LOCUS       NM_010189               1738 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus Fc fragment of IgG receptor and transporter (Fcgrt),
            transcript variant 1, mRNA.
ACCESSION   NM_010189
VERSION     NM_010189.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1738)
  AUTHORS   Stark,K., Kilani,B., Stockhausen,S., Busse,J., Schubert,I.,
            Tran,T.D., Gaertner,F., Leunig,A., Pekayvaz,K., Nicolai,L.,
            Fumagalli,V., Stermann,J., Stephan,F., David,C., Muller,M.B.,
            Heyman,B., Lux,A., da Palma Guerreiro,A., Frenzel,L.P.,
            Schmidt,C.Q., Dopler,A., Moser,M., Chandraratne,S., von Bruhl,M.L.,
            Lorenz,M., Korff,T., Rudelius,M., Popp,O., Kirchner,M., Mertins,P.,
            Nimmerjahn,F., Iannacone,M., Sperandio,M., Engelmann,B.,
            Verschoor,A. and Massberg,S.
  TITLE     Antibodies and complement are key drivers of thrombosis
  JOURNAL   Immunity 57 (9), 2140-2156 (2024)
   PUBMED   39226900
REFERENCE   2  (bases 1 to 1738)
  AUTHORS   Skeeters,S., Bagale,K., Stepanyuk,G., Thieker,D., Aguhob,A.,
            Chan,K.K., Dutzar,B., Shalygin,S., Shajahan,A., Yang,X.,
            DaRosa,P.A., Frazier,E., Sauer,M.M., Bogatzki,L.,
            Byrnes-Blake,K.A., Song,Y., Azadi,P., Tarcha,E., Zhang,L. and
            Procko,E.
  TITLE     Modulation of the pharmacokinetics of soluble ACE2 decoy receptors
            through glycosylation
  JOURNAL   Mol Ther Methods Clin Dev 32 (3), 101301 (2024)
   PUBMED   39185275
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1738)
  AUTHORS   Morimoto,K., Takahashi,R., Takahashi,G., Miyajima,M. and
            Nakajima,K.
  TITLE     Maternal immunoglobulins are distributed in the offspring's brain
            to support the maintenance of cortical interneurons in the
            postnatal period
  JOURNAL   Inflamm Regen 44 (1), 24 (2024)
   PUBMED   38750507
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1738)
  AUTHORS   Yu,L., Wan,Q., Liu,Q., Fan,Y., Zhou,Q., Skowronski,A.A., Wang,S.,
            Shao,Z., Liao,C.Y., Ding,L., Kennedy,B.K., Zha,S., Que,J.,
            LeDuc,C.A., Sun,L., Wang,L. and Qiang,L.
  TITLE     IgG is an aging factor that drives adipose tissue fibrosis and
            metabolic decline
  JOURNAL   Cell Metab 36 (4), 793-807 (2024)
   PUBMED   38378001
REFERENCE   5  (bases 1 to 1738)
  AUTHORS   Haddad,G. and Blaine,J.
  TITLE     Identification of Four Mouse FcRn Splice Variants and FcRn-Specific
            Vesicles
  JOURNAL   Cells 13 (7), 594 (2024)
   PUBMED   38607033
  REMARK    GeneRIF: Identification of Four Mouse FcRn Splice Variants and
            FcRn-Specific Vesicles.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1738)
  AUTHORS   Kalman,K., Nguyen,A., Tseng-Crank,J., Dukes,I.D., Chandy,G.,
            Hustad,C.M., Copeland,N.G., Jenkins,N.A., Mohrenweiser,H.,
            Brandriff,B., Cahalan,M., Gutman,G.A. and Chandy,K.G.
  TITLE     Genomic organization, chromosomal localization, tissue
            distribution, and biophysical characterization of a novel mammalian
            Shaker-related voltage-gated potassium channel, Kv1.7
  JOURNAL   J Biol Chem 273 (10), 5851-5857 (1998)
   PUBMED   9488722
REFERENCE   7  (bases 1 to 1738)
  AUTHORS   Ghetie,V., Hubbard,J.G., Kim,J.K., Tsen,M.F., Lee,Y. and Ward,E.S.
