LOCUS       NM_001177773            4183 bp    mRNA    linear   ROD 20-MAR-2024
DEFINITION  Mus musculus F-box and WD-40 domain protein 7 (Fbxw7), transcript
            variant 2, mRNA.
ACCESSION   NM_001177773
VERSION     NM_001177773.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4183)
  AUTHORS   Zhou,Z., Zhang,B., Deng,Y., Deng,S., Li,J., Wei,W., Wang,Y.,
            Wang,J., Feng,Z., Che,M., Yang,X., Meng,J., Li,Y., Hu,Y., Sun,Y.,
            Wen,L., Huang,F., Sheng,Y., Wan,C. and Yang,K.
  TITLE     FBW7/GSK3beta mediated degradation of IGF2BP2 inhibits
            IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung
            cancer
  JOURNAL   J Exp Clin Cancer Res 43 (1), 34 (2024)
   PUBMED   38281999
  REMARK    GeneRIF: FBW7/GSK3beta mediated degradation of IGF2BP2 inhibits
            IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung
            cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4183)
  AUTHORS   Song,Y., Zhao,X., Qu,H., Su,Y., He,R., Chen,L., Fang,L., Li,J.,
            Zou,Z., He,J., Li,Z., Xu,Y., Chen,X., Cheng,H., Xu,Y., Wang,Q. and
            Lai,L.
  TITLE     Epigenetic Regulation of IL-23 by E3 Ligase FBXW7 in Dendritic
            Cells Is Critical for Psoriasis-like Inflammation
  JOURNAL   J Immunol 211 (11), 1701-1713 (2023)
   PUBMED   37843504
  REMARK    GeneRIF: Epigenetic Regulation of IL-23 by E3 Ligase FBXW7 in
            Dendritic Cells Is Critical for Psoriasis-like Inflammation.
REFERENCE   3  (bases 1 to 4183)
  AUTHORS   Xia,H., Dufour,C.R., Medkour,Y., Scholtes,C., Chen,Y., Guluzian,C.,
            B'chir,W. and Giguere,V.
  TITLE     Hepatocyte FBXW7-dependent activity of nutrient-sensing nuclear
            receptors controls systemic energy homeostasis and NASH progression
            in male mice
  JOURNAL   Nat Commun 14 (1), 6982 (2023)
   PUBMED   37914694
  REMARK    GeneRIF: Hepatocyte FBXW7-dependent activity of nutrient-sensing
            nuclear receptors controls systemic energy homeostasis and NASH
            progression in male mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4183)
  AUTHORS   Brown,M., Leon,A., Kedzierska,K., Moore,C., Belnoue-Davis,H.L.,
            Flach,S., Lydon,J.P., DeMayo,F.J., Lewis,A., Bosse,T., Tomlinson,I.
            and Church,D.N.
  TITLE     Functional analysis reveals driver cooperativity and novel
            mechanisms in endometrial carcinogenesis
  JOURNAL   EMBO Mol Med 15 (10), e17094 (2023)
   PUBMED   37589076
REFERENCE   5  (bases 1 to 4183)
  AUTHORS   Duan,L., Ma,Y., Feng,C.G. and Yu,X.
  TITLE     High-fat diet aggravates the severity of the in vitro posttraumatic
            osteoarthritis model through macrophagic FBW7
  JOURNAL   Immun Inflamm Dis 11 (9), e988 (2023)
   PUBMED   37773720
  REMARK    GeneRIF: High-fat diet aggravates the severity of the in vitro
            posttraumatic osteoarthritis model through macrophagic FBW7.
REFERENCE   6  (bases 1 to 4183)
  AUTHORS   Li,J., Pauley,A.M., Myers,R.L., Shuang,R., Brashler,J.R., Yan,R.,
            Buhl,A.E., Ruble,C. and Gurney,M.E.
