LOCUS       NM_199012               4432 bp    mRNA    linear   ROD 21-DEC-2022
DEFINITION  Mus musculus FCH and double SH3 domains 2 (Fchsd2), transcript
            variant 1, mRNA.
ACCESSION   NM_199012 XM_149969
VERSION     NM_199012.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4432)
  AUTHORS   Becalska AN, Kelley CF, Berciu C, Stanishneva-Konovalova TB, Fu X,
            Wang S, Sokolova OS, Nicastro D and Rodal AA.
  TITLE     Formation of membrane ridges and scallops by the F-BAR protein
            Nervous Wreck
  JOURNAL   Mol Biol Cell 24 (15), 2406-2418 (2013)
   PUBMED   23761074
REFERENCE   2  (bases 1 to 4432)
  AUTHORS   Cao H, Yin X, Cao Y, Jin Y, Wang S, Kong Y, Chen Y, Gao J, Heller S
            and Xu Z.
  TITLE     FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and
            cuticular plate and regulate actin polymerization in vitro
  JOURNAL   PLoS One 8 (2), e56516 (2013)
   PUBMED   23437151
  REMARK    GeneRIF: Our results suggest that FCHSD1 and FCHSD2 could modulate
            F-actin assembly or maintenance in hair cell stereocilia and
            cuticular plate.
REFERENCE   3  (bases 1 to 4432)
  AUTHORS   Bulfone A, Carotenuto P, Faedo A, Aglio V, Garzia L, Bello AM,
            Basile A, Andre A, Cocchia M, Guardiola O, Ballabio A, Rubenstein
            JL and Zollo M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   4  (bases 1 to 4432)
  AUTHORS   Katoh M and Katoh M.
  TITLE     Identification and characterization of human FCHSD1 and FCHSD2
            genes in silico
  JOURNAL   Int J Mol Med 13 (5), 749-754 (2004)
   PUBMED   15067381
REFERENCE   5  (bases 1 to 4432)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Aizawa H, Yuasa S,
            Nakajima D, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   6  (bases 1 to 4432)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK141949.1 and BC060647.1.
            
            [WARNING] On May 2, 2023 this sequence was replaced by NM_199012.3.
            
            On Mar 24, 2009 this sequence version replaced NM_199012.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060647.1, AK122368.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AK141949.1         1-38
            39-4432             BC060647.1         1-4394
FEATURES             Location/Qualifiers
     source          1..4432
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7"
     gene            1..4432
                     /gene="Fchsd2"
                     /gene_synonym="mKIAA0769; NWK1; Sh3md3"
                     /note="FCH and double SH3 domains 2"
                     /db_xref="GeneID:207278"
                     /db_xref="MGI:MGI:2448475"
     exon            1..265
                     /gene="Fchsd2"
                     /gene_synonym="mKIAA0769; NWK1; Sh3md3"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..2539
                     /gene="Fchsd2"
                     /gene_synonym="mKIAA0769; NWK1; Sh3md3"
                     /note="isoform 1 is encoded by transcript variant 1; SH3
                     multiple domains 3; FCH and double SH3 domains protein 2;
                     SH3 multiple domains protein 3; F-BAR and double SH3
                     domains protein 2; protein nervous wreck 1"
                     /codon_start=1
                     /product="F-BAR and double SH3 domains protein 2 isoform
                     1"
