LOCUS       NM_007995               1317 bp    mRNA    linear   ROD 18-DEC-2022
DEFINITION  Mus musculus ficolin A (Fcna), mRNA.
ACCESSION   NM_007995
VERSION     NM_007995.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1317)
  AUTHORS   Zhu G, Zhao G, Lin J, Li C, Wang Q, Xu Q, Peng X and Zheng H.
  TITLE     FCN-A mediates the inflammatory response and the macrophage
            polarization in Aspergillus fumigatus keratitis of mice by
            activating the MAPK signaling pathway
  JOURNAL   Int Immunopharmacol 83, 106473 (2020)
   PUBMED   32272397
  REMARK    GeneRIF: FCN-A mediates the inflammatory response and the
            macrophage polarization in Aspergillus fumigatus keratitis of mice
            by activating the MAPK signaling pathway.
REFERENCE   2  (bases 1 to 1317)
  AUTHORS   Jarlhelt I, Genster N, Kirketerp-Moller N, Skjoedt MO and Garred P.
  TITLE     The ficolin response to LPS challenge in mice
  JOURNAL   Mol Immunol 108, 121-127 (2019)
   PUBMED   30818229
  REMARK    GeneRIF: Lipopolysaccharide-induced inflammation can induce a
            significant ficolin response.
REFERENCE   3  (bases 1 to 1317)
  AUTHORS   Ding Q, Shen Y, Li D, Yang J, Yu J, Yin Z and Zhang XL.
  TITLE     Ficolin-2 triggers antitumor effect by activating macrophages and
            CD8+ T cells
  JOURNAL   Clin Immunol 183, 145-157 (2017)
   PUBMED   28844702
  REMARK    GeneRIF: Ficolin-2 induces macrophage activation, promotes M1
            polarization and facilitates proliferation and antigen-specific
            cytotoxicity of CD8(+) T cells. Ficolin-2 binds to Toll-like
            receptor 4 (TLR4) on macrophages and DCs and promotes their
            antigen-presenting abilities to CD8(+) T cells.
REFERENCE   4  (bases 1 to 1317)
  AUTHORS   Banda NK, Acharya S, Scheinman RI, Mehta G, Takahashi M, Endo Y,
            Zhou W, Farrar CA, Sacks SH, Fujita T, Sekine H and Holers VM.
  TITLE     Deconstructing the Lectin Pathway in the Pathogenesis of
            Experimental Inflammatory Arthritis: Essential Role of the Lectin
            Ficolin B and Mannose-Binding Protein-Associated Serine Protease 2
  JOURNAL   J Immunol 199 (5), 1835-1845 (2017)
   PUBMED   28739878
REFERENCE   5  (bases 1 to 1317)
  AUTHORS   Yang YF, Zhou YD, Hu JC, Luo FL, Xie Y, Shen YY, Bian WX, Yin ZN,
            Li HL and Zhang XL.
  TITLE     Ficolin-A/2, acting as a new regulator of macrophage polarization,
            mediates the inflammatory response in experimental mouse colitis
  JOURNAL   Immunology 151 (4), 433-450 (2017)
   PUBMED   28380665
  REMARK    GeneRIF: this study shows that FCN-A/2 exacerbated the inflammatory
            pathogenesis of inflammatory bowel disease by stimulating M1
            polarization through the TLR4/MyD88/MAPK/NF-kappaB signalling
            pathway in macrophages
REFERENCE   6  (bases 1 to 1317)
  AUTHORS   Endo Y, Nakazawa N, Liu Y, Iwaki D, Takahashi M, Fujita T, Nakata M
            and Matsushita M.
  TITLE     Carbohydrate-binding specificities of mouse ficolin A, a splicing
            variant of ficolin A and ficolin B and their complex formation with
            MASP-2 and sMAP
  JOURNAL   Immunogenetics 57 (11), 837-844 (2005)
   PUBMED   16328467
  REMARK    GeneRIF: Ficolin A protein (smapshowed a potent complement
            activating capacity.These results suggest that ficolin A and its
            variant function as recognition molecules of the lectin pathway.
REFERENCE   7  (bases 1 to 1317)
  AUTHORS   Liu Y, Endo Y, Homma S, Kanno K, Yaginuma H and Fujita T.
  TITLE     Ficolin A and ficolin B are expressed in distinct ontogenic
            patterns and cell types in the mouse
  JOURNAL   Mol Immunol 42 (11), 1265-1273 (2005)
   PUBMED   15950722
  REMARK    GeneRIF: the expression pattern of ficolin A expression was closely
            similar to that of mannose-binding lectin-associated serine
            proteases, suggesting that these molecules may function in
            coordination as components of the lectin complement pathway
REFERENCE   8  (bases 1 to 1317)
  AUTHORS   Endo Y, Liu Y, Kanno K, Takahashi M, Matsushita M and Fujita T.
  TITLE     Identification of the mouse H-ficolin gene as a pseudogene and
            orthology between mouse ficolins A/B and human L-/M-ficolins
  JOURNAL   Genomics 84 (4), 737-744 (2004)
   PUBMED   15475251
REFERENCE   9  (bases 1 to 1317)
  AUTHORS   Ohashi T and Erickson HP.
