LOCUS       NM_001419005            3755 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus Fc receptor, IgG, low affinity IIb (Fcgr2b),
            transcript variant 3, mRNA.
ACCESSION   NM_001419005
VERSION     NM_001419005.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3755)
  AUTHORS   Stark,K., Kilani,B., Stockhausen,S., Busse,J., Schubert,I.,
            Tran,T.D., Gaertner,F., Leunig,A., Pekayvaz,K., Nicolai,L.,
            Fumagalli,V., Stermann,J., Stephan,F., David,C., Muller,M.B.,
            Heyman,B., Lux,A., da Palma Guerreiro,A., Frenzel,L.P.,
            Schmidt,C.Q., Dopler,A., Moser,M., Chandraratne,S., von Bruhl,M.L.,
            Lorenz,M., Korff,T., Rudelius,M., Popp,O., Kirchner,M., Mertins,P.,
            Nimmerjahn,F., Iannacone,M., Sperandio,M., Engelmann,B.,
            Verschoor,A. and Massberg,S.
  TITLE     Antibodies and complement are key drivers of thrombosis
  JOURNAL   Immunity 57 (9), 2140-2156 (2024)
   PUBMED   39226900
REFERENCE   2  (bases 1 to 3755)
  AUTHORS   Bennion,K.B., Liu,D., Dawood,A.S., Wyatt,M.M., Alexander,K.L.,
            Abdel-Hakeem,M.S., Paulos,C.M. and Ford,M.L.
  TITLE     CD8+ T cell-derived Fgl2 regulates immunity in a cell-autonomous
            manner via ligation of FcgammaRIIB
  JOURNAL   Nat Commun 15 (1), 5280 (2024)
   PUBMED   38902261
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3755)
  AUTHORS   He,C., Hua,G., Liu,Y. and Li,S.
  TITLE     Unveiling the hidden role of the interaction between CD36 and
            FcgammaRIIb: implications for autoimmune disorders
  JOURNAL   Cell Mol Biol Lett 29 (1), 76 (2024)
   PUBMED   38762740
  REMARK    GeneRIF: Unveiling the hidden role of the interaction between CD36
            and FcgammaRIIb: implications for autoimmune disorders.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3755)
  AUTHORS   Wei,S., Ling,D., Zhong,J., Chang,R., Ling,X., Chen,Z. and Duan,R.
  TITLE     Elk1 enhances inflammatory cell infiltration and exacerbates acute
            lung injury/acute respiratory distress syndrome by suppressing
            Fcgr2b transcription
  JOURNAL   Mol Med 30 (1), 53 (2024)
   PUBMED   38649840
  REMARK    GeneRIF: Elk1 enhances inflammatory cell infiltration and
            exacerbates acute lung injury/acute respiratory distress syndrome
            by suppressing Fcgr2b transcription.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3755)
  AUTHORS   Xu,Z., Moreno-Giro,A., Zhao,D., Kramer,A., Pandey,R.K., Xu,B.,
            Lundstrom,S.L. and Holmdahl,R.
  TITLE     Fcgr2b and Fcgr3 are the major genetic factors for cartilage
            antibody-induced arthritis, overriding the effect of Hc encoding
            complement C5
  JOURNAL   Eur J Immunol 54 (4), e2350659 (2024)
   PUBMED   38314895
  REMARK    GeneRIF: Fcgr2b and Fcgr3 are the major genetic factors for
            cartilage antibody-induced arthritis, overriding the effect of Hc
            encoding complement C5.
REFERENCE   6  (bases 1 to 3755)
  AUTHORS   Hoopes,C.W., Taketo,M., Ozato,K., Liu,Q., Howard,T.A., Linney,E.
            and Seldin,M.F.
  TITLE     Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors
            RXR alpha, RXR beta, and RXR gamma
  JOURNAL   Genomics 14 (3), 611-617 (1992)
   PUBMED   1358808
REFERENCE   7  (bases 1 to 3755)
  AUTHORS   Oakey,R.J., Watson,M.L. and Seldin,M.F.
  TITLE     Construction of a physical map on mouse and human chromosome 1:
            comparison of 13 Mb of mouse and 11 Mb of human DNA
  JOURNAL   Hum Mol Genet 1 (8), 613-620 (1992)
   PUBMED   1301170
REFERENCE   8  (bases 1 to 3755)
  AUTHORS   Capeless,C.G., Whitney,G. and Azen,E.A.
