LOCUS       NM_144559               1250 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus Fc receptor, IgG, low affinity IV (Fcgr4), mRNA.
ACCESSION   NM_144559
VERSION     NM_144559.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1250)
  AUTHORS   Zaytseva,O.O., Seeling,M., Kristic,J., Lauc,G., Pezer,M. and
            Nimmerjahn,F.
  TITLE     Fc-Linked IgG N-Glycosylation in FcgammaR Knock-Out Mice
  JOURNAL   Front Cell Dev Biol 8, 67 (2020)
   PUBMED   32195245
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1250)
  AUTHORS   Gordan,S., Albert,H., Danzer,H., Lux,A., Biburger,M. and
            Nimmerjahn,F.
  TITLE     The Immunological Organ Environment Dictates the Molecular and
            Cellular Pathways of Cytotoxic Antibody Activity
  JOURNAL   Cell Rep 29 (10), 3033-3046 (2019)
   PUBMED   31801071
REFERENCE   3  (bases 1 to 1250)
  AUTHORS   Bersellini Farinotti,A., Wigerblad,G., Nascimento,D., Bas,D.B.,
            Morado Urbina,C., Nandakumar,K.S., Sandor,K., Xu,B., Abdelmoaty,S.,
            Hunt,M.A., Angeby Moller,K., Baharpoor,A., Sinclair,J.,
            Jardemark,K., Lanner,J.T., Khmaladze,I., Borm,L.E., Zhang,L.,
            Wermeling,F., Cragg,M.S., Lengqvist,J., Chabot-Dore,A.J.,
            Diatchenko,L., Belfer,I., Collin,M., Kultima,K., Heyman,B.,
            Jimenez-Andrade,J.M., Codeluppi,S., Holmdahl,R. and Svensson,C.I.
  TITLE     Cartilage-binding antibodies induce pain through immune
            complex-mediated activation of neurons
  JOURNAL   J Exp Med 216 (8), 1904-1924 (2019)
   PUBMED   31196979
REFERENCE   4  (bases 1 to 1250)
  AUTHORS   Rahimi-Balaei,M., Jiao,X., Shabanipour,S., Dixit,R., Schuurmans,C.
            and Marzban,H.
  TITLE     Zebrin II Is Ectopically Expressed in Microglia in the Cerebellum
            of Neurogenin 2 Null Mice
  JOURNAL   Cerebellum 18 (1), 56-66 (2019)
   PUBMED   29909450
REFERENCE   5  (bases 1 to 1250)
  AUTHORS   Di Ceglie,I., Ascone,G., Cremers,N.A.J., Sloetjes,A.W.,
            Walgreen,B., Vogl,T., Roth,J., Verbeek,J.S., van de Loo,F.A.J.,
            Koenders,M.I., van der Kraan,P.M., Blom,A.B., van den Bosch,M.H.J.
            and van Lent,P.L.E.M.
  TITLE     Fcgamma receptor-mediated influx of S100A8/A9-producing neutrophils
            as inducer of bone erosion during antigen-induced arthritis
  JOURNAL   Arthritis Res Ther 20 (1), 80 (2018)
   PUBMED   29720243
  REMARK    GeneRIF: Fc gammaRIV (FcgammaRIV) mediates bone erosion in
            antigen-induced arthritis (AIA) by inducing the influx of
            S100A8/A9-producing neutrophils into the arthritic joint.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1250)
  AUTHORS   Kubota,T., Mukai,K., Minegishi,Y. and Karasuyama,H.
  TITLE     Different stabilities of the structurally related receptors for IgE
            and IgG on the cell surface are determined by length of the stalk
            region in their alpha-chains
  JOURNAL   J Immunol 176 (11), 7008-7014 (2006)
   PUBMED   16709862
  REMARK    GeneRIF: The length of the stalk region of the alpha-chain is an
            important determinant of Fc gamma receptor IIIA stability on the
            cell surface.
REFERENCE   7  (bases 1 to 1250)
  AUTHORS   Kaneko,Y., Nimmerjahn,F., Madaio,M.P. and Ravetch,J.V.
