LOCUS       NM_001291441            3310 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus F-box and WD-40 domain protein 10 (Fbxw10), transcript
            variant 1, mRNA.
ACCESSION   NM_001291441
VERSION     NM_001291441.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3310)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3310)
  AUTHORS   Lin,X.T., Zhang,J., Liu,Z.Y., Wu,D., Fang,L., Li,C.M., Yu,H.Q. and
            Xie,C.M.
  TITLE     Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via
            AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male
            transgenic mice
  JOURNAL   Cell Rep 42 (7), 112812 (2023)
   PUBMED   37450367
  REMARK    GeneRIF: Elevated FBXW10 drives hepatocellular carcinoma
            tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH
            ubiquitination in male transgenic mice.
REFERENCE   3  (bases 1 to 3310)
  AUTHORS   Liu,Z.Y., Lin,X.T., Zhang,Y.J., Gu,Y.P., Yu,H.Q., Fang,L., Li,C.M.,
            Wu,D., Zhang,L.D. and Xie,C.M.
  TITLE     FBXW10-S6K1 promotes ANXA2 polyubiquitination and KRAS activation
            to drive hepatocellular carcinoma development in males
  JOURNAL   Cancer Lett 566, 216257 (2023)
   PUBMED   37277019
REFERENCE   4  (bases 1 to 3310)
  AUTHORS   Luo,Y.D., Zhang,J., Fang,L., Zhu,Y.Y., You,Y.M., Zhang,C.C.,
            Zheng,P., Zhang,L.D., Yin,L.Y., Xia,F., Bie,P. and Xie,C.M.
  TITLE     FBXW10 promotes hepatocarcinogenesis in male patients and mice
  JOURNAL   Carcinogenesis 41 (5), 689-698 (2020)
   PUBMED   31400758
  REMARK    GeneRIF: FBXW10 promotes hepatocarcinogenesis in male patients and
            mice.
REFERENCE   5  (bases 1 to 3310)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645847.15.
            
            On Apr 14, 2022 this sequence version replaced NM_001291441.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141212.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-699               AL645847.15        15261-15959
            700-870             AL645847.15        18736-18906
            871-1071            AL645847.15        21119-21319
            1072-1199           AL645847.15        21429-21556
            1200-1322           AL645847.15        23450-23572
            1323-1432           AL645847.15        25850-25959
            1433-1633           AL645847.15        28004-28204
            1634-1755           AL645847.15        30794-30915
            1756-1904           AL645847.15        35685-35833
            1905-2047           AL645847.15        37176-37318
            2048-2221           AL645847.15        41535-41708
            2222-2469           AL645847.15        43106-43353
            2470-3310           AL645847.15        44788-45628
FEATURES             Location/Qualifiers
     source          1..3310
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 38.78 cM"
     gene            1..3310
                     /gene="Fbxw10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /note="F-box and WD-40 domain protein 10"
                     /db_xref="GeneID:213980"
                     /db_xref="MGI:MGI:3052463"
     exon            1..699
                     /gene="Fbxw10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..3263
                     /gene="Fbxw10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     F-box/WD repeat-containing protein 10; F-box and WD-40
                     domain-containing protein 10"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 10 isoform 1"
