LOCUS       NM_001360211            2976 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus farnesyl diphosphate farnesyl transferase 1 (Fdft1),
            transcript variant 1, mRNA.
ACCESSION   NM_001360211
VERSION     NM_001360211.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2976)
  AUTHORS   Kaji,S., Berghoff,S.A., Spieth,L., Schlaphoff,L., Sasmita,A.O.,
            Vitale,S., Buschgens,L., Kedia,S., Zirngibl,M., Nazarenko,T.,
            Damkou,A., Hosang,L., Depp,C., Kamp,F., Scholz,P., Ewers,D.,
            Giera,M., Ischebeck,T., Wurst,W., Wefers,B., Schifferer,M.,
            Willem,M., Nave,K.A., Haass,C., Arzberger,T., Jakel,S., Wirths,O.,
            Saher,G. and Simons,M.
  TITLE     Apolipoprotein E aggregation in microglia initiates Alzheimer's
            disease pathology by seeding beta-amyloidosis
  JOURNAL   Immunity 57 (11), 2651-2668 (2024)
   PUBMED   39419029
  REMARK    Erratum:[Immunity. 2025 Jan 14;58(1):263. doi:
            10.1016/j.immuni.2024.11.024.. PMID: 39637851]
REFERENCE   2  (bases 1 to 2976)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2976)
  AUTHORS   Gamart,J., Barozzi,I., Laurent,F., Reinhardt,R., Martins,L.R.,
            Oberholzer,T., Visel,A., Zeller,R. and Zuniga,A.
  TITLE     SMAD4 target genes are part of a transcriptional network that
            integrates the response to BMP and SHH signaling during early limb
            bud patterning
  JOURNAL   Development 148 (23) (2021)
   PUBMED   34822715
REFERENCE   4  (bases 1 to 2976)
  AUTHORS   Luo,L., Ambrozkiewicz,M.C., Benseler,F., Chen,C., Dumontier,E.,
            Falkner,S., Furlanis,E., Gomez,A.M., Hoshina,N., Huang,W.H.,
            Hutchison,M.A., Itoh-Maruoka,Y., Lavery,L.A., Li,W., Maruo,T.,
            Motohashi,J., Pai,E.L., Pelkey,K.A., Pereira,A., Philips,T.,
            Sinclair,J.L., Stogsdill,J.A., Traunmuller,L., Wang,J., Wortel,J.,
            You,W., Abumaria,N., Beier,K.T., Brose,N., Burgess,H.A.,
            Cepko,C.L., Cloutier,J.F., Eroglu,C., Goebbels,S., Kaeser,P.S.,
            Kay,J.N., Lu,W., Luo,L., Mandai,K., McBain,C.J., Nave,K.A.,
            Prado,M.A.M., Prado,V.F., Rothstein,J., Rubenstein,J.L.R.,
            Saher,G., Sakimura,K., Sanes,J.R., Scheiffele,P., Takai,Y.,
            Umemori,H., Verhage,M., Yuzaki,M., Zoghbi,H.Y., Kawabe,H. and
            Craig,A.M.
  TITLE     Optimizing Nervous System-Specific Gene Targeting with Cre Driver
            Lines: Prevalence of Germline Recombination and Influencing Factors
  JOURNAL   Neuron 106 (1), 37-65 (2020)
   PUBMED   32027825
REFERENCE   5  (bases 1 to 2976)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2976)
  AUTHORS   Shimano,H., Horton,J.D., Hammer,R.E., Shimomura,I., Brown,M.S. and
            Goldstein,J.L.
  TITLE     Overproduction of cholesterol and fatty acids causes massive liver
            enlargement in transgenic mice expressing truncated SREBP-1a
  JOURNAL   J Clin Invest 98 (7), 1575-1584 (1996)
   PUBMED   8833906
REFERENCE   7  (bases 1 to 2976)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   8  (bases 1 to 2976)
  AUTHORS   Shirasawa,H., Kinoshita,T., Shino,Y., Mori,K., Shimizu,K. and
            Simizu,B.
  TITLE     Cloning and sequencing of the murine farnesyltransferase
            alpha-encoding cDNA from a cell line which expresses the human
            papillomavirus type-16 E6 gene
  JOURNAL   Gene 164 (2), 373-374 (1995)
   PUBMED   7590362
REFERENCE   9  (bases 1 to 2976)
  AUTHORS   Inoue,T., Osumi,T. and Hata,S.
  TITLE     Molecular cloning and functional expression of a cDNA for mouse
            squalene synthase
  JOURNAL   Biochim Biophys Acta 1260 (1), 49-54 (1995)
   PUBMED   7999794
REFERENCE   10 (bases 1 to 2976)
  AUTHORS   Shechter,I., Conrad,D.G., Hart,I., Berger,R.C., McKenzie,T.L.,
            Bleskan,J. and Patterson,D.