  TITLE     SEL-10 interacts with presenilin 1, facilitates its ubiquitination,
            and alters A-beta peptide production
  JOURNAL   J Neurochem 82 (6), 1540-1548 (2002)
   PUBMED   12354302
REFERENCE   7  (bases 1 to 4183)
  AUTHORS   Maruyama,S., Hatakeyama,S., Nakayama,K., Ishida,N., Kawakami,K. and
            Nakayama,K.
  TITLE     Characterization of a mouse gene (Fbxw6) that encodes a homologue
            of Caenorhabditis elegans SEL-10
  JOURNAL   Genomics 78 (3), 214-222 (2001)
   PUBMED   11735228
REFERENCE   8  (bases 1 to 4183)
  AUTHORS   Oberg,C., Li,J., Pauley,A., Wolf,E., Gurney,M. and Lendahl,U.
  TITLE     The Notch intracellular domain is ubiquitinated and negatively
            regulated by the mammalian Sel-10 homolog
  JOURNAL   J Biol Chem 276 (38), 35847-35853 (2001)
   PUBMED   11461910
REFERENCE   9  (bases 1 to 4183)
  AUTHORS   Gupta-Rossi,N., Le Bail,O., Gonen,H., Brou,C., Logeat,F., Six,E.,
            Ciechanover,A. and Israel,A.
  TITLE     Functional interaction between SEL-10, an F-box protein, and the
            nuclear form of activated Notch1 receptor
  JOURNAL   J Biol Chem 276 (37), 34371-34378 (2001)
   PUBMED   11425854
REFERENCE   10 (bases 1 to 4183)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC060620.1 and BC066093.1.
            
            [WARNING] On Mar 22, 2024 this sequence was replaced by
            NM_001177773.2.
            
            Transcript Variant: This variant (2) lacks an internal exon in the
            5' UTR, as compared to variant 1. Both variants 1 and 2 encode the
            same isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060620.1, SRR1660819.163571.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2300              BC060620.1         1-2300
            2301-2613           BC066093.1         2211-2523
            2614-3367           BC060620.1         2613-3366
            3368-3368           BC066093.1         3279-3279
            3369-3964           BC060620.1         3367-3962
            3965-4183           BC066093.1         3877-4095
FEATURES             Location/Qualifiers
     source          1..4183
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 37.7 cM"
     gene            1..4183
                     /gene="Fbxw7"
                     /gene_synonym="1110001A17Rik; AGO; Cdc4; Fbw7; Fbwd6;
                     Fbx30; Fbxo30; Fbxw6; SEL-10"
                     /note="F-box and WD-40 domain protein 7"
                     /db_xref="GeneID:50754"
                     /db_xref="MGI:MGI:1354695"
     exon            1..193
                     /gene="Fbxw7"
                     /gene_synonym="1110001A17Rik; AGO; Cdc4; Fbw7; Fbwd6;
                     Fbx30; Fbxo30; Fbxw6; SEL-10"
                     /inference="alignment:Splign:2.1.0"
     exon            194..241
                     /gene="Fbxw7"
                     /gene_synonym="1110001A17Rik; AGO; Cdc4; Fbw7; Fbwd6;
                     Fbx30; Fbxo30; Fbxw6; SEL-10"
                     /inference="alignment:Splign:2.1.0"
     exon            242..305
                     /gene="Fbxw7"
                     /gene_synonym="1110001A17Rik; AGO; Cdc4; Fbw7; Fbwd6;
