LOCUS       NM_172283               3874 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Mus musculus fucose kinase (Fcsk), transcript variant 1, mRNA.
ACCESSION   NM_172283 NM_181666
VERSION     NM_172283.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3874)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3874)
  AUTHORS   Ng,B.G., Rosenfeld,J.A., Emrick,L., Jain,M., Burrage,L.C., Lee,B.,
            Craigen,W.J., Bearden,D.R., Graham,B.H. and Freeze,H.H.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     Pathogenic Variants in Fucokinase Cause a Congenital Disorder of
            Glycosylation
  JOURNAL   Am J Hum Genet 103 (6), 1030-1037 (2018)
   PUBMED   30503518
REFERENCE   3  (bases 1 to 3874)
  AUTHORS   Miller,E.N., Rupp,A.L., Lindberg,M.K. and Wiese,T.J.
  TITLE     Tissue distribution of L-fucokinase in rodents
  JOURNAL   Comp Biochem Physiol B Biochem Mol Biol 140 (3), 513-520 (2005)
   PUBMED   15694600
REFERENCE   4  (bases 1 to 3874)
  AUTHORS   Niittymaki,J., Mattila,P., Roos,C., Huopaniemi,L., Sjoblom,S. and
            Renkonen,R.
  TITLE     Cloning and expression of murine enzymes involved in the salvage
            pathway of GDP-L-fucose
  JOURNAL   Eur J Biochem 271 (1), 78-86 (2004)
   PUBMED   14686921
  REMARK    GeneRIF: cloning, expression and tissue distribution of murine
            L-fucokinase and GDP-L-fucose pyrophosphorylase
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK161763.1, AY223865.1 and AK164340.1.
            
            On or before Jun 14, 2012 this sequence version replaced
            NM_181666.1, NM_172283.2.
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ534942.1, AY223865.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AK161763.1         1-29
            30-3862             AY223865.1         1-3833
            3863-3874           AK164340.1         3930-3941
FEATURES             Location/Qualifiers
     source          1..3874
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.79 cM"
     gene            1..3874
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /note="fucose kinase"
                     /db_xref="GeneID:234730"
                     /db_xref="MGI:MGI:1916071"
     exon            1..67
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            68..172
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..3363
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /EC_number="2.7.1.52"
                     /note="mFLJ00241 protein; fucokinase"
                     /codon_start=1
                     /product="L-fucose kinase"
                     /protein_id="NP_758487.2"
                     /db_xref="CCDS:CCDS22666.1"
                     /db_xref="GeneID:234730"
                     /db_xref="MGI:MGI:1916071"
                     /translation="MEQSEGVNWTVIILTCQYKDSVQVFQRELEVRQRREQIPAGTML
                     LAVEDPQTRVGSGGATLNALLVAAEHLSARAGFTVVTSDVLHSAWILILHMGRDFPFD
                     DCGRAFTCLPVENPQAPVEALVCNLDCLLDIMTHRLGPGSPPGVWVCSTDMLLSVPPN
                     PGISWDGFRGARVIAFPGSLAYALNHGVYLTDSQGLVLDIYYQGTKAEIQRCVGPDGL
                     VPLVSGVVFFSVETAEHLLATHVSPPLDACTYMGLDSGAQPVQLSLFFDILLCMARNM
                     SRENFLAGRPPELGQGDMDVASYLKGARAQLWRELRDQPLTMVYVPDGGYSYMTTDAT
                     EFLHRLTMPGVAVAQIVHSQVEEPQLLEATCSVVSCLLEGPVHLGPRSVLQHCHLRGP
                     IRIGAGCFVSGLDTAHSEALHGLELHDVILQGHHVRLHGSLSRVFTLAGRLDSWERQG
                     AGMYLNMSWNEFFKKTGIRDWDLWDPDTPPSDRCLLTARLFPVLHPTRALGPQDVLWM
                     LHPRKHRGEALRAWRASWRLSWEQLQPCVDRAATLDFRRDLFFCQALQKARHVLEARQ
                     DLCLRPLIRAAVGEGCSGPLLATLDKVAAGAEDPGVAARALACVADVLGCMAEGRGGL