                     /protein_id="NP_950177.2"
                     /db_xref="CCDS:CCDS52327.1"
                     /db_xref="GeneID:207278"
                     /db_xref="MGI:MGI:2448475"
                     /translation="MQPPPRKVKVTQELRNIQGEQMTKLQAKHQAECDLLEDMRTFSQ
                     KKAAIEREYAQGIQKLASQYLKRDWPGIKTDDRNDYRSMYPVWKSFLEGTMQVAQSRI
                     NICENYKNFISEPARAVRSLKEQQLKRCVDQLTKIQTELQETVKDLVKGKKKYFETEQ
                     MAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNTKATHARNDYLLTLAAA
                     NAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAIQNTFQFLLENSSK
                     VVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSLKAAQLVDIELSPVSALRMTIAESR
                     QLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNELECHGVALSEQSRAELE
                     QKIDEARESIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENERWARPP
                     AVTSNGTLHSLNADAEREEGEEFEDNMDVFDDSSSSPSGTLRNYPLTCKVVYSYKASQ
                     PDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTSNSLLSMLQSLAA
                     LDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFPEGAIIRILNKE
                     NQDDDGFWEGEFSGRIGVFPSVLVEELSASENGDTPWTREIQISPSPKPHTSLPPLPL
                     YDQPPSSPYPSPDKRSSQFFPRSPSANENSLHAESPGFSQASRQTPDTSYGKLRPVRA
                     APPPPTQNHRRTTEKMEDVEITLV"
     exon            266..363
                     /gene="Fchsd2"
                     /gene_synonym="mKIAA0769; NWK1; Sh3md3"
                     /inference="alignment:Splign:2.1.0"
     exon            364..409
                     /gene="Fchsd2"
                     /gene_synonym="mKIAA0769; NWK1; Sh3md3"
                     /inference="alignment:Splign:2.1.0"
     exon            410..486
                     /gene="Fchsd2"
                     /gene_synonym="mKIAA0769; NWK1; Sh3md3"
                     /inference="alignment:Splign:2.1.0"
     exon            487..631
                     /gene="Fchsd2"
                     /gene_synonym="mKIAA0769; NWK1; Sh3md3"
                     /inference="alignment:Splign:2.1.0"
     exon            632..765
                     /gene="Fchsd2"
                     /gene_synonym="mKIAA0769; NWK1; Sh3md3"
                     /inference="alignment:Splign:2.1.0"
     exon            766..820
                     /gene="Fchsd2"
                     /gene_synonym="mKIAA0769; NWK1; Sh3md3"
                     /inference="alignment:Splign:2.1.0"
     exon            821..949
                     /gene="Fchsd2"
                     /gene_synonym="mKIAA0769; NWK1; Sh3md3"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1072
                     /gene="Fchsd2"
                     /gene_synonym="mKIAA0769; NWK1; Sh3md3"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1168
                     /gene="Fchsd2"
                     /gene_synonym="mKIAA0769; NWK1; Sh3md3"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1240
                     /gene="Fchsd2"
                     /gene_synonym="mKIAA0769; NWK1; Sh3md3"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1357
                     /gene="Fchsd2"
                     /gene_synonym="mKIAA0769; NWK1; Sh3md3"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1462
                     /gene="Fchsd2"
                     /gene_synonym="mKIAA0769; NWK1; Sh3md3"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1624