                     Fbx30; Fbxo30; Fbxw6; SEL-10"
                     /inference="alignment:Splign:2.1.0"
     exon            306..884
                     /gene="Fbxw7"
                     /gene_synonym="1110001A17Rik; AGO; Cdc4; Fbw7; Fbwd6;
                     Fbx30; Fbxo30; Fbxw6; SEL-10"
                     /inference="alignment:Splign:2.1.0"
     CDS             375..2507
                     /gene="Fbxw7"
                     /gene_synonym="1110001A17Rik; AGO; Cdc4; Fbw7; Fbwd6;
                     Fbx30; Fbxo30; Fbxw6; SEL-10"
                     /note="isoform 1 is encoded by transcript variant 2; f-box
                     only protein 30; F-box-WD40 repeat protein 6; F-box/WD
                     repeat-containing protein 7; F-box and WD-40
                     domain-containing protein 7; F-box and WD-40 domain
                     protein 7, archipelago homolog"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 7 isoform 1"
                     /protein_id="NP_001171244.1"
                     /db_xref="CCDS:CCDS50940.1"
                     /db_xref="GeneID:50754"
                     /db_xref="MGI:MGI:1354695"
                     /translation="MNQELLSVGSKRRRTGGSLRGNASSSQVDEGQMNRVVEEDPQQQ
                     ARHQEEEHTARNGELVGANPRPGDQNDTQQGQVEENNNRFISVDEDSSGNQEEQEEDE
                     EHAGEQEEEEEEEEEEEEMDQESDDFDPSDDSSREDEHTHNSNVTNCSSVSDLPAHQL
                     SSPFYTKTTKMKRKLDHGSEVRSFSLGKKPCKVSDYTSTTGLVPCSATPTTFGDLRAA
                     NGQGQQRRRITSVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIE
                     PQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGID
                     EPLHIKRRKIIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQF
                     CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWN
                     AETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVR
                     CVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSI
                     RVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPS
                     KHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASN
                     TKLVCAVGSRNGTEETKLLVLDFDVDMK"
     exon            885..967
                     /gene="Fbxw7"
                     /gene_synonym="1110001A17Rik; AGO; Cdc4; Fbw7; Fbwd6;
                     Fbx30; Fbxo30; Fbxw6; SEL-10"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1109
                     /gene="Fbxw7"
                     /gene_synonym="1110001A17Rik; AGO; Cdc4; Fbw7; Fbwd6;
                     Fbx30; Fbxo30; Fbxw6; SEL-10"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1244
                     /gene="Fbxw7"
                     /gene_synonym="1110001A17Rik; AGO; Cdc4; Fbw7; Fbwd6;
                     Fbx30; Fbxo30; Fbxw6; SEL-10"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1368
                     /gene="Fbxw7"
                     /gene_synonym="1110001A17Rik; AGO; Cdc4; Fbw7; Fbwd6;
                     Fbx30; Fbxo30; Fbxw6; SEL-10"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1505
                     /gene="Fbxw7"
                     /gene_synonym="1110001A17Rik; AGO; Cdc4; Fbw7; Fbwd6;
