LOCUS       NM_134469               1262 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus farnesyl diphosphate synthetase (Fdps), transcript
            variant 2, mRNA.
ACCESSION   NM_134469
VERSION     NM_134469.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1262)
  AUTHORS   Liu,J., Zhang,X., Zhang,Y., Qian,M., Yang,M., Yang,S. and Wang,L.
  TITLE     Farnesyl diphosphate synthase exacerbates nonalcoholic
            steatohepatitis via the activation of AHR-CD36 axis
  JOURNAL   FASEB J 37 (7), e23035 (2023)
   PUBMED   37310396
  REMARK    GeneRIF: Farnesyl diphosphate synthase exacerbates nonalcoholic
            steatohepatitis via the activation of AHR-CD36 axis.
REFERENCE   2  (bases 1 to 1262)
  AUTHORS   Gamart,J., Barozzi,I., Laurent,F., Reinhardt,R., Martins,L.R.,
            Oberholzer,T., Visel,A., Zeller,R. and Zuniga,A.
  TITLE     SMAD4 target genes are part of a transcriptional network that
            integrates the response to BMP and SHH signaling during early limb
            bud patterning
  JOURNAL   Development 148 (23) (2021)
   PUBMED   34822715
REFERENCE   3  (bases 1 to 1262)
  AUTHORS   Wang,X., Zhang,X., Chen,Y., Zhao,C., Zhou,W., Chen,W., Zhang,C.,
            Ding,K., Li,W., Xu,H., Lou,L., Chu,Z., Hu,S. and Yang,J.
  TITLE     Cardiac-specific deletion of FDPS induces cardiac remodeling and
            dysfunction by enhancing the activity of small GTP-binding proteins
  JOURNAL   J Pathol 255 (4), 438-450 (2021)
   PUBMED   34467534
REFERENCE   4  (bases 1 to 1262)
  AUTHORS   Wei,L., Zheng,Y.Y., Sun,J., Wang,P., Tao,T., Li,Y., Chen,X.,
            Sang,Y., Chong,D., Zhao,W., Zhou,Y., Wang,Y., Jiang,Z., Qiu,T.,
            Li,C.J., Zhu,M.S. and Zhang,X.
  TITLE     GGPP depletion initiates metaflammation through disequilibrating
            CYB5R3-dependent eicosanoid metabolism
  JOURNAL   J Biol Chem 295 (47), 15988-16001 (2020)
   PUBMED   32913122
REFERENCE   5  (bases 1 to 1262)
  AUTHORS   Dai,D., Sun,X., Ding,J., Chen,Y. and Hu,S.
  TITLE     Overexpression of farnesyl pyrophosphate synthase increases
            myocardial ischemia/reperfusion injury in mice
  JOURNAL   Gene 672, 72-78 (2018)
   PUBMED   29864496
  REMARK    GeneRIF: Overexpression of FPPS aggravates myocardial
            ischemia/reperfusion injury in mice.
REFERENCE   6  (bases 1 to 1262)
  AUTHORS   Schwarz,M., Davis,D.L., Vick,B.R. and Russell,D.W.
  TITLE     Genetic analysis of cholesterol accumulation in inbred mice
  JOURNAL   J Lipid Res 42 (11), 1812-1819 (2001)
   PUBMED   11714850
REFERENCE   7  (bases 1 to 1262)
  AUTHORS   Klingenspor,M., Xu,P., Cohen,R.D., Welch,C. and Reue,K.
  TITLE     Altered gene expression pattern in the fatty liver dystrophy mouse
            reveals impaired insulin-mediated cytoskeleton dynamics
  JOURNAL   J Biol Chem 274 (33), 23078-23084 (1999)
   PUBMED   10438476
REFERENCE   8  (bases 1 to 1262)
  AUTHORS   Castellani,L.W., Weinreb,A., Bodnar,J., Goto,A.M., Doolittle,M.,
            Mehrabian,M., Demant,P. and Lusis,A.J.
  TITLE     Mapping a gene for combined hyperlipidaemia in a mutant mouse
            strain
  JOURNAL   Nat Genet 18 (4), 374-377 (1998)
   PUBMED   9537422
REFERENCE   9  (bases 1 to 1262)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   10 (bases 1 to 1262)
  AUTHORS   Andalibi,A., Diep,A., Quon,D., Mohandas,T., Taylor,B.A. and
            Lusis,A.J.
  TITLE     Mapping of multiple mouse loci related to the farnesyl
            pyrophosphate synthetase gene
  JOURNAL   Mamm Genome 4 (4), 211-219 (1993)
   PUBMED   8499655
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ082244.1, BC048497.1 and BE994006.1.