  TITLE     Pathology and protection in nephrotoxic nephritis is determined by
            selective engagement of specific Fc receptors
  JOURNAL   J Exp Med 203 (3), 789-797 (2006)
   PUBMED   16520389
REFERENCE   8  (bases 1 to 1250)
  AUTHORS   Hamano,Y., Tsukamoto,K., Abe,M., Sun,G.D., Zhang,D., Fujii,H.,
            Matsuoka,S., Tanaka,M., Ishida-Okawara,A., Tachikawa,H.,
            Nishimura,H., Tokunaka,K., Hirose,S. and Suzuki,K.
  TITLE     Genetic dissection of vasculitis, myeloperoxidase-specific
            antineutrophil cytoplasmic autoantibody production, and related
            traits in spontaneous crescentic glomerulonephritis-forming/Kinjoh
            mice
  JOURNAL   J Immunol 176 (6), 3662-3673 (2006)
   PUBMED   16517735
REFERENCE   9  (bases 1 to 1250)
  AUTHORS   Nimmerjahn,F., Bruhns,P., Horiuchi,K. and Ravetch,J.V.
  TITLE     FcgammaRIV: a novel FcR with distinct IgG subclass specificity
  JOURNAL   Immunity 23 (1), 41-51 (2005)
   PUBMED   16039578
  REMARK    GeneRIF: Fc gammaRIV (Fc fragment of IgG, low affinity IIIa,
            receptor) is restricted to myeloid lineage cells, and binds to
            IgG2a and IgG2b with intermediate affinity.
REFERENCE   10 (bases 1 to 1250)
  AUTHORS   Mechetina,L.V., Najakshin,A.M., Alabyev,B.Y., Chikaev,N.A. and
            Taranin,A.V.
  TITLE     Identification of CD16-2, a novel mouse receptor homologous to
            CD16/Fc gamma RIII
  JOURNAL   Immunogenetics 54 (7), 463-468 (2002)
   PUBMED   12389094
  REMARK    GeneRIF: Identification of its gene
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK076532.1, AK087863.1 and AC115959.17.
            
            On Mar 12, 2009 this sequence version replaced NM_144559.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087863.1, AK076532.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-859               AK076532.1         7-865
            860-1150            AK087863.1         859-1149
            1151-1151           AC115959.17        28048-28048         c
            1152-1250           AK087863.1         1151-1249
FEATURES             Location/Qualifiers
     source          1..1250
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 78.53 cM"
     gene            1..1250
                     /gene="Fcgr4"
                     /gene_synonym="4833442P21Rik; CD16-2; FcgammaRIV; Fcgr3a;
                     FcgRIV; Fcrl3"
                     /note="Fc receptor, IgG, low affinity IV"
                     /db_xref="GeneID:246256"
                     /db_xref="MGI:MGI:2179523"
     exon            1..94
                     /gene="Fcgr4"
                     /gene_synonym="4833442P21Rik; CD16-2; FcgammaRIV; Fcgr3a;
                     FcgRIV; Fcrl3"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..804
                     /gene="Fcgr4"
                     /gene_synonym="4833442P21Rik; CD16-2; FcgammaRIV; Fcgr3a;
                     FcgRIV; Fcrl3"
                     /note="Fc receptor-like 3; Fc gammaRIV; Fc fragment of
                     IgG, low affinity IIIa, receptor for (CD16); Fc fragment
                     of IgG, low affinity III, receptor for (CD16); IgG Fc
                     receptor III-A; low affinity immunoglobulin gamma Fc
                     region receptor III-A; low affinity immunoglobulin gamma
                     Fc region receptor IV"
                     /codon_start=1
                     /product="low affinity immunoglobulin gamma Fc region
                     receptor III-A precursor"
