LOCUS       NM_183222               2466 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus Fc receptor-like 5 (Fcrl5), transcript variant 1,
            mRNA.
ACCESSION   NM_183222
VERSION     NM_183222.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2466)
  AUTHORS   Ono,C., Tanaka,S., Myouzen,K., Iwasaki,T., Ueda,M., Oda,Y.,
            Yamamoto,K., Kochi,Y. and Baba,Y.
  TITLE     Upregulated Fcrl5 disrupts B cell anergy and causes autoimmune
            disease
  JOURNAL   Front Immunol 14, 1276014 (2023)
   PUBMED   37841260
  REMARK    GeneRIF: Upregulated Fcrl5 disrupts B cell anergy causes autoimmune
            disease.
            Erratum:[Front Immunol. 2024 Jan 08;14:1356364. doi:
            10.3389/fimmu.2023.1356364.. PMID: 38259460]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2466)
  AUTHORS   Kim,C.C., Baccarella,A.M., Bayat,A., Pepper,M. and Fontana,M.F.
  TITLE     FCRL5+ Memory B Cells Exhibit Robust Recall Responses
  JOURNAL   Cell Rep 27 (5), 1446-1460 (2019)
   PUBMED   31042472
REFERENCE   3  (bases 1 to 2466)
  AUTHORS   Zhu,Z., Li,R., Li,H., Zhou,T. and Davis,R.S.
  TITLE     FCRL5 exerts binary and compartment-specific influence on
            innate-like B-cell receptor signaling
  JOURNAL   Proc Natl Acad Sci U S A 110 (14), E1282-E1290 (2013)
   PUBMED   23509253
  REMARK    GeneRIF: FCRL5 exerts binary and compartment-specific influence on
            innate-like B-cell receptor signaling.
REFERENCE   4  (bases 1 to 2466)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   5  (bases 1 to 2466)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   6  (bases 1 to 2466)
  AUTHORS   Fayngerts,S.A., Najakshin,A.M. and Taranin,A.V.
  TITLE     Species-specific evolution of the FcR family in endothermic
            vertebrates
  JOURNAL   Immunogenetics 59 (6), 493-506 (2007)
   PUBMED   17356879
REFERENCE   7  (bases 1 to 2466)
  AUTHORS   Taylor,A.I., Gould,H.J., Sutton,B.J. and Calvert,R.A.
  TITLE     The first avian Ig-like Fc receptor family member combines features
            of mammalian FcR and FCRL
  JOURNAL   Immunogenetics 59 (4), 323-328 (2007)
   PUBMED   17273841
REFERENCE   8  (bases 1 to 2466)
  AUTHORS   Won,W.J., Foote,J.B., Odom,M.R., Pan,J., Kearney,J.F. and
            Davis,R.S.
  TITLE     Fc receptor homolog 3 is a novel immunoregulatory marker of
            marginal zone and B1 B cells
  JOURNAL   J Immunol 177 (10), 6815-6823 (2006)
   PUBMED   17082595
  REMARK    GeneRIF: a novel immunoregulatory marker of splenic marginal zone
            and B1 type B lineage cells.
REFERENCE   9  (bases 1 to 2466)
  AUTHORS   Maltais,L.J., Lovering,R.C., Taranin,A.V., Colonna,M.,
            Ravetch,J.V., Dalla-Favera,R., Burrows,P.D., Cooper,M.D. and
            Davis,R.S.
  TITLE     New nomenclature for Fc receptor-like molecules
  JOURNAL   Nat Immunol 7 (5), 431-432 (2006)
   PUBMED   16622424
REFERENCE   10 (bases 1 to 2466)
  AUTHORS   Davis,R.S., Stephan,R.P., Chen,C.C., Dennis,G. Jr. and Cooper,M.D.
  TITLE     Differential B cell expression of mouse Fc receptor homologs
  JOURNAL   Int Immunol 16 (9), 1343-1353 (2004)
   PUBMED   15302849
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY158090.1 and AC163618.4.
