LOCUS       NM_013907               2243 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus F-box and WD-40 domain protein 4 (Fbxw4), transcript
            variant 1, mRNA.
ACCESSION   NM_013907
VERSION     NM_013907.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2243)
  AUTHORS   McCallum-Loudeac,J., Moody,E., Williams,J., Johnstone,G.,
            Sircombe,K.J., Clarkson,A.N. and Wilson,M.J.
  TITLE     Deletion of a conserved genomic region associated with adolescent
            idiopathic scoliosis leads to vertebral rotation in mice
  JOURNAL   Hum Mol Genet 33 (9), 787-801 (2024)
   PUBMED   38280229
REFERENCE   2  (bases 1 to 2243)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2243)
  AUTHORS   Cova,G., Glaser,J., Schopflin,R., Prada-Medina,C.A., Ali,S.,
            Franke,M., Falcone,R., Federer,M., Ponzi,E., Ficarella,R.,
            Novara,F., Wittler,L., Timmermann,B., Gentile,M., Zuffardi,O.,
            Spielmann,M. and Mundlos,S.
  TITLE     Combinatorial effects on gene expression at the Lbx1/Fgf8 locus
            resolve split-hand/foot malformation type 3
  JOURNAL   Nat Commun 14 (1), 1475 (2023)
   PUBMED   36928426
  REMARK    Erratum:[Nat Commun. 2023 May 18;14(1):2839. doi:
            10.1038/s41467-023-38736-7.. PMID: 37202388]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2243)
  AUTHORS   Hornblad,A., Bastide,S., Langenfeld,K., Langa,F. and Spitz,F.
  TITLE     Dissection of the Fgf8 regulatory landscape by in vivo
            CRISPR-editing reveals extensive intra- and inter-enhancer
            redundancy
  JOURNAL   Nat Commun 12 (1), 439 (2021)
   PUBMED   33469032
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2243)
  AUTHORS   Conte,D., Garaffo,G., Lo Iacono,N., Mantero,S., Piccolo,S.,
            Cordenonsi,M., Perez-Morga,D., Orecchia,V., Poli,V. and Merlo,G.R.
  TITLE     The apical ectodermal ridge of the mouse model of ectrodactyly
            Dlx5;Dlx6-/- shows altered stratification and cell polarity, which
            are restored by exogenous Wnt5a ligand
  JOURNAL   Hum Mol Genet 25 (4), 740-754 (2016)
   PUBMED   26685160
REFERENCE   6  (bases 1 to 2243)
  AUTHORS   Sidow,A., Bulotsky,M.S., Kerrebrock,A.W., Birren,B.W.,
            Altshuler,D., Jaenisch,R., Johnson,K.R. and Lander,E.S.
  TITLE     A novel member of the F-box/WD40 gene family, encoding dactylin, is
            disrupted in the mouse dactylaplasia mutant
  JOURNAL   Nat Genet 23 (1), 104-107 (1999)
   PUBMED   10471509
REFERENCE   7  (bases 1 to 2243)
  AUTHORS   Crackower,M.A., Motoyama,J. and Tsui,L.C.
  TITLE     Defect in the maintenance of the apical ectodermal ridge in the
            Dactylaplasia mouse
  JOURNAL   Dev Biol 201 (1), 78-89 (1998)
   PUBMED   9733575
REFERENCE   8  (bases 1 to 2243)
  AUTHORS   Seto,M.L., Nunes,M.E., MacArthur,C.A. and Cunningham,M.L.
  TITLE     Pathogenesis of ectrodactyly in the Dactylaplasia mouse: aberrant
            cell death of the apical ectodermal ridge
  JOURNAL   Teratology 56 (4), 262-270 (1997)
   PUBMED   9408977
REFERENCE   9  (bases 1 to 2243)
  AUTHORS   Johnson,K.R., Lane,P.W., Ward-Bailey,P. and Davisson,M.T.
  TITLE     Mapping the mouse dactylaplasia mutation, Dac, and a gene that
            controls its expression, mdac
  JOURNAL   Genomics 29 (2), 457-464 (1995)
   PUBMED   8666395
REFERENCE   10 (bases 1 to 2243)
  AUTHORS   Chai,C.K.
  TITLE     Dactylaplasia in mice a two-locus model for development anomalies
  JOURNAL   J Hered 72 (4), 234-237 (1981)
   PUBMED   7288137
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140332.3 and AC126454.3.
