LOCUS       NM_001406267            3360 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Mus musculus F-box and WD-40 domain protein 2 (Fbxw2), transcript
            variant 10, mRNA.
ACCESSION   NM_001406267 XM_006498117
VERSION     NM_001406267.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3360)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3360)
  AUTHORS   Ren,C., Han,X., Lu,C., Yang,T., Qiao,P., Sun,Y. and Yu,Z.
  TITLE     Ubiquitination of NF-kappaB p65 by FBXW2 suppresses breast cancer
            stemness, tumorigenesis, and paclitaxel resistance
  JOURNAL   Cell Death Differ 29 (2), 381-392 (2022)
   PUBMED   34465889
  REMARK    GeneRIF: Ubiquitination of NF-kappaB p65 by FBXW2 suppresses breast
            cancer stemness, tumorigenesis, and paclitaxel resistance.
REFERENCE   3  (bases 1 to 3360)
  AUTHORS   Yin,Y., Xie,C.M., Li,H., Tan,M., Chen,G., Schiff,R., Xiong,X. and
            Sun,Y.
  TITLE     The FBXW2-MSX2-SOX2 axis regulates stem cell property and drug
            resistance of cancer cells
  JOURNAL   Proc Natl Acad Sci U S A 116 (41), 20528-20538 (2019)
   PUBMED   31548378
REFERENCE   4  (bases 1 to 3360)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   5  (bases 1 to 3360)
  AUTHORS   Collette,N.M., Genetos,D.C., Murugesh,D., Harland,R.M. and
            Loots,G.G.
  TITLE     Genetic evidence that SOST inhibits WNT signaling in the limb
  JOURNAL   Dev Biol 342 (2), 169-179 (2010)
   PUBMED   20359476
REFERENCE   6  (bases 1 to 3360)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   7  (bases 1 to 3360)
  AUTHORS   Maruyama,S., Hatakeyama,S., Nakayama,K., Ishida,N., Kawakami,K. and
            Nakayama,K.
  TITLE     Characterization of a mouse gene (Fbxw6) that encodes a homologue
            of Caenorhabditis elegans SEL-10
  JOURNAL   Genomics 78 (3), 214-222 (2001)
   PUBMED   11735228
REFERENCE   8  (bases 1 to 3360)
  AUTHORS   Miura,M., Hatakeyama,S., Hattori,K. and Nakayama,K.
  TITLE     Structure and expression of the gene encoding mouse F-box protein,
            Fwd2
  JOURNAL   Genomics 62 (1), 50-58 (1999)
   PUBMED   10585767
REFERENCE   9  (bases 1 to 3360)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   10 (bases 1 to 3360)
  AUTHORS   Duff,K., Parsons,J. and Hodgman,T.C.
  TITLE     Secondary structure analysis identifies a putative mouse protein
            demonstrating similarity to the repeat units found in CDC4, the G
            protein beta subunits and related proteins
  JOURNAL   DNA Seq 3 (4), 213-220 (1992)
   PUBMED   1296816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929106.5.
            
            On May 11, 2022 this sequence version replaced XM_006498117.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422598.808041.1,
                                           ERR3363660.2078758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AL929106.5         117652-117697       c
            47-437              AL929106.5         117160-117550       c
            438-947             AL929106.5         114038-114547       c
            948-1142            AL929106.5         104295-104489       c
            1143-1276           AL929106.5         102463-102596       c
            1277-1363           AL929106.5         99994-100080        c
            1364-1533           AL929106.5         98758-98927         c
            1534-3360           AL929106.5         95653-97479         c
FEATURES             Location/Qualifiers
     source          1..3360
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..3360
                     /gene="Fbxw2"
                     /gene_synonym="2700071L08Rik; FBW2; Fwd2; MD6"
                     /note="F-box and WD-40 domain protein 2"
                     /db_xref="GeneID:30050"
                     /db_xref="MGI:MGI:1353435"
     exon            1..46
                     /gene="Fbxw2"
                     /gene_synonym="2700071L08Rik; FBW2; Fwd2; MD6"
                     /inference="alignment:Splign:2.1.0"
     exon            47..437