            
            On Dec 2, 2011 this sequence version replaced NM_134469.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2) is
            shorter at the N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087886.1, BC048497.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                CJ082244.1         1-22
            23-1242             BC048497.1         1-1220
            1243-1262           BE994006.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..1262
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.01 cM"
     gene            1..1262
                     /gene="Fdps"
                     /gene_synonym="6030492I17Rik; Fdpsl1; mKIAA1293"
                     /note="farnesyl diphosphate synthetase"
                     /db_xref="GeneID:110196"
                     /db_xref="MGI:MGI:104888"
     exon            1..106
                     /gene="Fdps"
                     /gene_synonym="6030492I17Rik; Fdpsl1; mKIAA1293"
                     /inference="alignment:Splign:2.1.0"
     exon            107..269
                     /gene="Fdps"
                     /gene_synonym="6030492I17Rik; Fdpsl1; mKIAA1293"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1190
                     /gene="Fdps"
                     /gene_synonym="6030492I17Rik; Fdpsl1; mKIAA1293"
                     /EC_number="2.5.1.1"
                     /EC_number="2.5.1.10"
                     /note="isoform 2 is encoded by transcript variant 2;
                     farnesyl pyrophosphate synthetase; farnesyl pyrophosphate
                     synthase; FPS; CR 39; FPP synthetase;
                     cholesterol-regulated 39 kDa protein; FPP synthase;
                     farnesyl diphosphate synthase; geranyltranstransferase;
                     dimethylallyltranstransferase; (2E,6E)-farnesyl
                     diphosphate synthase"
                     /codon_start=1
                     /product="farnesyl pyrophosphate synthase isoform 2"
                     /protein_id="NP_608219.1"
                     /db_xref="CCDS:CCDS17488.1"
                     /db_xref="GeneID:110196"
                     /db_xref="MGI:MGI:104888"
                     /translation="MNGNQKLDAYNQEKQNFIQHFSQIVKVLTEKELGHPEIGDAIAR
                     LKEVLEYNALGGKYNRGLTVVQAFQELVEPKKQDAESLQRALTVGWCVELLQAFFLVS
                     DDIMDSSLTRRGQICWYQKPGIGLDAINDALLLEASIYRLLKFYCREQPYYLNLLELF
                     LQSSYQTEIGQTLDLMTAPQGHVDLGRYTEKRYKSIVKYKTAFYSFYLPIAAAMYMAG
                     IDGEKEHANALKILMEMGEFFQVQDDYLDLFGDPSVTGKVGTDIQDNKCSWLVVQCLL
                     RASPQQRQILEENYGQKDPEKVARVKALYEALDLQSAFFKYEEDSYNRLKSLIEQCSA
                     PLPPSIFMELANKIYKRRK"
     exon            270..410
                     /gene="Fdps"
                     /gene_synonym="6030492I17Rik; Fdpsl1; mKIAA1293"
                     /inference="alignment:Splign:2.1.0"
     exon            411..491
                     /gene="Fdps"
                     /gene_synonym="6030492I17Rik; Fdpsl1; mKIAA1293"
                     /inference="alignment:Splign:2.1.0"
     exon            492..614
                     /gene="Fdps"
                     /gene_synonym="6030492I17Rik; Fdpsl1; mKIAA1293"
                     /inference="alignment:Splign:2.1.0"
     exon            615..703
                     /gene="Fdps"
                     /gene_synonym="6030492I17Rik; Fdpsl1; mKIAA1293"
                     /inference="alignment:Splign:2.1.0"
     exon            704..776
                     /gene="Fdps"
                     /gene_synonym="6030492I17Rik; Fdpsl1; mKIAA1293"
                     /inference="alignment:Splign:2.1.0"
     exon            777..854
                     /gene="Fdps"
                     /gene_synonym="6030492I17Rik; Fdpsl1; mKIAA1293"
                     /inference="alignment:Splign:2.1.0"
     exon            855..989
                     /gene="Fdps"
                     /gene_synonym="6030492I17Rik; Fdpsl1; mKIAA1293"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1245
                     /gene="Fdps"
                     /gene_synonym="6030492I17Rik; Fdpsl1; mKIAA1293"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1227..1232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fdps"
                     /gene_synonym="6030492I17Rik; Fdpsl1; mKIAA1293"
                     /note="hexamer: AATAAA"
     polyA_site      1245
                     /gene="Fdps"
                     /gene_synonym="6030492I17Rik; Fdpsl1; mKIAA1293"
                     /note="major polyA site"
ORIGIN      
        1 gagactggga actacaactc ccagagtgct gagcggatgc acgctcagct tttaggtgta
       61 agccgcaaac atcttggacc ccgggagaat ccgcgttgaa gaacagagca tttagctcct
      121 ctgtcagaat gaatgggaac cagaaattgg atgcttataa ccaagaaaag cagaatttca
      181 tccagcactt ctcccagatc gtcaaggtgc tgactgagaa ggagctggga cacccagaga
      241 taggggatgc tattgcccgg ctcaaggagg tcctagagta caatgcctta ggaggcaagt
      301 acaaccgggg tttgaccgtg gtacaagcct tccaggagct ggtggagccg aagaaacagg
      361 atgctgagag tcttcagcgg gccctgacag tgggctggtg tgtagaactg ctccaggctt
      421 tcttccttgt gtcagatgac atcatggact cttccctcac tcgccgggga cagatctgct
      481 ggtatcagaa gccaggcata ggcttggatg ccatcaacga cgctctgctt ctggaagcct
      541 ccatctatcg tttgctgaag ttctactgca gggagcagcc ctactacctg aacctgctgg
      601 agctctttct gcagagttcc tatcagacag agatcgggca gactctagac ctcatgacag
      661 caccccaggg ccatgtggat cttggtagat acactgaaaa gaggtacaaa tcgattgtca
      721 agtacaagac ggctttctac tctttctacc tgcctattgc ggccgccatg tacatggcag
      781 gcattgatgg ggagaaggaa cacgccaatg ccctgaagat cctgatggag atgggcgagt
      841 tcttccaggt ccaggacgac taccttgatc tctttggaga ccccagtgtg acgggaaagg
      901 tcggcactga catccaggac aacaaatgca gctggctggt ggttcagtgt ctgctacgag
      961 cctctcctca acagcgccag atcttagagg agaattatgg gcagaaggac ccagaaaaag
     1021 tggctcgggt gaaagcactg tatgaggcgc tggatctgca gtctgctttc ttcaagtatg
     1081 aggaagacag ttacaaccgc ctcaagagtc tcatagagca gtgctctgcg cccctgcccc
     1141 catccatctt catggaactt gcaaacaaga tctacaaacg gagaaagtga ccccggaatt
     1201 ggagaggctg ggagggaggg ggtctcaata aattattgtt caacaaaaaa aaaaaaaaaa
     1261 aa
//