  TITLE     Abnormally short serum half-lives of IgG in beta
            2-microglobulin-deficient mice
  JOURNAL   Eur J Immunol 26 (3), 690-696 (1996)
   PUBMED   8605939
REFERENCE   8  (bases 1 to 1738)
  AUTHORS   Kandil,E., Noguchi,M., Ishibashi,T. and Kasahara,M.
  TITLE     Structural and phylogenetic analysis of the MHC class I-like Fc
            receptor gene
  JOURNAL   J Immunol 154 (11), 5907-5918 (1995)
   PUBMED   7538537
REFERENCE   9  (bases 1 to 1738)
  AUTHORS   Story,C.M., Mikulska,J.E. and Simister,N.E.
  TITLE     A major histocompatibility complex class I-like Fc receptor cloned
            from human placenta: possible role in transfer of immunoglobulin G
            from mother to fetus
  JOURNAL   J Exp Med 180 (6), 2377-2381 (1994)
   PUBMED   7964511
REFERENCE   10 (bases 1 to 1738)
  AUTHORS   Ahouse,J.J., Hagerman,C.L., Mittal,P., Gilbert,D.J., Copeland,N.G.,
            Jenkins,N.A. and Simister,N.E.
  TITLE     Mouse MHC class I-like Fc receptor encoded outside the MHC
  JOURNAL   J Immunol 151 (11), 6076-6088 (1993)
   PUBMED   7504013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY063885.1, AK152879.1 and AK146933.1.
            
            On Mar 18, 2008 this sequence version replaced NM_010189.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146933.1, D37874.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                BY063885.1         32-96
            66-1258             AK152879.1         2-1194
            1259-1738           AK146933.1         1224-1703
FEATURES             Location/Qualifiers
     source          1..1738
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.12 cM"
     gene            1..1738
                     /gene="Fcgrt"
                     /gene_synonym="FcRn"
                     /note="Fc fragment of IgG receptor and transporter"
                     /db_xref="GeneID:14132"
                     /db_xref="MGI:MGI:103017"
     exon            1..183
                     /gene="Fcgrt"
                     /gene_synonym="FcRn"
                     /inference="alignment:Splign:2.1.0"
     exon            184..454
                     /gene="Fcgrt"
                     /gene_synonym="FcRn"
                     /inference="alignment:Splign:2.1.0"
     CDS             388..1485
                     /gene="Fcgrt"
                     /gene_synonym="FcRn"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; igG receptor FcRn large subunit p51; igG Fc
                     fragment receptor transporter alpha chain; neonatal Fc
                     receptor; Fc receptor, IgG, alpha chain transporter;
                     neonatal fragment crystallizable Fc receptor"
                     /codon_start=1
                     /product="IgG receptor FcRn large subunit p51 isoform 1
                     precursor"
                     /protein_id="NP_034319.2"
                     /db_xref="CCDS:CCDS52243.1"
                     /db_xref="GeneID:14132"
                     /db_xref="MGI:MGI:103017"
                     /translation="MGMPLPWALSLLLVLLPQTWGSETRPPLMYHLTAVSNPSTGLPS
                     FWATGWLGPQQYLTYNSLRQEADPCGAWMWENQVSWYWEKETTDLKSKEQLFLEALKT
                     LEKILNGTYTLQGLLGCELASDNSSVPTAVFALNGEEFMKFNPRIGNWTGEWPETEIV
                     ANLWMKQPDAARKESEFLLNSCPERLLGHLERGRRNLEWKEPPSMRLKARPGNSGSSV
                     LTCAAFSFYPPELKFRFLRNGLASGSGNCSTGPNGDGSFHAWSLLEVKRGDEHHYQCQ
