LOCUS       NM_178165               1982 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus Fc receptor-like 1 (Fcrl1), transcript variant 2,
            mRNA.
ACCESSION   NM_178165
VERSION     NM_178165.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1982)
  AUTHORS   DeLuca,J.M., Murphy,M.K., Wang,X. and Wilson,T.J.
  TITLE     FCRL1 Regulates B Cell Receptor-Induced ERK Activation through GRB2
  JOURNAL   J Immunol 207 (11), 2688-2698 (2021)
   PUBMED   34697226
REFERENCE   2  (bases 1 to 1982)
  AUTHORS   Zhao,X., Xie,H., Zhao,M., Ahsan,A., Li,X., Wang,F., Yi,J., Yang,Z.,
            Wu,C., Raman,I., Li,Q.Z., Kim,T.J. and Liu,W.
  TITLE     Fc receptor-like 1 intrinsically recruits c-Abl to enhance B cell
            activation and function
  JOURNAL   Sci Adv 5 (7), eaaw0315 (2019)
   PUBMED   31328160
  REMARK    GeneRIF: These findings reveal a critical BCR signal-enhancing
            function of FcRL1 through its intrinsic recruitment to B cell
            immunological synapses and subsequent recruitment of c-Abl upon BCR
            cross-linking.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1982)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   4  (bases 1 to 1982)
  AUTHORS   Fayngerts,S.A., Najakshin,A.M. and Taranin,A.V.
  TITLE     Species-specific evolution of the FcR family in endothermic
            vertebrates
  JOURNAL   Immunogenetics 59 (6), 493-506 (2007)
   PUBMED   17356879
REFERENCE   5  (bases 1 to 1982)
  AUTHORS   Taylor,A.I., Gould,H.J., Sutton,B.J. and Calvert,R.A.
  TITLE     The first avian Ig-like Fc receptor family member combines features
            of mammalian FcR and FCRL
  JOURNAL   Immunogenetics 59 (4), 323-328 (2007)
   PUBMED   17273841
REFERENCE   6  (bases 1 to 1982)
  AUTHORS   Maltais,L.J., Lovering,R.C., Taranin,A.V., Colonna,M.,
            Ravetch,J.V., Dalla-Favera,R., Burrows,P.D., Cooper,M.D. and
            Davis,R.S.
  TITLE     New nomenclature for Fc receptor-like molecules
  JOURNAL   Nat Immunol 7 (5), 431-432 (2006)
   PUBMED   16622424
REFERENCE   7  (bases 1 to 1982)
  AUTHORS   Davis,R.S., Stephan,R.P., Chen,C.C., Dennis,G. Jr. and Cooper,M.D.
  TITLE     Differential B cell expression of mouse Fc receptor homologs
  JOURNAL   Int Immunol 16 (9), 1343-1353 (2004)
   PUBMED   15302849
REFERENCE   8  (bases 1 to 1982)
  AUTHORS   Guselnikov,S.V., Ershova,S.A., Mechetina,L.V., Najakshin,A.M.,
            Volkova,O.Y., Alabyev,B.Y. and Taranin,A.V.
  TITLE     A family of highly diverse human and mouse genes structurally links
            leukocyte FcR, gp42 and PECAM-1
  JOURNAL   Immunogenetics 54 (2), 87-95 (2002)
   PUBMED   12037601
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK041750.1 and AK038494.1.