  TITLE     Localization of the squalene synthase gene (FDFT1) to human
            chromosome 8p22-p23.1
  JOURNAL   Genomics 20 (1), 116-118 (1994)
   PUBMED   8020937
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY293142.1, AK169317.1 and BC054722.1.
            
            [WARNING] On Mar 6, 2025 this sequence was replaced by
            NM_001360211.2.
            
            Transcript Variant: This variant (1) represents transcription from
            a major CAGE transcription cluster, and represents the shorter
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054722.1, BC138302.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BY293142.1         2-25
            25-1707             AK169317.1         2-1684
            1708-2976           BC054722.1         1614-2882
FEATURES             Location/Qualifiers
     source          1..2976
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 33.24 cM"
     gene            1..2976
                     /gene="Fdft1"
                     /gene_synonym="SQS; SS"
                     /note="farnesyl diphosphate farnesyl transferase 1"
                     /db_xref="GeneID:14137"
                     /db_xref="MGI:MGI:102706"
     exon            1..205
                     /gene="Fdft1"
                     /gene_synonym="SQS; SS"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1357
                     /gene="Fdft1"
                     /gene_synonym="SQS; SS"
                     /EC_number="2.5.1.21"
                     /note="FPP:FPP farnesyltransferase; farnesyl-diphosphate
                     farnesyltransferase"
                     /codon_start=1
                     /product="squalene synthase"
                     /protein_id="NP_001347140.1"
                     /db_xref="CCDS:CCDS27198.1"
                     /db_xref="GeneID:14137"
                     /db_xref="MGI:MGI:102706"
                     /translation="MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDQDSLSSSLKTCY
                     KYLNQTSRSFAAVIQALDGDIRHAICVFYLVLRALDTVEDDMSISVEKKIPLLCNFHT
                     FLYDPEWRFTESKEKDRQVLEDFPTISLEFRNLAEKYQTVIDDICHRMGCGMAEFVDK
                     DVTSKQDWDKYCHYVAGLVGIGLSRLFSASEFEDPIVGEDIECANSMGLFLQKTNIIR
                     DYLEDQQEGRKFWPQEVWGRYIKKLEDFAKPENVDVAVQCLNELITNTLQHIPDVLTY
                     LSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGVVKIRKGQAVTLMMDATNMPAV
                     KAIIYQYIEEIYHRIPNSDPSSSKTKQVISKIRTQNLPNCQLISRSHYSPIYLSFIML
                     LAALSWQYLSTLSQVTEDYVQREH"
     exon            206..303
                     /gene="Fdft1"
                     /gene_synonym="SQS; SS"
                     /inference="alignment:Splign:2.1.0"
     exon            304..487
                     /gene="Fdft1"
                     /gene_synonym="SQS; SS"
                     /inference="alignment:Splign:2.1.0"
     exon            488..616
                     /gene="Fdft1"
                     /gene_synonym="SQS; SS"
                     /inference="alignment:Splign:2.1.0"
     exon            617..808
                     /gene="Fdft1"
                     /gene_synonym="SQS; SS"
                     /inference="alignment:Splign:2.1.0"
     exon            809..985
                     /gene="Fdft1"
                     /gene_synonym="SQS; SS"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1138
                     /gene="Fdft1"
                     /gene_synonym="SQS; SS"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..2957
                     /gene="Fdft1"
                     /gene_synonym="SQS; SS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1694..1699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fdft1"
                     /gene_synonym="SQS; SS"
                     /note="hexamer: AATGAA"
     polyA_site      1726
                     /gene="Fdft1"
                     /gene_synonym="SQS; SS"
                     /note="major polyA site"
     regulatory      1904..1909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fdft1"
