LOCUS       NP_038545                331 aa            linear   ROD 02-APR-2024
DEFINITION  low affinity immunoglobulin epsilon Fc receptor isoform A [Mus
            musculus].
ACCESSION   NP_038545
VERSION     NP_038545.1
DBSOURCE    REFSEQ: accession NM_013517.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 331)
  AUTHORS   Cichon,M.A., Klas,K., Buchberger,M., Hammer,M., Sere,K., Zenke,M.,
            Tschachler,E. and Elbe-Burger,A.
  TITLE     Distinct Distribution of RTN1A in Immune Cells in Mouse Skin and
            Lymphoid Organs
  JOURNAL   Front Cell Dev Biol 8, 608876 (2021)
   PUBMED   33542915
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 331)
  AUTHORS   Engeroff,P., Caviezel,F., Mueller,D., Thoms,F., Bachmann,M.F. and
            Vogel,M.
  TITLE     CD23 provides a noninflammatory pathway for IgE-allergen complexes
  JOURNAL   J Allergy Clin Immunol 145 (1), 301-311 (2020)
   PUBMED   31437490
  REMARK    GeneRIF: IgE-ICs are noninflammatory through reduced engagement by
            FcepsilonRI but increased targeting of the CD23 pathway.
REFERENCE   3  (residues 1 to 331)
  AUTHORS   Shan,M., Carrillo,J., Yeste,A., Gutzeit,C., Segura-Garzon,D.,
            Walland,A.C., Pybus,M., Grasset,E.K., Yeiser,J.R., Matthews,D.B.,
            van de Veen,W., Comerma,L., He,B., Boonpiyathad,T., Lee,H.,
            Blanco,J., Osborne,L.C., Siracusa,M.C., Akdis,M., Artis,D.,
            Mehandru,S., Sampson,H.A., Berin,M.C., Chen,K. and Cerutti,A.
  TITLE     Secreted IgD Amplifies Humoral T Helper 2 Cell Responses by Binding
            Basophils via Galectin-9 and CD44
  JOURNAL   Immunity 49 (4), 709-724 (2018)
   PUBMED   30291028
REFERENCE   4  (residues 1 to 331)
  AUTHORS   Guo,Y., Chang,Q., Cheng,L., Xiong,S., Jia,X., Lin,X. and Zhao,X.
  TITLE     C-Type Lectin Receptor CD23 Is Required for Host Defense against
            Candida albicans and Aspergillus fumigatus Infection
  JOURNAL   J Immunol 201 (8), 2427-2440 (2018)
   PUBMED   30185519
REFERENCE   5  (residues 1 to 331)
  AUTHORS   Maamary,J., Wang,T.T., Tan,G.S., Palese,P. and Ravetch,J.V.
  TITLE     Increasing the breadth and potency of response to the seasonal
            influenza virus vaccine by immune complex immunization
  JOURNAL   Proc Natl Acad Sci U S A 114 (38), 10172-10177 (2017)
   PUBMED   28874545
REFERENCE   6  (residues 1 to 331)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   7  (residues 1 to 331)
  AUTHORS   Richards,M.L., Katz,D.H. and Liu,F.T.
  TITLE     Complete genomic sequence of the murine low affinity Fc receptor
            for IgE. Demonstration of alternative transcripts and conserved
            sequence elements
  JOURNAL   J Immunol 147 (3), 1067-1074 (1991)
   PUBMED   1861070
REFERENCE   8  (residues 1 to 331)
  AUTHORS   Gollnick,S.O., Trounstine,M.L., Yamashita,L.C., Kehry,M.R. and
            Moore,K.W.
  TITLE     Isolation, characterization, and expression of cDNA clones encoding
            the mouse Fc receptor for IgE (Fc epsilon RII)1
  JOURNAL   J Immunol 144 (5), 1974-1982 (1990)
   PUBMED   2137845
REFERENCE   9  (residues 1 to 331)
  AUTHORS   Bettler,B., Hofstetter,H., Rao,M., Yokoyama,W.M., Kilchherr,F. and
            Conrad,D.H.