  TITLE     Chromosome mapping of Soa, a gene influencing gustatory sensitivity
            to sucrose octaacetate in mice
  JOURNAL   Behav Genet 22 (6), 655-663 (1992)
   PUBMED   1290451
REFERENCE   9  (bases 1 to 3755)
  AUTHORS   Oakey,R.J., Howard,T.A., Hogarth,P.M., Tani,K. and Seldin,M.F.
  TITLE     Chromosomal mapping of the high affinity Fc gamma receptor gene
  JOURNAL   Immunogenetics 35 (4), 279-282 (1992)
   PUBMED   1347284
REFERENCE   10 (bases 1 to 3755)
  AUTHORS   Dickles,H.B., Ahmed,A. and Sachs,D.H.
  TITLE     B-lymphocyte Fc receptor-associated non-H-2 antigens are determined
            by a single polymorphic locus which is linked to the Mls locus
  JOURNAL   J Exp Med 146 (6), 1678-1692 (1977)
   PUBMED   303687
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115959.17.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M16367.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164135
                                           [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AC115959.17        81138-81273
            137-291             AC115959.17        81365-81519
            292-438             AC115959.17        81663-81809
            439-459             AC115959.17        88216-88236
            460-714             AC115959.17        89476-89730
            715-969             AC115959.17        91010-91264
            970-1092            AC115959.17        91886-92008
            1093-1233           AC115959.17        94245-94385
            1234-1271           AC115959.17        96477-96514
            1272-3755           AC115959.17        96610-99093
FEATURES             Location/Qualifiers
     source          1..3755
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 78.02 cM"
     gene            1..3755
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; F630109E10Rik; Fcgr2; Fcgr2a; FcgRII;
                     Fcr-2; Fcr-3; fcRII; Fc[g]RII; Ly-17; Ly-m20; Lym-1;
                     LyM-1"
                     /note="Fc receptor, IgG, low affinity IIb"
                     /db_xref="GeneID:14130"
                     /db_xref="MGI:MGI:95499"
     exon            1..136
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; F630109E10Rik; Fcgr2; Fcgr2a; FcgRII;
                     Fcr-2; Fcr-3; fcRII; Fc[g]RII; Ly-17; Ly-m20; Lym-1;
                     LyM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            137..291
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; F630109E10Rik; Fcgr2; Fcgr2a; FcgRII;
                     Fcr-2; Fcr-3; fcRII; Fc[g]RII; Ly-17; Ly-m20; Lym-1;
                     LyM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            292..438
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; F630109E10Rik; Fcgr2; Fcgr2a; FcgRII;
                     Fcr-2; Fcr-3; fcRII; Fc[g]RII; Ly-17; Ly-m20; Lym-1;
                     LyM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..459
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; F630109E10Rik; Fcgr2; Fcgr2a; FcgRII;
                     Fcr-2; Fcr-3; fcRII; Fc[g]RII; Ly-17; Ly-m20; Lym-1;
                     LyM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            460..714
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; F630109E10Rik; Fcgr2; Fcgr2a; FcgRII;
                     Fcr-2; Fcr-3; fcRII; Fc[g]RII; Ly-17; Ly-m20; Lym-1;
                     LyM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..969