                     /gene="Fbxw2"
                     /gene_synonym="2700071L08Rik; FBW2; Fwd2; MD6"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..1822
                     /gene="Fbxw2"
                     /gene_synonym="2700071L08Rik; FBW2; Fwd2; MD6"
                     /note="isoform 8 is encoded by transcript variant 10;
                     F-box/WD repeat-containing protein 2; F-box and WD-40
                     domain-containing protein 2"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 2 isoform 8"
                     /protein_id="NP_001393196.1"
                     /db_xref="GeneID:30050"
                     /db_xref="MGI:MGI:1353435"
                     /translation="MMKCGQVVYKMQNVVVCVGRHHACVYALKTGKYFHNLMERKDFE
                     TWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELS
                     FYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKNLGWQIDDSVQDSLHWKKVY
                     LKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCV
                     YGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYSDELD
                     ILVSGSADFAVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSAD
                     KYEIKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASY
                     DILRVIKTPEVANLALLGFGDVFALLFDNHYLYIMDLRTESLISRWPLPEYRKSKRGS
                     SFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHC"
     exon            438..947
                     /gene="Fbxw2"
                     /gene_synonym="2700071L08Rik; FBW2; Fwd2; MD6"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1142
                     /gene="Fbxw2"
                     /gene_synonym="2700071L08Rik; FBW2; Fwd2; MD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1276
                     /gene="Fbxw2"
                     /gene_synonym="2700071L08Rik; FBW2; Fwd2; MD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1363
                     /gene="Fbxw2"
                     /gene_synonym="2700071L08Rik; FBW2; Fwd2; MD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1533
                     /gene="Fbxw2"
                     /gene_synonym="2700071L08Rik; FBW2; Fwd2; MD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..3360
                     /gene="Fbxw2"
                     /gene_synonym="2700071L08Rik; FBW2; Fwd2; MD6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2176..2181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxw2"
                     /gene_synonym="2700071L08Rik; FBW2; Fwd2; MD6"
                     /note="hexamer: ATTAAA"
     polyA_site      2195
                     /gene="Fbxw2"
                     /gene_synonym="2700071L08Rik; FBW2; Fwd2; MD6"
                     /note="major polyA site"
     polyA_site      2287
                     /gene="Fbxw2"
                     /gene_synonym="2700071L08Rik; FBW2; Fwd2; MD6"
     regulatory      2511..2516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxw2"
                     /gene_synonym="2700071L08Rik; FBW2; Fwd2; MD6"
                     /note="hexamer: GATAAA"
     polyA_site      2534
                     /gene="Fbxw2"
                     /gene_synonym="2700071L08Rik; FBW2; Fwd2; MD6"
     regulatory      2652..2657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxw2"
                     /gene_synonym="2700071L08Rik; FBW2; Fwd2; MD6"
                     /note="hexamer: AATAAA"
     polyA_site      2671
                     /gene="Fbxw2"
                     /gene_synonym="2700071L08Rik; FBW2; Fwd2; MD6"
     regulatory      3341..3346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxw2"
                     /gene_synonym="2700071L08Rik; FBW2; Fwd2; MD6"
                     /note="hexamer: AATAAA"
     polyA_site      3360
                     /gene="Fbxw2"
                     /gene_synonym="2700071L08Rik; FBW2; Fwd2; MD6"
ORIGIN      
        1 gctcccctgt gaggctgcgg acccagagca gcggccgtag gtccaggcgc catggctgtg
       61 gagcggaccc ggccgctgcg acgctctggc ggcccgagcg cgcctagtcg gtgtgagccc
