LOCUS       NM_010188               1353 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus Fc receptor, IgG, low affinity III (Fcgr3), transcript
            variant 1, mRNA.
ACCESSION   NM_010188
VERSION     NM_010188.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1353)
  AUTHORS   Huang,C., Zhu,W., Li,Q., Lei,Y., Chen,X., Liu,S., Chen,D.,
            Zhong,L., Gao,F., Fu,S., He,D., Li,J. and Xu,H.
  TITLE     Antibody Fc-receptor FcepsilonR1gamma stabilizes cell surface
            receptors in group 3 innate lymphoid cells and promotes
            anti-infection immunity
  JOURNAL   Nat Commun 15 (1), 5981 (2024)
   PUBMED   39013884
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1353)
  AUTHORS   Morimoto,K., Takahashi,R., Takahashi,G., Miyajima,M. and
            Nakajima,K.
  TITLE     Maternal immunoglobulins are distributed in the offspring's brain
            to support the maintenance of cortical interneurons in the
            postnatal period
  JOURNAL   Inflamm Regen 44 (1), 24 (2024)
   PUBMED   38750507
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1353)
  AUTHORS   Xu,Z., Moreno-Giro,A., Zhao,D., Kramer,A., Pandey,R.K., Xu,B.,
            Lundstrom,S.L. and Holmdahl,R.
  TITLE     Fcgr2b and Fcgr3 are the major genetic factors for cartilage
            antibody-induced arthritis, overriding the effect of Hc encoding
            complement C5
  JOURNAL   Eur J Immunol 54 (4), e2350659 (2024)
   PUBMED   38314895
  REMARK    GeneRIF: Fcgr2b and Fcgr3 are the major genetic factors for
            cartilage antibody-induced arthritis, overriding the effect of Hc
            encoding complement C5.
REFERENCE   4  (bases 1 to 1353)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 1353)
  AUTHORS   da Silveira,B.P., Barhoumi,R., Bray,J.M., Cole-Pfeiffer,H.M.,
            Mabry,C.J., Burghardt,R.C., Cohen,N.D. and Bordin,A.I.
  TITLE     Impact of surface receptors TLR2, CR3, and FcgammaRIII on
            Rhodococcus equi phagocytosis and intracellular survival in
            macrophages
  JOURNAL   Infect Immun 92 (1), e0038323 (2024)
   PUBMED   38018994
  REMARK    GeneRIF: Impact of surface receptors TLR2, CR3, and FcgammaRIII on
            Rhodococcus equi phagocytosis and intracellular survival in
            macrophages.
REFERENCE   6  (bases 1 to 1353)
  AUTHORS   Hoopes,C.W., Taketo,M., Ozato,K., Liu,Q., Howard,T.A., Linney,E.
            and Seldin,M.F.
  TITLE     Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors
            RXR alpha, RXR beta, and RXR gamma
  JOURNAL   Genomics 14 (3), 611-617 (1992)
   PUBMED   1358808
REFERENCE   7  (bases 1 to 1353)
  AUTHORS   Oakey,R.J., Watson,M.L. and Seldin,M.F.
  TITLE     Construction of a physical map on mouse and human chromosome 1:
            comparison of 13 Mb of mouse and 11 Mb of human DNA
  JOURNAL   Hum Mol Genet 1 (8), 613-620 (1992)
   PUBMED   1301170
REFERENCE   8  (bases 1 to 1353)
  AUTHORS   Takizawa,F., Adamczewski,M. and Kinet,J.P.
  TITLE     Identification of the low affinity receptor for immunoglobulin E on
            mouse mast cells and macrophages as Fc gamma RII and Fc gamma RIII
  JOURNAL   J Exp Med 176 (2), 469-475 (1992)
   PUBMED   1386873
REFERENCE   9  (bases 1 to 1353)
  AUTHORS   Bonnerot,C., Marloie,M.A., Daeron,M. and Fridman,W.H.
  TITLE     Sequence and length heterogeneity of alpha Fc gamma R transcripts
            in AKR mice
  JOURNAL   Mol Immunol 29 (3), 353-361 (1992)
   PUBMED   1372955
REFERENCE   10 (bases 1 to 1353)
  AUTHORS   Kulczycki,A. Jr., Webber,J., Soares,H.A., Onken,M.D.,
            Thompson,J.A., Chaplin,D.D., Loh,D.Y. and Tillinghast,J.P.
  TITLE     Genomic organization of mouse Fc gamma receptor genes
  JOURNAL   Proc Natl Acad Sci U S A 87 (7), 2856-2860 (1990)
   PUBMED   2138787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY199827.1, AK151557.1 and AC115959.17.