  TITLE     Oligomeric structure and tissue distribution of ficolins from
            mouse, pig and human
  JOURNAL   Arch Biochem Biophys 360 (2), 223-232 (1998)
   PUBMED   9851834
REFERENCE   10 (bases 1 to 1317)
  AUTHORS   Fujimori Y, Harumiya S, Fukumoto Y, Miura Y, Yagasaki K, Tachikawa
            H and Fujimoto D.
  TITLE     Molecular cloning and characterization of mouse ficolin-A
  JOURNAL   Biochem Biophys Res Commun 244 (3), 796-800 (1998)
   PUBMED   9535745
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB582883.1, AK133539.1 and AV290365.1.
            
            [WARNING] On Apr 25, 2023 this sequence was replaced by
            NM_007995.4.
            
            On Apr 28, 2007 this sequence version replaced NM_007995.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133539.1, AK159651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BB582883.1         4-26
            24-1315             AK133539.1         1-1292
            1316-1317           AV290365.1         208-209
FEATURES             Location/Qualifiers
     source          1..1317
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..1317
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /note="ficolin A"
                     /db_xref="GeneID:14133"
                     /db_xref="MGI:MGI:1340905"
     exon            1..226
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1143
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /note="ficolin-1; M-ficolin; ficolin-alpha;
                     collagen/fibrinogen domain-containing protein 1"
                     /codon_start=1
                     /product="ficolin-1 precursor"
                     /protein_id="NP_032021.1"
                     /db_xref="CCDS:CCDS15785.1"
                     /db_xref="GeneID:14133"
                     /db_xref="MGI:MGI:1340905"
                     /translation="MQWPTLWAFSGLLCLCPSQALGQERGACPDVKVVGLGAQDKVVV
                     IQSCPGFPGPPGPKGEPGSPAGRGERGFQGSPGKMGPAGSKGEPGTMGPPGVKGEKGD
                     TGAAPSLGEKELGDTLCQRGPRSCKDLLTRGIFLTGWYTIHLPDCRPLTVLCDMDVDG
                     GGWTVFQRRVDGSIDFFRDWDSYKRGFGNLGTEFWLGNDYLHLLTANGNQELRVDLQD
                     FQGKGSYAKYSSFQVSEEQEKYKLTLGQFLEGTAGDSLTKHNNMSFTTHDQDNDANSM
                     NCAALFHGAWWYHNCHQSNLNGRYLSGSHESYADGINWGTGQGHHYSYKVAEMKIRAS
                     "
     exon            227..340
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /inference="alignment:Splign:2.1.0"
     exon            341..394
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..430
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..466
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /inference="alignment:Splign:2.1.0"
     exon            467..502
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..630
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /inference="alignment:Splign:2.1.0"
     exon            631..760
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /inference="alignment:Splign:2.1.0"
     exon            761..895
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1317
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1298..1303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /note="putative"
     polyA_site      1315
                     /gene="Fcna"
                     /gene_synonym="Fcn1"
                     /note="putative"
ORIGIN      
        1 ttttaacttg cactccttct caggagaaaa agctgagccg tgaggaatcc aggcagtgag
       61 ggtcttcact tcgttcatca gtgcctcagc ctccgtccag agccagggag tcaaggagtg
      121 gctgctgtac ccagagcaat gcagtggcct acgctgtggg ccttttcagg actgctctgt
      181 ctctgtccct cccaggccct gggtcaggag agaggtgcct gtccagatgt taaggtcgta
      241 ggtctggggg cccaggacaa ggtggttgtc atccaaagtt gccctggctt tcctggccca
      301 cctgggccca aaggggagcc tggaagccct gctggaagag gagaacgggg ctttcagggc
      361 agcccaggaa agatgggacc tgccggcagc aaaggagagc caggaaccat ggggcccccg
      421 ggagttaaag gggagaaagg cgatacagga gctgcgccat ctctgggtga aaaggagctg
      481 ggagacaccc tgtgccagag aggaccccgg agctgcaaag acttgctgac acggggcatc
      541 ttcctgactg gctggtacac catccatctt cctgactgcc ggccactgac tgtgctctgt
      601 gacatggatg tggacggtgg gggctggacc gtttttcaac gacgagtgga cgggtctatc
      661 gatttcttcc gagactggga ctcctataaa agaggctttg gcaacctggg cacggagttc
      721 tggttgggta atgactacct gcacctgctc acagccaatg ggaaccaaga gctccgagtt
      781 gacttacaag atttccaagg gaaaggctcc tatgccaagt acagctcatt ccaggtatct
      841 gaagaacagg agaaatacaa gctgaccttg gggcagtttc tggagggcac tgcaggagac
      901 tccctgacaa agcacaacaa catgtcattt acaacccatg accaagataa tgatgcaaat
      961 agcatgaact gtgcagcttt gttccatgga gcctggtggt accacaactg ccaccagtcc
     1021 aacctcaacg ggcgctactt gtctggctcc catgagagtt atgcggatgg catcaactgg
     1081 ggaactggcc aaggtcacca ctactcctac aaggttgccg agatgaaaat ccgagcatct
     1141 taaggtgccc cagtctccac ccagcctttc agccatgtcc aggccatgtg gggacactga
     1201 agggagggat ctctagaagt tgaagtctgt gtgcttatct attgtgggct ctctacactc
     1261 ccctctggac actgtccagc cctgactact atgcactaat aaaggtcaga gaagcag
//