                     /gene="Fchsd2"
                     /gene_synonym="mKIAA0769; NWK1; Sh3md3"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1759
                     /gene="Fchsd2"
                     /gene_synonym="mKIAA0769; NWK1; Sh3md3"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1843
                     /gene="Fchsd2"
                     /gene_synonym="mKIAA0769; NWK1; Sh3md3"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..2021
                     /gene="Fchsd2"
                     /gene_synonym="mKIAA0769; NWK1; Sh3md3"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2242
                     /gene="Fchsd2"
                     /gene_synonym="mKIAA0769; NWK1; Sh3md3"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2372
                     /gene="Fchsd2"
                     /gene_synonym="mKIAA0769; NWK1; Sh3md3"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2455
                     /gene="Fchsd2"
                     /gene_synonym="mKIAA0769; NWK1; Sh3md3"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..4411
                     /gene="Fchsd2"
                     /gene_synonym="mKIAA0769; NWK1; Sh3md3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccttcccg gcgctcctcc ttctctccac actcgctgcg acccggctgc tcctgccgct
       61 cgcctgcctc gcagcctccg ggccgattcc tcttccttct ccttcccagg ctctcctttc
      121 acacacacac aagcgcgcgc cctggcttgc tgggccgccc cattttctcc aaccctcctc
      181 accctcacag tcctttaaac gccgccgtca ggggtgggcg gaggattgat gtcccttcag
      241 catcatgcag ccgccgccga ggaaggtgaa agttacacaa gagctgagaa acattcaagg
      301 tgagcagatg acaaaacttc aagccaaaca tcaggcagaa tgtgacttac ttgaagacat
      361 gaggactttc agtcagaaga aggctgctat tgaaagagag tatgcacagg gtatccagaa
      421 gttggctagt caatacctga agagagattg gcctggaata aaaactgatg atcggaatga
      481 ttacaggagt atgtatcctg tttggaaatc ttttctcgag ggaacaatgc aggtagccca
      541 gtctcggatc aatatatgtg aaaactataa aaacttcatt tctgaacctg caagagcagt
      601 aagaagctta aaagaacagc aactaaaacg gtgtgtggat cagttgacaa agatccaaac
      661 agaattacag gaaactgtga aagatttagt gaaaggcaaa aagaagtact ttgagactga
      721 acagatggct catgcagtaa gagagaaagc tgacatcgaa gcaaagtcta aacttagtct
      781 ttttcaatca agaatcagtt tacagaaagc aagtgtgaag ttaaaagccc ggcgatctga
      841 atgtaatacc aaagctaccc atgcaaggaa tgattacctt ctgacgctag cagcagctaa
      901 cgcacatcag gaccgctact atcaaacaga cttagttaac atcatgaagg ctcttgatgg
      961 aaacgtgtat gaccacctca aggattattt aatagccttc agccggaccg agctagaaac
     1021 ttgccaagct atacagaata cattccagtt tttactagaa aactccagca aggtggtacg
     1081 ggactataac cttcagctgt ttctacaaga gaatgctgta tttcacaagc ctcagccctt
     1141 ccagttccag ccttgtgaca gtgatactag tttaaaagcc gcccaactgg tggatattga
     1201 gctctcccct gtcagtgctc tgagaatgac gatagctgag agtcgacaat tagaatcaga
     1261 aactggtacc acagaggaac acagtctaaa taaggaggct cggaaatggg ccacacgtgt
     1321 ggcacgtgag cacaaaaata ttgttcatca gcagcgggtt ctaaatgaac tagaatgtca
     1381 tggagttgct ctatcagaac agagccgagc agagctggaa cagaaaatag atgaagcaag
     1441 agaaagtatc cgtaaagcag agatcattaa attgaaagct gaagcccggc tagacctact
     1501 gaagcagatt ggggtttctg tagatacgtg gttaaagagt gccatgaacc aagtgatgga
     1561 ggaactagaa aatgagcggt gggcccgtcc tccagccgtg accagcaatg gcactctaca
     1621 ctcgcttaat gcagatgctg aaagagaaga aggagaagag tttgaagaca acatggatgt
     1681 ttttgatgac agcagctcca gcccttctgg caccttgaga aattatccac tcacctgcaa
