LOCUS       NM_001160215            1661 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus Fc receptor-like A (Fcrla), transcript variant 1,
            mRNA.
ACCESSION   NM_001160215
VERSION     NM_001160215.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1661)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1661)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 1661)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1661)
  AUTHORS   Reshetnikova,E.S., Mechetina,L.V., Volkova,O.Y., Guselnikov,S.V.,
            Chikaev,N.A., Kovesdi,D., Alabyev,B., Sarmay,G., Burrows,P.D.,
            Najakshin,A.M. and Taranin,A.V.
  TITLE     Differential expression of FCRLA in naive and activated mouse B
            cells
  JOURNAL   Cell Immunol 272 (2), 182-192 (2012)
   PUBMED   22078318
  REMARK    GeneRIF: High expression of FCRLA in subset(s) of terminally
            differentiated B-cells suggests that, being an ER protein, FCRLA
            may participate in the regulation of immunoglobulin assembly and
            secretion.
REFERENCE   5  (bases 1 to 1661)
  AUTHORS   Wilson,T.J., Gilfillan,S. and Colonna,M.
  TITLE     Fc receptor-like A associates with intracellular IgG and IgM but is
            dispensable for antigen-specific immune responses
  JOURNAL   J Immunol 185 (5), 2960-2967 (2010)
   PUBMED   20668221
  REMARK    GeneRIF: FcRLA protein is expressed exclusively in all mouse B
            cells, where it plays a role in immunoglobulin assembly that can be
            compensated for by other proteins.
REFERENCE   6  (bases 1 to 1661)
  AUTHORS   Wilson,T.J. and Colonna,M.
  TITLE     A new Fc receptor homolog, FREB2, found in germinal center B cells
  JOURNAL   Genes Immun 6 (4), 341-346 (2005)
   PUBMED   15815692
REFERENCE   7  (bases 1 to 1661)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   8  (bases 1 to 1661)
  AUTHORS   Davis,R.S., Li,H., Chen,C.C., Wang,Y.H., Cooper,M.D. and
            Burrows,P.D.
  TITLE     Definition of an Fc receptor-related gene (FcRX) expressed in human
            and mouse B cells
  JOURNAL   Int Immunol 14 (9), 1075-1083 (2002)
   PUBMED   12202404
  REMARK    GeneRIF: may function as a secreted or intracellular protein in
            normal and neoplastic B cells
REFERENCE   9  (bases 1 to 1661)
  AUTHORS   Facchetti,F., Cella,M., Festa,S., Fremont,D.H. and Colonna,M.
  TITLE     An unusual Fc receptor-related protein expressed in human
            centroblasts
  JOURNAL   Proc Natl Acad Sci U S A 99 (6), 3776-3781 (2002)
   PUBMED   11891275
REFERENCE   10 (bases 1 to 1661)
  AUTHORS   Mechetina,L.V., Najakshin,A.M., Volkova,O.Y., Guselnikov,S.V.,
            Faizulin,R.Z., Alabyev,B.Y., Chikaev,N.A., Vinogradova,M.S. and
            Taranin,A.V.
  TITLE     FCRL, a novel member of the leukocyte Fc receptor family possesses
            unique structural features
  JOURNAL   Eur J Immunol 32 (1), 87-96 (2002)
   PUBMED   11754007
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC064708.1 and BB219290.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064708.1, AF531424.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1377              BC064708.1         1-1377
            1378-1661           BB219290.2         395-678
FEATURES             Location/Qualifiers
     source          1..1661
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 77.65 cM"
     gene            1..1661
                     /gene="Fcrla"
                     /gene_synonym="FCRL; FCRL1; Fcrlm1; Fcrx; FREB; Freb1;
                     mFcrX; mFREB"
                     /note="Fc receptor-like A"
                     /db_xref="GeneID:98752"
                     /db_xref="MGI:MGI:2138647"
     exon            1..122
                     /gene="Fcrla"
                     /gene_synonym="FCRL; FCRL1; Fcrlm1; Fcrx; FREB; Freb1;
                     mFcrX; mFREB"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1105
                     /gene="Fcrla"
                     /gene_synonym="FCRL; FCRL1; Fcrlm1; Fcrx; FREB; Freb1;
                     mFcrX; mFREB"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; Fc receptor-like mucin-like 1; Fc receptor
                     related protein X; fc receptor-like protein; fc
                     receptor-related protein X; fc receptor homolog expressed
