LOCUS       NM_001419220            2059 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus Fc receptor like 2 (Fcrl2), transcript variant 1,
            mRNA.
ACCESSION   NM_001419220 XM_006502369
VERSION     NM_001419220.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2059)
  AUTHORS   Kaiser,T., Dattero,J., Li,L., Chen,M., Jiang,M., Harrahill,A.,
            Butovsky,O. and Feng,G.
  TITLE     Transgenic Targeting of Fcrls Creates a Highly Efficient
            Constitutively Active Microglia Cre Line with Differentiated
            Specificity
  JOURNAL   eNeuro 11 (7) (2024)
   PUBMED   38926085
  REMARK    GeneRIF: Transgenic Targeting of Fcrls Creates a Highly Efficient
            Constitutively Active Microglia Cre Line with Differentiated
            Specificity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2059)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2059)
  AUTHORS   Khanam,A., Yu,J. and Zempleni,J.
  TITLE     Class A scavenger receptor-1/2 facilitates the uptake of bovine
            milk exosomes in murine bone marrow-derived macrophages and
            C57BL/6J mice
  JOURNAL   Am J Physiol Cell Physiol 321 (3), C607-C614 (2021)
   PUBMED   34378992
  REMARK    GeneRIF: Class A scavenger receptor-1/2 facilitates the uptake of
            bovine milk exosomes in murine bone marrow-derived macrophages and
            C57BL/6J mice.
REFERENCE   4  (bases 1 to 2059)
  AUTHORS   Rosin,J.M., Sinha,S., Biernaskie,J. and Kurrasch,D.M.
  TITLE     A subpopulation of embryonic microglia respond to maternal stress
            and influence nearby neural progenitors
  JOURNAL   Dev Cell 56 (9), 1326-1345 (2021)
   PUBMED   33887203
REFERENCE   5  (bases 1 to 2059)
  AUTHORS   Rosin,J.M., Marsters,C.M., Malik,F., Far,R., Adnani,L.,
            Schuurmans,C., Pittman,Q.J. and Kurrasch,D.M.
  TITLE     Embryonic Microglia Interact with Hypothalamic Radial Glia during
            Development and Upregulate the TAM Receptors MERTK and AXL
            following an Insult
  JOURNAL   Cell Rep 34 (1), 108587 (2021)
   PUBMED   33406432
REFERENCE   6  (bases 1 to 2059)
  AUTHORS   Maltais,L.J., Lovering,R.C., Taranin,A.V., Colonna,M.,
            Ravetch,J.V., Dalla-Favera,R., Burrows,P.D., Cooper,M.D. and
            Davis,R.S.
  TITLE     New nomenclature for Fc receptor-like molecules
  JOURNAL   Nat Immunol 7 (5), 431-432 (2006)
   PUBMED   16622424
REFERENCE   7  (bases 1 to 2059)
  AUTHORS   Davis,R.S., Stephan,R.P., Chen,C.C., Dennis,G. Jr. and Cooper,M.D.
  TITLE     Differential B cell expression of mouse Fc receptor homologs
  JOURNAL   Int Immunol 16 (9), 1343-1353 (2004)
   PUBMED   15302849
REFERENCE   8  (bases 1 to 2059)
  AUTHORS   Makranz,C., Cohen,G., Baron,A., Levidor,L., Kodama,T., Reichert,F.
            and Rotshenker,S.
  TITLE     Phosphatidylinositol 3-kinase, phosphoinositide-specific
            phospholipase-Cgamma and protein kinase-C signal myelin
            phagocytosis mediated by complement receptor-3 alone and combined
            with scavenger receptor-AI/II in macrophages
  JOURNAL   Neurobiol Dis 15 (2), 279-286 (2004)
   PUBMED   15006698
  REMARK    Erratum:[Neurobiol Dis. 2004 Aug;16(3):659]
REFERENCE   9  (bases 1 to 2059)
  AUTHORS   Kunjathoor,V.V., Febbraio,M., Podrez,E.A., Moore,K.J.,
            Andersson,L., Koehn,S., Rhee,J.S., Silverstein,R., Hoff,H.F. and
            Freeman,M.W.
  TITLE     Scavenger receptors class A-I/II and CD36 are the principal
            receptors responsible for the uptake of modified low density
            lipoprotein leading to lipid loading in macrophages
  JOURNAL   J Biol Chem 277 (51), 49982-49988 (2002)
   PUBMED   12376530
  REMARK    GeneRIF: SR-A and CD36 are responsible for the preponderance of
            modified LDL uptake in macrophages and that other scavenger
            receptors do not compensate for their absence
REFERENCE   10 (bases 1 to 2059)
  AUTHORS   Guselnikov,S.V., Ershova,S.A., Mechetina,L.V., Najakshin,A.M.,
            Volkova,O.Y., Alabyev,B.Y. and Taranin,A.V.
  TITLE     A family of highly diverse human and mouse genes structurally links
            leukocyte FcR, gp42 and PECAM-1
  JOURNAL   Immunogenetics 54 (2), 87-95 (2002)
   PUBMED   12037601
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091682.26.
