LOCUS       NM_010186               2589 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus Fc receptor, IgG, high affinity I (Fcgr1), mRNA.
ACCESSION   NM_010186
VERSION     NM_010186.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2589)
  AUTHORS   De Ponti,F.F., Bujko,A., Liu,Z., Collins,P.J., Schuermans,S.,
            Maueroder,C., Amstelveen,S., Thone,T., Martens,L., McKendrick,J.G.,
            Louwe,P.A., Sanchez Cruz,A., Saelens,W., Matchett,K.P.,
            Waller,K.J., Zwicker,C., Buglar-Lamb,A., Vanneste,B.,
            Parmentier,F., Binte Abdul Latib,M., Remmerie,A., Kertesz,L.,
            Kremer,A., Verbeke,J., Ipsen,D.H., Pfister,D.R., Liu,Z.,
            Guilliams,M., Henderson,N.C., Ravichandran,K., Marques,P.E. and
            Scott,C.L.
  TITLE     Spatially restricted and ontogenically distinct hepatic macrophages
            are required for tissue repair
  JOURNAL   Immunity 58 (2), 362-380 (2025)
   PUBMED   39862865
REFERENCE   2  (bases 1 to 2589)
  AUTHORS   Ben-Shaanan,T.L., Knopper,K., Duan,L., Liu,R., Taglinao,H., Xu,Y.,
            An,J., Plikus,M.V. and Cyster,J.G.
  TITLE     Dermal TRPV1 innervations engage a macrophage- and
            fibroblast-containing pathway to activate hair growth in mice
  JOURNAL   Dev Cell 59 (21), 2818-2833 (2024)
   PUBMED   38851191
REFERENCE   3  (bases 1 to 2589)
  AUTHORS   Farhat-Younis,L., Na,M., Zarfin,A., Khateeb,A., Santana-Magal,N.,
            Richter,A., Gutwillig,A., Rasoulouniriana,D., Gleiberman,A.,
            Beck,L., Giger,T., Ashkenazi,A., Barzel,A., Rider,P. and Carmi,Y.
  TITLE     Expression of modified FcgammaRI enables myeloid cells to elicit
            robust tumor-specific cytotoxicity
  JOURNAL   Elife 12, 91999 (2024)
   PUBMED   38885133
  REMARK    GeneRIF: Expression of modified FcgammaRI enables myeloid cells to
            elicit robust tumor-specific cytotoxicity.
            Erratum:[Elife. 2024 Jul 02;13:e101165. doi: 10.7554/eLife.101165.
            PMID: 38953289]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2589)
  AUTHORS   Morimoto,K., Takahashi,R., Takahashi,G., Miyajima,M. and
            Nakajima,K.
  TITLE     Maternal immunoglobulins are distributed in the offspring's brain
            to support the maintenance of cortical interneurons in the
            postnatal period
  JOURNAL   Inflamm Regen 44 (1), 24 (2024)
   PUBMED   38750507
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2589)
  AUTHORS   Zhang,X., Yuan,L., Tan,Z., Wu,H., Chen,F., Huang,J., Wang,P.,
            Hambly,B.D., Bao,S. and Tao,K.
  TITLE     CD64 plays a key role in diabetic wound healing
  JOURNAL   Front Immunol 15, 1322256 (2024)
   PUBMED   38524127
  REMARK    GeneRIF: CD64 plays a key role in diabetic wound healing.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2589)
  AUTHORS   Osman,N., Kozak,C.A., McKenzie,I.F. and Hogarth,P.M.
  TITLE     Structure and mapping of the gene encoding mouse high affinity Fc
            gamma RI and chromosomal location of the human Fc gamma RI gene
  JOURNAL   J Immunol 148 (5), 1570-1575 (1992)
   PUBMED   1531670
REFERENCE   7  (bases 1 to 2589)
  AUTHORS   McAleer,M.A., Aitman,T.J., Cornall,R.J., Ghosh,S., Hall,J.R.,
            Hearne,C.M., Love,J.M., Prins,J.B., Ramachandran,S., Rodrigues,N.
            et al.
  TITLE     Linkage analysis of 84 microsatellite markers in intra- and
            interspecific backcrosses
  JOURNAL   Mamm Genome 3 (8), 457-460 (1992)
   PUBMED   1643308
REFERENCE   8  (bases 1 to 2589)
  AUTHORS   Dower,N.A., Seldin,M.F., Pugh,S. and Stone,J.C.
  TITLE     Organization and chromosomal locations of Rap1a/Krev sequences in
            the mouse
  JOURNAL   Mamm Genome 3 (3), 162-167 (1992)
   PUBMED   1617222
REFERENCE   9  (bases 1 to 2589)
  AUTHORS   Oakey,R.J., Howard,T.A., Hogarth,P.M., Tani,K. and Seldin,M.F.