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; F630109E10Rik; Fcgr2; Fcgr2a; FcgRII;
                     Fcr-2; Fcr-3; fcRII; Fc[g]RII; Ly-17; Ly-m20; Lym-1;
                     LyM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1092
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; F630109E10Rik; Fcgr2; Fcgr2a; FcgRII;
                     Fcr-2; Fcr-3; fcRII; Fc[g]RII; Ly-17; Ly-m20; Lym-1;
                     LyM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1233
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; F630109E10Rik; Fcgr2; Fcgr2a; FcgRII;
                     Fcr-2; Fcr-3; fcRII; Fc[g]RII; Ly-17; Ly-m20; Lym-1;
                     LyM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1271
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; F630109E10Rik; Fcgr2; Fcgr2a; FcgRII;
                     Fcr-2; Fcr-3; fcRII; Fc[g]RII; Ly-17; Ly-m20; Lym-1;
                     LyM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..3755
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; F630109E10Rik; Fcgr2; Fcgr2a; FcgRII;
                     Fcr-2; Fcr-3; fcRII; Fc[g]RII; Ly-17; Ly-m20; Lym-1;
                     LyM-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1793..1798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; F630109E10Rik; Fcgr2; Fcgr2a; FcgRII;
                     Fcr-2; Fcr-3; fcRII; Fc[g]RII; Ly-17; Ly-m20; Lym-1;
                     LyM-1"
                     /note="hexamer: AGTAAA"
     polyA_site      1814
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; F630109E10Rik; Fcgr2; Fcgr2a; FcgRII;
                     Fcr-2; Fcr-3; fcRII; Fc[g]RII; Ly-17; Ly-m20; Lym-1;
                     LyM-1"
                     /note="major polyA site"
     regulatory      3736..3741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; F630109E10Rik; Fcgr2; Fcgr2a; FcgRII;
                     Fcr-2; Fcr-3; fcRII; Fc[g]RII; Ly-17; Ly-m20; Lym-1;
                     LyM-1"
                     /note="hexamer: AATAAA"
     polyA_site      3755
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; F630109E10Rik; Fcgr2; Fcgr2a; FcgRII;
                     Fcr-2; Fcr-3; fcRII; Fc[g]RII; Ly-17; Ly-m20; Lym-1;
                     LyM-1"
ORIGIN      
        1 acttacagag gagcgagtgg agaggaatgt atgtgaagga tgagtgttct actgctgttc
       61 tcacatatgg cctagctttt ggtctacaat ccaacagtga gctggggatt gtgataacag
      121 agaaacccag atggtgactg aggcaaatga cttctgagct gcgttggggt gaagttttcc
      181 ctctctgtac cagacgtcca ggtcagctac ggctccagca gaacatgaag ggagttgttt
      241 ctcagtgtct aaaaaatttt ctgtgatttg agctgaatcc agtttattct gccgggaggg
      301 aagcctgtgc ctgcagctga ctcgctccag agctgatggg aatcctgccg ttcctactga
      361 tccccatgga gagcaactgg actgtccatg tgttctcacg gactttgtgc catatgctac
      421 tgtggacagc cgtgctaaat cttgctgctg ggactcatga tcttccaaag gctgtggtca
      481 aactcgagcc cccgtggatc caggtgctca aggaagacac ggtgacactg acatgcgaag
      541 ggacccacaa ccctgggaac tcttctaccc agtggttcca caatgggagg tccatccgga
      601 gccaggtcca agccagctac acgtttaagg ccacagtcaa tgacagtgga gaatatcggt
      661 gtcaaatgga gcagacccgc ctcagcgacc ctgtagatct gggagtgatt tctgactggc
      721 tgctgctcca gacccctcag ctggtgtttc tggaagggga aaccatcacg ctaaggtgcc
      781 atagctggag gaacaaacta ctgaacagga tctcgttctt ccataatgaa aaatccgtga
      841 ggtatcatca ctacagtagt aatttctcta tcccaaaagc caaccacagt cacagtgggg
      901 actactactg caaaggaagt ctaggaagga cactgcacca gtccaagcct gtcaccatca
      961 ctgtccaagg gcccaagtcc agcaggtctt taccagtatt gacaattgtg gctgctgtca
