LOCUS       NM_172721               4978 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus F-box and WD-40 domain protein 8 (Fbxw8), mRNA.
ACCESSION   NM_172721
VERSION     NM_172721.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4978)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4978)
  AUTHORS   Gobe,C., Elzaiat,M., Meunier,N., Andre,M., Sellem,E., Congar,P.,
            Jouneau,L., Allais-Bonnet,A., Naciri,I., Passet,B., Pailhoux,E. and
            Pannetier,M.
  TITLE     Dual role of DMXL2 in olfactory information transmission and the
            first wave of spermatogenesis
  JOURNAL   PLoS Genet 15 (2), e1007909 (2019)
   PUBMED   30735494
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4978)
  AUTHORS   Bae,K.B., Yu,D.H., Lee,K.Y., Yao,K., Ryu,J., Lim,D.Y., Zykova,T.A.,
            Kim,M.O., Bode,A.M. and Dong,Z.
  TITLE     Serine 347 Phosphorylation by JNKs Negatively Regulates OCT4
            Protein Stability in Mouse Embryonic Stem Cells
  JOURNAL   Stem Cell Reports 9 (6), 2050-2064 (2017)
   PUBMED   29153991
REFERENCE   4  (bases 1 to 4978)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 4978)
  AUTHORS   Halbach,M.V., Stehning,T., Damrath,E., Jendrach,M., Sen,N.E.,
            Basak,A.N. and Auburger,G.
  TITLE     Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into
            insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression
            is dysregulated
  JOURNAL   PLoS One 10 (3), e0121089 (2015)
   PUBMED   25790475
  REMARK    GeneRIF: FBXW8 and PARK2 are sequestrated into insolubility by
            ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4978)
  AUTHORS   Skaar,J.R., Florens,L., Tsutsumi,T., Arai,T., Tron,A.,
            Swanson,S.K., Washburn,M.P. and DeCaprio,J.A.
  TITLE     PARC and CUL7 form atypical cullin RING ligase complexes
  JOURNAL   Cancer Res 67 (5), 2006-2014 (2007)
   PUBMED   17332328
REFERENCE   7  (bases 1 to 4978)
  AUTHORS   Okabe,H., Lee,S.H., Phuchareon,J., Albertson,D.G., McCormick,F. and
            Tetsu,O.
  TITLE     A critical role for FBXW8 and MAPK in cyclin D1 degradation and
            cancer cell proliferation
  JOURNAL   PLoS One 1 (1), e128 (2006)
   PUBMED   17205132
  REMARK    GeneRIF: Depletion of FBXW8 caused a significant accumulation of
            cyclin D1, as well as sequestration of CDK1 in the cytoplasm. This
            resulted in a severe reduction of cell proliferation.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4978)
  AUTHORS   Tsunematsu,R., Nishiyama,M., Kotoshiba,S., Saiga,T., Kamura,T. and
            Nakayama,K.I.
  TITLE     Fbxw8 is essential for Cul1-Cul7 complex formation and for
            placental development
  JOURNAL   Mol Cell Biol 26 (16), 6157-6169 (2006)
   PUBMED   16880526
  REMARK    GeneRIF: Cul7 forms a heterodimeric complex with Cul1 in a manner
            dependent on Fbxw8.
REFERENCE   9  (bases 1 to 4978)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   10 (bases 1 to 4978)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053794.1, AK034447.1 and BY468586.1.