                     Fbx30; Fbxo30; Fbxw6; SEL-10"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1619
                     /gene="Fbxw7"
                     /gene_synonym="1110001A17Rik; AGO; Cdc4; Fbw7; Fbwd6;
                     Fbx30; Fbxo30; Fbxw6; SEL-10"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1801
                     /gene="Fbxw7"
                     /gene_synonym="1110001A17Rik; AGO; Cdc4; Fbw7; Fbwd6;
                     Fbx30; Fbxo30; Fbxw6; SEL-10"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..2027
                     /gene="Fbxw7"
                     /gene_synonym="1110001A17Rik; AGO; Cdc4; Fbw7; Fbwd6;
                     Fbx30; Fbxo30; Fbxw6; SEL-10"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2238
                     /gene="Fbxw7"
                     /gene_synonym="1110001A17Rik; AGO; Cdc4; Fbw7; Fbwd6;
                     Fbx30; Fbxo30; Fbxw6; SEL-10"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..4164
                     /gene="Fbxw7"
                     /gene_synonym="1110001A17Rik; AGO; Cdc4; Fbw7; Fbwd6;
                     Fbx30; Fbxo30; Fbxw6; SEL-10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcgagcgg ggccgccacc gccgcctcta tcccagcagc gcggaagaga cccgggtagc
       61 tgcttggtgg agcgacgcta gcaccgcttc ttcctcagtt ccgcgcctag ccagccttcc
      121 gcagctgccc gcctcagccc gaaggaggaa gggagccagc cacattgtca gcgccaccgc
      181 tcgactctga agcgaaatct cagctatcaa ggagactttt aaaaggctct ctaaatattt
      241 ggtacgagaa tttcttctct ttatatcttt tgtgatccct ctacacattg tgtctagaca
      301 atcagaatgt gaaaaccttt gcatcttctg atagtctagc caaggtccaa gaagtagcaa
      361 gctggctttt ggaaatgaat caggaactgc tctctgtggg cagcaaaaga cgacgaactg
      421 gaggctctct gagagggaat gcttcctcaa gccaggttga tgagggacag atgaatcgcg
      481 tggttgagga ggatccacag cagcaagcga gacatcaaga ggaggagcac actgcgcgga
      541 atggtgaact tgtgggtgca aaccctaggc ctggagacca gaacgatacc cagcaaggac
      601 aagtggagga aaataataac cgctttattt cagtagatga ggactcttcg ggaaatcagg
      661 aagagcaaga ggaagatgaa gagcatgctg gggaacagga ggaggaagag gaggaagagg
      721 aagaggagga ggagatggac caggagagtg atgattttga tccgtctgat gacagtagca
      781 gagaagatga acatacgcac aatagcaatg tcacaaactg cagtagtgtc tcggacctgc
      841 ccgctcacca gctctcctct ccattctata caaagacaac aaaaatgaaa agaaagttgg
      901 accatggttc tgaagttcgt tccttttctt tgggaaagaa accatgcaaa gtctcagatt
      961 ataccagtac cactggcctt gtaccatgtt cagcaacacc aacaactttt ggggacctga
     1021 gagcagccaa tgggcaaggg cagcagcggc ggaggattac atctgtccaa ccacccacag
     1081 gccttcaaga gtggctgaaa atgtttcaga gctggagcgg accagagaag ttgctggctt
     1141 tagatgagct cattgacagc tgtgaaccaa cacaagtgaa gcatatgatg caagtgatag
     1201 agccccagtt ccagcgagac ttcatctcct tgcttcctaa agagttggca ctctatgtgc
     1261 tttcattcct ggaacccaaa gacctgctgc aagcggctca gacttgtcga tactggagaa
     1321 ttttggctga ggataacctt ctctggagag agaaatgtaa agaagagggg attgatgaac
     1381 cgttgcacat caagagaaga aaaataataa aaccaggttt catacacagc ccatggaaga
     1441 gtgcgtatat cagacagcac agaattgata caaactggag acgaggagaa ctcaaatctc
     1501 ctaaggtgct gaaagggcat gatgaccatg tgatcacatg cctacagttt tgtggcaacc
     1561 gcatagttag tggttctgat gacaacactt taaaagtttg gtcagcggtc acgggcaagt