            
            On Jun 17, 2008 this sequence version replaced NM_010188.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052819.1, AK152875.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BY199827.1         1-42
            43-1327             AK151557.1         3-1287
            1328-1353           AC115959.17        6516-6541
FEATURES             Location/Qualifiers
     source          1..1353
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 78.8 cM"
     gene            1..1353
                     /gene="Fcgr3"
                     /gene_synonym="CD16"
                     /note="Fc receptor, IgG, low affinity III"
                     /db_xref="GeneID:14131"
                     /db_xref="MGI:MGI:95500"
     exon            1..135
                     /gene="Fcgr3"
                     /gene_synonym="CD16"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..854
                     /gene="Fcgr3"
                     /gene_synonym="CD16"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; low affinity immunoglobulin gamma Fc region
                     receptor III; Fc gamma receptor III; fcRIII; fc-gamma
                     RIII; igG Fc receptor III; FcgammaRIII; Fcg receptor III"
                     /codon_start=1
                     /product="low affinity immunoglobulin gamma Fc region
                     receptor III isoform 1 precursor"
                     /protein_id="NP_034318.2"
                     /db_xref="CCDS:CCDS15477.2"
                     /db_xref="GeneID:14131"
                     /db_xref="MGI:MGI:95500"
                     /translation="MTLDTQMFQNAHSGSQWLLPPLTILLLFAFADRQSAALPKAVVK
                     LDPPWIQVLKEDMVTLMCEGTHNPGNSSTQWFHNWSSIRSQVQSSYTFKATVNDSGEY
                     RCQMEQTRLSDPVDLGVISDWLLLQTPQRVFLEGETITLRCHSWRNKLLNRISFFHNE
                     KSVRYHHYKSNFSIPKANHSHSGDYYCKGSLGSTQHQSKPVTITVQDPATTSSISLVW
                     YHTAFSLVMCLLFAVDTGLYFYVRRNLQTPRDYWRKSLSIRKHQAPQDK"
     exon            136..156
                     /gene="Fcgr3"
                     /gene_synonym="CD16"
                     /inference="alignment:Splign:2.1.0"
     exon            157..414
                     /gene="Fcgr3"
                     /gene_synonym="CD16"
                     /inference="alignment:Splign:2.1.0"
     exon            415..669
                     /gene="Fcgr3"
                     /gene_synonym="CD16"
                     /inference="alignment:Splign:2.1.0"
     exon            670..1353
                     /gene="Fcgr3"
                     /gene_synonym="CD16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttttgtagt tcatctcctg aacctcatca gactctgatc cagttcttga atgactttgg
       61 acacccagat gtttcagaat gcacactctg gaagccaatg gctacttcca ccactgacaa
      121 ttctgctgct gtttgctttt gcagacaggc agagtgcagc tcttccgaag gctgtggtga
      181 aactggaccc cccatggatc caggtgctca aggaagacat ggtgacactg atgtgcgaag
      241 ggacccacaa ccctgggaac tcttctactc agtggttcca caactggagt tccatccgga
      301 gccaggtcca atccagctac acgtttaagg ccacagtcaa tgacagtgga gaatatcggt
      361 gtcaaatgga gcagacccgc ctcagcgacc ctgtagatct gggagtgatt tctgactggc
      421 tgctgctcca gacccctcag cgggtgtttc tggaagggga aaccatcacg ctaaggtgcc
      481 atagctggag gaacaaacta ctgaacagga tctcgttctt ccataatgaa aaatccgtga
      541 ggtatcatca ctacaaaagt aatttctcta tcccaaaagc caaccacagt cacagtgggg
      601 actactactg caaaggaagt ctaggaagta cacagcacca gtccaagcct gtcaccatca
      661 ctgtccaaga cccagcaact acatcctcca tctctctagt ctggtaccac actgctttct
      721 ccctagtgat gtgcctcctg tttgcagtgg acacgggcct ttatttctat gtacggagaa
      781 atcttcaaac cccgagggat tactggagga agtccctgtc aatcagaaag caccaggctc
      841 ctcaagacaa gtgacacccc atccatcgta tggcaaaaca tcggtggcag cagcaacttt
      901 tcagccacac agccttcctt tgaaagcaac ttacaagcag gccgggatgt ttggttcttc
      961 aatcacaacg acttaggagg ctgaggaagg aggatcgcca gttcaaggcc tgcctgggtc
     1021 atacagagag agtgagtgca agtctagcct ggataaccca gtgagatcct gggtttaggc
     1081 ggctcatcag gaaagagaac ctattgctaa tctcacaaac aagatgccta ctgcccatgt
     1141 ggccaaagga aagaacaagg tcctggaagt tgtcctctga cctccaccat ccaccatggc
     1201 aggtgcacac aataaattaa aatgtcatgt atatttttaa acaagagaca ggggcaggct
     1261 aagggttgat ggcatagctg ttatccagta cacataatgc cctgggtttg acctcctata
     1321 ataaagcaaa aaaaatcaac ggtgggctaa gga
//
