LOCUS       NM_001029984            1284 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus Fc receptor-like B (Fcrlb), mRNA.
ACCESSION   NM_001029984
VERSION     NM_001029984.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1284)
  AUTHORS   Chessum,L., Matern,M.S., Kelly,M.C., Johnson,S.L., Ogawa,Y.,
            Milon,B., McMurray,M., Driver,E.C., Parker,A., Song,Y., Codner,G.,
            Esapa,C.T., Prescott,J., Trent,G., Wells,S., Dragich,A.K.,
            Frolenkov,G.I., Kelley,M.W., Marcotti,W., Brown,S.D.M., Elkon,R.,
            Bowl,M.R. and Hertzano,R.
  TITLE     Helios is a key transcriptional regulator of outer hair cell
            maturation
  JOURNAL   Nature 563 (7733), 696-700 (2018)
   PUBMED   30464345
REFERENCE   2  (bases 1 to 1284)
  AUTHORS   Jackson,T.A., Haga,C.L., Ehrhardt,G.R., Davis,R.S. and Cooper,M.D.
  TITLE     FcR-like 2 Inhibition of B cell receptor-mediated activation of B
            cells
  JOURNAL   J Immunol 185 (12), 7405-7412 (2010)
   PUBMED   21068405
  REMARK    GeneRIF: a negative immunomodulatory function for FCRL2 in the
            regulation of memory B cells.
REFERENCE   3  (bases 1 to 1284)
  AUTHORS   Masuda,K., Mori,H., Ohara,O., Nakayama,M., Wang,J.Y. and
            Burrows,P.D.
  TITLE     Defining the immunological phenotype of Fc receptor-like B (FCRLB)
            deficient mice: Confounding role of the inhibitory FcgammaRIIb
  JOURNAL   Cell Immunol 266 (1), 24-31 (2010)
   PUBMED   20869045
  REMARK    GeneRIF: In FCRLB knock-out mice, B-cell developmemt and in vitro
            response were normal, but in vivo antibody responses to a
            T-dependent antigen were elevated. The latter response may be due
            to a promoter polymorphism in the 129/Sv knock-out strain's Fcgr2b
            allele.
REFERENCE   4  (bases 1 to 1284)
  AUTHORS   Fayngerts,S.A., Najakshin,A.M. and Taranin,A.V.
  TITLE     Species-specific evolution of the FcR family in endothermic
            vertebrates
  JOURNAL   Immunogenetics 59 (6), 493-506 (2007)
   PUBMED   17356879
REFERENCE   5  (bases 1 to 1284)
  AUTHORS   Taylor,A.I., Gould,H.J., Sutton,B.J. and Calvert,R.A.
  TITLE     The first avian Ig-like Fc receptor family member combines features
            of mammalian FcR and FCRL
  JOURNAL   Immunogenetics 59 (4), 323-328 (2007)
   PUBMED   17273841
REFERENCE   6  (bases 1 to 1284)
  AUTHORS   Maltais,L.J., Lovering,R.C., Taranin,A.V., Colonna,M.,
            Ravetch,J.V., Dalla-Favera,R., Burrows,P.D., Cooper,M.D. and
            Davis,R.S.
  TITLE     New nomenclature for Fc receptor-like molecules
  JOURNAL   Nat Immunol 7 (5), 431-432 (2006)
   PUBMED   16622424
REFERENCE   7  (bases 1 to 1284)
  AUTHORS   Masuda,K., Davis,R.S., Maruyama,T., Zhang,J., He,T., Cooper,M.D.,
            O-Wang,J. and Burrows,P.D.
  TITLE     FcRY, an Fc receptor related gene differentially expressed during B
            lymphocyte development and activation
  JOURNAL   Gene 363, 32-40 (2005)
   PUBMED   16263223
  REMARK    GeneRIF: Fcry is upregulated by short-term treatment with
            BAFF/BLyS, which promotes B cell survival rather than proliferation
REFERENCE   8  (bases 1 to 1284)
  AUTHORS   Wilson,T.J. and Colonna,M.
  TITLE     A new Fc receptor homolog, FREB2, found in germinal center B cells
  JOURNAL   Genes Immun 6 (4), 341-346 (2005)
   PUBMED   15815692
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ119292.1 and AC113490.10.
