LOCUS       NM_001418706            4277 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus FCH and double SH3 domains 1 (Fchsd1), transcript
            variant 2, mRNA.
ACCESSION   NM_001418706 XM_006526003
VERSION     NM_001418706.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4277)
  AUTHORS   Kawasaki,T., Sugihara,F., Fukushima,K., Matsuki,T., Nabeshima,H.,
            Machida,T., Mitsui,Y., Fujimura,S., Sagawa,R., Gaheun,L.,
            Kuniyoshi,K., Tanaka,H., Narazaki,M., Kumanogoh,A., Akira,S. and
            Satoh,T.
  TITLE     Loss of FCHSD1 leads to amelioration of chronic obstructive
            pulmonary disease
  JOURNAL   Proc Natl Acad Sci U S A 118 (26) (2021)
   PUBMED   34168078
  REMARK    GeneRIF: Loss of FCHSD1 leads to amelioration of chronic
            obstructive pulmonary disease.
REFERENCE   2  (bases 1 to 4277)
  AUTHORS   Becalska,A.N., Kelley,C.F., Berciu,C., Stanishneva-Konovalova,T.B.,
            Fu,X., Wang,S., Sokolova,O.S., Nicastro,D. and Rodal,A.A.
  TITLE     Formation of membrane ridges and scallops by the F-BAR protein
            Nervous Wreck
  JOURNAL   Mol Biol Cell 24 (15), 2406-2418 (2013)
   PUBMED   23761074
REFERENCE   3  (bases 1 to 4277)
  AUTHORS   Cao,H., Yin,X., Cao,Y., Jin,Y., Wang,S., Kong,Y., Chen,Y., Gao,J.,
            Heller,S. and Xu,Z.
  TITLE     FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and
            cuticular plate and regulate actin polymerization in vitro
  JOURNAL   PLoS One 8 (2), e56516 (2013)
   PUBMED   23437151
  REMARK    GeneRIF: Our results suggest that FCHSD1 and FCHSD2 could modulate
            F-actin assembly or maintenance in hair cell stereocilia and
            cuticular plate.
REFERENCE   4  (bases 1 to 4277)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   5  (bases 1 to 4277)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human FCHSD1 and FCHSD2
            genes in silico
  JOURNAL   Int J Mol Med 13 (5), 749-754 (2004)
   PUBMED   15067381
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129315.3.
            
            On Mar 22, 2023 this sequence version replaced XM_006526003.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219379.55468.1,
                                           SRR17784648.895858.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AC129315.3         170020-170089       c
            71-168              AC129315.3         169669-169766       c
            169-214             AC129315.3         169064-169109       c
            215-282             AC129315.3         168528-168595       c
            283-424             AC129315.3         168074-168215       c
            425-561             AC129315.3         167852-167988       c
            562-625             AC129315.3         167677-167740       c
            626-754             AC129315.3         166755-166883       c
            755-877             AC129315.3         166213-166335       c
            878-973             AC129315.3         165965-166060       c
            974-1093            AC129315.3         165105-165224       c
            1094-1198           AC129315.3         164628-164732       c
            1199-1360           AC129315.3         164322-164483       c
            1361-1489           AC129315.3         163607-163735       c
            1490-1573           AC129315.3         163442-163525       c
            1574-1691           AC129315.3         163234-163351       c
            1692-1912           AC129315.3         162887-163107       c
            1913-2000           AC129315.3         161561-161648       c
            2001-2056           AC129315.3         160092-160147       c
            2057-4277           AC129315.3         157748-159968       c