            
            On Nov 17, 2022 this sequence version replaced NM_013907.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB022163.1, BC027031.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-712               AC140332.3         39593-40304
            713-808             AC140332.3         59559-59654
            809-994             AC140332.3         63632-63817
            995-1127            AC140332.3         64213-64345
            1128-1222           AC140332.3         69121-69215
            1223-1288           AC140332.3         108286-108351
            1289-1429           AC126454.3         180034-180174       c
            1430-1571           AC126454.3         179502-179643       c
            1572-2243           AC126454.3         178635-179306       c
FEATURES             Location/Qualifiers
     source          1..2243
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.75 cM"
     gene            1..2243
                     /gene="Fbxw4"
                     /gene_synonym="Dac; dactylin; dactylyn; Fbw4; SHFM3;
                     SHSF3"
                     /note="F-box and WD-40 domain protein 4"
                     /db_xref="GeneID:30838"
                     /db_xref="MGI:MGI:1354698"
     exon            1..712
                     /gene="Fbxw4"
                     /gene_synonym="Dac; dactylin; dactylyn; Fbw4; SHFM3;
                     SHSF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1691
                     /gene="Fbxw4"
                     /gene_synonym="Dac; dactylin; dactylyn; Fbw4; SHFM3;
                     SHSF3"
                     /note="F-box protein Fbw4; protein hagoromo; F-box and
                     WD-40 domain-containing protein 4; dactylaplasia"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 4"
                     /protein_id="NP_038935.2"
                     /db_xref="CCDS:CCDS29863.1"
                     /db_xref="GeneID:30838"
                     /db_xref="MGI:MGI:1354698"
                     /translation="MSSQGRSGPPGNRGPREGEGGEARKLQEARVARGKQGKGKGKGK
                     AGTGHGGRGSGAEGKPGLQPERKAAGPAAEAGRGQEGEGGEEERPRSSGKRDEGSAEP
                     GKEERRVGAGRREDDSLERGQEQGPQACGGIPGTRTAMAEDAAEDAAAAAVEPATRPA
                     AGPALWRLPEELLLLICSYLDTRALGRLAQVCRWLRRFTSCDLLWRPIARASLNTGFT
                     RLGTDLMAGIPVKERVKLSQNWRLGRCRDRILLKWRYSQMPWMQLQDASLYLSQANFI
                     LAYQFRPDGASLNRRPFRVFSGHDEDVCHFVLANSHIVSAGGDGKIGVHKIHSTFTVK
                     YSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHTIQTEDRVWSIAISPL
                     LSSFVTGTACCGHFSPLRIWDLNSGQLITHLGSDFPPGAGVLDVMYESPSTLLSCGYD
                     TYVRYWDLRTSTRKCVMEWEEPHDSTFYCLQTDGNHLLATGSSYYGLVRLWDRRQRAC
                     LHAFSLTSTPLSSPVYCLRFTTRHLYAALSYNLHVLDFQNP"
     exon            713..808
                     /gene="Fbxw4"
                     /gene_synonym="Dac; dactylin; dactylyn; Fbw4; SHFM3;
                     SHSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            809..994
                     /gene="Fbxw4"
                     /gene_synonym="Dac; dactylin; dactylyn; Fbw4; SHFM3;
                     SHSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1127
                     /gene="Fbxw4"
                     /gene_synonym="Dac; dactylin; dactylyn; Fbw4; SHFM3;
                     SHSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1222
                     /gene="Fbxw4"
                     /gene_synonym="Dac; dactylin; dactylyn; Fbw4; SHFM3;
                     SHSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1288
                     /gene="Fbxw4"
                     /gene_synonym="Dac; dactylin; dactylyn; Fbw4; SHFM3;
                     SHSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1429
                     /gene="Fbxw4"