      121 ggcgcgaggt cccgggcccc ggggcgctcg ctcaggtcag tgccgcgcgg aacacggctc
      181 caggagcagg ggaccaaggg agtcacgaac gggctgagag actcggagtt aattttagac
      241 aggaaaatta gagctaagag ttcctgcctt ctggtgcttc ggtttttcct agccgcgaaa
      301 cgagttaaca ttgatgcccc aaggctagca ctttaattaa ttaaagatga tgaaatgtgg
      361 acaggtggtt tataaaatgc agaacgtagt agtatgtgta ggaaggcacc atgcttgtgt
      421 gtatgccttg aaaacaggta aatatttcca taaccttatg gagagaaagg actttgagac
      481 atggcttgat aacatttctg ttacatttct ttctctgacg gacttgcaga aaaatgaaac
      541 tctggaccac ctgattagtc tgagtggggc agtccagctc aggcatctct ccaataacct
      601 ggagactctc ctcaagcggg acttcctcaa actccttccc ctggagctca gtttttattt
      661 gttaaaatgg ctcgatcctc agactttact cacatgctgc ctggtctcta agcagtggaa
      721 taaggtgata agtgcctgta cagaggtgtg gcagactgca tgtaaaaatt tgggctggca
      781 gatagatgat tctgttcagg actcattgca ctggaagaag gtttatttga aggctatttt
      841 gaggatgaag caactggagg accatgaagc ctttgagacc tcttcgttaa ttggacatag
      901 tgccagagtg tatgcacttt actacaaaga tggacttctc tgtacagggt cagatgactt
      961 gtctgcaaag ctgtgggatg taagcacagg gcagtgtgtt tacggcatcc agacccacac
     1021 ttgtgcagct gtgaagttcg atgaacagaa gcttgtgaca ggctcctttg acaacactgt
     1081 ggcctgctgg gagtggagtt ccggagccag gacccagcac ttccgggggc acacgggggc
     1141 ggtgttcagt gtggactaca gtgatgaact ggatattttg gtgagtggct ctgcggactt
     1201 cgctgtgaaa gtatgggctt tatctgctgg gacatgcctg aatacactca ctgggcatac
     1261 tgaatgggtc accaaggtgg ttttgcagaa gtgcaaagtc aagtctctct tgcacagccc
     1321 tggagactac atcctcttaa gtgcagacaa atatgagatc aagatttggc caattgggag
     1381 agaaatcaac tgtaagtgct tgaagacact gtctgtctct gaggatagaa gtatctgcct
     1441 gcagccaaga cttcattttg atggaaaata cattgtctgt agttcagccc tgggtctgta
     1501 ccagtgggac tttgccagtt atgatattct cagggtcatc aagacacctg aggtagcaaa
     1561 cttggccttg cttggctttg gagatgtctt cgccctgctg tttgacaacc actacctata
     1621 tatcatggac ttgaggacag agagcctaat tagccgctgg cctctgccag agtacaggaa
     1681 atcaaagaga ggctccagct tcctggcagg cgaagcgtcc tggttgaatg gattggatgg
     1741 gcacaatgac acgggcttag tctttgccac cagcatgcct gaccacagta ttcacctggt
     1801 gttatggaag gagcattgct gacaccagga gctaccaccg ctgactgact ttgggtgcca
     1861 gggctgcggg ttttgggtgc aatgtctatg gcagccaact gcatgaacca aagttctcac
     1921 ctaaaggtat catcacgcag tgcacaatca tttatctgtt tgccagggct ggggcgggga
     1981 gggcttgttt actgacatac accgcagcat gctaatggga tacaccattg acttcatttg
     2041 tacttagtta tgttggtcag tgtaagagag gttgcatttt tggatttatc tttctgagtg
     2101 gaatattgag taaagaaagt taaatgattc actaatctgc taattggttg cccataaaat
     2161 cacatggagt ctgttattaa agtttttttc caatagcctt tgttctttga aattgaagca
     2221 aaggtgctat gttatagcaa cttttctcac atggggttta gattttaaaa gagccattgt
     2281 taaaacatct ttgaattctg tgacattcat taactttcta ctagatccct taaatctaca
     2341 aatgtcttcc aacacagatc tgagtctgct ggttgactgc actgggctat aacccatagt
     2401 tcttggcaga ggcagggttg gctatgttaa gatataaagg ttttctgaag ctttagttta
     2461 catgtaaaaa gctagtccct aactggctgg tggcacaggt gacctggagt gataaagagc
     2521 tctgagctgg aaaatgagtg tctggcatta cttcagtcat gtgctttttc tggcttgttt
     2581 cctcagatgt gtgatcggct aagattcctc taggctaaaa tatacacttg tacacacata
     2641 aatacactga caataaagca gattaatctg ataaaaacta tttaaaacta tttccagggc
     2701 agggaatttc cctaattttt gattaactac taagaaaaaa attacaattt tttggtgtag
     2761 gctggagaaa tgactcggat taagagcaca tactgctctt gtagagggcc tgggttctat
     2821 gaccagcact catgtcaggt gtttgcaatg tcagatgttt acaactgctt atacctgcag
     2881 ctccagagag atataacgtt gcctctggag gtgtgtgtgc aaattccccc ccccctccca
     2941 gacaacagta gatatgaatt cagggccagc ctagtctgta aagtgcattc tggaacagct
     3001 agggctacac agagaaacca aaaataaaat aaatctaaaa gcacacaaca ggaactggag
     3061 tggttccagt taaaagagct tactactcct actaagacta ggttcaattc ccaccaccct
     3121 ctgctctgcc agcaccaaca tacacatgtt gcacataaac tcacacaggt acgcttacac
     3181 atacataaat aacacatctt ttttaaaaaa ttcagggctg ggaagatggc tcagcgggta
     3241 agagcactga ctgctcttcc aaaggtcctg agttcaaatc ccagcaacca catggtggct
     3301 cacaaatatc tgtacagcta cagtgtattc atatacataa aataaataaa tctaaaaaaa
//
