LOCUS       NM_134015               4136 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus F-box and WD-40 domain protein 11 (Fbxw11), transcript
            variant 1, mRNA.
ACCESSION   NM_134015
VERSION     NM_134015.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4136)
  AUTHORS   Tan,P., Cai,S., Huang,Z., Li,M., Liu,S., Chen,J., Fu,W. and Zhao,L.
  TITLE     E3 ubiquitin ligase FBXW11 as a novel inflammatory biomarker is
            associated with immune infiltration and NF-kappaB pathway
            activation in pancreatitis and pancreatic cancer
  JOURNAL   Cell Signal 116, 111033 (2024)
   PUBMED   38182068
  REMARK    GeneRIF: E3 ubiquitin ligase FBXW11 as a novel inflammatory
            biomarker is associated with immune infiltration and NF-kappaB
            pathway activation in pancreatitis and pancreatic cancer.
REFERENCE   2  (bases 1 to 4136)
  AUTHORS   Sun,J., Qin,X., Zhang,X., Wang,Q., Zhang,W. and Wang,M.
  TITLE     FBXW11 deletion alleviates Alzheimer's disease by reducing
            neuroinflammation and amyloid-beta plaque formation via repression
            of ASK1 signaling
  JOURNAL   Biochem Biophys Res Commun 548, 104-111 (2021)
   PUBMED   33640602
  REMARK    GeneRIF: FBXW11 deletion alleviates Alzheimer's disease by reducing
            neuroinflammation and amyloid-beta plaque formation via repression
            of ASK1 signaling.
REFERENCE   3  (bases 1 to 4136)
  AUTHORS   Morohoshi,A., Nakagawa,T., Nakano,S., Nagasawa,Y. and Nakayama,K.
  TITLE     The ubiquitin ligase subunit beta-TrCP in Sertoli cells is
            essential for spermatogenesis in mice
  JOURNAL   Dev Biol 445 (2), 178-188 (2019)
   PUBMED   30391586
  REMARK    GeneRIF: Investigated beta-TrCP function in Sertoli cells by
            generating mice with targeted deletion of the beta-TrCP2 gene in
            Sertoli cells on a background of whole-body beta-TrCP1 knockout.
            Loss of beta-TrCP in Sertoli cells caused infertility due to a
            reduction in the number of mature sperm.
REFERENCE   4  (bases 1 to 4136)
  AUTHORS   Cheng,R., Takeda,K., Naguro,I., Hatta,T., Iemura,S.I., Natsume,T.,
            Ichijo,H. and Hattori,K.
  TITLE     beta-TrCP-dependent degradation of ASK1 suppresses the induction of
            the apoptotic response by oxidative stress
  JOURNAL   Biochim Biophys Acta Gen Subj 1862 (10), 2271-2280 (2018)
   PUBMED   30031111
  REMARK    GeneRIF: beta-TrCP was identified as a novel interacting partner of
            ASK1 that is capable of ubiquitinating and degrading ASK1 through
            the ubiquitin-proteasome system. These findings suggest that
            beta-TrCP is capable of suppressing oxidative stress-induced
            caspase 3-dependent apoptosis through suppression of ASK1.
REFERENCE   5  (bases 1 to 4136)
  AUTHORS   D'Alessandro,M., Beesley,S., Kim,J.K., Jones,Z., Chen,R., Wi,J.,
            Kyle,K., Vera,D., Pagano,M., Nowakowski,R. and Lee,C.
  TITLE     Stability of Wake-Sleep Cycles Requires Robust Degradation of the
            PERIOD Protein
  JOURNAL   Curr Biol 27 (22), 3454-3467 (2017)
   PUBMED   29103939
REFERENCE   6  (bases 1 to 4136)
  AUTHORS   Seo,E., Kim,H., Kim,R., Yun,S., Kim,M., Han,J.K., Costantini,F. and
            Jho,E.H.
