LOCUS       NM_013517               2241 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus Fc receptor, IgE, low affinity II, alpha polypeptide
            (Fcer2a), transcript variant 1, mRNA.
ACCESSION   NM_013517
VERSION     NM_013517.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2241)
  AUTHORS   Cichon,M.A., Klas,K., Buchberger,M., Hammer,M., Sere,K., Zenke,M.,
            Tschachler,E. and Elbe-Burger,A.
  TITLE     Distinct Distribution of RTN1A in Immune Cells in Mouse Skin and
            Lymphoid Organs
  JOURNAL   Front Cell Dev Biol 8, 608876 (2021)
   PUBMED   33542915
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2241)
  AUTHORS   Engeroff,P., Caviezel,F., Mueller,D., Thoms,F., Bachmann,M.F. and
            Vogel,M.
  TITLE     CD23 provides a noninflammatory pathway for IgE-allergen complexes
  JOURNAL   J Allergy Clin Immunol 145 (1), 301-311 (2020)
   PUBMED   31437490
  REMARK    GeneRIF: IgE-ICs are noninflammatory through reduced engagement by
            FcepsilonRI but increased targeting of the CD23 pathway.
REFERENCE   3  (bases 1 to 2241)
  AUTHORS   Shan,M., Carrillo,J., Yeste,A., Gutzeit,C., Segura-Garzon,D.,
            Walland,A.C., Pybus,M., Grasset,E.K., Yeiser,J.R., Matthews,D.B.,
            van de Veen,W., Comerma,L., He,B., Boonpiyathad,T., Lee,H.,
            Blanco,J., Osborne,L.C., Siracusa,M.C., Akdis,M., Artis,D.,
            Mehandru,S., Sampson,H.A., Berin,M.C., Chen,K. and Cerutti,A.
  TITLE     Secreted IgD Amplifies Humoral T Helper 2 Cell Responses by Binding
            Basophils via Galectin-9 and CD44
  JOURNAL   Immunity 49 (4), 709-724 (2018)
   PUBMED   30291028
REFERENCE   4  (bases 1 to 2241)
  AUTHORS   Guo,Y., Chang,Q., Cheng,L., Xiong,S., Jia,X., Lin,X. and Zhao,X.
  TITLE     C-Type Lectin Receptor CD23 Is Required for Host Defense against
            Candida albicans and Aspergillus fumigatus Infection
  JOURNAL   J Immunol 201 (8), 2427-2440 (2018)
   PUBMED   30185519
REFERENCE   5  (bases 1 to 2241)
  AUTHORS   Maamary,J., Wang,T.T., Tan,G.S., Palese,P. and Ravetch,J.V.
  TITLE     Increasing the breadth and potency of response to the seasonal
            influenza virus vaccine by immune complex immunization
  JOURNAL   Proc Natl Acad Sci U S A 114 (38), 10172-10177 (2017)
   PUBMED   28874545
REFERENCE   6  (bases 1 to 2241)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   7  (bases 1 to 2241)
  AUTHORS   Richards,M.L., Katz,D.H. and Liu,F.T.
  TITLE     Complete genomic sequence of the murine low affinity Fc receptor
            for IgE. Demonstration of alternative transcripts and conserved
            sequence elements
  JOURNAL   J Immunol 147 (3), 1067-1074 (1991)
   PUBMED   1861070
REFERENCE   8  (bases 1 to 2241)
  AUTHORS   Gollnick,S.O., Trounstine,M.L., Yamashita,L.C., Kehry,M.R. and
            Moore,K.W.
  TITLE     Isolation, characterization, and expression of cDNA clones encoding
            the mouse Fc receptor for IgE (Fc epsilon RII)1
  JOURNAL   J Immunol 144 (5), 1974-1982 (1990)
   PUBMED   2137845
REFERENCE   9  (bases 1 to 2241)
  AUTHORS   Bettler,B., Hofstetter,H., Rao,M., Yokoyama,W.M., Kilchherr,F. and
            Conrad,D.H.
  TITLE     Molecular structure and expression of the murine lymphocyte
            low-affinity receptor for IgE (Fc epsilon RII)
  JOURNAL   Proc Natl Acad Sci U S A 86 (19), 7566-7570 (1989)
   PUBMED   2529542
REFERENCE   10 (bases 1 to 2241)
  AUTHORS   Holmes,K.L. and Morse,H.C. 3rd.