  TITLE     Chromosomal mapping of the high affinity Fc gamma receptor gene
  JOURNAL   Immunogenetics 35 (4), 279-282 (1992)
   PUBMED   1347284
REFERENCE   10 (bases 1 to 2589)
  AUTHORS   Sears,D.W., Osman,N., Tate,B., McKenzie,I.F. and Hogarth,P.M.
  TITLE     Molecular cloning and expression of the mouse high affinity Fc
            receptor for IgG
  JOURNAL   J Immunol 144 (1), 371-378 (1990)
   PUBMED   2136886
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC093350.15.
            
            On Oct 19, 2007 this sequence version replaced NM_010186.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033874.1, M31314.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC093350.15        118544-118608       c
            66-86               AC093350.15        118158-118178       c
            87-344              AC093350.15        116892-117149       c
            345-593             AC093350.15        111623-111871       c
            594-878             AC093350.15        110448-110732       c
            879-2589            AC093350.15        107548-109258       c
FEATURES             Location/Qualifiers
     source          1..2589
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 41.72 cM"
     gene            1..2589
                     /gene="Fcgr1"
                     /gene_synonym="CD64; FcgammaRI; IGGHAFC"
                     /note="Fc receptor, IgG, high affinity I"
                     /db_xref="GeneID:14129"
                     /db_xref="MGI:MGI:95498"
     exon            1..65
                     /gene="Fcgr1"
                     /gene_synonym="CD64; FcgammaRI; IGGHAFC"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..1222
                     /gene="Fcgr1"
                     /gene_synonym="CD64; FcgammaRI; IGGHAFC"
                     /note="IgG high affinity Fc receptor; high affinity
                     immunoglobulin gamma Fc receptor I; fcRI; fc-gamma RI; igG
                     Fc receptor I"
                     /codon_start=1
                     /product="high affinity immunoglobulin gamma Fc receptor I
                     precursor"
                     /protein_id="NP_034316.1"
                     /db_xref="CCDS:CCDS17639.1"
                     /db_xref="GeneID:14129"
                     /db_xref="MGI:MGI:95498"
                     /translation="MILTSFGDDMWLLTTLLLWVPVGGEVVNATKAVITLQPPWVSIF
                     QKENVTLWCEGPHLPGDSSTQWFINGTAVQISTPSYSIPEASFQDSGEYRCQIGSSMP
                     SDPVQLQIHNDWLLLQASRRVLTEGEPLALRCHGWKNKLVYNVVFYRNGKSFQFSSDS
                     EVAILKTNLSHSGIYHCSGTGRHRYTSAGVSITVKELFTTPVLRASVSSPFPEGSLVT
                     LNCETNLLLQRPGLQLHFSFYVGSKILEYRNTSSEYHIARAEREDAGFYWCEVATEDS
                     SVLKRSPELELQVLGPQSSAPVWFHILFYLSVGIMFSLNTVLYVKIHRLQREKKYNLE
                     VPLVSEQGKKANSFQQVRSDGVYEEVTATASQTTPKEAPDGPRSSVGDCGPEQPEPLP
                     PSDSTGAQTSQS"
     exon            66..86
                     /gene="Fcgr1"
                     /gene_synonym="CD64; FcgammaRI; IGGHAFC"
                     /inference="alignment:Splign:2.1.0"
     exon            87..344
                     /gene="Fcgr1"
                     /gene_synonym="CD64; FcgammaRI; IGGHAFC"
                     /inference="alignment:Splign:2.1.0"
     exon            345..593
                     /gene="Fcgr1"
                     /gene_synonym="CD64; FcgammaRI; IGGHAFC"
                     /inference="alignment:Splign:2.1.0"
     exon            594..878
                     /gene="Fcgr1"
                     /gene_synonym="CD64; FcgammaRI; IGGHAFC"
                     /inference="alignment:Splign:2.1.0"
     exon            879..2589
                     /gene="Fcgr1"