  TITLE     Multiple isoforms of beta-TrCP display differential activities in
            the regulation of Wnt signaling
  JOURNAL   Cell Signal 21 (1), 43-51 (2009)
   PUBMED   18929646
REFERENCE   7  (bases 1 to 4136)
  AUTHORS   Ohsaki,K., Oishi,K., Kozono,Y., Nakayama,K., Nakayama,K.I. and
            Ishida,N.
  TITLE     The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm
            generation by mediating degradation of clock protein PER2
  JOURNAL   J Biochem 144 (5), 609-618 (2008)
   PUBMED   18782782
  REMARK    GeneRIF: Data show that beta-TrCP2 and beta-TrCP1 target PER2
            protein in vitro, and also show that the beta-TrCP binding site of
            PER2 is recognized by both beta-TrCP1 and beta-TrCP2 [beta-TrCP2].
REFERENCE   8  (bases 1 to 4136)
  AUTHORS   Tian,Y., Kolb,R., Hong,J.H., Carroll,J., Li,D., You,J., Bronson,R.,
            Yaffe,M.B., Zhou,J. and Benjamin,T.
  TITLE     TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase
            complex
  JOURNAL   Mol Cell Biol 27 (18), 6383-6395 (2007)
   PUBMED   17636028
REFERENCE   9  (bases 1 to 4136)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   10 (bases 1 to 4136)
  AUTHORS   Bhatia,N., Herter,J.R., Slaga,T.J., Fuchs,S.Y. and Spiegelman,V.S.
  TITLE     Mouse homologue of HOS (mHOS) is overexpressed in skin tumors and
            implicated in constitutive activation of NF-kappaB
  JOURNAL   Oncogene 21 (10), 1501-1509 (2002)
   PUBMED   11896578
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669844.20 and AL669951.18.
            
            On Nov 18, 2022 this sequence version replaced NM_134015.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034261.1, AY038079.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AL669844.20        182991-183168
            179-280             AL669844.20        220434-220535
            281-343             AL669951.18        28905-28967
            344-569             AL669951.18        32489-32714
            570-756             AL669951.18        41189-41375
            757-847             AL669951.18        42772-42862
            848-985             AL669951.18        52053-52190
            986-1104            AL669951.18        54217-54335
            1105-1354           AL669951.18        55855-56104
            1355-1473           AL669951.18        59079-59197
            1474-1584           AL669951.18        59873-59983
            1585-1663           AL669951.18        60904-60982
            1664-1849           AL669951.18        63176-63361
            1850-4136           AL669951.18        65247-67533
FEATURES             Location/Qualifiers
     source          1..4136
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 19.02 cM"
     gene            1..4136
                     /gene="Fbxw11"
                     /gene_synonym="2310065A07Rik; BTRC2; BTRCP2; Fbxw1b; HOS"
                     /note="F-box and WD-40 domain protein 11"
                     /db_xref="GeneID:103583"
                     /db_xref="MGI:MGI:2144023"
     exon            1..178
                     /gene="Fbxw11"
                     /gene_synonym="2310065A07Rik; BTRC2; BTRCP2; Fbxw1b; HOS"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1825
                     /gene="Fbxw11"
                     /gene_synonym="2310065A07Rik; BTRC2; BTRCP2; Fbxw1b; HOS"
                     /note="isoform a is encoded by transcript variant 1; F-box