            
            On Mar 29, 2023 this sequence version replaced XM_006502369.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4263393.1,
                                           SRR7652917.1247011.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AC091682.26        74170-74231         c
            63-194              AC091682.26        73937-74068         c
            195-215             AC091682.26        72671-72691         c
            216-482             AC091682.26        69858-70124         c
            483-764             AC091682.26        69358-69639         c
            765-1073            AC091682.26        67800-68108         c
            1074-1352           AC091682.26        67124-67402         c
            1353-1673           AC091682.26        62928-63248         c
            1674-2059           AC091682.26        61503-61888         c
FEATURES             Location/Qualifiers
     source          1..2059
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.19 cM"
     gene            1..2059
                     /gene="Fcrl2"
                     /gene_synonym="2810439C17Rik; 9330158F12; Fcrh2; FcRH2sc;
                     Fcrls; IFGP2; IgSR; MMAN-g; moFcRH2sc; Msr2"
                     /note="Fc receptor like 2"
                     /db_xref="GeneID:80891"
                     /db_xref="MGI:MGI:1933397"
     exon            1..62
                     /gene="Fcrl2"
                     /gene_synonym="2810439C17Rik; 9330158F12; Fcrh2; FcRH2sc;
                     Fcrls; IFGP2; IgSR; MMAN-g; moFcRH2sc; Msr2"
                     /inference="alignment:Splign:2.1.0"
     exon            63..194
                     /gene="Fcrl2"
                     /gene_synonym="2810439C17Rik; 9330158F12; Fcrh2; FcRH2sc;
                     Fcrls; IFGP2; IgSR; MMAN-g; moFcRH2sc; Msr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1693
                     /gene="Fcrl2"
                     /gene_synonym="2810439C17Rik; 9330158F12; Fcrh2; FcRH2sc;
                     Fcrls; IFGP2; IgSR; MMAN-g; moFcRH2sc; Msr2"
                     /note="macrophage scavenger receptor 2; immunoglobulin
                     scavenger receptor; Fc receptor-like S, scavenger
                     receptor"
                     /codon_start=1
                     /product="Fc receptor-like protein 2 precursor"
                     /protein_id="NP_001406149.1"
                     /db_xref="GeneID:80891"
                     /db_xref="MGI:MGI:1933397"
                     /translation="MPLCLLLLVFAPVGVQSDWLSISLPHRSYEGDQVVISCTGKNNG
                     DIKRLKYFKDGYHIETYSSASSYTIRNARRGDSGSYSCKADRKFFLFIDTTEETGSKW
                     LNVQELFPAPGLTASPLQPVEGSSVTLSCNTWLPSDRATTQLRYSFFKDGHTLQSGWT
                     SSKFTISAISKEDSGNYWCEAMTASRSVSKQSHRSYIDVERIPVSQVTMEIQPSRGWG
                     VEGEPLVVEGEPLVLACSVAKGTGLITFSWHRQDTKESVGKKSQRSQRVELEIPTIRE
                     SHAGGYYCTADNNYGLIQSAIVNITVKIPVLNPLLSISVPGVLPFIGDVAELHCEDKR
                     ASPPVLYWFYHENITLANTSAPFGGKASFKLSLTAGHSGNYSCEAENAWGTKRSEVVT
                     LNVTEPPPKVRLVNGPHHCEGRVEVEQEGRWGTVCDDGWDMRDVAVVCRELGCGAAQH
                     TPIAMLYPPAVDEALPVLIQVALCNGTEKTLAECDQVEAFDCGHDEDAGAVCEVLPST
                     F"
     exon            195..215
                     /gene="Fcrl2"
                     /gene_synonym="2810439C17Rik; 9330158F12; Fcrh2; FcRH2sc;
                     Fcrls; IFGP2; IgSR; MMAN-g; moFcRH2sc; Msr2"
                     /inference="alignment:Splign:2.1.0"
     exon            216..482
                     /gene="Fcrl2"
                     /gene_synonym="2810439C17Rik; 9330158F12; Fcrh2; FcRH2sc;
                     Fcrls; IFGP2; IgSR; MMAN-g; moFcRH2sc; Msr2"
                     /inference="alignment:Splign:2.1.0"
     exon            483..764
                     /gene="Fcrl2"
                     /gene_synonym="2810439C17Rik; 9330158F12; Fcrh2; FcRH2sc;
                     Fcrls; IFGP2; IgSR; MMAN-g; moFcRH2sc; Msr2"
                     /inference="alignment:Splign:2.1.0"
     exon            765..1073