            
            On Dec 29, 2006 this sequence version replaced NM_172721.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034447.1, AK134291.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-914               AK053794.1         2-915
            915-4960            AK034447.1         843-4888
            4961-4978           BY468586.1         341-358
FEATURES             Location/Qualifiers
     source          1..4978
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 57.92 cM"
     gene            1..4978
                     /gene="Fbxw8"
                     /gene_synonym="4930438M06Rik; FBW6; FBW8; Fbx29; FBXO29"
                     /note="F-box and WD-40 domain protein 8"
                     /db_xref="GeneID:231672"
                     /db_xref="MGI:MGI:1923041"
     exon            1..395
                     /gene="Fbxw8"
                     /gene_synonym="4930438M06Rik; FBW6; FBW8; Fbx29; FBXO29"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1874
                     /gene="Fbxw8"
                     /gene_synonym="4930438M06Rik; FBW6; FBW8; Fbx29; FBXO29"
                     /note="F-box protein FBX29; F-box and WD-40
                     domain-containing protein 8"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 8"
                     /protein_id="NP_766309.2"
                     /db_xref="CCDS:CCDS19609.1"
                     /db_xref="GeneID:231672"
                     /db_xref="MGI:MGI:1923041"
                     /translation="MDDHNLEEFRRHWQEELAQSQALRRRRRLEAGERRSPRRPEAGA
                     RGEPASGYLGLAQGLLEGAGRPPAPRPGRGGDRKDTSSRSRSPPDRDATEPEPLVDQL
                     IRDLNELDDVPFFDVRLPYELAINIFQYLNRRELGLCAQVSKTWKVIAEDEVLWYRLC
                     RQEGHLPHSRFSDYTCWKLILQECLAKEHTLRANWKNRKGAVSELEHVPDAVLCDVRS
                     HDGVVIAGYTSGDVRVWDTRTWDYVAPFLESESEEEDPGMQPYVSFVRINSSLAVAAY
                     EDGILNIWDLRTGRFPIFRFEHDARIQALALSQEKPIVATASAFDVVMLYPNEEGHWH
                     VASEFEVQKLVDYLEIVPNTGRYPVAIATAGDLVYLLKADDSARTLHYVYGQPATCLD
                     VSASQVAFGVKSLGWVYEGNKILVYSLEAERCLSKLGNALGDFTCVNIRDSPPNLMVS
                     GNMDRRVRIHDLRSDKIALSLSAHQLGVSAVQMDDWKVVSGGEEGLVSVWDYRMNQKL
                     WEVHSRHPVRYLSFNSHSLITANVPYEKVLRNSDLDNFACHRRHRGLIHAYEFAVDQL
                     AFQSPLPVCRLPRDIMAGYSYDLALSFPHDSI"
     exon            396..500
                     /gene="Fbxw8"
                     /gene_synonym="4930438M06Rik; FBW6; FBW8; Fbx29; FBXO29"
                     /inference="alignment:Splign:2.1.0"
     exon            501..665
                     /gene="Fbxw8"
                     /gene_synonym="4930438M06Rik; FBW6; FBW8; Fbx29; FBXO29"
                     /inference="alignment:Splign:2.1.0"
     exon            666..754
                     /gene="Fbxw8"
                     /gene_synonym="4930438M06Rik; FBW6; FBW8; Fbx29; FBXO29"
                     /inference="alignment:Splign:2.1.0"
     exon            755..912
                     /gene="Fbxw8"
                     /gene_synonym="4930438M06Rik; FBW6; FBW8; Fbx29; FBXO29"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1109
                     /gene="Fbxw8"
                     /gene_synonym="4930438M06Rik; FBW6; FBW8; Fbx29; FBXO29"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1316
                     /gene="Fbxw8"
                     /gene_synonym="4930438M06Rik; FBW6; FBW8; Fbx29; FBXO29"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1444
                     /gene="Fbxw8"
                     /gene_synonym="4930438M06Rik; FBW6; FBW8; Fbx29; FBXO29"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1618
                     /gene="Fbxw8"