                     and WD-40 domain protein 1B; F-box/WD repeat-containing
                     protein 11; homologous to Slimb protein; F-box/WD
                     repeat-containing protein 1B; F-box and WD repeats protein
                     beta-TrCP2"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 11 isoform a"
                     /protein_id="NP_598776.1"
                     /db_xref="CCDS:CCDS36125.1"
                     /db_xref="GeneID:103583"
                     /db_xref="MGI:MGI:2144023"
                     /translation="MEPDSVIEDKTIELMCSVPRSLWLGCANLVESMCALSCLQSMPS
                     VRCLQNTSVMEDQNEDESPKKSALWQISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFD
                     QWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENILSYL
                     DARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRPT
                     DGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDDKIIS
                     GLRDNSIKIWDKSSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVL
                     NTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF
                     DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWD
                     IECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRT
                     LVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR"
     exon            179..280
                     /gene="Fbxw11"
                     /gene_synonym="2310065A07Rik; BTRC2; BTRCP2; Fbxw1b; HOS"
                     /inference="alignment:Splign:2.1.0"
     exon            281..343
                     /gene="Fbxw11"
                     /gene_synonym="2310065A07Rik; BTRC2; BTRCP2; Fbxw1b; HOS"
                     /inference="alignment:Splign:2.1.0"
     exon            344..569
                     /gene="Fbxw11"
                     /gene_synonym="2310065A07Rik; BTRC2; BTRCP2; Fbxw1b; HOS"
                     /inference="alignment:Splign:2.1.0"
     exon            570..756
                     /gene="Fbxw11"
                     /gene_synonym="2310065A07Rik; BTRC2; BTRCP2; Fbxw1b; HOS"
                     /inference="alignment:Splign:2.1.0"
     exon            757..847
                     /gene="Fbxw11"
                     /gene_synonym="2310065A07Rik; BTRC2; BTRCP2; Fbxw1b; HOS"
                     /inference="alignment:Splign:2.1.0"
     exon            848..985
                     /gene="Fbxw11"
                     /gene_synonym="2310065A07Rik; BTRC2; BTRCP2; Fbxw1b; HOS"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1104
                     /gene="Fbxw11"
                     /gene_synonym="2310065A07Rik; BTRC2; BTRCP2; Fbxw1b; HOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1354
                     /gene="Fbxw11"
                     /gene_synonym="2310065A07Rik; BTRC2; BTRCP2; Fbxw1b; HOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1473
                     /gene="Fbxw11"
                     /gene_synonym="2310065A07Rik; BTRC2; BTRCP2; Fbxw1b; HOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1584
                     /gene="Fbxw11"
                     /gene_synonym="2310065A07Rik; BTRC2; BTRCP2; Fbxw1b; HOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1663
                     /gene="Fbxw11"
                     /gene_synonym="2310065A07Rik; BTRC2; BTRCP2; Fbxw1b; HOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1849