                     /gene_synonym="CD64; FcgammaRI; IGGHAFC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1258..1263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fcgr1"
                     /gene_synonym="CD64; FcgammaRI; IGGHAFC"
                     /note="hexamer: AATAAA"
     polyA_site      1281
                     /gene="Fcgr1"
                     /gene_synonym="CD64; FcgammaRI; IGGHAFC"
                     /note="major polyA site"
ORIGIN      
        1 acattacatg attcttacca gctttggaga tgacatgtgg cttctaacaa ctctgctact
       61 ttgggttcca gtcggtgggg aagtggttaa tgccaccaag gctgtgatca ccttgcagcc
      121 tccatgggtc agtattttcc agaaggaaaa tgtcacttta tggtgtgagg ggcctcacct
      181 gcctggagac agttccacac aatggtttat caacggaaca gccgttcaga tctccacgcc
      241 tagttatagc atcccagagg ccagttttca ggacagtggc gaatacaggt gtcagatagg
      301 ttcctcaatg ccaagtgacc ctgtgcagtt gcaaatccac aatgattggc tgctactcca
      361 ggcctcccgc agagtcctca cagaaggaga acccctggcc ttgaggtgtc acggatggaa
      421 gaataaactg gtgtacaatg tggttttcta tagaaatgga aaatcctttc agttttcttc
      481 agattcggag gtcgccattc tgaaaaccaa cctgagtcac agcggcatct accactgctc
      541 aggcacggga agacaccgct acacatctgc aggagtgtcc atcacggtga aagagctgtt
      601 taccacgcca gtgctgagag catccgtgtc atctcccttc ccggagggga gtctggtcac
      661 cctgaactgt gagacgaatt tgctcctgca gagacccggc ttacagcttc acttctcctt
      721 ctacgtgggc agcaagatcc tggagtacag gaacacatcc tcagagtacc atatagcaag
      781 ggcggaaaga gaagatgctg gattctactg gtgtgaggta gccacggagg acagcagtgt
      841 ccttaagcgc agccctgagt tggagctcca agtgcttggt ccccagtcat cagctcctgt
      901 ctggtttcac atcctgtttt atctgtcagt gggaataatg ttttcgttga acacggttct
      961 ctatgtgaaa atacacaggc tgcagagaga gaagaaatac aacttagaag tccctttggt
     1021 ttctgagcag ggaaagaaag caaattcctt tcagcaagtt agaagcgatg gcgtgtatga
     1081 agaagtaaca gccactgcga gccagaccac accaaaagaa gcgcccgatg gacctcgaag
     1141 ctcagtgggt gactgtggac ccgagcagcc tgaacccctt cctcccagtg acagtactgg
     1201 ggcacaaact tcccaaagtt gaccctgaaa ctgtgggacc atggcatgca actcttaaat
     1261 aaagcaaata tacagactgg atccggctga gacaagctgg gtaatcagac atttgaaagg
     1321 agacctatac caaagggatc ttgcaacaca tggagtcagg tcacagcggg ggttgtcgaa
     1381 tgtttgacct tatggagcag ggaaacagga agtgaatccc acaggactcc ccccccccgc
     1441 ccatccccct ccaggccgcc ccggacagga cccagctctg gaagactcca gtctgagact
     1501 tgcggaacca gagcaggggt gagattcctg cccagaaggg acagctgtgc catcccctca
     1561 cagggtggat gggttcaggg aaaggcctcc ccagggacgg cctgcgtgtc aggggagcag
     1621 acgctgatac agacagctcc atagcctggg ctaaagctgg ctaagacccg gtggtcatcc
     1681 tgagagcatc ggaatttgtg ctctccttcc taccgtctct cttcatgcac cctccccaga
     1741 tttgctgccc acgaccctca aaggacatag tggcggcagc taaagagtga agtgtcagca
     1801 gtaatccatc catctaacct ccctcaggtc cagatacccc cacccccaaa ctcccacact
     1861 ctaggggcct tttcaggcag cctgcatgtg gtgtcttagc agagctatgg tacaaaggct
     1921 tttagctcta tcattatctg acaagcagac agcaccctca ggtgctctca ttgggtggtg
     1981 agagctttct ccagcctgta ccacctgtaa gctggagtgt ggggcgggaa cactggccca
     2041 aagcgtccct attggaaggc acggcttaca tgggtgtcac aaatgccctt agaccacgca
     2101 ggaagaccga attctagaaa caaggagtag atcatgtctc cacttactgt cactcctaag
     2161 gatcccctga aggtcttgga gcttcacatc cctggaactc tagggtctgc cgtgctagag
     2221 gtcccagtct gcagagtggg tgtggcatag cctgagcctc cctggatgtg aacattagca
     2281 aggtatattg ggacctttat aaccagggac caataggcat gagagggacc gggataatgg
     2341 accacagtca caggaggaga tacactctgt tgtacaatgc atgcagaaac tgtcaaaaac
     2401 agtgtgggag ctggagagat gatcaggggt taagaacact tcctgctctt ccagaggacc
     2461 tgagttcact ttttgtaact gcttgtaagt ccagatgtcg tcttctgatc tctttcaagc
     2521 acccacatgt gcagggcatg cagacacaga catatgaaca agaacaatta aaaaataaat
     2581 tataactgc
//
