LOCUS       NM_199036               1520 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus F-box and WD-40 domain protein 15 (Fbxw15), mRNA.
ACCESSION   NM_199036 XM_356190
VERSION     NM_199036.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1520)
  AUTHORS   Pham,A.H., Emori,C., Ishikawa-Yamauchi,Y., Tokuhiro,K.,
            Kamoshita,M., Fujihara,Y. and Ikawa,M.
  TITLE     Thirteen Ovary-Enriched Genes Are Individually Not Essential for
            Female Fertility in Mice
  JOURNAL   Cells 13 (10), 802 (2024)
   PUBMED   38786026
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1520)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1520)
  AUTHORS   Zou,C., Chen,Y., Smith,R.M., Snavely,C., Li,J., Coon,T.A.,
            Chen,B.B., Zhao,Y. and Mallampalli,R.K.
  TITLE     SCF(Fbxw15) mediates histone acetyltransferase binding to origin
            recognition complex (HBO1) ubiquitin-proteasomal degradation to
            regulate cell proliferation
  JOURNAL   J Biol Chem 288 (9), 6306-6316 (2013)
   PUBMED   23319590
  REMARK    GeneRIF: Modulation of Fbxw15 levels was able to differentially
            regulate histone H3K14 acetylation and cellular proliferation by
            altering HBO1 levels.
REFERENCE   4  (bases 1 to 1520)
  AUTHORS   De La Chesnaye,E., Kerr,B., Paredes,A., Merchant-Larios,H.,
            Mendez,J.P. and Ojeda,S.R.
  TITLE     Fbxw15/Fbxo12J is an F-box protein-encoding gene selectively
            expressed in oocytes of the mouse ovary
  JOURNAL   Biol Reprod 78 (4), 714-725 (2008)
   PUBMED   18094359
  REMARK    GeneRIF: specific expression of Fbxw15/Fbxp12J protein in oocytes
            and its developmental pattern of expression suggest a role for this
            gene in the regulation of oocyte physiology
REFERENCE   5  (bases 1 to 1520)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK087669.1, DQ067445.1 and CO795020.1.
            
            On Sep 22, 2006 this sequence version replaced NM_199036.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087669.1, DQ067445.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849380 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-804               AK087669.1         2-805
            805-805             DQ067445.1         773-773
            806-1486            AK087669.1         807-1487
            1487-1520           CO795020.1         508-541
FEATURES             Location/Qualifiers
     source          1..1520
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.67 cM"
     gene            1..1520
                     /gene="Fbxw15"
                     /gene_synonym="Fbxo12J"
                     /note="F-box and WD-40 domain protein 15"
                     /db_xref="GeneID:382105"
                     /db_xref="MGI:MGI:3505701"
     exon            1..122
                     /gene="Fbxw15"
                     /gene_synonym="Fbxo12J"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1433
                     /gene="Fbxw15"
                     /gene_synonym="Fbxo12J"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 15"
                     /protein_id="NP_950201.2"
                     /db_xref="CCDS:CCDS23553.1"
                     /db_xref="GeneID:382105"
                     /db_xref="MGI:MGI:3505701"
                     /translation="MAIHLPCLPMMKILSYLDAYSLLQAAQVNKDWNELASSDVLWRK
                     LCQKRWLYCDMDTLQLQGKETWKQFFIDRIWQERAKFRAKAKDFTYKEIPLMCGLFGY
                     ACYISGCGLTRKGQDKSVVCMVNSKNTISTWDVHKSVITWKSPEQPASIKLLTTLPEM
                     HIAVTVDIQSTIKLWDCHNREALATNNLKSPCKSLKAVFTKDGPIVLIGDTLGNIHIF
                     RIPDLYLISTVNVLPYGFDGIYCSPQKKWVLLSKKHPHILPKVFYMSSFLRTSEFSAP
                     VSTVLKLSLYERVFWTPRREDRITLMSRSGFPQVKMFETYDIKLEEFGNKRIVKGKLI