                     /gene="Fbxw11"
                     /gene_synonym="2310065A07Rik; BTRC2; BTRCP2; Fbxw1b; HOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..4136
                     /gene="Fbxw11"
                     /gene_synonym="2310065A07Rik; BTRC2; BTRCP2; Fbxw1b; HOS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3960..3965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxw11"
                     /gene_synonym="2310065A07Rik; BTRC2; BTRCP2; Fbxw1b; HOS"
                     /note="hexamer: AACAAA"
     polyA_site      3987
                     /gene="Fbxw11"
                     /gene_synonym="2310065A07Rik; BTRC2; BTRCP2; Fbxw1b; HOS"
                     /note="major polyA site"
     regulatory      4003..4008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxw11"
                     /gene_synonym="2310065A07Rik; BTRC2; BTRCP2; Fbxw1b; HOS"
                     /note="hexamer: AATAAA"
     polyA_site      4030
                     /gene="Fbxw11"
                     /gene_synonym="2310065A07Rik; BTRC2; BTRCP2; Fbxw1b; HOS"
                     /note="major polyA site"
     regulatory      4090..4095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxw11"
                     /gene_synonym="2310065A07Rik; BTRC2; BTRCP2; Fbxw1b; HOS"
                     /note="hexamer: AATAAA"
     polyA_site      4107
                     /gene="Fbxw11"
                     /gene_synonym="2310065A07Rik; BTRC2; BTRCP2; Fbxw1b; HOS"
     polyA_site      4136
                     /gene="Fbxw11"
                     /gene_synonym="2310065A07Rik; BTRC2; BTRCP2; Fbxw1b; HOS"
ORIGIN      
        1 gcgggcggcc cgggcgggct ggcagctaga gtgggtgcga gagctgcctc caccgccgcc
       61 gccgccaccg cctcctccgc ccgggccgat cgctgctgag cggagagagc gaggcggggc
      121 cgccggggcc gccatggagc ccgactcggt gattgaagac aagaccatcg agctcatgtg
      181 ttctgtgcca aggtctttgt ggctaggctg cgccaacctg gtagagagca tgtgcgcact
      241 gagttgcctg cagagcatgc ccagtgtcag atgtctccag aacacttcag ttatggaaga
      301 tcaaaatgaa gatgagtccc caaagaaaag tgctctttgg cagatcagta atggaacgtc
      361 atctgtgatt gtctccagaa agaggccgtc agaggggaac taccagaaag aaaaggactt
      421 gtgcattaag tactttgacc agtggtctga atcagatcag gtggaatttg tggagcatct
      481 tatctcacgg atgtgtcatt atcagcatgg acatattaac tcttacctga agcccatgtt
      541 gcagcgggac tttatcactg ctttaccaga gcaaggctta gatcacatag cagaaaacat
      601 tctctcctac ctggatgcca ggtctctgtg tgcagcagag ctggtgtgta aagaatggca
      661 gcgagtgatc tcagaaggga tgctttggaa gaagctgatt gagaggatgg tgcgcaccga
      721 ccctctctgg aagggactct cagaaagaag aggctgggat cagtacctgt ttaaaaacag
      781 acctacagat ggccctccca actcatttta tagatcatta tacccaaaga ttatccagga
      841 catagagacc atagaatcca actggcggtg tggacgacac aacttgcaga ggatccagtg
      901 ccgctctgaa aatagtaagg gtgtctactg tttgcaatat gatgatgaca aaattatcag
      961 tggcctccgg gacaactcta tcaagatctg ggataaaagc agcttggaat gtttgaaagt
     1021 gctaacgggc cacacaggct ctgtcctctg cctccagtat gatgagcgag tcattgtaac
     1081 tggttcttca gactccacgg tgagagtctg ggatgtgaac actggtgagg tgctcaacac
     1141 actcatccac cacaatgaag ccgtactgca cttacgcttc agcaatggac tgatggtgac
     1201 ttgttccaag gaccgttcca ttgccgtgtg ggacatggct tctgccaccg atatcacttt
     1261 acgccgtgtt ctggttggcc accgtgctgc tgtcaatgta gtagactttg atgataaata
     1321 catcgtgtct gcttcaggag acaggaccat taaagtgtgg agcacgagca catgtgagtt
     1381 tgtccgcact ctgaatgggc acaagcgagg catcgcctgt ctgcagtacc gcgaccggct