            
            On Mar 30, 2007 this sequence version replaced NM_001029984.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY513660.1, DQ119292.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                DQ119292.1         1-69
            70-307              AC113490.10        9377-9614
            308-574             AC113490.10        12741-13007
            575-853             AC113490.10        13510-13788
            854-1284            AC113490.10        13936-14366
FEATURES             Location/Qualifiers
     source          1..1284
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 77.56 cM"
     gene            1..1284
                     /gene="Fcrlb"
                     /gene_synonym="FcRL2; Fcrlm2; Fcry; FREB-2; FREB2; mFCRL2"
                     /note="Fc receptor-like B"
                     /db_xref="GeneID:435653"
                     /db_xref="MGI:MGI:3576487"
     CDS             1..1284
                     /gene="Fcrlb"
                     /gene_synonym="FcRL2; Fcrlm2; Fcry; FREB-2; FREB2; mFCRL2"
                     /note="Fc receptor-like mucin-like 2; fc receptor-like
                     protein 2; fc receptor-related protein Y; fc receptor-like
                     and mucin-like protein 2; fc receptor homolog expressed in
                     B cells protein 2; Fc receptor related Y; Fc receptor
                     homolog expressed in B-cells protein 2"
                     /codon_start=1
                     /product="Fc receptor-like B precursor"
                     /protein_id="NP_001025155.2"
                     /db_xref="CCDS:CCDS15475.1"
                     /db_xref="GeneID:435653"
                     /db_xref="MGI:MGI:3576487"
                     /translation="MWMLAALLLLVPRSGKAATLEKPVLTLHPPWTTIFKGERVTLRC
                     DGYHPLLLELRPISTLWYLGHVLLPSHKKSIEVQAPGVYRCQTRGAPVSDPIHLSVSN
                     DWLILQVPYAAVFEGEPLVMRCRGWYDKVVYKLHYYHDGQAVRYFHSSTNYTVLQARA
                     SDSGHYQCSGTMRIPVESAPMFSSKVAVTVQELFQTPVLRTLSPQEARGRVVLRCETR
                     LHPQKRDTPLQFAFYKYSRPVRRFDWGAEYTVPESEVEELESYWCEAATTSRSVRKRS
                     PWLQLPGRGPVLDLASTTAPVAQAAALGPGDKPLSFRKTPVSRSVQSVTSIPNSTFAG
                     LQFPAGHVATAGPHACAPLPASAEQSREALQPKVDLLLREMQLLKGLLSRVVLGLKDP
                     QALHELTETPETPNSHVTVNPATPETTVMEGRVDS"
     exon            1..31
                     /gene="Fcrlb"
                     /gene_synonym="FcRL2; Fcrlm2; Fcry; FREB-2; FREB2; mFCRL2"
                     /inference="alignment:Splign:2.1.0"
     exon            32..52
                     /gene="Fcrlb"
                     /gene_synonym="FcRL2; Fcrlm2; Fcry; FREB-2; FREB2; mFCRL2"
                     /inference="alignment:Splign:2.1.0"
     exon            53..307
                     /gene="Fcrlb"
                     /gene_synonym="FcRL2; Fcrlm2; Fcry; FREB-2; FREB2; mFCRL2"
                     /inference="alignment:Splign:2.1.0"
     exon            308..574
                     /gene="Fcrlb"
                     /gene_synonym="FcRL2; Fcrlm2; Fcry; FREB-2; FREB2; mFCRL2"
                     /inference="alignment:Splign:2.1.0"
     exon            575..853
                     /gene="Fcrlb"
                     /gene_synonym="FcRL2; Fcrlm2; Fcry; FREB-2; FREB2; mFCRL2"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1284
                     /gene="Fcrlb"
                     /gene_synonym="FcRL2; Fcrlm2; Fcry; FREB-2; FREB2; mFCRL2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtggatgc ttgcagccct cctgcttctg gttccaagaa gtggaaaagc tgctactctg
       61 gagaagcctg tactgactct acacccacct tggaccacca tcttcaaggg agagcgagta
      121 accctgagat gtgatggata ccaccctctg ctgctggagc tccggcccat tagcactctc
      181 tggtacctgg gccatgtcct cctgccttcc cacaagaaga gcatcgaggt gcaggcacca
      241 ggggtgtatc gatgtcagac acgaggagca cccgtcagtg atcctatcca cctctctgtg
      301 tctaacgact ggctaattct gcaagtgccg tatgctgcgg tgttcgaggg agagcccttg
      361 gtgatgcgct gccgtggctg gtacgacaaa gtcgtctaca aacttcacta ctaccacgac
      421 ggccaggctg tgagatattt ccactctagc accaactaca cggtgctgca agcgcgagcc
      481 agcgacagcg gtcactacca gtgctctggc accatgcgta tcccagtgga gagtgcgccc
      541 atgttctcct ccaaggtggc cgtgaccgtg caagagctgt tccagacacc ggtgctgagg
      601 acgttaagcc cgcaggaggc gcgcggccgc gtggtgctgc gctgcgagac gcgcctgcac
      661 ccgcagaagc gggacacgcc gctgcagttc gccttctaca agtacagccg gccggtgcgc
      721 cgcttcgact ggggcgccga gtacactgtc cccgagtccg aggtcgagga gctcgaatcg
      781 tactggtgtg aggccgccac caccagccgg agtgtacgga aacgcagccc gtggctgcag
      841 ctccctgggc ggggccctgt cctggatctg gcgtccacca ccgcgccagt cgcacaggct
      901 gcagccttgg ggccggggga caagccgctt tccttccgga agaccccagt gtccagatcc
      961 gttcagtcag tcacttccat cccgaacagc acctttgcag ggctgcagtt ccccgcgggc
     1021 catgttgcca ccgccgggcc acacgcctgc gcgcccctgc cagcgtccgc ggagcagtcg
     1081 cgcgaagctc ttcagcccaa ggtggacctc ctgcttcgcg agatgcagct gctcaaaggc
     1141 cttctgagcc gcgtggtcct gggattaaag gacccacagg ccctccatga gcttacagag
     1201 acccccgaga cacccaattc tcacgttact gtgaaccccg caaccccaga gaccactgtc
     1261 atggagggcc gagtggacag ctag
//