FEATURES             Location/Qualifiers
     source          1..4277
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.84 cM"
     gene            1..4277
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /note="FCH and double SH3 domains 1"
                     /db_xref="GeneID:319262"
                     /db_xref="MGI:MGI:2441771"
     exon            1..70
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            71..168
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            169..214
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            215..282
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            283..424
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            425..561
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            562..625
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            626..754
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            755..877
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            878..973
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1093
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1198
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1360
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1489
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1573
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1691
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1912
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2000
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2056
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..4277
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2574..2579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /note="hexamer: AATAAA"
     polyA_site      2594
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /note="major polyA site"
     regulatory      4257..4262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /note="hexamer: AATAAA"
     polyA_site      4277
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /note="major polyA site"
ORIGIN      
        1 ctccccgagt tccggagtag agtgtctggc agcctttgct ggagccgcga tgcagccgcc
       61 gccccgaaaa gtgaagccag cccaggaggt taaacttcgc tttttggagc agctgagcat
      121 ccttcagacc cggcagcaga gggaggcgga tctactggag gacatcagat cttacagcaa
      181 gcaaagggca gccattgaac gggagtatgg ccaggccctc cagaagctgg ctgggccatt
      241 cctgaagaga gaagggcagc ggagtggaga ggcagacagc aggggtagga cagtgtttgg
      301 tgcctggcgc tgccttctgg atgccactgt ggctggaggc caaaccagac tccaggcgtc
      361 tgaccgatat cgcgacctag cagggggtac tgggagaagc gccaaggagc aggtgcttag
      421 aaaggggaca gagagcctcc agcaggcaca ggctgaggtg ttacagtctg tccgggagct
      481 gagccgaagt cggaagctct atgggcagcg acagcgtgta tgggccttgg cccaggagaa
      541 ggcagctgat gtccaggcca ggctgaaccg aagtgaccat gggatcttcc attctcggac
      601 cagcctccag aaactgagca ccaagctgtc tgcccagtca gcccagtatt cccagcagct
      661 gagagcagcc cgcaatgagt acctgctaaa tttggtggcc accaatgctc accttgccca
      721 ctactaccaa gaggaattgc cagcactgct caaggtcctg gtaagtgagc tgtcagaata
      781 cttgagggac cccctgactt tactgggaca cacagagctg gaagctgcgg agatgatcct
      841 ggagcatgcc cgccatgggg ggaaggcaac gtctcaggta aactgggaac aagatgtgaa
      901 gctgtttctt caggggcctg gagtcttttc tcccacccca cctcagcagt tccagccggc
      961 aggggctgat caggtatgtg gcctggagtg gggagcagga ggcatggctg gagagagtgg
     1021 cctggagaaa gaggttcagc gctggacaag cagggctgcc cgggactaca agatccagca
     1081 tcacgggcat cgggtcctgc agcgactgga gcagaggcgt cagcaggccc cggggcgaga
     1141 agctccaggc gtagaacagc ggctacagga agtgagggag aacatccgac gggcacaggt
     1201 gagccaggtg aaaggggccg cccggctggc cctgttacag gaggctggtc tcgatgtaca
     1261 gcgctggctg aagccagcca tgacccaagc ccaggatgag gtggaacagg agcggcgact
