LOCUS       NM_144960               1743 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus Fc receptor, IgA, IgM, high affinity (Fcamr),
            transcript variant 2, mRNA.
ACCESSION   NM_144960
VERSION     NM_144960.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1743)
  AUTHORS   Noval Rivas,M., Wakita,D., Franklin,M.K., Carvalho,T.T.,
            Abolhesn,A., Gomez,A.C., Fishbein,M.C., Chen,S., Lehman,T.J.,
            Sato,K., Shibuya,A., Fasano,A., Kiyono,H., Abe,M., Tatsumoto,N.,
            Yamashita,M., Crother,T.R., Shimada,K. and Arditi,M.
  TITLE     Intestinal Permeability and IgA Provoke Immune Vasculitis Linked to
            Cardiovascular Inflammation
  JOURNAL   Immunity 51 (3), 508-521 (2019)
   PUBMED   31471109
REFERENCE   2  (bases 1 to 1743)
  AUTHORS   Tanabe,S. and Yamashita,T.
  TITLE     B-1a lymphocytes promote oligodendrogenesis during brain
            development
  JOURNAL   Nat Neurosci 21 (4), 506-516 (2018)
   PUBMED   29507409
REFERENCE   3  (bases 1 to 1743)
  AUTHORS   Liu,J., Zhu,H., Qian,J., Xiong,E., Zhang,L., Wang,Y.Q., Chu,Y.,
            Kubagawa,H., Tsubata,T. and Wang,J.Y.
  TITLE     Fcmicro Receptor Promotes the Survival and Activation of Marginal
            Zone B Cells and Protects Mice against Bacterial Sepsis
  JOURNAL   Front Immunol 9, 160 (2018)
   PUBMED   29459869
  REMARK    GeneRIF: These results reveal a critical role for FcmuR in the
            survival and activation of marginal zone B cells and in protection
            against acute bacterial infection.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1743)
  AUTHORS   Nguyen,T.T.T., Graf,B.A., Randall,T.D. and Baumgarth,N.
  TITLE     sIgM-FcmuR Interactions Regulate Early B Cell Activation and Plasma
            Cell Development after Influenza Virus Infection
  JOURNAL   J Immunol 199 (5), 1635-1646 (2017)
   PUBMED   28747342
REFERENCE   5  (bases 1 to 1743)
  AUTHORS   Honda,S., Sato,K., Totsuka,N., Fujiyama,S., Fujimoto,M., Miyake,K.,
            Nakahashi-Oda,C., Tahara-Hanaoka,S., Shibuya,K. and Shibuya,A.
  TITLE     Marginal zone B cells exacerbate endotoxic shock via interleukin-6
            secretion induced by Fcalpha/muR-coupled TLR4 signalling
  JOURNAL   Nat Commun 7, 11498 (2016)
   PUBMED   27146354
  REMARK    GeneRIF: Toll-like receptor 4 (TLR4) requires physical and
            functional association with Fcalpha-mu protein (Fcalpha/muR) for
            its oligomer formation and interleukin-6 (IL-6) production from
            marginal zone (MZ) B cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1743)
  AUTHORS   Kurita,N., Honda,S., Usui,K., Shimizu,Y., Miyamoto,A.,
            Tahara-Hanaoka,S., Shibuya,K. and Shibuya,A.
  TITLE     Identification of the Fcalpha/muR isoform specifically expressed in
            the kidney tubules
  JOURNAL   Mol Immunol 46 (4), 749-753 (2009)
   PUBMED   19027165
REFERENCE   7  (bases 1 to 1743)
  AUTHORS   Cho,Y., Usui,K., Honda,S., Tahara-Hanaoka,S., Shibuya,K. and
            Shibuya,A.
  TITLE     Molecular characteristics of IgA and IgM Fc binding to the
            Fcalpha/muR
  JOURNAL   Biochem Biophys Res Commun 345 (1), 474-478 (2006)
   PUBMED   16681999
REFERENCE   8  (bases 1 to 1743)
  AUTHORS   Nakahara,J., Seiwa,C., Shibuya,A., Aiso,S. and Asou,H.