                     /gene_synonym="SQS; SS"
                     /note="hexamer: AATGAA"
     polyA_site      1929
                     /gene="Fdft1"
                     /gene_synonym="SQS; SS"
ORIGIN      
        1 gtccggcgct ggccccgcct cctcgccctg cccactcccc ggcgtctaaa cacaggtggg
       61 agcgggagat cccgacaggt gagccccgcg cccagcagtc gcaaggatgg agttcgtcaa
      121 gtgtctaggc cacccggagg agttctataa cctgctgcga ttccgcatgg gaggccggcg
      181 gaattttata cccaagatgg accaggactc actcagcagc agcttgaaga cctgctacaa
      241 gtatctcaat cagaccagtc gcagctttgc cgcggttatc caggcgctgg atggggacat
      301 acggcacgcc atatgtgtgt tctacctggt tctccgagcc ctggatacag tggaggatga
      361 catgagcatc agtgtggaga agaagatccc actgctgtgt aacttccaca ctttcctcta
      421 tgacccagag tggcggttca ctgagagcaa ggagaaggac cgacaagtgc tggaggactt
      481 ccccacgatc tccctggagt ttagaaattt ggctgagaaa tatcaaacag tgatcgatga
      541 catctgccac cggatggggt gtgggatggc agaatttgta gacaaggatg tgacctccaa
      601 acaggactgg gacaagtact gccactacgt tgctgggctg gtgggaattg gcctttctcg
      661 tctattctct gcctcagagt ttgaagaccc catagttggt gaagacatag agtgtgccaa
      721 ctcaatgggt ctgttcctgc agaaaacaaa tatcattcgt gattatctgg aagaccaaca
      781 ggaaggaagg aagttttggc ctcaggaggt gtggggcaga tacattaaga agttggaaga
      841 ctttgctaag ccagagaacg tagatgtggc cgtgcagtgc ttgaatgaac tcataaccaa
      901 caccctacag cacatccctg acgtcctcac ctacctgtca aggctccgga accagagtgt
      961 gtttaacttc tgtgctattc cacaggtaat ggccattgcc acactggctg cctgttacaa
     1021 taaccagcag gtattcaaag gagtagtgaa gattcggaag gggcaagcag tcaccctcat
     1081 gatggatgcc accaacatgc ctgccgtcaa agctatcata taccagtaca tagaagagat
     1141 ttatcaccgg atccccaact cagacccatc atcaagcaaa accaagcagg tcatctccaa
     1201 gatcaggaca cagaaccttc ccaactgcca gctcatctcc cgaagccact actcccccat
     1261 ttacctgtca tttatcatgc tcttggctgc cctgagctgg cagtacctga gcaccctgtc
     1321 ccaggtcaca gaagactatg tccagagaga acactgattt tgtttagccg gaagtggaag
     1381 ttcccgtgga gtgggttttt ccttttcctc cagctggatt ttgacttccc ttgtttttcc
     1441 tcctactcta aaatctttgg gagaactgag tgtgggacct ttaggaactg ggcagaggaa
     1501 aggatgcctt gccctcagca gcctggtgct ggctgggact tggttcctct gcctcttgta
     1561 gccactggca gcgtgccgac tgctgcactt gtgaggccac gtgtgatggt cacaagagcc
     1621 tagtgaacct ggctagaatg ctgattggat ttatttaatt tgaaacagcc tttgaatacc
     1681 tatgacaata gaaaatgaaa gcaactggtc cttgtctttc tcatgagttt gacagtggaa
     1741 gtgttaatcc gtgttgttct gcgcgatgct gtgagctccc gagactgcag gcttggcctt
     1801 ctcacccagg gggagcttaa gcccccatcg gtgccgttgg ccacttgtca gcgcgtcctc
     1861 caggaaaggc ttttgatgtt gagatttttt tgtaatagca tagaatgaat gcacacagta
     1921 acatgctcac atcccttgta aggactgagt ttgtccggtg cagctcacct gaaagcccag
     1981 aaagatggcc tagtgatctc aggactgggt cctccatcac cacagcaaga gtgttgctga
     2041 tgagggtaag gaaagcaggc agtgcggtca cctctctgct ttagcctgcc actgctgttt
     2101 gcccctccct ccagtctcct ctacagtcat ttgctttggt ttttcttgaa gtctcaaaag
     2161 acaaatgatg acaggaaaac cagttctata ttggtaggtt tttaattgca gcgtggttag
     2221 ttggctacat tgtcatggtg gcctctgaca ccctgtgtat ctgaaaacca gtgtttgagc
     2281 ggtggagagg ctctaggcaa ccactctgac tgtaggacaa gatacctgag gccaactgct
     2341 ttaccaagga aagaggattg tttatgtaac agcttaggag gatgaaagta caagatgagg
     2401 ggggccccat ctttagccct tggacggcct tgtgagaaat gacactacag tagagagagg
     2461 acatgcagga gagagcacgt gacaggaagc aggagtcgac gccctggcat gctgacactt
     2521 gtacactgta actgtagctc aggttggcct gcaagtctat gtagccttga atttaatggt
     2581 gatcccactg cctcagcctt ctgaatgtac gagttatagg cacgagccac cccactgttg
     2641 tccacagagc ttggtctctg gagccctaac tctggaagac tagcattgag cccttttgag
     2701 aacagtgcct cagctacctg tcattttgtg aacctgtata tgaccctttg gggtacgctc
     2761 agaccacaga gacatgtaga gcatagtctg ctcccctctt aagcctgctg cgtatgttga
     2821 cttcatcact gaggtgcctc ggccagttca gtggtccatt caactttgta agcacagatt
     2881 ccttgctgga ttactggggc atggagactt cattggtcac ttgctctaag ccttgaacaa
     2941 ataccacccc gctgaaaaaa aaaaaaaaaa aaaaaa
//