     1321 tagtgaagct cgactgtccc agagggacct ctctcccacg gctgaggatg ctgagctttc
     1381 tgacttcgat gaatgtgagg aagctgggga gctctttgag gagcctgccc caccagccct
     1441 ggctaccaga cccctcccct gccctgcaca tgtagtgttc ggctatcagg caggacgtga
     1501 ggatgagctg accatcacag agggtgagtg gctggaggtc atagaggaag gagatgctga
     1561 cgagtgggtt aaggctcgga accagcacgg tgaagcgggc tttgtccctg agcgatatct
     1621 caacttcccg gatctctccc tgcctgagag ctgccatggc atcgacaatc cctcaggagg
     1681 agagcccaca gcattcttgg cacgcgctct gtacagctac acgggacaga gtgaagagga
     1741 gctaagtttc cctgaagggg cactcatccg cctgttgccc agggctcaag atggagtgga
     1801 tgatggcttc tggaggggag aatttggggg ccatgttgga gtcttcccat ctctcctggt
     1861 agaggaactg cttggtcccc cggggccacc tgagctctct gaccctgaac agatgctgcc
     1921 gtccccttct cctcccagct tctcccctcc tgcacccacc tgtgccttgg acggatctac
     1981 tgcgcctgct ctgccttctg acaaagtcct tgactgccct ggacccctag acatgatggt
     2041 gcctcgactt aggccgatgc gtccaccacc tcccccacca gccaaagccc cggaccctgg
     2101 tcatcccgat cctctcactt gaaggccagg agtcattgcc cgccagtgat gctgctgtcc
     2161 ctgtctccac gctgacagaa accacccctt caatggtctg gagtgacata ggcaaaagct
     2221 gcaatctttc tcgatgtccg ttctcacctc catgggtgga gacttaccct gttcccattt
     2281 ctgggatttg gacccatgca tcaccccctc ccattgttct catgtcattt ctggaagtac
     2341 tcttttgact tcttgccatc accccatatc taaggtgggc tggaacccat ctcccaaagc
     2401 cttgcacggc tctggctcat ctccgtcttc cccctgcctc tgtggtcaac cccaccctga
     2461 atgccagggt cactaggcct ggggccagga gaggagcaga ccttggaagt cagaaggagc
     2521 tggagccagg atgcagagca actgtaatgg tctgagcgga tttattgaca gtgaataaag
     2581 ggtatgaagt ccaagccagg gcctgggcct cttgtgccaa gatggcaggg ggcctaaggt
     2641 gctattgctt taggggccca ccgagggtag ggcctggtcc cagcagccac gctctagcat
     2701 gtggagcgag gttttgggga aggcaggcca ggcaacctgt tggcaggtgg ggaaagggaa
     2761 cagaatgagg ggctgggaat tgggaggggc tcctcctgag ggctctcagc cggggaccat
     2821 gtatctccag atggaagtag agttggtccc tcaactgagg ggcagagctg tccagtggag
     2881 gggagagcct tcctggctat ccgtcccctg gcaatgcctg ctggtaaccc atcagcacag
     2941 tgaagactga ggcttggaag aaaggaaggg aagcagtgtt gttgcctagt caagctctgt
     3001 tctccaggca ttgtattgta tctcctggag gaacctgtgc ccgctcccca cacactaagc
     3061 ttacagttca cccacctcca ggattcaggg agttgatggg cttgagtagt ttagatagag
     3121 ggcaggaggg tgagattacc tgatctggag ctcagggaga cttggctcac ataccccctg
     3181 cttctggtgg tagagactcc tgagaggagg gggaaggatt cagtgggaac aggaagtgga
     3241 tcatacccac gttgcccaga gtagggatgg taagatgtgt gtccgccact gcccagtgca
     3301 gccctgggca tgtcttcata cctgctgacc tgaggtgtcc agtttggttg gctgtccatt
     3361 tgcttcttga ctagacagcc ctgggcttgg gtctctccct ctagggccca agttcagttc
     3421 tgcagaggtt ccaggggtcc cctcaagtgt acaagggacg aggctggcat cctggagtct
     3481 tccgttctgc actgagtggg tggctgcggc ctgggagggt ggcggctcag ggagcagcct
     3541 ctcaatggca gctgtccctg tcctaggctg ccctcctcca gccgcctgac taccccctgg
     3601 ctcctgccct ccaccagagc cccagcttct gtccgtaggg gaaccatcac gatgttcatg
     3661 taggccgtag cgcttctcaa tgtgtgttac tcggaatctg ggtgggaaga gaatgttgca
     3721 actcaggctt acagctcaga ggctcctaaa cgtccctccc tgggtttgac cttgggtagg
     3781 gaagccttct gagactgtgg gatactgtgc cacctgaccc ctgctgtagt tgcctagagg
     3841 aaattcagag gaaagaattg gggcccaact tttggggggt caggattatt ggggctccag
     3901 tttaacctcc cttttcttgg actactatat ccccacctgc ccactgaaaa aacagtggtc
     3961 tctccaggtc tgggacggct ttttccttcc ttagagcgac cctgacggac aagtgggggc
     4021 ctcttgctgc ggctgcagtg gatgcaagga gctgcagagc caaggtgcac tgtgtgatga
     4081 tgggaggggg ctccgtcctg caggctggag gtggcatcca cactggacca cagaagggaa
     4141 gggagcagaa acgatatctt caattccctt cctgctcttt cgtcctgttc tttcaatatg
     4201 ctcttcagac ttcctcaaac cccaccttcc ccaggtctca acatcccttt gcctgtaata
     4261 aattcactgt taagcca
//