            
            On Oct 31, 2008 this sequence version replaced NM_178165.3.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1, resulting in
            an isoform (2) that is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK038494.1, AY506554.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AK041750.1         3-63
            62-1982             AK038494.1         2-1922
FEATURES             Location/Qualifiers
     source          1..1982
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.19 cM"
     gene            1..1982
                     /gene="Fcrl1"
                     /gene_synonym="A230020G22Rik; Bxmas1; Bxmh1; Bxmh1b;
                     Fcrh1; Fcrh1l; Fcrh1s; Ifgp1"
                     /note="Fc receptor-like 1"
                     /db_xref="GeneID:229499"
                     /db_xref="MGI:MGI:2442862"
     exon            1..139
                     /gene="Fcrl1"
                     /gene_synonym="A230020G22Rik; Bxmas1; Bxmh1; Bxmh1b;
                     Fcrh1; Fcrh1l; Fcrh1s; Ifgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            140..160
                     /gene="Fcrl1"
                     /gene_synonym="A230020G22Rik; Bxmas1; Bxmh1; Bxmh1b;
                     Fcrh1; Fcrh1l; Fcrh1s; Ifgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            161..442
                     /gene="Fcrl1"
                     /gene_synonym="A230020G22Rik; Bxmas1; Bxmh1; Bxmh1b;
                     Fcrh1; Fcrh1l; Fcrh1s; Ifgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..721
                     /gene="Fcrl1"
                     /gene_synonym="A230020G22Rik; Bxmas1; Bxmh1; Bxmh1b;
                     Fcrh1; Fcrh1l; Fcrh1s; Ifgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            722..850
                     /gene="Fcrl1"
                     /gene_synonym="A230020G22Rik; Bxmas1; Bxmh1; Bxmh1b;
                     Fcrh1; Fcrh1l; Fcrh1s; Ifgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..875
                     /gene="Fcrl1"
                     /gene_synonym="A230020G22Rik; Bxmas1; Bxmh1; Bxmh1b;
                     Fcrh1; Fcrh1l; Fcrh1s; Ifgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            876..958
                     /gene="Fcrl1"
                     /gene_synonym="A230020G22Rik; Bxmas1; Bxmh1; Bxmh1b;
                     Fcrh1; Fcrh1l; Fcrh1s; Ifgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1030
                     /gene="Fcrl1"
                     /gene_synonym="A230020G22Rik; Bxmas1; Bxmh1; Bxmh1b;
                     Fcrh1; Fcrh1l; Fcrh1s; Ifgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1062
                     /gene="Fcrl1"
                     /gene_synonym="A230020G22Rik; Bxmas1; Bxmh1; Bxmh1b;
                     Fcrh1; Fcrh1l; Fcrh1s; Ifgp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1982
                     /gene="Fcrl1"
                     /gene_synonym="A230020G22Rik; Bxmas1; Bxmh1; Bxmh1b;
                     Fcrh1; Fcrh1l; Fcrh1s; Ifgp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1574..1579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fcrl1"
                     /gene_synonym="A230020G22Rik; Bxmas1; Bxmh1; Bxmh1b;
                     Fcrh1; Fcrh1l; Fcrh1s; Ifgp1"
                     /note="hexamer: ATTAAA"
     regulatory      1590..1595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fcrl1"
                     /gene_synonym="A230020G22Rik; Bxmas1; Bxmh1; Bxmh1b;
