LOCUS       NP_081252                422 aa            linear   ROD 11-MAR-2025
DEFINITION  immunoglobulin mu Fc receptor isoform 1 precursor [Mus musculus].
ACCESSION   NP_081252 XP_129390
VERSION     NP_081252.1
DBSOURCE    REFSEQ: accession NM_026976.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 422)
  AUTHORS   Kampe,L., Melcher,C., Westphal,K., Brand,K., Foger,N. and Lee,K.H.
  TITLE     Acquisition of innate B cell properties and generation of
            autoreactive IgA antibodies by follicular B cells during
            homeostatic proliferation
  JOURNAL   Front Immunol 16, 1506628 (2025)
   PUBMED   39911392
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 422)
  AUTHORS   Stark,K., Kilani,B., Stockhausen,S., Busse,J., Schubert,I.,
            Tran,T.D., Gaertner,F., Leunig,A., Pekayvaz,K., Nicolai,L.,
            Fumagalli,V., Stermann,J., Stephan,F., David,C., Muller,M.B.,
            Heyman,B., Lux,A., da Palma Guerreiro,A., Frenzel,L.P.,
            Schmidt,C.Q., Dopler,A., Moser,M., Chandraratne,S., von Bruhl,M.L.,
            Lorenz,M., Korff,T., Rudelius,M., Popp,O., Kirchner,M., Mertins,P.,
            Nimmerjahn,F., Iannacone,M., Sperandio,M., Engelmann,B.,
            Verschoor,A. and Massberg,S.
  TITLE     Antibodies and complement are key drivers of thrombosis
  JOURNAL   Immunity 57 (9), 2140-2156 (2024)
   PUBMED   39226900
REFERENCE   3  (residues 1 to 422)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 422)
  AUTHORS   McGettigan,S.E., Aira,L.E., Kumar,G., Ballet,R., Butcher,E.C.,
            Baumgarth,N. and Debes,G.F.
  TITLE     Secreted IgM modulates IL-10 expression in B cells
  JOURNAL   Nat Commun 15 (1), 324 (2024)
   PUBMED   38182585
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 422)
  AUTHORS   Mahmoudi Aliabadi,P., Al-Qaisi,K., Jani,P.K., Honjo,K., Klemm,U.,
            Lee,K.H., Baumgarth,N., Radbruch,A., Melchers,F. and Kubagawa,H.
  TITLE     Enhanced Mott cell formation linked with IgM Fc receptor (FcmuR)
            deficiency
  JOURNAL   Eur J Immunol 53 (7), e2250315 (2023)
   PUBMED   37098762
REFERENCE   6  (residues 1 to 422)
  AUTHORS   Ouchida,R., Mori,H., Hase,K., Takatsu,H., Kurosaki,T., Tokuhisa,T.,
            Ohno,H. and Wang,J.Y.
  TITLE     Critical role of the IgM Fc receptor in IgM homeostasis, B-cell
            survival, and humoral immune responses
  JOURNAL   Proc Natl Acad Sci U S A 109 (40), E2699-E2706 (2012)
   PUBMED   22988094
REFERENCE   7  (residues 1 to 422)
  AUTHORS   Honjo,K., Kubagawa,Y., Jones,D.M., Dizon,B., Zhu,Z., Ohno,H.,
            Izui,S., Kearney,J.F. and Kubagawa,H.
  TITLE     Altered Ig levels and antibody responses in mice deficient for the
            Fc receptor for IgM (FcmuR)
  JOURNAL   Proc Natl Acad Sci U S A 109 (39), 15882-15887 (2012)
   PUBMED   22984178
REFERENCE   8  (residues 1 to 422)
  AUTHORS   Nguyen,X.H., Lang,P.A., Lang,K.S., Adam,D., Fattakhova,G.,
            Foger,N., Kamal,M.A., Prilla,P., Mathieu,S., Wagner,C., Mak,T.,
            Chan,A.C. and Lee,K.H.