                     /gene_synonym="Dac; dactylin; dactylyn; Fbw4; SHFM3;
                     SHSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1571
                     /gene="Fbxw4"
                     /gene_synonym="Dac; dactylin; dactylyn; Fbw4; SHFM3;
                     SHSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..2243
                     /gene="Fbxw4"
                     /gene_synonym="Dac; dactylin; dactylyn; Fbw4; SHFM3;
                     SHSF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2221..2226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxw4"
                     /gene_synonym="Dac; dactylin; dactylyn; Fbw4; SHFM3;
                     SHSF3"
                     /note="hexamer: AATAAA"
     polyA_site      2243
                     /gene="Fbxw4"
                     /gene_synonym="Dac; dactylin; dactylyn; Fbw4; SHFM3;
                     SHSF3"
                     /note="major polyA site"
ORIGIN      
        1 ggcgtcttcg gctgtgcgtc gagccggccc cgcggccgct catgagcagc cagggccgct
       61 cgggtccccc cgggaaccgc gggcccaggg aaggcgaggg cggggaggcg aggaaactgc
      121 aggaggcgag ggtcgcgcgg ggaaagcaag ggaaagggaa agggaagggg aaagcaggta
      181 ccgggcacgg cggaagagga agcggggcgg aaggaaagcc gggcctgcag ccggagagga
      241 aggcagcggg gccggcggct gaggcaggcc ggggacagga aggcgaggga ggcgaggagg
      301 aaaggccgag aagctccggg aagcgggatg agggcagcgc agagccgggg aaggaggagc
      361 ggagggtcgg ggccgggcgg cgggaggacg acagcctgga gagaggacag gagcagggac
      421 ctcaggcgtg cggcggcatc ccgggaaccc ggacggccat ggcggaggac gcggcggagg
      481 atgccgcagc ggcggccgtg gagccggcca cccgtccggc cgcggggccc gcgctctggc
      541 gcctgccgga ggagctgctg ctgctcatct gctcctacct cgacacgcgg gccctcggcc
      601 gcctggccca agtctgccgc tggctgcggc gcttcaccag ctgcgacctg ctctggcgcc
      661 cgatagcccg ggcctcgctc aacaccggct tcacgcggct cggcaccgac ctcatggcag
      721 gcattccagt aaaggagcgc gtgaaactgt ctcagaactg gcggctgggg cgctgccgag
      781 atcggattct gctgaagtgg agatatagtc agatgccttg gatgcagcta caggatgctt
      841 ctctgtacct atcacaggct aatttcatcc tggcctacca gttccgcccg gatggtgcaa
      901 gcttgaaccg acggcccttc agagtcttct ctgggcatga tgaggacgtc tgtcactttg
      961 tgctggccaa ctcccacatc gtcagtgcag gaggagacgg gaagatcggt gttcacaaga
     1021 tccacagcac cttcactgtc aagtactcgg ctcacgagca ggaggtgaac tgtgtggact
     1081 gtaaaggtgg catcattgtg agtggctccc gggacaggac agccaaggta tggcctctgg
     1141 cctcgggccg gctggggcag tgcttacaca ccatccagac cgaagaccga gtctggtcca
     1201 ttgctatcag cccattactc agctcttttg tgactggaac agcttgttgt gggcacttct
     1261 cacctctgag aatctgggac ctcaacagtg ggcagctgat cacacatctg ggcagtgact
     1321 ttcccccagg ggctggggtg ctagatgtca tgtatgagtc cccctctaca ctgctgtcct
     1381 gtggttatga cacctatgtt cgctattggg acctccgcac aagtacacgg aaatgtgtca
     1441 tggagtggga ggagcctcat gacagtacct tctactgcct acagacagac ggcaaccacc
     1501 tgctggccac aggctcctcc tactacggtc tcgtgcggct gtgggaccga cgccagcggg
     1561 cttgcctgca tgccttctca ttgacgtcga ccccactcag cagccctgtg tactgcctgc
     1621 ggttcaccac taggcatctc tatgctgcgc tgtcttacaa cctccacgtc ttagactttc
     1681 agaacccatg acagagcagc cctgcttagg gggctgggca agtcagctac tcagggacct
     1741 ctcctgcctg gcaggtgagg ggatacctca ctcttcttcc cagccctgct gagtgagctc
     1801 ctaggtctct ggccaccatg ccctggcacc tgaagcactg agtcctggac gctgggctga
     1861 ctctgacgtg ggccctcctg tgctcttagg agaatgtacc tgaacttagg tgtttacagt
     1921 agggtcaggc cttctcctga gcccttccca gcactactgc agcctacaga gtgaaatgag
     1981 ggctctcacc atcccggaca gaaagagatg cagttgctag aacttgtgct ggtcccagcc
     2041 acctcctcag tcagatggta actctggcca acatcttgga gctgggctcg tgcctgaggt
     2101 accagtctgc tttgctttga aacgaaggaa ggacaaagaa agcctgtcag cttggggttc
     2161 cggactagct gttcctcagt cctgctatgg gaaacatgct accattgtaa tttttataaa
     2221 aataaaattt aattgttgac aaa
//