  TITLE     Expression of Fc receptor for immunoglobulin M in oligodendrocytes
            and myelin of mouse central nervous system
  JOURNAL   Neurosci Lett 337 (2), 73-76 (2003)
   PUBMED   12527391
  REMARK    GeneRIF: expressed in oligodendrocytes, their precursor cells, and
            myelin
REFERENCE   9  (bases 1 to 1743)
  AUTHORS   Shimizu,Y., Honda,S., Yotsumoto,K., Tahara-Hanaoka,S., Eyre,H.J.,
            Sutherland,G.R., Endo,Y., Shibuya,K., Koyama,A., Nakauchi,H. and
            Shibuya,A.
  TITLE     Fc(alpha)/mu receptor is a single gene-family member closely
            related to polymeric immunoglobulin receptor encoded on Chromosome
            1
  JOURNAL   Immunogenetics 53 (8), 709-711 (2001)
   PUBMED   11797105
REFERENCE   10 (bases 1 to 1743)
  AUTHORS   Shibuya,A., Sakamoto,N., Shimizu,Y., Shibuya,K., Osawa,M.,
            Hiroyama,T., Eyre,H.J., Sutherland,G.R., Endo,Y., Fujita,T.,
            Miyabayashi,T., Sakano,S., Tsuji,T., Nakayama,E., Phillips,J.H.,
            Lanier,L.L. and Nakauchi,H.
  TITLE     Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes
  JOURNAL   Nat Immunol 1 (5), 441-446 (2000)
   PUBMED   11062505
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC110550.1, BC110549.1 and AB048834.1.
            
            On Dec 14, 2007 this sequence version replaced NM_144960.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. The
            resulting isoform (2) lacks an internal segment, compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB048834.1, BC110550.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1501              BC110550.1         4-1504
            1502-1599           BC110549.1         1673-1770
            1600-1711           BC110550.1         1603-1714
            1712-1743           AB048834.1         1724-1755
FEATURES             Location/Qualifiers
     source          1..1743
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 56.89 cM"
     gene            1..1743
                     /gene="Fcamr"
                     /note="Fc receptor, IgA, IgM, high affinity"
                     /db_xref="GeneID:64435"
                     /db_xref="MGI:MGI:1927803"
     exon            1..87
                     /gene="Fcamr"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1656
                     /gene="Fcamr"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; high affinity immunoglobulin alpha and
                     immunoglobulin mu Fc receptor; Fca/m receptor; Fc IgA/IgM
                     receptor; mFcamR; fc alpha/mu receptor"
                     /codon_start=1
                     /product="high affinity immunoglobulin alpha and
                     immunoglobulin mu Fc receptor isoform 2 precursor"
                     /protein_id="NP_659209.2"
                     /db_xref="CCDS:CCDS15259.1"
                     /db_xref="GeneID:64435"
                     /db_xref="MGI:MGI:1927803"
                     /translation="MDQGAPAKPSEQKVPSLRTRWEILLLTLCLLHGSSMTPPHRRSH
                     SRWLQAGSPQFRTHLYNVEAHTAPTPLCCWKNSLSGTNALRGPRLVTGNTGGAVTIHC
                     HYAPSSVNRHQRKYWCRLGSPLWICHTVVSTNQYTHPDYRGRAALTDIPQSGLFVVRL
                     LRLSLGDVGLYRCGIGDRNDMLFFSVNLTVSAGPSNTTYAAAPASGEPTTASPGAASS