                     /protein_id="NP_653142.2"
                     /db_xref="CCDS:CCDS15476.1"
                     /db_xref="GeneID:246256"
                     /db_xref="MGI:MGI:2179523"
                     /translation="MWQLLLPTALVLTAFSGIQAGLQKAVVNLDPKWVRVLEEDSVTL
                     RCQGTFSPEDNSIKWFHNESLIPHQDANYVIQSARVKDSGMYRCQTALSTISDPVQLE
                     VHMGWLLLQTTKWLFQEGDPIHLRCHSWQNRPVRKVTYLQNGKGKKYFHENSELLIPK
                     ATHNDSGSYFCRGLIGHNNKSSASFRISLGDPGSPSMFPPWHQITFCLLIGLLFAIDT
                     VLYFSVRRGLQSPVADYEEPKIQWSKEPQDK"
     exon            95..115
                     /gene="Fcgr4"
                     /gene_synonym="4833442P21Rik; CD16-2; FcgammaRIV; Fcgr3a;
                     FcgRIV; Fcrl3"
                     /inference="alignment:Splign:2.1.0"
     exon            116..370
                     /gene="Fcgr4"
                     /gene_synonym="4833442P21Rik; CD16-2; FcgammaRIV; Fcgr3a;
                     FcgRIV; Fcrl3"
                     /inference="alignment:Splign:2.1.0"
     exon            371..625
                     /gene="Fcgr4"
                     /gene_synonym="4833442P21Rik; CD16-2; FcgammaRIV; Fcgr3a;
                     FcgRIV; Fcrl3"
                     /inference="alignment:Splign:2.1.0"
     exon            626..1250
                     /gene="Fcgr4"
                     /gene_synonym="4833442P21Rik; CD16-2; FcgammaRIV; Fcgr3a;
                     FcgRIV; Fcrl3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1217..1222
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fcgr4"
                     /gene_synonym="4833442P21Rik; CD16-2; FcgammaRIV; Fcgr3a;
                     FcgRIV; Fcrl3"
                     /note="hexamer: AATAAA"
     polyA_site      1236
                     /gene="Fcgr4"
                     /gene_synonym="4833442P21Rik; CD16-2; FcgammaRIV; Fcgr3a;
                     FcgRIV; Fcrl3"
                     /note="major polyA site"
ORIGIN      
        1 ggcccttaag ggttccggat atctgtggtg acattttcta tctgcttcag cagcatgtgg
       61 cagctactac taccaacagc tctggtactt acagctttct ctggcattca agctggtctc
      121 caaaaggctg tggtgaacct agaccccaag tgggtcaggg tgcttgagga agacagcgtg
      181 accctcagat gccaaggcac tttctccccc gaggacaatt ctatcaagtg gttccataac
      241 gaaagcctca tcccacacca ggatgccaac tatgtcatcc aaagtgccag agttaaggac
      301 agtggaatgt acaggtgcca gacagccctc tccacgatca gtgacccagt gcaactagag
      361 gtccatatgg gctggctatt gcttcagacc actaagtggc tgttccagga gggggacccc
      421 attcatctga gatgccacag ttggcaaaac agacctgtac ggaaggtcac ctatttacag
      481 aacggcaaag gcaagaagta tttccatgaa aattctgaat tactcattcc aaaagctaca
      541 cacaatgaca gtggctccta cttctgcaga gggctcattg gacacaacaa caaatcttca
      601 gcatcctttc gtataagcct aggcgatcca gggtctccat ccatgtttcc accgtggcat
      661 caaatcacat tctgcctgct gataggactc ttgtttgcaa tagacacagt gctgtatttc
      721 tctgtgcgga ggggtcttca aagtcctgtg gctgactatg aggaacccaa gattcaatgg
      781 agcaaggaac ctcaggacaa gtgagctctt atcgcatgcg atgataagag caatggtgta
      841 gaacccatga gcctccctgg gagcttgcaa cctcaccagc tgcattggtc accatgcttt
      901 gagcagcaga aataatacaa aggccccttc cccaactgtt ttttgtttgt ttgtttgttt
      961 gttttgtttt gttttttggt gttgtatgtt catttgtttg tttgtctctc tccaatggac
     1021 tatctcaggg gaaagggaaa gcctgaggtc ttcaaggacc aacagtgata cagcaatgcg
     1081 cacgcagcta ccctcccaag aagcgattct tcagaatttt acactttctc tgccccaaac
     1141 attccattag agcaaagcag cagcctggac tctgggtggc gatggcgatc ctttccgtgc
     1201 ttagccattg ctcctaaata aacttctgtc gaaaagggaa tggctgcttg
//