                     RSGPAANPEWIQPFSYLECGDLMRGVEALAQEREKWLTRPALLVRAARHYEGAEQILI
                     RQAVMTARHFVSTQPVELPAPGQWVVTECPARVDFSGGWSDTPPIAYELGGAVLGLAV
                     RVDGRRPIGAKARRIPEPELWLAVGPRQDEMTMRIVCRSLDDLRDYCQPHAPGALLKA
                     AFICAGIVHLHSELPLLEQLLHSFNGGFELHTWSELPHGSGLGTSSILAGAALAALQR
                     AAGRAVGTEALIHAVLHLEQVLTTGGGWQDQVSGLMPGIKVGRSRAQLPLKVEVEEIT
                     VPEGFVQKINDHLLLVYTGKTRLARNLLQDVLRNWYARLPVVVQNARRLVRQTEKCAE
                     AFRQGNLPLLGQYLTSYWEQKKLMAPGCEPLAVQRMMDVLAPYAYGQSLAGAGGGGFL
                     YLLTKEPRQKETLEAVLAKAEGLGNYSVHLVEVDPQGLSLQLLGHDTRLCGAGPSEVG
                     TT"
     exon            173..324
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            325..375
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            376..501
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            502..574
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            575..672
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            673..753
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            754..873
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1045
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1158
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1260
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1431
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1496
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1867
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2078
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2245
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2467
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2611
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2731
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2919
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..3019
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            3020..3243
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /inference="alignment:Splign:2.1.0"
     exon            3244..3874
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3844..3849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /note="hexamer: AATAAA"
     polyA_site      3862
                     /gene="Fcsk"
                     /gene_synonym="1110046B12Rik; Fuk"
                     /note="major polyA site"
ORIGIN      
        1 agggtgcgcc gcgctgcatg cgcagccgcg ttaaagagcc ggctctgcga gcgctgggcg
       61 gacgcaggaa gcccctccat tttggccaga atggagcagt cagagggagt caattggact
      121 gtcattatcc tgacatgcca gtacaaggac agtgtccagg tctttcagag agagctggag
      181 gtaaggcaga gacgggagca gattcctgcg gggacgatgt tactggctgt ggaggatccc
      241 cagactcgag tcggcagcgg aggagccacc ctcaacgcac tgctggtggc tgctgaacac
      301 ttgagtgccc gagctggctt cactgtggtc acgtccgatg tcctgcactc tgcctggatc
      361 ctcatcttgc acatgggccg agacttcccc ttcgatgact gtggcagggc cttcacttgc
      421 ctccctgtgg agaacccaca ggcccctgtg gaggccttgg tatgcaacct ggactgcctg
      481 ttggatatca tgacccaccg gctgggtcca ggttccccac caggtgtgtg ggtctgcagc
      541 accgacatgc ttctgtctgt tcctccaaac cctgggatca gttgggatgg cttccgggga
      601 gccagagtga tcgcctttcc tgggagcctg gcctatgcgt tgaaccacgg tgtctacctc
      661 actgactcac agggcttggt tttggacatt tactaccagg gcactaaggc ggagatacaa
      721 cgttgtgtcg gacctgatgg gctggtacca ttggtctccg gggtcgtctt cttctctgtg
      781 gagactgctg agcacctcct agccacccat gtgagcccac cgctggatgc ctgcacctat
      841 atgggcttgg actctggagc ccagcctgtg cagctgtctc tgtttttcga catcctgctc
      901 tgcatggctc ggaatatgag cagggagaac ttcctggctg ggcggccccc ggagttgggg
      961 caaggtgaca tggatgtagc aagttacctg aagggagccc gggcccagct gtggagggag