                     AGNGWTSGITQILEGSGSEWDRTVPTTGTSKTTSSANGRQTLRTARTMVPGTGSREEG
                     SIRAAVPTPEGPSPKSRSMSSTTQGVWLWSTRNSVTPSVTTSEGRRQGTTPETDGPRD
                     ETDVRVSPEAPRKTTGTTRPSALISEHVTWETLQDKTEVSKQQMLHSLEELSPAPSAQ
                     TLNATCLEVASEEGRSIDGSLENTTEESSPPTPSQLSVAGPVWVSVKGPSMKSALMEG
                     ESHTRILTPVSTVLALLLIAALILLKRSLGRQRTSQKKERVPRITLIQMTHFLPDKLP
                     DEGKNFQQSNLLPPQASLTVLENDPRP"
     exon            88..145
                     /gene="Fcamr"
                     /inference="alignment:Splign:2.1.0"
     exon            146..286
                     /gene="Fcamr"
                     /inference="alignment:Splign:2.1.0"
     exon            287..625
                     /gene="Fcamr"
                     /inference="alignment:Splign:2.1.0"
     exon            626..1382
                     /gene="Fcamr"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1501
                     /gene="Fcamr"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1743
                     /gene="Fcamr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcctcagat aaaagaaagg gtccaagttg atcttgctca ggactaacat ggaccaaggt
       61 gccccagcta agcccagtga acaaaaggtc cccagcctga gaacgagatg ggaaatactt
      121 cttctcacac tctgtctgct ccatggttca tccatgaccc ctccacacag aaggtcacat
      181 tccagatggc tgcaggctgg ctctcctcag ttcaggaccc atctctacaa tgtggaagca
      241 cacacagctc ccacgcccct ttgctgctgg aagaactccc tttcaggtac aaatgcattg
      301 agaggcccgc gactggtgac tgggaacact gggggagctg tcaccatcca ttgccattac
      361 gccccctcct cagtcaacag gcatcaaaga aaatactggt gccgcctggg gtctccattg
      421 tggatctgtc acactgtcgt gtccaccaac caatacactc accctgacta ccgtgggcgc
      481 gcggctctca ctgacattcc acagagcggt ttgtttgtgg tgaggctgct ccgactgtcc
      541 ctgggtgacg tgggacttta ccgctgtggc ataggagacc gaaacgacat gctattcttc
      601 agcgtgaatc tgactgtgtc tgcaggtcca tccaacacca cctatgcagc agcaccagct
      661 tccggtgagc ccaccacagc atctcctgga gcagcatcct cagcaggcaa cggatggacc
      721 tcaggcatca cccagatcct agaaggctca ggctcagaat gggacagaac agttccaacc
      781 acaggtacca gcaaaactac atcttcagcc aatggaagac aaaccttaag aacagccagg
      841 acaatggttc cggggacagg cagcagagag gagggctcta tcagggcagc agtccccact
      901 ccagagggtc cgtctccaaa atcaagaagc atgtccagca caacacaggg tgtttggctg
      961 tggagcacca ggaactcagt aacacccagt gttaccacga gtgaaggaag gaggcaaggc
     1021 acaaccccag agactgatgg gccacgagat gaaacagacg tcagggtgtc tccagaagca
     1081 cccaggaaga ccacaggaac cacgaggcca tcggccctga tctcagaaca tgtgacctgg
     1141 gaaactctcc aagacaaaac agaggtgtct aagcaacaaa tgctgcactc cctggaggag
     1201 ttatcaccag ctccaagtgc acagacctta aatgctacct gtttggaagt ggcatccgag
     1261 gaaggaagga gcattgatgg gagtcttgaa aacactacag aagaaagcag ccccccaaca
     1321 ccaagccagc tttcagtagc aggccctgtg tgggtttctg tcaaggggcc atccatgaag
     1381 agtgctctga tggaaggaga aagccacact cggatcctga ctccagtctc cactgtgctg
     1441 gccctgcttc taattgctgc tctgatccta ttgaaaagga gccttggcag acagaggaca
     1501 tctcagaaga aagaaagggt acccaggatc actctaattc agatgacaca tttcctacca
     1561 gataagctcc ctgatgaggg aaagaacttt caacagagta accttcttcc tccccaagcc
     1621 agcctgaccg tcctggagaa tgacccaaga ccctgatgat ggaaaggtaa atagctcagt
     1681 caccatgaag ggaagaccaa atccaaacag ctttatcctc ttctcctttc cctccaccca
     1741 cac
//
