LOCUS       NM_026976               1492 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus Fc fragment of IgM receptor (Fcmr), transcript variant
            1, mRNA.
ACCESSION   NM_026976 XM_129390
VERSION     NM_026976.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1492)
  AUTHORS   Kampe,L., Melcher,C., Westphal,K., Brand,K., Foger,N. and Lee,K.H.
  TITLE     Acquisition of innate B cell properties and generation of
            autoreactive IgA antibodies by follicular B cells during
            homeostatic proliferation
  JOURNAL   Front Immunol 16, 1506628 (2025)
   PUBMED   39911392
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1492)
  AUTHORS   Stark,K., Kilani,B., Stockhausen,S., Busse,J., Schubert,I.,
            Tran,T.D., Gaertner,F., Leunig,A., Pekayvaz,K., Nicolai,L.,
            Fumagalli,V., Stermann,J., Stephan,F., David,C., Muller,M.B.,
            Heyman,B., Lux,A., da Palma Guerreiro,A., Frenzel,L.P.,
            Schmidt,C.Q., Dopler,A., Moser,M., Chandraratne,S., von Bruhl,M.L.,
            Lorenz,M., Korff,T., Rudelius,M., Popp,O., Kirchner,M., Mertins,P.,
            Nimmerjahn,F., Iannacone,M., Sperandio,M., Engelmann,B.,
            Verschoor,A. and Massberg,S.
  TITLE     Antibodies and complement are key drivers of thrombosis
  JOURNAL   Immunity 57 (9), 2140-2156 (2024)
   PUBMED   39226900
REFERENCE   3  (bases 1 to 1492)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1492)
  AUTHORS   McGettigan,S.E., Aira,L.E., Kumar,G., Ballet,R., Butcher,E.C.,
            Baumgarth,N. and Debes,G.F.
  TITLE     Secreted IgM modulates IL-10 expression in B cells
  JOURNAL   Nat Commun 15 (1), 324 (2024)
   PUBMED   38182585
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1492)
  AUTHORS   Mahmoudi Aliabadi,P., Al-Qaisi,K., Jani,P.K., Honjo,K., Klemm,U.,
            Lee,K.H., Baumgarth,N., Radbruch,A., Melchers,F. and Kubagawa,H.
  TITLE     Enhanced Mott cell formation linked with IgM Fc receptor (FcmuR)
            deficiency
  JOURNAL   Eur J Immunol 53 (7), e2250315 (2023)
   PUBMED   37098762
REFERENCE   6  (bases 1 to 1492)
  AUTHORS   Ouchida,R., Mori,H., Hase,K., Takatsu,H., Kurosaki,T., Tokuhisa,T.,
            Ohno,H. and Wang,J.Y.
  TITLE     Critical role of the IgM Fc receptor in IgM homeostasis, B-cell
            survival, and humoral immune responses
  JOURNAL   Proc Natl Acad Sci U S A 109 (40), E2699-E2706 (2012)
   PUBMED   22988094
REFERENCE   7  (bases 1 to 1492)
  AUTHORS   Honjo,K., Kubagawa,Y., Jones,D.M., Dizon,B., Zhu,Z., Ohno,H.,
            Izui,S., Kearney,J.F. and Kubagawa,H.
  TITLE     Altered Ig levels and antibody responses in mice deficient for the
            Fc receptor for IgM (FcmuR)
  JOURNAL   Proc Natl Acad Sci U S A 109 (39), 15882-15887 (2012)
   PUBMED   22984178
REFERENCE   8  (bases 1 to 1492)
  AUTHORS   Nguyen,X.H., Lang,P.A., Lang,K.S., Adam,D., Fattakhova,G.,
            Foger,N., Kamal,M.A., Prilla,P., Mathieu,S., Wagner,C., Mak,T.,
            Chan,A.C. and Lee,K.H.
  TITLE     Toso regulates the balance between apoptotic and nonapoptotic death
            receptor signaling by facilitating RIP1 ubiquitination
  JOURNAL   Blood 118 (3), 598-608 (2011)
   PUBMED   21613257
REFERENCE   9  (bases 1 to 1492)
  AUTHORS   Shima,H., Takatsu,H., Fukuda,S., Ohmae,M., Hase,K., Kubagawa,H.,
            Wang,J.Y. and Ohno,H.