                     VEHEGLAQPLTVDLDSSARSSVPVVGIVLGLLLVVVAIAGGVLLWGRMRSGLPAPWLS
                     LSGDDSGDLLPGGNLPPEAEPQGANAFPATS"
     exon            455..712
                     /gene="Fcgrt"
                     /gene_synonym="FcRn"
                     /inference="alignment:Splign:2.1.0"
     exon            713..988
                     /gene="Fcgrt"
                     /gene_synonym="FcRn"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1258
                     /gene="Fcgrt"
                     /gene_synonym="FcRn"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1375
                     /gene="Fcgrt"
                     /gene_synonym="FcRn"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1738
                     /gene="Fcgrt"
                     /gene_synonym="FcRn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1653..1658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fcgrt"
                     /gene_synonym="FcRn"
                     /note="hexamer: CATAAA"
     polyA_site      1670
                     /gene="Fcgrt"
                     /gene_synonym="FcRn"
                     /note="major polyA site"
ORIGIN      
        1 aggagctagt gggtggagtt ggatgccctc agagttctcc agtcctaact gtgtacagac
       61 aggatgtaag agaagaactg gaggctctaa gcagaggatc catcggctgc aggcagaggg
      121 aagagggcct ctgtgaggaa caggctgagc gtcagaggag gaggcccagg cctggttctc
      181 tagctctgta attaattaac taaagtggat caaatgagaa ggtgaaagtt cacagaggaa
      241 cactcctgtc tgtcgtcttg gactgggtct ccatcccacc atccagcgtc ctggtctacg
      301 aagagtccac agggaccttg tgaagaatca acaaggcggg gtccagagga gtcacgtgtc
      361 ccttccactc cgggtcaccc tgtcggaatg gggatgccac tgccctgggc cctcagcctc
      421 ttgttggtcc tcctgcctca gacctggggc tcagagaccc gccccccact gatgtatcat
      481 ctcacggctg tgtcaaaccc atctacgggg cttccctctt tctgggctac aggctggttg
      541 ggtcctcagc agtatctgac ctacaacagc ctgcggcagg aagctgaccc ctgtggggcc
      601 tggatgtggg aaaatcaggt gtcttggtat tgggagaagg agaccacaga cctcaaaagc
      661 aaagaacagc tcttcttgga ggccctcaag accctggaga agatattaaa tgggacctac
      721 acactgcagg gcctgctggg ctgtgaactg gcctcggata attcctcagt gcccacggct
      781 gtgtttgccc tcaatggtga ggagtttatg aaattcaacc caagaatcgg caattggact
      841 ggggagtggc ctgagacgga aatcgttgct aatctgtgga tgaagcagcc tgatgcggcc
      901 aggaaggaga gcgagttcct gctaaactct tgtccggagc gactgctagg ccacctggag
      961 aggggccgac ggaacctgga gtggaaggag ccgccgtcta tgcgcctgaa ggcccgtcct
     1021 ggcaactctg gctcctccgt gctgacctgt gctgctttct ccttctaccc accggagctc
     1081 aagttccgat tcctgcgcaa tgggctagcc tcaggctccg ggaattgcag cactggtccc
     1141 aatggagatg gctctttcca cgcatggtca ttgctggagg tcaaacgtgg agatgagcac
     1201 cattatcaat gtcaagtgga gcatgagggg ctggcacagc ctctcactgt ggacctagat
     1261 tcatcagcca gatcttctgt gcctgtggtt ggaatcgttc ttggtttatt gctggtggta
     1321 gtggccatcg caggcggtgt gctgttgtgg ggcaggatgc gcagcggtct gccagcccca
     1381 tggctttctc tcagcggcga tgactctggt gacctgttgc ctggtgggaa cttgccccca
     1441 gaagctgaac ctcaaggtgc aaatgccttt ccagccactt cctgatgcag actcgggccc
     1501 cctgcccact gcagcctttc gggctgtgtg acctcctgaa ctgtctccga gcctcctgag
     1561 ggagcctggg cccgatgtcc tcccatggat ccctgctttt gtggcctgct tcagtttccc
     1621 ttcttaatgt acatggttgt tttccatctc cacataaatt tggccccaaa tctgtgtgtg
     1681 catcgttatt ctcaagtttc aagcagctgg aataaattga acgcgtctgg gaaagatc
//