                     ASFELQCHKVNPQRFGVSDKNVIVCSTESSLLLFDINGLRLKTFQYCPEMIVKLSVDP
                     LHVIVICNTGSMDVYAWEERSLLLRKCYRLHIERPLPLYGFIYKAACDDVSIIQLITD
                     ELSLSSLTSYALNICS"
     exon            123..160
                     /gene="Fbxw15"
                     /gene_synonym="Fbxo12J"
                     /inference="alignment:Splign:2.1.0"
     exon            161..324
                     /gene="Fbxw15"
                     /gene_synonym="Fbxo12J"
                     /inference="alignment:Splign:2.1.0"
     exon            325..443
                     /gene="Fbxw15"
                     /gene_synonym="Fbxo12J"
                     /inference="alignment:Splign:2.1.0"
     exon            444..653
                     /gene="Fbxw15"
                     /gene_synonym="Fbxo12J"
                     /inference="alignment:Splign:2.1.0"
     exon            654..812
                     /gene="Fbxw15"
                     /gene_synonym="Fbxo12J"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1023
                     /gene="Fbxw15"
                     /gene_synonym="Fbxo12J"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1202
                     /gene="Fbxw15"
                     /gene_synonym="Fbxo12J"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1327
                     /gene="Fbxw15"
                     /gene_synonym="Fbxo12J"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1495
                     /gene="Fbxw15"
                     /gene_synonym="Fbxo12J"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1470..1475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxw15"
                     /gene_synonym="Fbxo12J"
                     /note="hexamer: AATAAA"
     polyA_site      1493
                     /gene="Fbxw15"
                     /gene_synonym="Fbxo12J"
                     /note="major polyA site"
ORIGIN      
        1 agaagagtca gtgtggactt aggccactga agatggcgat ccatttacct tgtttgccga
       61 tgatgaaaat cctctcctat ctggatgcct acagtttgct acaggctgcc caagtgaaca
      121 aggactggaa tgaacttgcc agcagtgatg tcctgtggag gaaattgtgt cagaagagat
      181 ggctctactg tgacatggat accctgcagc tccagggcaa agagacatgg aagcagttct
      241 tcattgatcg aatatggcaa gaacgtgcca agttccgtgc aaaggcaaaa gatttcactt
      301 acaaggaaat tcctttgatg tgtggacttt ttggatatgc atgttatatc tcagggtgtg
      361 gcttaacaag aaagggacaa gacaagtctg ttgtctgtat ggtgaattcc aagaatacaa
      421 tttccacctg ggatgttcac aagagcgtta taacctggaa aagcccagaa cagccggcaa
      481 gtatcaagct gttgactacc ctccctgaga tgcacattgc agtcactgta gatattcaat
      541 caactatcaa actgtgggac tgtcacaaca gggaagctct ggcgactaac aacctgaagt
      601 ctccatgcaa atcactgaaa gctgtcttta ccaaggatgg cccaattgtc ttgataggtg
      661 ataccttggg taacatccac atctttagga ttccagattt atacctcatt tccacagtca
      721 atgtattgcc atatggtttt gatggaatct actgttctcc tcagaagaaa tgggtcttac
      781 tgagtaagaa acacccacat attttgccaa aggtgtttta catgagcagc tttctgagga
      841 catcagaatt ctctgcccct gtgtctaccg ttctcaaatt atccttatat gaaagagtct
      901 tctggacacc aagaagggaa gacaggataa ccctgatgtc cagaagtggt ttcccccaag
      961 tcaaaatgtt tgaaacatat gatatcaagc tggaagagtt tgggaacaaa agaattgtta
     1021 aaggaaaatt gatagcaagc ttcgagttac aatgtcacaa ggtgaaccca cagaggtttg
     1081 gagtcagtga taagaacgtg attgtttgtt caactgaatc ctctctcttg ctcttcgaca
     1141 taaatggtct ccgtctaaag acatttcagt actgcccaga aatgatcgtg aaactcagtg
     1201 tggaccccct tcatgtcatt gtcatttgta acactggctc tatggatgtg tatgcatggg
     1261 aggagagaag cctgctgctc aggaagtgtt atcgactgca cattgagaga cctctgccac
     1321 tgtacggctt catttataaa gcagcatgtg atgatgtgag cataattcag ttgattacag
     1381 atgagctcag cctcagctct ctgacttcat atgccttgaa catctgctct tgaaaactga
     1441 atgggttgtg tatcctcttc ctcaaagata ataaaggcct atttgcaagc ccaggaaaaa
     1501 aaaaaaaaaa aaaaaaaaaa
//