  TITLE     Identification of TOSO/FAIM3 as an Fc receptor for IgM
  JOURNAL   Int Immunol 22 (3), 149-156 (2010)
   PUBMED   20042454
  REMARK    GeneRIF: These results identify TOSO/FAIM3 as a receptor for IgM
REFERENCE   10 (bases 1 to 1492)
  AUTHORS   Song,Y. and Jacob,C.O.
  TITLE     The mouse cell surface protein TOSO regulates Fas/Fas
            ligand-induced apoptosis through its binding to Fas-associated
            death domain
  JOURNAL   J Biol Chem 280 (10), 9618-9626 (2005)
   PUBMED   15632112
  REMARK    GeneRIF: mTOSO overexpressing primary T lymphocytes are resistant
            to Fas/Fas ligand-induced apoptosis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165322.12.
            
            On May 5, 2022 this sequence version replaced NM_026976.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155943.1, AK007714.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AC165322.12        130321-130440       c
            121-453             AC165322.12        121837-122169       c
            454-585             AC165322.12        121064-121195       c
            586-805             AC165322.12        120035-120254       c
            806-957             AC165322.12        118313-118464       c
            958-1116            AC165322.12        117876-118034       c
            1117-1175           AC165322.12        117706-117764       c
            1176-1492           AC165322.12        115426-115742       c
FEATURES             Location/Qualifiers
     source          1..1492
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 56.89 cM"
     gene            1..1492
                     /gene="Fcmr"
                     /gene_synonym="1810037B05Rik; Faim3; FcmuR; IgM FcR; Toso"
                     /note="Fc fragment of IgM receptor"
                     /db_xref="GeneID:69169"
                     /db_xref="MGI:MGI:1916419"
     exon            1..120
                     /gene="Fcmr"
                     /gene_synonym="1810037B05Rik; Faim3; FcmuR; IgM FcR; Toso"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1352
                     /gene="Fcmr"
                     /gene_synonym="1810037B05Rik; Faim3; FcmuR; IgM FcR; Toso"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; regulator of Fas-induced apoptosis Toso; Fas
                     apoptotic inhibitory molecule 3; IgM Fc fragment receptor;
                     immunoglobulin mu Fc receptor"
                     /codon_start=1
                     /product="immunoglobulin mu Fc receptor isoform 1
                     precursor"
                     /protein_id="NP_081252.1"
                     /db_xref="CCDS:CCDS15261.1"
                     /db_xref="GeneID:69169"
                     /db_xref="MGI:MGI:1916419"
                     /translation="MDFWLWLLYFLPVSGALRVLPEVQLNVEWGGSIIIECPLPQLHV
                     RMYLCRQMAKPGICSTVVSNTFVKKEYERRVTLTPCLDKKLFLVEMTQLTENDDGIYA
                     CGVGMKTDKGKTQKITLNVHNEYPEPFWEDEWTSERPRWLHRFLQHQMPWLHGSEHPS
                     SSGVIAKVTTPTPKTEAPPVHQPSSITSVTQHPRVYRAFSVSATKSPALLPATTASKT
                     STQQAIRPLEASYSHHTRLHEQRTRHHGPHYGREDRGLHIPIPEFHILIPTFLGFLLL
                     VLLGLVVKRAIQRRRASSRRAGRLAMRRRGRGASRPFPTQRRDASQRPRSQNNVYSAC
                     PRRARGPDSLGPAEAPLLNAPASASPASPQVLEAPWPHTPSLKMSCEYVSLGYQPAVN
                     LEDPDSDDYINIPDPSHLPSYAPGPRSSCQ"
     exon            121..453
                     /gene="Fcmr"
                     /gene_synonym="1810037B05Rik; Faim3; FcmuR; IgM FcR; Toso"