                     /protein_id="NP_001278370.1"
                     /db_xref="CCDS:CCDS78968.1"
                     /db_xref="GeneID:213980"
                     /db_xref="MGI:MGI:3052463"
                     /translation="MENREPKLKQAPYFRCEKGPNWVPVCQKCEACVLAWKIFATKEW
                     FRRVNDISQRRFLVSILGQLNSLYLLQYFQNILETTQGKDFIYNRSRIKLSRKGGKEE
                     EVVKSSLNQMLDKTVERKMKEILYWFGNSTHRTKANYTLLLLQMCDSNLLLTAANVIR
                     VLFMKEWNSISGLHDDTPDVMFFPEKKYSGTQDTSYVSWAARPKPVSFPMSKHLGNKL
                     GTENVDRETTEGKGESSLQCIHEMNRQIFGKGGMSRLGDDPCNLLLSLDHVQLLSSGY
                     SKYRDFIRDLPLHLSKYILRMLDKHSLNRCIFVSQHWATLAQQVKVDQSMHSFIQNQI
                     SLLQGSYTRGIDPNYANKVSIPVPKIVDDGKRSRSKNQKWKLRTKTDYNLWNAYQNQE
                     TQLVQMEERNVFCGTYNIRVLSDTFDQNRIIHYNGGDLMAISSNRKIHLLDIMQTKEL
                     PIEFRGHAGSVRALFLSEEDNILLSGSYDLSIRYWDVKTGACVRIFYGHQGTITCLDV
                     YKNRLVSGAKDGQVKEWDIETGKCLKTFKHKDPILAAKISETYIVSSCERGIVKVWHV
                     VTAQLQKTLTGHEGAVKCLFFNEWHLVSGGADGLVMAWSMVGKYERCLMAFKHPKEVL
                     QVSLLYLRVISACGDGKIRIYNFLNGNCLKVIKVDARGDPVLSFFYQGNRWVVGRMVA
                     HTDSNILVFQFENVKWQYSSDKNKVKKSKDKEEEREETSLGDEHSRSTIQGHSLKDSV
                     SSKQEFSKSRVHLKQTKNLSSDDMETPVGEVSHPLQKLWKVPMTPDRFLLTISALQQA
                     HNSEEFAYPHRPRPQVIDAWGPSIPYPRKVLSLKGKSVQHAVDQLRSSNLPTGVRQTN
                     IPLEIQKLQPNLKKSLHSPRVQATVPQPSLIRPKVSDSLRGDEHLTSSIDGTMRRAGP
                     LTSMQVIKPNRMLAPRGGTATLSPKKERPRFYTTLDPLRMNTGFMLMTVKEEKEFAEA
                     KMKEYEASVSTKEVDPGKASKAAWIRKIKGLPIDNFMKEGKTAAPELGQNVFI"
     exon            700..870
                     /gene="Fbxw10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1071
                     /gene="Fbxw10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1199
                     /gene="Fbxw10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1322
                     /gene="Fbxw10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1432
                     /gene="Fbxw10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1633
                     /gene="Fbxw10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1755
                     /gene="Fbxw10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1904
                     /gene="Fbxw10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2047
                     /gene="Fbxw10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2221
                     /gene="Fbxw10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2469
                     /gene="Fbxw10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..3310
                     /gene="Fbxw10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3289..3294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxw10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /note="hexamer: ATTACA"
     regulatory      3294..3299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxw10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /note="hexamer: AACAAA"
     polyA_site      3306
                     /gene="Fbxw10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /note="major polyA site"
     polyA_site      3310
                     /gene="Fbxw10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /note="major polyA site"
ORIGIN      
        1 agacttctac aggcagtttc tgggtcagat cagtttacca tccatcgcag tgccttacgg