                     in B-cells; fc receptor-like and mucin-like protein 1; Fc
                     receptor related X"
                     /codon_start=1
                     /product="Fc receptor-like A isoform 1 precursor"
                     /protein_id="NP_001153687.1"
                     /db_xref="CCDS:CCDS48440.1"
                     /db_xref="GeneID:98752"
                     /db_xref="MGI:MGI:2138647"
                     /translation="MKLSCTLTQWALYVCPAVLLATQMLLAAASSETLKCEGLVSTEQ
                     GSCQAAAEEDEGDEDDGDMTQSSEAGFQFKGYTFSKPFHLSVSYDWLILQGPATLIFE
                     GDTLVLHCRAWQDWPLTQVIFYREGSALGPPGPKSEFSITMVQKSDGGHYHCSGIFRS
                     PGPGSREAASPVAITVQELFAAPVLKALPSSEPQEGGSVTLSCQTKLALQRSASRLLF
                     SFYKDGRSLSVRGVSSELKIPKASEEHSGSYWCEAVTEDRQISKQSPQLEIWVQALQK
                     PTASETPPTEALGPLPPPPASSAEQPRFSSPDPHLHHQMQLLLKQIQDVRALLGHLVM
                     ELRDLSVYLKPGTTKVADK"
     exon            123..308
                     /gene="Fcrla"
                     /gene_synonym="FCRL; FCRL1; Fcrlm1; Fcrx; FREB; Freb1;
                     mFcrX; mFREB"
                     /inference="alignment:Splign:2.1.0"
     exon            309..575
                     /gene="Fcrla"
                     /gene_synonym="FCRL; FCRL1; Fcrlm1; Fcrx; FREB; Freb1;
                     mFcrX; mFREB"
                     /inference="alignment:Splign:2.1.0"
     exon            576..860
                     /gene="Fcrla"
                     /gene_synonym="FCRL; FCRL1; Fcrlm1; Fcrx; FREB; Freb1;
                     mFcrX; mFREB"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1661
                     /gene="Fcrla"
                     /gene_synonym="FCRL; FCRL1; Fcrlm1; Fcrx; FREB; Freb1;
                     mFcrX; mFREB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1237..1242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fcrla"
                     /gene_synonym="FCRL; FCRL1; Fcrlm1; Fcrx; FREB; Freb1;
                     mFcrX; mFREB"
                     /note="hexamer: AATAAA"
     polyA_site      1265
                     /gene="Fcrla"
                     /gene_synonym="FCRL; FCRL1; Fcrlm1; Fcrx; FREB; Freb1;
                     mFcrX; mFREB"
                     /note="major polyA site"
ORIGIN      
        1 aaatcagtat gttggggttg caggaggtat aaacccagtc accatgaagc tgagctgcac
       61 gctcacacag tgggcccttt atgtctgccc tgctgtgctc ctggcaaccc agatgttact
      121 ggcagctgcc agttcagaga ctctgaagtg tgaaggactt gtcagcactg agcaaggcag
      181 ctgccaggct gctgctgagg aagacgaggg tgatgaagat gatggcgata tgacccaatc
      241 cagtgaagct ggcttccagt tcaagggcta cacattcagt aaacccttcc atctcagcgt
      301 gtcctatgac tggctgatcc ttcaaggtcc agctacattg atatttgaag gagacacatt
      361 ggttctgcac tgccgcgcct ggcaagactg gccactgact caggttatct tctaccgaga
      421 gggctccgcc ttgggtcctc ctggacctaa aagtgaattc tccatcacca tggtgcaaaa
      481 gtcagacggt gggcactacc actgcagtgg catcttcagg agccctggtc ctgggagccg
      541 agaggctgca tcccctgtgg ctatcactgt ccaagagttg tttgcagccc cagttctcaa
      601 agccttacct tctagtgagc cccaagaggg aggctcagta accctgagct gtcagacaaa
      661 gctggccctg cagaggtcag cttcccgcct cctcttctct ttctacaagg atggaaggtc
      721 actgagtgtc agaggagtct cttcagaact caagatcccc aaagcctcag aagaacactc
      781 tggctcctac tggtgtgagg cagtgactga ggacagacag atttcgaagc agagcccaca
      841 actggagatc tgggtacagg ctcttcagaa accaaccgct tcggaaactc ctcccacaga
      901 agctctcggt cctctgcccc caccacctgc ttcttctgct gagcagccaa gattctcctc
      961 cccagacccc caccttcatc accagatgca gcttcttctc aaacaaatac aagatgtaag
     1021 agctctcctc ggtcatctgg tcatggagct gagggacttg tctgtctacc tgaagcctgg
     1081 taccacgaag gttgctgaca aatgaaagtg agctattcac ctgcgctata ttcaaccacc
     1141 gcaataattc cagctctttc tggactatgc atatacaggc atagttttgc aagctggttt
     1201 gatacttagt taaactaatg gaactgttcg agtgtaaata aatgcataca gggttatacc
     1261 cagaatttcc ctataactat gttttcttta gccatgacaa agtcattttg cattctagac
     1321 caggaatttc tttctgttgc ctagaacaga atttaaagag aaataaaaac aaaaaaagtg
     1381 gattttgtac tgcaatttca actggagggg ggtaatttct cttctctata ttcccatgga
     1441 aacatttagc agtgtctcct agacagttgg gtttcacaca gggtgagaag gatgtctgtg
     1501 ctggtagaat ttaatgagtt aaggcattta caagccaagg aggctgataa ccatcctata
     1561 atgcatagga caaccctttt ccccaataaa aaatttcctg tccccaaatc ttattaatgt
     1621 taaagttatg aaatataaga ctaataaaag ctaggtgtca a
//