     1441 tgttgttagt ggatcatcag ataataccat ccggttatgg gatattgaat gtggtgcctg
     1501 tttaagagtc ctagaggggc acgaagaatt ggtccggtgc atccgttttg ataacaagag
     1561 gattgtcagt ggcgcctatg atgggaagat taaagtctgg gacttgcagg ctgctcttga
     1621 ccctcgggcc ccagcaagca cattgtgtct gcgcaccttg gtggaacact ctggacgtgt
     1681 gtttcggctg cagtttgatg agtttcagat catcagcagc tcccatgatg acactatttt
     1741 gatttgggat ttcttaaatg tgcctcccag tgcccagaat gagacccgct ctccctccag
     1801 aacctacacc tatatctcca gatagcagcc tgcactttgg cccaatctgg gtttcctggt
     1861 cttgaactac tggctatatg gctatcacat gcctaaggga gttcgttcac agctgagttt
     1921 ggggctggac tggttccaga tgctgggtag atacagagca gccccacccc tcaagccctg
     1981 acattctcac tgcaccccag ctctacttgg agaaggactc cttagctctc cactgcaagt
     2041 agagcagcag ctcatgtccc tcccttcagt gaagacccca gcgcttccca tgcacacgtt
     2101 cccacgaagg acacagcaag gactgtcagg agaagccctg cttctaactt atgtcgtcgc
     2161 tttgcgcctt ggtttggtac taaaagcagc cttgcattct cggtgaagtg ctgggtgcca
     2221 aacgactaca cagcgtcttc agggctttcc tctccagcag cagcttctcc ttagaccgtc
     2281 agtcacagtc accgtcgctc tgacgtgcat aggaatgtgt cggacaatgg gcagatctgg
     2341 attatcttag tatttttgga ttacactttc tttctgtttg tttcttttaa tttaaagaat
     2401 aagtgggcta tattacctct gcacaggtga tatagctatt ttcttttatt aactgttctc
     2461 tgttcttcct catcttctga tatttggtag agtaacacct ttatccgagt gcttgcctcc
     2521 taatttaaaa tactgtatcc gcatgtagat agagtgtaca taacagtcca agctcaaggg
     2581 tgctggccgg ccccctgcac ctgagacact actgtggaga ttgtcacacc tactccaggg
     2641 ttgctgtgct ggcctagagc ctccttcagt attcacttgg gttttagttg tcactgtctt
     2701 tgtgtgtgct gtgtgttttc agacagaact tgagaagtct cccatgttta tttgttgtgt
     2761 ggcatctgca gtgggcaggt atcttcacag tctccacatt gctgttcttt tcctcacgct
     2821 tacccctaga gctagtgctc acctccttgg ggtgatcatt agcttctctg tccaacatcc
     2881 taccacacgg cagtgaccct gagatggaga tggcggccag tggacagggc tcctggctct
     2941 gggctccctg tactcggatg ggtgttgggg gctatagagt tagagcctgt ggagcaggtc
     3001 agctggccag agcccacatt agggacaagg cactcctctg tgtgtggggc acagcctcag
     3061 gccctgtcag ctctgctgtc actcatcact gtgagagtgg cacccaggca ggacattggt
     3121 gacattattt ccctctttca aaattaggtt ttgatttccc cttgccattg tttccaaaga
     3181 tgaaggaatg ttagtacggt tttaaaggac caaccagccc ctcccagtga atgaagcctc
     3241 ttcccatgga agcacactct aggagagaga aggcctctgg gctccacctg gcctggcatt
     3301 atgaatgcag tggggtcagt gtgtggtgga tgtgtgtact gggttggctt tcctttttag
     3361 tttttttact ttttagttta gtttgttctt ttccttcccc aataaatcat tctcacatgc
     3421 ttccatgttt gtttctgaga ggtgggggct caaatgtata gaaagtaggc cccagtccat
     3481 aaggaggtgt gaacacaccc ccttactgct tatcacccat ttgacaggaa cgcccaggag
     3541 gggaggggga ggggaagaag tgagttctgc acagtcggac atttctgttg cttttgcatg
     3601 tttaatatag acgttcctgt cgatccttgg gagatcatgg ccttcagata tgcacacgac
     3661 ctttgaattg tgcctactaa ttatagcagg ggacttgggt acccaaggaa ttccaatttc
     3721 tgggattaca gtagtaattc ccagctgtac tctggacttg attttgctaa ctgtaactga
     3781 gcaactgtaa attactgcta tattaatgtg ttaaagcact ggggtagtct aattctaact
     3841 ggtaattatg tttgccaatt atctgtttga aataaatatg tgtctgaaca gctattgaaa
     3901 ctgttaaatt gtacagatat tatcatgacg gctttgtact gtggaatgtg cttaataaaa
     3961 acaaaagttt gacctttgtc caataaattg ctaagtaatg tcaataaatc aagatgagta
     4021 ttatgcagta cacctgacct ggcttcctgg cgattgttac ttcagctact gattcaagcc
     4081 aatcctctaa ataaagtgtt gcagtgctcc tctgttctgt cacatttctc agaaaa
//