                     /gene="Fcrl2"
                     /gene_synonym="2810439C17Rik; 9330158F12; Fcrh2; FcRH2sc;
                     Fcrls; IFGP2; IgSR; MMAN-g; moFcRH2sc; Msr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1352
                     /gene="Fcrl2"
                     /gene_synonym="2810439C17Rik; 9330158F12; Fcrh2; FcRH2sc;
                     Fcrls; IFGP2; IgSR; MMAN-g; moFcRH2sc; Msr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1673
                     /gene="Fcrl2"
                     /gene_synonym="2810439C17Rik; 9330158F12; Fcrh2; FcRH2sc;
                     Fcrls; IFGP2; IgSR; MMAN-g; moFcRH2sc; Msr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..2059
                     /gene="Fcrl2"
                     /gene_synonym="2810439C17Rik; 9330158F12; Fcrh2; FcRH2sc;
                     Fcrls; IFGP2; IgSR; MMAN-g; moFcRH2sc; Msr2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2035..2040
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fcrl2"
                     /gene_synonym="2810439C17Rik; 9330158F12; Fcrh2; FcRH2sc;
                     Fcrls; IFGP2; IgSR; MMAN-g; moFcRH2sc; Msr2"
                     /note="hexamer: AACAAA"
     polyA_site      2059
                     /gene="Fcrl2"
                     /gene_synonym="2810439C17Rik; 9330158F12; Fcrh2; FcRH2sc;
                     Fcrls; IFGP2; IgSR; MMAN-g; moFcRH2sc; Msr2"
                     /note="major polyA site"
ORIGIN      
        1 taaaaggaag gcgtcctacg caggaagaag catgtcgcac cagcgagcaa atatctaagc
       61 aaatccctgc tgaaccacag tgttctatcc cagatctgtg gtccatctgc cctaaggact
      121 tgagctgcac ctgtctcaaa gggagctact tgcctcgagt ctcatgcctc tgtgcttgct
      181 gcttctggtc ttcgctcctg tcggagtcca gtccgactgg ttgagcatca gccttccaca
      241 ccgttcttat gaaggagacc aagtagttat aagctgcaca gggaaaaata atggtgacat
      301 aaagagactg aagtacttca aggatggata tcacatagaa acttacagca gtgcttcaag
      361 ctacaccatt aggaatgcaa gacgcggtga cagtggctcc tattcctgta aggcagatag
      421 gaaatttttc ctatttatag acacaacaga agaaacagga tctaagtggc tgaatgtcca
      481 agagctgttt ccagcacctg ggctgacagc cagccccctg cagcccgtag aggggagttc
      541 agtgaccctg tcctgcaaca cctggctccc ttcagatagg gcaacgaccc agctacgcta
      601 ttccttcttc aaagatggcc acactttgca atcgggctgg acctcatcaa aatttaccat
      661 ctcagcaata tcgaaggaag actcaggaaa ttactggtgt gaagcaatga ctgcctctcg
      721 cagtgtctca aagcagagtc accggtccta catagatgta gagaggatcc ctgtatctca
      781 agtcaccatg gagatccagc cttcaagagg ctggggagtt gaaggggagc cactggtcgt
      841 tgaaggggag cccctggtcc ttgcttgttc tgtggctaaa ggcactgggc taatcacatt
      901 ctcctggcat aggcaggaca ctaaggaaag tgtggggaag aaaagtcagc gttcccagag
      961 agtggagctg gagatcccta ctatcaggga aagccatgct ggggggtact actgcacagc
     1021 agacaacaac tacggcctga tccagagtgc aatcgtgaac atcaccgtga aaattccagt
     1081 gttgaacccg ctcctctcca tcagtgttcc tggggtcttg cccttcatcg gagatgtggc
     1141 ggagcttcac tgtgaagaca agagagcatc tcctccggtt ctctactggt tttatcatga
     1201 aaatatcact ctggctaaca cctcggcacc ttttggagga aaggcatcct ttaagctctc
     1261 tctgactgca gggcattctg ggaactactc ttgtgaggct gaaaacgcct ggggtaccaa
     1321 gcgcagtgag gtggtaacgc tcaatgtcac agagccccca cccaaagtgc gtttggtgaa
     1381 tggcccccac cactgtgaag gacgcgtaga ggttgaacag gaaggtcgct ggggcactgt
     1441 atgtgatgat ggctgggaca tgagggatgt ggctgtggtg tgccgagagc tgggctgtgg
     1501 agcagcccaa cacacaccta tagccatgct gtatccacca gcagttgatg aagctctgcc
     1561 tgtgctcatt caggtagccc tgtgcaatgg cacagaaaag accctggctg aatgtgacca
     1621 ggttgaggcc tttgattgtg gacatgatga ggatgctgga gctgtgtgtg aagtcttacc
     1681 cagcactttc tgaagatcta gagaccagag accatcagac ctcctacttt ctgcactggg
     1741 cctcacagcc ctcacggtct gcagctccca gtggacttcc agacttcagc tgtggcttat
     1801 cattcaagag gactcaaaac tatattaatc tgctctgaga taatgttcca aaagctccaa
     1861 agaaagcccg agtcccttgc ccccagaggc caagcttgga aaaattgttc ccctgtccag
     1921 gttccctgcc tttctagctc cttcttgcta tctccttggg cagacgtgcg cagaggtggc
     1981 gcaagtgagg atcacataca tgtgcctggg cttccatctg gtagaatgtg gtctaacaaa
     2041 gcacatacaa caaaagaaa
//