                     Fcrh1; Fcrh1l; Fcrh1s; Ifgp1"
                     /note="hexamer: ATTAAA"
     polyA_site      1596
                     /gene="Fcrl1"
                     /gene_synonym="A230020G22Rik; Bxmas1; Bxmh1; Bxmh1b;
                     Fcrh1; Fcrh1l; Fcrh1s; Ifgp1"
     polyA_site      1616
                     /gene="Fcrl1"
                     /gene_synonym="A230020G22Rik; Bxmas1; Bxmh1; Bxmh1b;
                     Fcrh1; Fcrh1l; Fcrh1s; Ifgp1"
                     /note="major polyA site"
     regulatory      1921..1926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fcrl1"
                     /gene_synonym="A230020G22Rik; Bxmas1; Bxmh1; Bxmh1b;
                     Fcrh1; Fcrh1l; Fcrh1s; Ifgp1"
                     /note="hexamer: ATTAAA"
     polyA_site      1948
                     /gene="Fcrl1"
                     /gene_synonym="A230020G22Rik; Bxmas1; Bxmh1; Bxmh1b;
                     Fcrh1; Fcrh1l; Fcrh1s; Ifgp1"
ORIGIN      
        1 agagaagctg agggcagtta tctgtgacac ctctgtgagt agtctggttt tgcttttttt
       61 tcttttggtg agaggcacct tcaagttacc atccccagcc tggtcctcat gctaccttgg
      121 ctcctgctac tgatctgtgc tctaccgtgt gaacctgctg gaatctctga tgtgagcttg
      181 aagacacggc ccccaggagg atgggtgatg gagggagaca agctggtcct catctgctcg
      241 gttgatagag tcactgggaa tataacttac ttctggtaca gaggggccct gggtttccaa
      301 ctggaaacaa agacacaacc ttcactaaca gcagagtttg agatcagtga catgaagcag
      361 agcgatgctg atcaatatta ctgtgcggct aacgatggcc acgaccctat ccccagtgag
      421 ctggtgagca tccacgtcag agttccagtg tctcgccctg tccttacgtt tggggactct
      481 ggaacccagg ctgtgctagg ggacctggtg gagcttcact gtaaggccct gagaggctca
      541 cccccaatct tctaccagtt ttatcatgag agcatcatcc tggggaacag ttcagcaccc
      601 tctggaggag gagcatcctt caacttctcc ctgactgcag aacattctgg aaacttctcc
      661 tgtgaggcca gcaatggaca gggtgcccaa cgaagtgagg tggtggctct caacttaaca
      721 ggtctctcct tagtgcctac tgagaatgga atcagccatc tctccttagg actcactggg
      781 tggctgcttg gctgtcttag cctcatcacc atggccttaa tattttgcta ctggctcaag
      841 agaaaaatag gaagacaatc agaggatcca gtcaggagcc ctcctcagac tgtgctccaa
      901 ggatccacct accccaaacc ccccgactca aggcagccag agcccctgta tgagaacgtg
      961 aacgttgtaa gtggcaatga agtgtactct ctggtgtacc acaccccgca ggtgctggaa
     1021 ccagcagcag ctcagcatgt gaggacacac ggagtaagtg agtcctttca ggtctcctct
     1081 ggactctatt ctaagccaag gataaacatt gcacatatgg actatgaaga cgccatgtag
     1141 aattatgtaa acagcaacta tggagtgcta catacaagcc caaggcctga tgtggcctcc
     1201 aaggatactg gggacaggga tagcttgcca gcccaatttc cccacacact gcggttcatt
     1261 agatgggtcc ttcacctacc ctgtgtgaag ctggagcaag tcctgcagaa accacccagg
     1321 aaaaccaact tagacggaga agccagaagc atttgcatct ggttgttgcc cattcatgtt
     1381 ggcacacgaa cttttattta caggaggaaa atggtgtgat gaaagcaact aaggtcttac
     1441 agcagaggga caatgcgact cagagagcac aaagccgaga tcaatggctt tgcgggtctg
     1501 ctgtggagac agagccatgc ttcctctgta cacataccct agagtacttc tgagtcactg
     1561 tcatcaactt agaattaaaa cacagttgca ttaaaatgta ctgtggcgac acttcatttt
     1621 agtggcactg tgttttgttg tatgcaggct aggctaaacc ctcttgggtt tataatagtc
     1681 tttgaaaggt tcaccaagtt ctaagttttg aacttgatgc aacatttaga ctaagcttta
     1741 tgagaatgct ttgcagacca aattttccta gaatttgaga ttatcctgct tcagtcttcc
     1801 aagaactggg tttacagttg gtgtgccacc aaatgttatt tgttttatca gttttaaatg
     1861 tatggtccag gaacatcatc tactttcaca acattttaat acttttgata actgacggac
     1921 attaaagttg cttcagattt tcataggatt aacgcagtgc ccattaaatg tcttcacatt
     1981 tg
//