     1021 cttcgagatc agcccctcac aatggtgtat gtccctgacg gcggctacag ctacatgacg
     1081 actgatgcca ccgagttcct gcacagactc acgatgcctg gagtagctgt ggcacagatt
     1141 gttcactccc aggtggagga gccacagctg ctagaggcta cgtgctcggt ggtcagctgc
     1201 ctgctcgagg gccctgtgca cctggggcct cgaagtgtcc tgcagcactg tcacctgagg
     1261 ggccccattc gcatcggcgc tggctgcttt gtgagtggtc tggatacagc ccactcggag
     1321 gcactgcatg gcctggagct ccatgatgtc atcctgcagg gacaccatgt gcggctgcat
     1381 ggctccctga gccgtgtatt tactcttgct ggccgtctgg acagctggga aagacagggg
     1441 gcaggcatgt atctcaacat gtcctggaat gagttcttca agaagacagg cattcgagac
     1501 tgggacctgt gggacccaga tacacccccc tcagatcgat gcctcctcac tgcccgcctt
     1561 ttccctgtgc tccaccccac gagggccctg gggccccagg atgtgctgtg gatgctgcac
     1621 ccccgcaaac acagaggtga ggcccttcgg gcctggcgag cctcctggcg tctgtcctgg
     1681 gagcagctgc aaccttgtgt ggaccgggct gccacactgg acttccgccg agatctgttc
     1741 ttctgccagg ccttgcagaa ggcaaggcat gtgttagagg cgcggcagga cctctgccta
     1801 cgtccactga tccgggccgc tgtcggggaa ggttgctctg ggcccctgct ggccacactt
     1861 gacaaggttg cagctggggc agaagatcct ggcgtggcag cccgggctct ggcttgtgtg
     1921 gccgatgtgc tgggctgcat ggcagagggc cgaggaggct tgcgcagtgg gccagctgcc
     1981 aaccctgagt ggattcagcc tttctcatac ttggagtgtg gagacctgat gaggggtgtg
     2041 gaggcgcttg cccaggagag agagaagtgg ctgaccaggc ctgccttgct ggttcgagct
     2101 gcccgccatt acgagggggc cgagcagatc ctgatccgcc aggctgtgat gacagcccgg
     2161 cacttcgtct ccacccagcc cgtggagctg cccgcacccg ggcagtgggt ggtgactgag
     2221 tgcccagccc gtgtggattt ctctgggggc tggagtgaca caccgcccat tgcctatgag
     2281 cttggtggag cagtgttggg cctggctgtg cgggtggatg gccgccggcc catcggggcc
     2341 aaagcacgcc gcatcccgga gcctgagctc tggctggcag tgggacctcg gcaggatgag
     2401 atgaccatga ggatagtgtg ccggagcctg gatgacctgc gggattactg ccagcctcat
     2461 gccccagggg ccttgctgaa ggcagccttt atctgtgctg gcattgtgca tctccactca
     2521 gagctccctc tgcttgaaca gttgttacac tcctttaatg gtggctttga gctgcacacg
     2581 tggtcagagc tgccgcacgg ctctggtctt ggcaccagca gcatcctggc aggggctgcc
     2641 ctggctgcct tacagcgggc tgcaggccgg gcagtgggca cggaggctct catccacgca
     2701 gtgctgcacc tggagcaggt gctcaccaca ggaggtggct ggcaggacca agtcagtggc
     2761 ctaatgcctg gcatcaaagt ggggcgctcc cgggcccagc tgcccctcaa ggtggaggtg
     2821 gaggaaatca ctgtgcctga gggctttgtc cagaagatca atgaccatct gctcctggtt
     2881 tataccggca agacccgatt ggcccggaat ctgctgcagg acgtgctgag gaactggtac
     2941 gctcggttgc ccgttgtggt acagaatgcc cgcagactgg tgcgacagac cgagaagtgc
     3001 gctgaagctt tccgccaagg aaacctgcct ctgctgggac agtacctgac ctcatactgg
     3061 gagcagaaga agcttatggc cccaggctgc gagccgctgg ccgtgcagcg aatgatggat
     3121 gtcctggccc cgtatgcgta tggccaaagc ctggcagggg caggtggtgg gggctttctc
     3181 tatctattga ccaaggaacc ccggcagaaa gagactctgg aagctgtcct ggccaaggct
     3241 gagggccttg gcaactacag tgtccacctg gtggaagtgg atcctcaggg cctgagcctg
     3301 cagctgctgg gacacgacac ccgtctttgt ggggccgggc cctctgaagt gggcaccacc
     3361 tagagctgca gctgcgcgtc ccttcagtgg ggctcacttt gttatccctt acctacctct
     3421 tcaagtctgc tgctaaggaa ggaagcaaga cttggacaga agaggcagtg tttgcaaaca
     3481 gtactgtgct tcatggtggg cagtggctga gacttggcct ctatctcatc tggattaagg
     3541 gaggtcttag tcacagtgtc tcatgtgcac tctacaaatt ccatggccca gtgtaggcct
     3601 cctagggccc tgcaaaggat gacaatcaga ccaactctaa agatagactt tcaggcattc
     3661 ccataccaac tctgattcta cagcaggggc cagggaagag tgaaggtgtg ttctcaggtc
     3721 tgtggtagtg aaccactctc tgccacagtc tacagcaagc ttttgataac ctaagccttt
     3781 ctaacaacac tacagtgtca aaggaacctg ggggtagtgg gttctcaaca cccgcatcct
     3841 tggaataaat tctaattttc aagtttgtct tcag
//