  TITLE     Murine hematopoietic cell surface antigen expression
  JOURNAL   Immunol Today 9 (11), 344-350 (1988)
   PUBMED   3076405
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M34163.1 and AC087183.9.
            
            On Oct 19, 2007 this sequence version replaced NM_013517.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and it encodes the longest protein (isoform A).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M34163.1, AK172591.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1259              M34163.1           3-1261
            1260-2241           AC087183.9         26346-27327         c
FEATURES             Location/Qualifiers
     source          1..2241
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 1.92 cM"
     gene            1..2241
                     /gene="Fcer2a"
                     /gene_synonym="CD23; Fce2; Fcer2; Ly-42"
                     /note="Fc receptor, IgE, low affinity II, alpha
                     polypeptide"
                     /db_xref="GeneID:14128"
                     /db_xref="MGI:MGI:95497"
     exon            1..91
                     /gene="Fcer2a"
                     /gene_synonym="CD23; Fce2; Fcer2; Ly-42"
                     /inference="alignment:Splign:2.1.0"
     exon            92..194
                     /gene="Fcer2a"
                     /gene_synonym="CD23; Fce2; Fcer2; Ly-42"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1168
                     /gene="Fcer2a"
                     /gene_synonym="CD23; Fce2; Fcer2; Ly-42"
                     /note="isoform A is encoded by transcript variant 1; low
                     affinity immunoglobulin epsilon Fc receptor;
                     fc-epsilon-RII; lymphocyte IgE receptor; FC epsilon RII;
                     low-affinity IgE receptor"
                     /codon_start=1
                     /product="low affinity immunoglobulin epsilon Fc receptor
                     isoform A"
                     /protein_id="NP_038545.1"
                     /db_xref="CCDS:CCDS22071.1"
                     /db_xref="GeneID:14128"
                     /db_xref="MGI:MGI:95497"
                     /translation="MEENEYSGYWEPPRKRCCCARRGTQLMLVGLLSTAMWAGLLALL
                     LLWHWETEKNLKQLGDTAIQNVSHVTKDLQKFQSNQLAQKSQVVQMSQNLQELQAEQK
                     QMKAQDSRLSQNLTGLQEDLRNAQSQNSKLSQNLNRLQDDLVNIKSLGLNEKRTASDS
                     LEKLQEEVAKLWIEILISKGTACNICPKNWLHFQQKCYYFGKGSKQWIQARFACSDLQ
                     GRLVSIHSQKEQDFLMQHINKKDSWIGLQDLNMEGEFVWSDGSPVGYSNWNPGEPNNG
                     GQGEDCVMMRGSGQWNDAFCRSYLDAWVCEQLATCEISAPLASVTPTRPTPKSEP"
     exon            195..314
                     /gene="Fcer2a"
                     /gene_synonym="CD23; Fce2; Fcer2; Ly-42"
                     /inference="alignment:Splign:2.1.0"
     exon            315..368
                     /gene="Fcer2a"
                     /gene_synonym="CD23; Fce2; Fcer2; Ly-42"
                     /inference="alignment:Splign:2.1.0"
     exon            369..431
                     /gene="Fcer2a"
                     /gene_synonym="CD23; Fce2; Fcer2; Ly-42"
                     /inference="alignment:Splign:2.1.0"
     exon            432..494
                     /gene="Fcer2a"
                     /gene_synonym="CD23; Fce2; Fcer2; Ly-42"
                     /inference="alignment:Splign:2.1.0"
     exon            495..557
                     /gene="Fcer2a"
                     /gene_synonym="CD23; Fce2; Fcer2; Ly-42"
                     /inference="alignment:Splign:2.1.0"
     exon            558..620
                     /gene="Fcer2a"
                     /gene_synonym="CD23; Fce2; Fcer2; Ly-42"
