagtcaact attagaaggc
      901 agctgatata ataaattcct tatgtatttt accatgagtg tgtttggtga ttttagtaaa
      961 acattactgt gtaatctcat gtctgctttt taaaaaggta attttaaata gtaccattag
     1021 tgctggaaaa ttaggtcagc aattaagagc actgaccgtt cttccagagg acccagttca
     1081 agtctgacag ctacatggtg cctcataatg gtctgtaatt ccatttctag cccctaaata
     1141 catgtggtat attgacataa taaggaaaac attcatacac aagaaataaa aataaaattt
     1201 caagaaatgt aaaaaaaaaa aaaaaaa
//