     1741 agttgtttat tcctataagg cttctcaacc agatgagttg accattgagg aacatgaggt
     1801 gttagaagtg attgaagatg gagatatgga agactgggta aaggctcgaa ataaagttgg
     1861 ccaagtgggt tatgtgccag aaaagtacct acaatttccc acctcgaaca gcctactgag
     1921 catgctacag tctttggctg ctttggacag tcggtcacac acatccagca attccacaga
     1981 agcagaactc gtttcaggca gcctgaatgg agatgccagt gtctgttttg tgaaagcact
     2041 ttatgattat gagggccaga cagatgatga gctgtccttt cccgagggag caattattcg
     2101 catcttgaac aaagaaaacc aagatgatga tggcttctgg gaaggggagt tcagtggtcg
     2161 aatcggtgtt ttcccatcgg tgctagtgga agagctctca gcctccgaga atggcgacac
     2221 tccatggaca agagagatcc agatctctcc atcccccaag cctcacacat ccctgcctcc
     2281 actgcctctg tatgaccagc cacccagcag cccgtatccc agtccagata agaggagctc
     2341 ccagttcttc ccccggtctc cttcagccaa tgaaaacagc cttcatgctg aatcaccagg
     2401 attctcacag gcctcaagac agactcctga cacctcatat ggcaagctgc ggcctgttcg
     2461 ggcggcgccg ccaccaccca cacagaacca ccggcggaca actgagaaga tggaggacgt
     2521 ggagatcaca ctggtgtgac agtggattta ccttccgtta ctgctacaat caaggccagg
     2581 cttggagttt ggccagtctc attttttagg cacctttgca tgatgatgac tcttgaaagg
     2641 agcaaaacca aggaggattc gatgggactg gttggcctga ttgtgccttt tttgttgtcg
     2701 ttttttatgt catctctcct accatagcac aaatcatagc gggtcctaga agcagagggg
     2761 agcagctctc atgccttata gtggcccatt tttatatgag actcaaggcc aggcctagat
     2821 ccagggcaca gacccagaat taccaattgt gtgaactcgt acagtatatt actgtggcca
     2881 tgcacagggc tgtggcaaag atctcatctt tcctcaagtg gattttgctc ttctgattgt
     2941 tattcaaatc aagttgactg tgtaaggaaa tccaggagag gctggctcct ccccaggttc
     3001 attcccatac tgaaaatgca accttattga gaagaaagtg gactgcctga gcttagcgcc
     3061 aattgcataa tgcacatctc ttcctcaact aacagattta aaataacagt gtcctttgta
     3121 ttaatattta tgccattcat ttagtattag tgggctaacc tggaggggct gaggccacat
     3181 ctttcccatc acatagacta gaagggaggc taaggaagaa gcagaaatgg agcttccaca
     3241 tctgaaatga gccactttaa tgttcctttt gtctttgggt atgtttcctc ttggttttta
     3301 cagtgtatac cctctgacca gtatcctttg aatccaagtg tctggctgca ttgaggacaa
     3361 aggcctacat tgctcagctt ctctactgga gaggccctta tattatttta ttcccaagcc
     3421 agagtattgg cctagacatc tgggttgtga ttggtgcaga ccagctgtcg ccttctgaaa
     3481 gtacagcttc aggtcccact gccctgacat ttgtccagag tgaagaatct atgggccctg
     3541 gaggaagcct gctttctgtg gaaaggatac aggactgtac acctgcccag gtgagaccaa
     3601 ggaggctagc accttctgca ggtcagggaa gagcctcatg gcgccctggc ctcagcctag
     3661 aaggtcaagc actctgtgga cggtagatct tgacctaggg aacaaagcaa tgcttgccaa
     3721 tcctctttta ccttggctgg gaaaagaaat ttacagattt aaaggttgta tgatgctttg
     3781 aaatttccat cccttctgag aatctctaaa aacttgaaat ggtcacatgt ccccgtggga
     3841 tttttgactg atatcggagc tgaagggatt ttcagtcatt tgatcacttt agcaatgata
     3901 ctctgatgaa tcttctccat gaatttggat ttttggtttt tacatttatc tgttgatcta
     3961 tttgaggtct ttttatgttt atcaaactta ttcttaagtt taaaaaatta aaagggtatt
     4021 ttaagatttt caaatttgct gatcttcaaa gtgcttataa tagagcagtt cctgctacca
     4081 gtcctgtatt ctgtttagct aaccaaattg tccttggatt tgagtttccc acaacctcag
     4141 agttatttga actcttttgt tatattttaa aatatttttt ggaagagctg ctaattttat
     4201 tttaagaaac aaagttgtaa aaatatgcct cctttttaaa aataaataaa taaataaccc
     4261 ttctctccag gccgaataac ccggcgtcac catgcacagg tcagggctca aagggagcct
     4321 ccgtgcaggt gcgctttctt tacagtggct gtaaaaagtt tgtatttatt atgtataaaa
     4381 tgttgaataa taaaaaatga aattaagttt taaaaaaaaa aaaaaaaaaa aa
//