                     /gene_synonym="4930438M06Rik; FBW6; FBW8; Fbx29; FBXO29"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1729
                     /gene="Fbxw8"
                     /gene_synonym="4930438M06Rik; FBW6; FBW8; Fbx29; FBXO29"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..4978
                     /gene="Fbxw8"
                     /gene_synonym="4930438M06Rik; FBW6; FBW8; Fbx29; FBXO29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3326..3331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxw8"
                     /gene_synonym="4930438M06Rik; FBW6; FBW8; Fbx29; FBXO29"
                     /note="hexamer: ATTAAA"
     polyA_site      3344
                     /gene="Fbxw8"
                     /gene_synonym="4930438M06Rik; FBW6; FBW8; Fbx29; FBXO29"
                     /note="major polyA site"
     regulatory      4591..4596
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxw8"
                     /gene_synonym="4930438M06Rik; FBW6; FBW8; Fbx29; FBXO29"
                     /note="hexamer: ATTAAA"
     polyA_site      4620
                     /gene="Fbxw8"
                     /gene_synonym="4930438M06Rik; FBW6; FBW8; Fbx29; FBXO29"
ORIGIN      
        1 ggacacttcc ggcggatgga cagtccgtcc ccattctggc agcccctggg tgccgcgtcg
       61 gcctgggcgc gtcaagcatg gacgaccaca acctggagga gttccgccgg cactggcagg
      121 aggagttggc gcagtcacag gcgctgaggc gacggcggcg gctcgaggct ggggagcggc
      181 ggtcgccgcg aaggcccgag gcgggagcgc gaggcgagcc ggcctcgggc tacctggggc
      241 tggcgcaggg gctgctggag ggcgcgggcc gacccccggc gcccaggcct ggccggggag
      301 gcgacaggaa ggatacgtcc agccgatcgc gctcaccccc agaccgcgac gccacggagc
      361 ccgagccgct ggtggatcag ctcatccgcg acttgaatga gctggatgac gtgcccttct
      421 ttgatgtccg tctgccttac gaactggcca tcaatatatt ccagtatctg aacagaagag
      481 agctgggact gtgtgctcag gtgagcaaga catggaaggt gattgctgaa gacgaggtgc
      541 tgtggtaccg gctgtgccga caggaggggc accttcccca cagcagattc tccgattaca
      601 cctgctggaa gctcatcttg caagagtgcc tcgccaagga gcacacatta agagccaact
      661 ggaagaatcg caaaggtgcc gtgagcgagc tggagcatgt tcccgacgct gttttgtgtg
      721 acgtgcgttc tcacgatggt gtggtcattg ctggatacac gtcaggggat gtgcgggtgt
      781 gggacacccg cacctgggac tacgtggccc ccttcctgga gtctgagtct gaggaggagg
      841 atcctggaat gcagccatat gtctcctttg tgaggatcaa cagctcgctg gcagtggcgg
      901 cttacgagga tgggatcctt aacatttggg acctgagaac cggaaggttc cctatctttc
      961 gttttgagca tgacgcaaga atacaagccc ttgcgctgag ccaagaaaag cccattgttg
     1021 ccacggcttc tgcttttgac gttgtgatgt tgtaccccaa cgaggagggg cattggcatg
     1081 tggcctcgga gtttgaagtt cagaagctgg ttgactacct tgaaatagtt ccgaatactg
     1141 ggaggtaccc tgtggcaata gccacagccg gggatctggt gtacctgctg aaggccgacg
     1201 actcagccag aacccttcat tatgtctatg gccagcctgc cacatgtctg gatgtctcag
     1261 ccagccaggt tgcctttgga gtgaagagtc taggatgggt gtatgaagga aacaagatcc
     1321 tggtgtacag cctggaagca gagcgctgcc tctcgaagct gggcaatgca cttggagact
     1381 ttacctgtgt caacatccgg gatagccctc ccaacctcat ggtcagcggc aacatggaca
     1441 ggagagtgag gatccatgac ctccgcagcg ataagatcgc cctgtcgctg tctgcccatc
     1501 agctgggggt gtccgcagtc cagatggatg actggaaggt tgtcagtgga ggcgaggagg
     1561 ggctggtgtc tgtgtgggat taccgcatga accagaagct gtgggaagtg cactccaggc
     1621 accctgtgcg ctatctctcc ttcaatagcc acagcctcat cactgccaac gtgccctacg
     1681 agaaggtgct gcgaaactcc gacctcgaca actttgcctg tcacaggaga catcgtggcc
     1741 tgatccatgc ctatgaattt gctgtggacc agctggcctt tcagagcccc cttcctgtct
     1801 gccgcttacc ccgtgacatc atggctggat acagctatga cctcgcactg tctttccccc
     1861 atgacagtat ttagggtgtc acctcatgta gacgtggaaa gggcagtttt acaaatgtta
     1921 gagttggaga gaggctctgc agcacatggt gggagtttgg ggacagtgtc ctgtatgact
     1981 gtggccacac agccctgttg ccctgtacag aaccagactc cattgctgcc tttctcctcc