            
            On Jan 3, 2008 this sequence version replaced NM_183222.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the
            reference genome strain was available for the full length of the
            gene. The extent of this transcript is supported by transcript
            alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY158090.1, AY506558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-584               AY158090.1         1-584
            585-699             AC163618.4         137306-137420
            700-882             AY158090.1         697-879
            883-988             AC163618.4         137866-137971
            989-1138            AY158090.1         986-1135
            1139-1230           AC163618.4         140025-140116
            1231-1695           AY158090.1         1228-1692
            1696-1696           AC163618.4         150748-150748
            1697-1923           AY158090.1         1694-1920
            1924-2439           AC163618.4         160647-161162
            2440-2466           AY158090.1         2437-2463
FEATURES             Location/Qualifiers
     source          1..2466
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.19 cM"
     gene            1..2466
                     /gene="Fcrl5"
                     /gene_synonym="Fcrh3; mBXMH2"
                     /note="Fc receptor-like 5"
                     /db_xref="GeneID:329693"
                     /db_xref="MGI:MGI:3053558"
     exon            1..167
                     /gene="Fcrl5"
                     /gene_synonym="Fcrh3; mBXMH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1894
                     /gene="Fcrl5"
                     /gene_synonym="Fcrh3; mBXMH2"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; Fc receptor-like protein 3; Fc receptor-like
                     protein 5; BXMAS1-like protein 2; moFcRH3; fcR-like
                     protein 5; fc receptor homolog 3"
                     /codon_start=1
                     /product="Fc receptor-like protein 5 isoform a precursor"
                     /protein_id="NP_899045.3"
                     /db_xref="CCDS:CCDS50943.1"
                     /db_xref="GeneID:329693"
                     /db_xref="MGI:MGI:3053558"
                     /translation="MSGSFSPCVVFTQMWLTLLVVTPVNGQHEAAQQSVVSLQPPWTT
                     FFRGEVVTLTCYRFGFSVPQKTKWYQKRKTVKQTPGALVIKAHTLKVHESGEYWCQAD
                     SLLPSMHVNVEFSEDFLVLQAPPAVFEGDSVVLRCYAKKGIEAETLTFYKDGKALTLH
                     PQSSEFYIHRANLKDNGQYKCTSKKKWSFGSLYTSNTVVVQVQELFPRPVLRARPSHP
                     IDGSPVTLTCQTQLSAQKSDARLQFCFFRNLQLLGSGCSRSSEFHIPAIWTEESKRYQ
                     CKAETVNSQVSKQSTAFIIPVQRASARFQTHIIPASKLVFEGQLLLLNCSVKGVPGPL
                     KFSWYKKDMLNKETKILKSSNAEFKISQVNISDAGEYYCEANNSRRSFVSRAFPITIK
                     VPVSQPVLTLSTGKTQALEGDLMTLHCQSQRGSPCILYEFFYENVSLGNSSILSGGGA
                     YFNFSMSTERSGNYYCTADNGLGAQCSEAIRISIFDMTKNRSVPMAAGITVGLLIMAV
                     GVFLFYCWFSRKAGGKPTSDDSRNPSDSEPQEPTYYNVPACIELQPVYSNEPEENVIY
                     TEVRRTQPRQKHADQESESPRSRCQMAEKK"
     exon            168..188
                     /gene="Fcrl5"
                     /gene_synonym="Fcrh3; mBXMH2"
                     /inference="alignment:Splign:2.1.0"
     exon            189..452
                     /gene="Fcrl5"
                     /gene_synonym="Fcrh3; mBXMH2"
                     /inference="alignment:Splign:2.1.0"
     exon            453..713
                     /gene="Fcrl5"
                     /gene_synonym="Fcrh3; mBXMH2"
                     /inference="alignment:Splign:2.1.0"
     exon            714..998
                     /gene="Fcrl5"
                     /gene_synonym="Fcrh3; mBXMH2"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1280
                     /gene="Fcrl5"
                     /gene_synonym="Fcrh3; mBXMH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1559
                     /gene="Fcrl5"
