LOCUS       NP_001405635             690 aa            linear   ROD 01-MAY-2025
DEFINITION  F-BAR and double SH3 domains protein 1 isoform 2 [Mus musculus].
ACCESSION   NP_001405635 XP_006526066
VERSION     NP_001405635.1
DBSOURCE    REFSEQ: accession NM_001418706.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 690)
  AUTHORS   Kawasaki,T., Sugihara,F., Fukushima,K., Matsuki,T., Nabeshima,H.,
            Machida,T., Mitsui,Y., Fujimura,S., Sagawa,R., Gaheun,L.,
            Kuniyoshi,K., Tanaka,H., Narazaki,M., Kumanogoh,A., Akira,S. and
            Satoh,T.
  TITLE     Loss of FCHSD1 leads to amelioration of chronic obstructive
            pulmonary disease
  JOURNAL   Proc Natl Acad Sci U S A 118 (26) (2021)
   PUBMED   34168078
  REMARK    GeneRIF: Loss of FCHSD1 leads to amelioration of chronic
            obstructive pulmonary disease.
REFERENCE   2  (residues 1 to 690)
  AUTHORS   Becalska,A.N., Kelley,C.F., Berciu,C., Stanishneva-Konovalova,T.B.,
            Fu,X., Wang,S., Sokolova,O.S., Nicastro,D. and Rodal,A.A.
  TITLE     Formation of membrane ridges and scallops by the F-BAR protein
            Nervous Wreck
  JOURNAL   Mol Biol Cell 24 (15), 2406-2418 (2013)
   PUBMED   23761074
REFERENCE   3  (residues 1 to 690)
  AUTHORS   Cao,H., Yin,X., Cao,Y., Jin,Y., Wang,S., Kong,Y., Chen,Y., Gao,J.,
            Heller,S. and Xu,Z.
  TITLE     FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and
            cuticular plate and regulate actin polymerization in vitro
  JOURNAL   PLoS One 8 (2), e56516 (2013)
   PUBMED   23437151
  REMARK    GeneRIF: Our results suggest that FCHSD1 and FCHSD2 could modulate
            F-actin assembly or maintenance in hair cell stereocilia and
            cuticular plate.
REFERENCE   4  (residues 1 to 690)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   5  (residues 1 to 690)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human FCHSD1 and FCHSD2
            genes in silico
  JOURNAL   Int J Mol Med 13 (5), 749-754 (2004)
   PUBMED   15067381
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129315.3.
            
            On Mar 22, 2023 this sequence version replaced XP_006526066.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219379.55468.1,
                                           SRR17784648.895858.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..690
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.84 cM"
     Protein         1..690
                     /product="F-BAR and double SH3 domains protein 1 isoform
                     2"
                     /note="FCH and double SH3 domains protein 1; F-BAR and
                     double SH3 domains protein 1; protein nervous wreck 2"
                     /calculated_mol_wt=76338
     Region          16..275
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Site            order(21,24..25,29,31..32,35..36,38..39,49..50,52..53,
                     56..57,59..60,63,92,95..96,219,222..223,225,228,231..232,
                     234..235,238..239,242..243,245..246,249..250,252..253)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153271"
     Site            444
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86WN1; propagated from
                     UniProtKB/Swiss-Prot (Q6PFY1.1)"
     Region          470..526
                     /region_name="SH3_FCHSD_1"
                     /note="First Src Homology 3 domain of FCH and double SH3
                     domains proteins; cd11761"
                     /db_xref="CDD:212695"
     Site            order(477,479,482,486,505..506,520,522..523)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212695"
     Region          550..607
                     /region_name="SH3_FCHSD1_2"
                     /note="Second Src Homology 3 domain of FCH and double SH3
                     domains protein 1; cd11895"
                     /db_xref="CDD:212828"
     Site            order(555,557,560,564,586..587,600,602..603)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212828"
     Region          609..690
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PFY1.1)"
     CDS             1..690
                     /gene="Fchsd1"
                     /gene_synonym="A030002D08Rik; NWK2"
                     /coded_by="NM_001418706.1:50..2122"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:319262"
                     /db_xref="MGI:MGI:2441771"
ORIGIN      
        1 mqppprkvkp aqevklrfle qlsilqtrqq readlledir syskqraaie reygqalqkl
       61 agpflkregq rsgeadsrgr tvfgawrcll datvaggqtr lqasdryrdl aggtgrsake
      121 qvlrkgtesl qqaqaevlqs vrelsrsrkl ygqrqrvwal aqekaadvqa rlnrsdhgif
      181 hsrtslqkls tklsaqsaqy sqqlraarne yllnlvatna hlahyyqeel pallkvlvse
      241 lseylrdplt llghteleaa emileharhg gkatsqvnwe qdvklflqgp gvfsptppqq
      301 fqpagadqvc glewgaggma gesglekevq rwtsraardy kiqhhghrvl qrleqrrqqa
      361 pgreapgveq rlqevrenir raqvsqvkga arlallqeag ldvqrwlkpa mtqaqdeveq
      421 errlsearls qrdlsptaed aelsdfdece eagelfeepa ppalatrplp cpahvvfgyq
      481 agredeltit egewleviee gdadewvkar nqhgeagfvp erylnfpdls lpeschgidn
      541 psggeptafl aralysytgq seeelsfpeg alirllpraq dgvddgfwrg efgghvgvfp
      601 sllveellgp pgppelsdpe qmlpspspps fsppaptcal dgstapalps dkvldcpgpl
      661 dmmvprlrpm rppppppaka pdpghpdplt
//