     2041 tcctcctcct cctcaggctt tggtaggact ggctgatgac tcagagttaa cctttccagg
     2101 ggtggctcct ccccctcagc ctatggcagc agtgacaccc cccctcgttc cataggccag
     2161 ggacacaggg ccttcacttg cactgtctcc tgggtgtggt gctgagggtg gaaccagaat
     2221 ctcacacgca taggcaagcg tcagcctcca agctgcctcc ccagctgtca gcctccccag
     2281 ctgtctcctc caggcaccct ccagtgcagc ccctcctctg ggattcacac cgttgataat
     2341 tatagggcca ccttacctgt aggagctgtt ctgtcctgta catgtgctat gaaggagaca
     2401 gccatccttc ctgcagaggg aaagggtcat tgcacaggga tagggtcagt ctccaagcct
     2461 agccggtggt gtctcttcct gacaaacgca gccatagctc acccactctg ccttcagagt
     2521 gtcatggaca aatccacaca tagtggccag gagacccagt cagagctctt cagaatcccc
     2581 acagaccagg cacctaacac acctgcacag aggccaccag gtctcaggag acaaagttcc
     2641 tctcccaggg aataccagct caaaaaacaa gtgggctggc aaactccaca ttgggtctgc
     2701 cgagagcaag aaaaaagagg ggggtggggg agctccatgg ggtggatccc aggctggcag
     2761 caggaaggtg ctggaaggcc tgagagggtg tgcagtgccc tccccgagcc ctggtggtct
     2821 cctcctgtgt gctgggatgg agtctagtgg gtttgtggca tgatctcaga tcttggcatt
     2881 gaggcctctc cccatgcaca agtgcccagg ggagctcacc tccctcttgc tgggctggcg
     2941 ccccctgctg gcctggtctt gctgtgtcct cactcgagca ttcccagtcc taagctgtcc
     3001 actggagaca tttctgtcag agaaattggc tgtgcggtca gctcctttct gggcttcgca
     3061 gccatgaaag gccactgaag agcagaggtg actagagtag tttcaagcat acatgccctt
     3121 ctagccccca atccctgccc cctaccccca cagagcatct gtcctcgctg gctcctgcca
     3181 ctgcacctgc tcccagggtg ggggacaggc tggctccctg tgctgcctct gaagccagaa
     3241 gacaccagga cacagccctg ggagccaggg gtggtcacac atctgcagct tgccttttgc
     3301 cttaagcggc cacttctgct ctgttattaa aggttctaca ctgatgagcg tgtgtgctgc
     3361 tcctgtaagg actcgtttga agtcttcctc tgccctgtgt agtctggttt atttcccccg
     3421 gctgggggtg caggggcaca acatgacatg tgcacacaga ctaggctgtc catgcaggcg
     3481 acatgctgct cctgaagctc agacagcagt tcccatggca gagtctaggg tactgtggtg
     3541 tctttcagct gagcgacagg attgccagcc tccctcagca ggggcacttg gtacccccat
     3601 aagggtggca tgccccagtc cacttgttac agggcagggc agtaccacga gctagttagt
     3661 tgcttggaat taagaacagc ctcccctagt gaggggtttc aggtgatgac tgccccgtga
     3721 cagtggctca gatggagaca ctacccatgg gctcttgctt gaagcagcag atggcacggg
     3781 ccatggcacc gtggcccaca cagccaagcc agatgggtta cctggctcct gcggcaggcc
     3841 tgcggtgact tggccagcac tgcccgtgtg cgaggtggca gagcccctcc tgtgcagcag
     3901 cctgggccta ctgcggtgca ctagggaact tctccctgga acagaagagg agcaccagcc
     3961 tgtgcctggc cgagccgagc ttgtgctgtg gcagctgccc ttcccaagac agacgtgctg
     4021 cctctcaccg cggcaggggc cctttgagtc cccccacttt ccctgtgggg acaagcctgt
     4081 cccttgctgg cttagtgtta ctgttttgcc accctgccct ggccagagtt ccgagtcctc
     4141 ctgtggccat gttcctgccc caagccctgt tggcatttgt ccaactcatg aagacaaagg
     4201 tgccagtgat gccatcggga gtggcctggt tccggcactg gctccctcaa ggtcacggca
     4261 tacaaggaca gcctttatgg caggtgtttg ccaaacctca aggtgacttg cacttctgcc
     4321 tctccttcca ccaacttggg cctcttccag cacagtggaa cttggactgg tcaactgcag
     4381 aggatcagac ctgagggcct gccctctccc acctaacaga ggggctttgt tcacgtctcg
     4441 aagagcctgg tttgccaagt ggtcagagtg gcaggctgct ctgggcttgc tctgtttctt
     4501 acccataagt tctgtgtcac taggctgcag gtatccatcc agccatgtct atgaggtttg
     4561 tatcacacag ccctccgggg aaagtatcag attaaacatt agcctccaac caccaccaaa
     4621 ctgggggagg ggacaacttt ataagtagag cattgtgatg ccacacacac acactcgctg
     4681 agtgtcccac cactcaggag gattttaagt ttgaggacca atctctagaa tcaattgtca
     4741 gtaacaggac agtactgtag ggtagatctc gctttcagtc tgctacagaa tagagagcac
     4801 acccaacctc cacccagcca ctgaggcccc agctctgcct gcttctctac ccacagccct
     4861 actcccagct cctcagcagt agccttgggt gccaccaagt cagcttcagt gtggttgatg
     4921 aagagcctgt acttacctgt ccccaaataa atgttagcac aaagcctgct tcacactg
//