                     /gene_synonym="Fcrh3; mBXMH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1667
                     /gene="Fcrl5"
                     /gene_synonym="Fcrh3; mBXMH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1695
                     /gene="Fcrl5"
                     /gene_synonym="Fcrh3; mBXMH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1778
                     /gene="Fcrl5"
                     /gene_synonym="Fcrh3; mBXMH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1841
                     /gene="Fcrl5"
                     /gene_synonym="Fcrh3; mBXMH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1911
                     /gene="Fcrl5"
                     /gene_synonym="Fcrh3; mBXMH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2441
                     /gene="Fcrl5"
                     /gene_synonym="Fcrh3; mBXMH2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acactcaact gttttagaag agcagttccc cagatttctc cttggagctg tgagtgacta
       61 ccattgcgag caagagcaag aggaaagcac tacctgtgag cagatgtctg gttcattctc
      121 accctgtgtg gtgttcacac agatgtggct gactctactg gttgtgactc ctgtcaatgg
      181 acagcatgaa gctgcacagc agtctgtggt ttcccttcag cctccatgga ccactttctt
      241 tcgaggagag gtcgtcacac tgacttgtta tagattcggc ttctccgtac cccagaaaac
      301 aaaatggtac cagaaaagaa aaacagtgaa gcaaacccca ggtgctttgg taattaaagc
      361 acatacctta aaggtccatg agtccggaga gtattggtgc caagccgaca gcttacttcc
      421 gagcatgcac gtgaacgtag agttttctga agattttctg gtgctgcaag ctccacctgc
      481 tgtgtttgaa ggagactctg tggttctgag gtgctacgca aagaaaggca tagaagcaga
      541 gaccctgaca ttttacaagg atggtaaagc tctgacatta catcctcaaa gttctgagtt
      601 ctatattcat cgtgcaaatc tgaaggacaa cggtcaatac aaatgcactt cgaagaagaa
      661 gtggtctttt gggtccctct atacttccaa tacggtcgta gttcaagtcc aagagttgtt
      721 cccacggcct gtgctgagag ccagaccctc ccatcccata gatggaagtc cagtgaccct
      781 gacgtgtcag acccagctct ctgcacagaa gtcagatgcc cggctccagt tctgtttctt
      841 cagaaacctc cagcttctgg ggtcaggctg cagccgctcc tcggagtttc acattcctgc
      901 catatggact gaagagtcaa agagatacca gtgcaaggca gaaacagtga attcccaagt
      961 tagtaaacaa agtacagcgt tcataattcc agtgcagaga gcttctgcga gattccaaac
     1021 acacatcatc ccagcctcaa agttggtgtt tgaagggcag ttgctgttac tcaactgctc
     1081 agtaaaagga gtcccaggac ccctcaaatt ctcctggtat aaaaaggaca tgctgaataa
     1141 agaaacaaag attcttaagt cctccaacgc agaattcaag atctcccagg tgaacatcag
     1201 tgacgcaggg gagtattact gtgaagctaa caacagccgc cgaagctttg tcagcagggc
     1261 atttcccatc accataaaag tcccagtatc tcaaccagtt ctcaccctaa gcacaggcaa
     1321 gacccaggcc cttgagggag acttgatgac acttcattgt caatcccaga ggggctctcc
     1381 atgtatcctg tatgaattct tctatgagaa tgtctccctg gggaatagct ctatactctc
     1441 tggaggagga gcatacttca atttctctat gagcacagag cgatctggaa actactactg
     1501 cacagcagac aatggcctgg gagcccagtg cagtgaagct ataaggatct ctatctttga
     1561 catgacaaag aacagaagtg ttcctatggc tgccggaatc actgtgggac tgctcatcat
     1621 ggctgttgga gtgtttctgt tttattgctg gttctctaga aaagcaggag gaaagcctac
     1681 ctctgatgac tccaggaacc cttcagattc agaaccccag gagcccacct attacaacgt
     1741 accagcctgt atagaactgc agccagtgta cagcaatgag cctgaggaaa acgtgattta
     1801 cacagaagta cggagaactc aaccaagaca gaaacatgca gatcaggagt ctgaaagccc
     1861 aagatcaagg tgccagatgg ctgagaaaaa gtaggatatg tctcctccaa gaacagctcc
     1921 agagaagaaa cccgaagctt cctcagtcta atttcaccga tgcttctact gggcctgcac
     1981 ttccctaccc acggatggct ccacagatca tggacagcaa ggaaacggcc aactctccta
     2041 agactgggcc aacatcccca tcttctcttt ggtttcccag agccacgcca ccccaaagtc
     2101 agcaggaagt tgcaaaagat cacaacgacc ctattcctgt tttgtaacca cccccagcct
     2161 gaagcaggct gagccagacc ttgaccttgc tgccactaag aagtttacct agggtggagc
     2221 ctgcctccct agatcactct attgttcaac cactgccact gttctccatc aagacactgc
     2281 tacctgctgg gaggccactg agctattcca gagactacac cctatcctgc acatcgtcac
     2341 ctgtagcctg ttccaggctc caagaatgaa ttggcggcaa tgggcctccc ccctaccccc
     2401 tttataagcg catttgccat taaacatttg ggctttgatc aaaaaaaaaa aaaaaaaaaa
     2461 aaaaaa
//