                     /inference="alignment:Splign:2.1.0"
     exon            621..710
                     /gene="Fcer2a"
                     /gene_synonym="CD23; Fce2; Fcer2; Ly-42"
                     /inference="alignment:Splign:2.1.0"
     exon            711..862
                     /gene="Fcer2a"
                     /gene_synonym="CD23; Fce2; Fcer2; Ly-42"
                     /inference="alignment:Splign:2.1.0"
     exon            863..969
                     /gene="Fcer2a"
                     /gene_synonym="CD23; Fce2; Fcer2; Ly-42"
                     /inference="alignment:Splign:2.1.0"
     exon            970..2241
                     /gene="Fcer2a"
                     /gene_synonym="CD23; Fce2; Fcer2; Ly-42"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagactac tgtcttcaac acactagcct gagctacctt atccaagtgc tccacatatt
       61 ccagaaggag aaggacagac ttcaagttca aatcacttcc agagctgtga gtgacaagtg
      121 ccttggcagg tagtgcacgc ctcatcactg aaaggatcca aacaagactg ccatggaaga
      181 aaatgaatac tcaggatact gggaacctcc tagaaagcgt tgctgctgtg caagacgtgg
      241 gacacagctc atgttggtgg ggctgctgag cacagcaatg tgggctggcc tgctggccct
      301 gcttcttctg tggcactggg aaacggagaa gaatctaaaa cagctgggag acactgcaat
      361 tcagaatgtc tctcatgtta ccaaggactt acaaaaattc cagagtaatc aattggccca
      421 gaagtcccag gttgttcaga tgtcacaaaa cttgcaagaa ctccaagctg aacagaagca
      481 aatgaaagct caggactctc ggctctccca gaacctgacc ggactccagg aggatctaag
      541 gaacgcccaa tcccagaact caaaactctc ccagaacctg aacagactcc aagacgatct
      601 agtcaacatc aaatccctgg gcttgaatga gaagcgcaca gcctccgatt ctctagagaa
      661 actccaggaa gaggtggcaa agctgtggat agagatactg atttcaaagg gaactgcatg
      721 caacatatgt cccaagaact ggctccattt ccaacagaag tgctactatt ttggcaaggg
      781 ctccaagcag tggatccagg ccaggttcgc ctgcagtgac ctgcaagggc gactagtcag
      841 catccacagc caaaaggaac aggacttcct gatgcaacac atcaacaaga aggattcctg
      901 gattggcctc caggatctca atatggaggg agagtttgta tggtcggacg ggagccctgt
      961 gggttatagc aactggaatc caggggagcc caataacggg ggccagggtg aggactgtgt
     1021 gatgatgcgg ggatccggcc agtggaacga cgccttctgc cgcagctact tggatgcatg
     1081 ggtgtgtgag cagctggcaa catgtgagat atctgccccc ttagcctctg tgactccaac
     1141 aaggcccacc ccaaaaagtg aaccctgaca aacttctgct cacactcttc tggatttctc
     1201 ctctaccttt atcgtggaaa cagctgggcc ctgaggatac ccctatcagg gcccagggcc
     1261 ctctctgtga ccgaaggctt tgattatgtt cccacccata ctgaagcagc tggtggatgc
     1321 cagctcctgc cagctaccca gaaaccctct ccagctctcc agctaagctg gccatcccat
     1381 tccatctgcc ttcctcaaac ctgggcccca gccttgctag ctccctgact acgggcatgc
     1441 atgtgggcag ctgagccaac cagggagctg ctgagaacaa agatttcgaa ggcttctttt
     1501 gcagtcccca cctcctatca agttccccac tttctccccc tcggcatcag agaacagggg
     1561 ttccctttcc ccaggatctg ggatgagtcc tcccatcaag tttgcatcag tggtcccagc
     1621 actccgaccc tccttggagg ctgcaccagg tgtgctcctg gtgcgggagg tattgaagga
     1681 actctaaaca gctccagcaa ggcgagcctg gctctgtctg gtaggcctgg cccttctctc
     1741 ccattccttc taccttacta aaagctgtta gagaacagtc ctaaagctag cccccaaggt
     1801 ctattccctt atttggccac ttcctcctcc tgaggctgac tacaaggtcc agctatccaa
     1861 gtactgaagt ctaacatcaa aagccccctt tgtctcacct aagtagcaat gcccaatcaa
     1921 aatacaccat cacatcatag cccagtctaa cagaccgccc tttttctctt cataaaatta
     1981 cacctgcaac caggcgtagt ggtgcaggcc tttagtccca gcacttggga ggcagagaca
     2041 agcgaatttc tgagttcgag gccagcctgg tctacaaagt gagttccagg acagccaggg
     2101 ctacacagag aaaccctgtc tcgaagaaag aaaaaaaaaa aaaattacac ctgcaaggtc
     2161 acttgcaggc tgctgttttt ctgcctgagt cagagggcag ccacttaact tttcttccct
     2221 gcttaataaa ggatctctgt g
//