     1021 ctgggattgc tgtcgcagcc attgttatta tcctagtatc cttggtctat ctcaagaaaa
     1081 agcaggttcc agctctccca ggaaaccctg atcacaggga aatgggagaa acccttccag
     1141 aggaagtagg tgagtacaga cagccctctg ggggctcagt gcctgtcagc ccagggcctc
     1201 catctggact ggagccaaca agcagcagcc catacaatcc tcctgatctg gaagaagctg
     1261 ccaaaactga ggctgagaat acgatcacct actcacttct caagcatccc gaagccctgg
     1321 atgaagaaac agagcatgat taccagaacc acatttagtc tcccttggca ttgggaaaag
     1381 caagccagaa aggccaggat ctagtgtctc ctggtccaag ggatgctgta gatattaaag
     1441 aaaacatcca gagtcacttc tgtgagtcct gaaaccaaca gacactacga gattggttcc
     1501 caatggttga ctgtactaat gactcccata acttacagct tcccaactca agactcttct
     1561 gctatcgatc cacactgcca ctaaaattaa tcaacttact gccgttaaga gactgcagca
     1621 acgtgggaac tgcttataat tcacgctaag ataaggagaa caattaatgt taggatgcat
     1681 catctcggtg atgataaacc agacttgtac caacctgtca aagatgatgc ttctttataa
     1741 ggaacttcaa tttttttttt atttttctat aaaggtcaca tgttacttta atagtaaaat
     1801 gttgtaaaaa caaaccatct ttctatttac tttttcaagg ctgcaatgat tggaatatag
     1861 gctgagctct ctggggtttg ttggtcttct gcgagaagac tcttggggag atgggttaac
     1921 tttcccctgg ggagacataa gagtcttagg tagagccctc gtgacagacc aaagtcatat
     1981 gattacactc aagtctagtt tggtgcacca gtgagtttat ccagcttatt tgtggggaca
     2041 tgagtgaagg gttcctttca ggggtgtgga agatcttata acaacagtct tagcaccaat
     2101 gacgtcttta cagccacata gatggccccc caccccctct ttagtttgtc tccctcaaac
     2161 tcccagtcct gaagcctgtg cctttagacc tccaggataa cgagcatgca cgactatcca
     2221 ccaccacacc tggcctggta gcagtagata ggaggtagag gagaggacag acagggattt
     2281 ggagtagagg gccagtgccc ctcccttcaa actgaacatg cttccagtga acttgtcttt
     2341 ttgtttccac ttccttcttc tcttttctcc tatgacaaac agagtaatca ctttgttatg
     2401 taacaggagt tctcaggaag tcaaactttg gatgaaagcc agtggtaact gaaggatgac
     2461 cttgaactcc tgatcttgct actcccacct cctagttgct tggatcatat tatgtttgta
     2521 tgttcacaaa aatcactcag gcagctattt aagcttgctg taaccacatg agttcagagt
     2581 gtagacatat aaatgaaaaa aaaagggaga aattctatgt tgtcctcatt ccccttgctg
     2641 ctgctgctgc ttcttcttct tcttcttctt cttcttcttc ttcttcttct tcttcttctt
     2701 cttcttcttc ttcttcttct tcttcttctt cttcttcttc ttcttcttct tcttcttctt
     2761 ctccttctcc ttctccttct ccttctcctt ctccttctcc ttctccttct ccttctcctt
     2821 ctccttctcc ttctccttct ccttctcctt ctccttctcc ttctccttct ccttctcctt
     2881 ctccttctcc tcctcctcct cctcctcctc ctcctcctcc tcctcctcct cctcctcctc
     2941 ctcctcttcc tccttctcct cctcctcctc ctccttcttc ttcttcttct ctctctctct
     3001 ctccatctct ctttctctgt ctatctctgc ctctctcaaa tgaataacca ttgttgtagg
     3061 tgttgtgtac attcagggta tatatatttg atattgtttt tagaaagcct atacatgtga
     3121 ttatattgtt gacttatttt gactgggcct ttctggatgt tagcctagct tcgggctcat
     3181 tgaaagaccc tctctcaaag gattaagcag agagagatag agcagggtat cagatgtttt
     3241 cctttgacct ctgcacacca cacataggca gcccacacac atgtgtgcct atgacacaca
     3301 caaataaaat aaacaataat aattttaaaa aatcactcca gaatttctgc tttgaactct
     3361 ctgataacca agccgtggtt gcacgggtcc atccttgtgt ggatcttagt ggttcaatcc
     3421 aaacacacag aacaaataag gttgtctgac actagggaga cctcccgaag ctcttgcctt
     3481 cctaatgtgc acctttgagt gtgcctcatg gaatcgagtc agttctttct catatcctct
     3541 ttagcaagac ccttcctgga cactgctctt tgtttttatt ttctccatgg tacagtgtag
     3601 ataattatgc atctccttct tttatatatt ctcatatata ctaaaatgta agctcacaac
     3661 agccctgtgt tttcattttt cactaacata gtccagagac cagaacaatg caatagattg
     3721 ttaaatgaat taataaataa aacttgcctc tcata
//