                     /inference="alignment:Splign:2.1.0"
     exon            454..585
                     /gene="Fcmr"
                     /gene_synonym="1810037B05Rik; Faim3; FcmuR; IgM FcR; Toso"
                     /inference="alignment:Splign:2.1.0"
     exon            586..805
                     /gene="Fcmr"
                     /gene_synonym="1810037B05Rik; Faim3; FcmuR; IgM FcR; Toso"
                     /inference="alignment:Splign:2.1.0"
     exon            806..957
                     /gene="Fcmr"
                     /gene_synonym="1810037B05Rik; Faim3; FcmuR; IgM FcR; Toso"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1116
                     /gene="Fcmr"
                     /gene_synonym="1810037B05Rik; Faim3; FcmuR; IgM FcR; Toso"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1175
                     /gene="Fcmr"
                     /gene_synonym="1810037B05Rik; Faim3; FcmuR; IgM FcR; Toso"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1492
                     /gene="Fcmr"
                     /gene_synonym="1810037B05Rik; Faim3; FcmuR; IgM FcR; Toso"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1469..1474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fcmr"
                     /gene_synonym="1810037B05Rik; Faim3; FcmuR; IgM FcR; Toso"
                     /note="hexamer: ATTACA"
     polyA_site      1492
                     /gene="Fcmr"
                     /gene_synonym="1810037B05Rik; Faim3; FcmuR; IgM FcR; Toso"
                     /note="major polyA site"
ORIGIN      
        1 agcatagctt tcaagcaccc agttgtagaa ggctcccagg tgatcggtgt gtgtcagcct
       61 cactccaggg cctccaggga accatggact tttggctttg gttactttac ttcctgccag
      121 tgtctggggc cctgagagtc ctcccagaag tacagctgaa tgtagagtgg ggtggatcca
      181 ttatcatcga atgcccactc cctcaactac acgtaaggat gtatctgtgt cggcagatgg
      241 ccaaacctgg gatatgctcc actgtggtgt ccaacacctt tgtcaagaag gaatatgaaa
      301 ggcgagtcac cctgacgcca tgcttggata agaagctatt cctagtggag atgacacagc
      361 tgacggaaaa tgacgatgga atctatgcct gtggtgtggg catgaagaca gacaaaggca
      421 agacccagaa aatcaccctg aatgtccata atgaataccc agaaccattc tgggaagatg
      481 aatggacctc tgagcggcca agatggttgc acagatttct gcagcaccag atgccctggc
      541 tccacgggag tgaacatccc agctcttctg gagtcatagc caaagttacc acgccaactc
      601 caaagactga ggcccctccg gttcaccagc cctccagcat cacttcagta acccaacatc
      661 ccagagttta cagagcattt tctgtgtcag ctaccaagtc cccagcgctc ctgccagcaa
      721 ccacagcctc aaagacttcc actcagcaag caatcaggcc cctagaggcc agctacagcc
      781 accacaccag acttcatgag caaaggacac gccaccatgg cccacactat gggagagaag
      841 accgagggct tcacatcccc atcccagaat ttcacatcct gattccgacc ttcctgggct
      901 ttctcttgct ggttcttttg ggactggtgg taaaaagagc cattcaaagg aggagagcct
      961 cctccagacg tgcgggccga ctagcgatga ggaggcgagg ccggggggct tcccgcccgt
     1021 tccccacaca gcgccgggat gcctcgcaga ggccgcgctc gcagaacaac gtctacagcg
     1081 cctgcccccg gcgcgcacgg ggaccagaca gcttgggtcc agcggaggct ccgctcctca
     1141 acgccccagc ctcagcgtcc cccgcttctc cgcaggtact tgaagctcct tggccccaca
     1201 ccccatctct gaagatgagc tgtgaatacg tgagcttggg ctaccagcct gctgtcaacc
     1261 tggaagaccc tgattcagat gattacatca atattcctga cccatctcat ctccctagct
     1321 atgccccagg gcccagatct tcatgccaat gagttctgcc tgtttgctga tgtctagcac
     1381 gttttcctta taggatccct gtcatggcgt atgtcctata ccctaagtcg actctcacct
     1441 gactatctga atgccttgag aatgatcaat tacaggctaa tttttcaccc ca
//