     1621 gtctgagaac gttagtggga catacaggtg gagtgtggtc atcacagatg agagacaata
     1681 tcatcatcag tggatcgact gaccggactc tcaaagtgtg gaatgctgaa actggagagt
     1741 gtatacatac tttatatggg cacacttcta ctgtacggtg tatgcatctc catgaaaaaa
     1801 gggttgtaag cggttctcga gatgccactc tcagggtttg ggatattgag accggccagt
     1861 gtttacacgt cctgatgggt cacgtagcag cggtccgctg cgttcagtat gatggcagga
     1921 gggttgttag tggagcttat gattttatgg tgaaggtgtg ggatccagag actgagacct
     1981 gtctacacac gttacaggga cacactaata gagtctattc attacagttt gatggcatcc
     2041 atgtggtgag tggatctctt gatacatcaa tccgagtctg ggatgtggag acagggaatt
     2101 gtattcacac gctaacagga caccagtcat taacgagtgg aatggaactc aaagacaata
     2161 ttcttgtctc tgggaatgca gattctacag ttaagatctg ggatatcaaa acaggacagt
     2221 gtttacaaac tttgcaaggt cccagcaagc atcagagcgc tgtgacctgc ttacagttca
     2281 acaagaactt cgtaattacc agctcagacg acggaacggt caaactctgg gacttgaaaa
     2341 cgggtgaatt tatccgaaac ctcgtcacat tggagagtgg ggggagcggg ggagttgtgt
     2401 ggcggatcag ggcctcaaac acaaagctgg tgtgtgcagt cgggagtcgg aatggaactg
     2461 aggaaaccaa gctcctggtg ctggactttg atgtggacat gaaatgaaaa gcagacatga
     2521 tgaattttgt ccaactgtgt agacaatata ctccctaccc ttccccctgc gcaaaaaaca
     2581 aaaacaaaca aacaaaaaaa tgaaaaaaaa aaacagaaaa aaaaaaagag aaaaaagaaa
     2641 aggaaaaaaa tcccttgtac tcagtggtgc aggatgttgg cttgggacaa cagactgaaa
     2701 agacctacag actaagaagg caagaagaga caagagaccg taactgacag gaggcggcag
     2761 ctgtcgcatc tcgcaaaggc ctcacttgtg actgaggggc agcttggcaa gacgactctc
     2821 taaatccaac caggtgcaat tattctttgt tttcttctcc agtggtcatt gagcagagct
     2881 acatcagcgt tgttaccgtc acctagaaag gagtggcagt aatatccaaa cacgggctgc
     2941 ttatcttcta atcagagcat ctgcaacaaa ccgtcatttt tctgaagtgg aaaagcttaa
     3001 aacaattact gtgaattgtt tttgtacagt tatcatgaag ctttcttttt tctctttttc
     3061 ctgtttctct tcttttcttt tttctttttt ttttttgcca accattgcca atgtcaatca
     3121 atcacagtat tagcctctgt taatctatct ctttactgtt gcttctactc ttcaatgcat
     3181 atgttgctca aaggtggcaa gttgtcctgg gttgtgtgag tcctgagatg gatataattc
     3241 ttgatgctgg tgctagaagt aggtcttcaa atccggggtc gttgtcccac ccctgtactg
     3301 tactcccagt ggccaaactt atttatgctg ctaaatgaaa gaaagaaaaa gcaaattatt
     3361 ttttttttat tttttttctg ctgtgacgtt ttagtcccag actgaattcc aaatttgctc
     3421 tagtttggtt acagaaaaaa aagacttttt tgccactgaa acttgagcca tctgtgcctc
     3481 taagaggctg agaatggaaa agtttcagat aataaagagt gaagtttgcc tgcaaataaa
     3541 gaattgagag tgtgtgcaaa gcttattttc ttttatctgg gcaaaaatta aaacacattc
     3601 cttgggacag agcctgaggt gcctgttctg tggagaaact tctttttgag ggctgtggtg
     3661 aatggaagaa catacatagc aaaactgaca agatatttta aagatatata aaacacaaag
     3721 gaaaaggagg ttgctggtca gtcgtagcat cttacagtat tggggaaaac aactgttaca
     3781 gtttcattgc tctgagtgac tgacgtgaga ggaattcgct ctgcagtgac gctgtctgtc
     3841 actcgcctac cagctcgacg agcaagagag cgggagtcag atggtccgcc tcattcacca
     3901 ggagccgtaa ctcaagctga actgtgaaag tggttaacac tgtatcctag gccgtctttt
     3961 ttttcctcct cctgtttatt ttttgtttgt tttatttata gtctgattta aaacaatcag
     4021 attcaagttg gttaatttta gttatgtaac aacctgacgt gatggaggaa acaacctgta
     4081 aagggattgt gtctatggtt tgattcactt agaaatttta ttttcttata acttaagtgc
     4141 aataaaatgt gttttttcat gttaaaaaaa aaaaaaaaaa aaa
//