  TITLE     Molecular structure and expression of the murine lymphocyte
            low-affinity receptor for IgE (Fc epsilon RII)
  JOURNAL   Proc Natl Acad Sci U S A 86 (19), 7566-7570 (1989)
   PUBMED   2529542
REFERENCE   10 (residues 1 to 331)
  AUTHORS   Holmes,K.L. and Morse,H.C. 3rd.
  TITLE     Murine hematopoietic cell surface antigen expression
  JOURNAL   Immunol Today 9 (11), 344-350 (1988)
   PUBMED   3076405
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M34163.1 and AC087183.9.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and it encodes the longest protein (isoform A).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M34163.1, AK172591.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..331
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 1.92 cM"
     Protein         1..331
                     /product="low affinity immunoglobulin epsilon Fc receptor
                     isoform A"
                     /note="low affinity immunoglobulin epsilon Fc receptor;
                     fc-epsilon-RII; lymphocyte IgE receptor; FC epsilon RII;
                     low-affinity IgE receptor"
                     /calculated_mol_wt=37517
     Site            24..49
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P20693.1)"
     Region          50..>175
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Site            65
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P20693.1)"
     Region          71..91
                     /region_name="Repetitive region"
                     /note="propagated from UniProtKB/Swiss-Prot (P20693.1)"
     Region          92..112
                     /region_name="Repetitive region"
                     /note="propagated from UniProtKB/Swiss-Prot (P20693.1)"
     Region          113..133
                     /region_name="Repetitive region"
                     /note="propagated from UniProtKB/Swiss-Prot (P20693.1)"
     Site            114
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P20693.1)"
     Region          186..306
                     /region_name="CLECT_DC-SIGN_like"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in human dendritic cell (DC)-specific intercellular
                     adhesion molecule 3-grabbing non-integrin (DC-SIGN) and
                     the related receptor, DC-SIGN receptor (DC-SIGNR);
                     cd03590"
                     /db_xref="CDD:153060"
     Site            order(242,272,274,280,286..287,292..295)
                     /site_type="other"
                     /note="carbohydrate binding site"
                     /db_xref="CDD:153060"
     Site            order(248,252,275,280..281)
                     /site_type="other"
                     /note="calcium binding site 1 [ion binding]"
                     /db_xref="CDD:153060"
     Site            order(252,281)
                     /site_type="other"
                     /note="calcium binding site 3 [ion binding]"
                     /db_xref="CDD:153060"
     Site            319
                     /site_type="glycosylation"
                     /note="O-linked (Xyl...) (chondroitin sulfate) serine.
                     /evidence=ECO:0000250|UniProtKB:P06734; propagated from
                     UniProtKB/Swiss-Prot (P20693.1)"
     CDS             1..331
                     /gene="Fcer2a"
                     /gene_synonym="CD23; Fce2; Fcer2; Ly-42"
                     /coded_by="NM_013517.4:173..1168"
                     /note="isoform A is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS22071.1"
                     /db_xref="GeneID:14128"
                     /db_xref="MGI:MGI:95497"
ORIGIN      
        1 meeneysgyw epprkrccca rrgtqlmlvg llstamwagl lallllwhwe teknlkqlgd
       61 taiqnvshvt kdlqkfqsnq laqksqvvqm sqnlqelqae qkqmkaqdsr lsqnltglqe
      121 dlrnaqsqns klsqnlnrlq ddlvnikslg lnekrtasds leklqeevak lwieiliskg
      181 tacnicpknw lhfqqkcyyf gkgskqwiqa rfacsdlqgr lvsihsqkeq dflmqhinkk
      241 dswiglqdln megefvwsdg spvgysnwnp gepnnggqge dcvmmrgsgq wndafcrsyl
      301 dawvceqlat ceisaplasv tptrptpkse p
//