  TITLE     Toso regulates the balance between apoptotic and nonapoptotic death
            receptor signaling by facilitating RIP1 ubiquitination
  JOURNAL   Blood 118 (3), 598-608 (2011)
   PUBMED   21613257
REFERENCE   9  (residues 1 to 422)
  AUTHORS   Shima,H., Takatsu,H., Fukuda,S., Ohmae,M., Hase,K., Kubagawa,H.,
            Wang,J.Y. and Ohno,H.
  TITLE     Identification of TOSO/FAIM3 as an Fc receptor for IgM
  JOURNAL   Int Immunol 22 (3), 149-156 (2010)
   PUBMED   20042454
  REMARK    GeneRIF: These results identify TOSO/FAIM3 as a receptor for IgM
REFERENCE   10 (residues 1 to 422)
  AUTHORS   Song,Y. and Jacob,C.O.
  TITLE     The mouse cell surface protein TOSO regulates Fas/Fas
            ligand-induced apoptosis through its binding to Fas-associated
            death domain
  JOURNAL   J Biol Chem 280 (10), 9618-9626 (2005)
   PUBMED   15632112
  REMARK    GeneRIF: mTOSO overexpressing primary T lymphocytes are resistant
            to Fas/Fas ligand-induced apoptosis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165322.12.
            
            On May 17, 2005 this sequence version replaced XP_129390.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155943.1, AK007714.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..422
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 56.89 cM"
     Protein         1..422
                     /product="immunoglobulin mu Fc receptor isoform 1
                     precursor"
                     /note="regulator of Fas-induced apoptosis Toso; Fas
                     apoptotic inhibitory molecule 3; IgM Fc fragment receptor;
                     immunoglobulin mu Fc receptor"
                     /calculated_mol_wt=45592
     sig_peptide     1..16
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1958
     Region          18..120
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          33..37
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409031"
     Region          45..49
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409031"
     Region          86..90
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409031"
     Site            91
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q5M871; propagated from
                     UniProtKB/Swiss-Prot (A1KXC4.2)"
     Region          100..105
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409031"
     Region          114..117
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409031"
     Site            263..283
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (A1KXC4.2)"
     Site            264
                     /site_type="other"
                     /note="Receptor capping.
                     /evidence=ECO:0000250|UniProtKB:O60667; propagated from
                     UniProtKB/Swiss-Prot (A1KXC4.2)"
     Region          290..367
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A1KXC4.2)"
     Site            382
                     /site_type="other"
                     /note="Receptor-mediated endocytosis.
                     /evidence=ECO:0000250|UniProtKB:O60667; propagated from
                     UniProtKB/Swiss-Prot (A1KXC4.2)"
     Site            401
                     /site_type="other"
                     /note="Receptor-mediated endocytosis.
                     /evidence=ECO:0000250|UniProtKB:O60667; propagated from
                     UniProtKB/Swiss-Prot (A1KXC4.2)"
     CDS             1..422
                     /gene="Fcmr"
                     /gene_synonym="1810037B05Rik; Faim3; FcmuR; IgM FcR; Toso"
                     /coded_by="NM_026976.4:84..1352"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS15261.1"
                     /db_xref="GeneID:69169"
                     /db_xref="MGI:MGI:1916419"
ORIGIN      
        1 mdfwlwllyf lpvsgalrvl pevqlnvewg gsiiiecplp qlhvrmylcr qmakpgicst
       61 vvsntfvkke yerrvtltpc ldkklflvem tqltenddgi yacgvgmktd kgktqkitln
      121 vhneypepfw edewtserpr wlhrflqhqm pwlhgsehps ssgviakvtt ptpkteappv
      181 hqpssitsvt qhprvyrafs vsatkspall pattasktst qqairpleas yshhtrlheq
      241 rtrhhgphyg redrglhipi pefhiliptf lgflllvllg lvvkraiqrr rassrragrl
      301 amrrrgrgas rpfptqrrda sqrprsqnnv ysacprrarg pdslgpaeap llnapasasp
      361 aspqvleapw phtpslkmsc eyvslgyqpa vnledpdsdd yinipdpshl psyapgprss
      421 cq
//