       61 tttctccaga tgttcatccc gaagaggctc caaaaaggct atttctctgc ttaccctgtc
      121 cctctggtgt ttggtggggt tgctaacggg caaggtttaa atgaactgaa tgtcatctca
      181 gagtcatgga aaacagggaa ccaaaactca agcaggcccc ctattttcgt tgtgaaaagg
      241 gacccaactg ggtccccgtg tgccagaagt gtgaagcctg tgtcttagca tggaagatct
      301 ttgccaccaa agagtggttc cggagggtca acgacatatc ccagaggaga tttctagtca
      361 gcatcttggg gcagttaaat agcctgtatt tgttacagta tttccagaat atcctagaga
      421 ccacccaggg gaaggacttc atctacaaca ggtctcggat caaactcagt aggaaggggg
      481 ggaaggagga ggaggttgta aagtcctcct tgaaccagat gttggataaa acggtggaac
      541 ggaagatgaa ggagatcctc tactggtttg gcaacagcac ccaccgaact aaggcaaatt
      601 atactctctt gctgctgcag atgtgcgact caaatttact gctcactgct gccaatgtga
      661 tcagagtcct gttcatgaaa gagtggaaca gtatttcagg ccttcatgat gacactcctg
      721 atgtgatgtt cttccctgag aaaaagtaca gcggtacaca ggacacctca tatgtctctt
      781 gggcagctag acccaaacct gtgtcattcc caatgtccaa acatttaggt aataaactcg
      841 ggactgaaaa tgtggacaga gaaacaaccg agggaaaagg ggagagttcg ctccagtgta
      901 tccatgaaat gaatagacag atttttggaa aagggggcat gtccaggctg ggagatgatc
      961 cgtgcaacct gctgctgagc ctggatcatg tccaactcct gtcttctggg tacagcaaat
     1021 atcgggactt tatacgcgac ctgcctctcc acctctccaa gtacattcta agaatgctgg
     1081 ataagcacag tctgaacagg tgtatctttg taagccagca ctgggccact ctggcccagc
     1141 aggtcaaggt ggaccagtcc atgcactcct tcattcagaa ccagatttct ctcctgcagg
     1201 ggtcctacac aaggggaata gatcctaatt atgccaacaa agtctcaatc ccagtgccca
     1261 agatagtaga tgatgggaag cgttcacggt caaaaaatca gaagtggaaa ctgagaacaa
     1321 agactgatta caacttgtgg aatgcctacc agaaccagga aacccagctg gtccagatgg
     1381 aggagaggaa cgttttctgc ggcacctaca acatccgcgt cctctctgac acgtttgacc
     1441 aaaacagaat cattcactat aacgggggag acctaatggc catatcatcc aatcggaaga
     1501 tccaccttct agatatcatg cagaccaagg agctgcccat cgagttccga ggccatgccg
     1561 gcagcgtcag ggctctcttc ctgtctgagg aggacaatat tctcctgagt gggagttacg
     1621 atctgagcat aagatactgg gatgtgaaaa ccggggcttg tgtacgaatc ttttatggcc
     1681 accaggggac aatcacttgc ctggatgtct ataagaacag gcttgtatct ggagcaaaag
     1741 atggacaggt gaaagaatgg gacatagaga cagggaagtg cctgaagacc tttaaacaca
     1801 aagatcccat cttggctgcc aagatcagtg agacctacat tgtgagcagc tgtgagcgag
     1861 gcatagtcaa ggtgtggcac gttgtcacag ctcagctgca aaagactctc actgggcacg
     1921 agggagctgt gaagtgcctg ttctttaacg aatggcatct cgtctctgga ggtgctgacg
     1981 gcctggtcat ggcctggagc atggtgggaa agtacgaacg gtgcctgatg gccttcaagc
     2041 atcctaagga ggtgctgcag gtgtctctcc tctacctccg ggtcatcagt gcctgtggag
     2101 acggcaagat ccgaatttat aatttcctca atgggaactg tctgaaggtg ataaaagtcg
     2161 acgccagagg tgaccccgtg ctatccttct tttatcaggg caacaggtgg gtggtaggca
     2221 ggatggtggc ccacacggac agcaacattc tcgtgttcca gtttgaaaat gtcaagtggc
     2281 agtacagctc agacaagaac aaagtaaaga agagcaagga caaagaggag gagagggaag
     2341 agaccagcct cggggatgag cattccaggt ctaccattca ggggcacagc ctgaaggact
     2401 ctgtgtctag taaacaggag ttctcaaagt cccgggttca cctgaaacaa accaagaacc
     2461 tatcttcaga tgatatggaa actcctgtag gcgaagtcag tcatcccttg caaaagctct
     2521 ggaaagtccc tatgacacct gaccgattcc ttctgactat cagtgccttg caacaagccc
     2581 acaattctga agagtttgcc tatccccata ggcccagacc tcaagtcatt gatgcttggg
     2641 ggccttccat tccatatccg aggaaagtcc tatcactcaa aggaaaatca gttcaacacg
     2701 cagttgatca gctgcgatcc agcaatcttc ctacaggtgt gagacaaacc aacattcccc
     2761 ttgaaatcca gaaacttcag cccaacttga aaaagtcctt gcacagtccc agagtccagg
     2821 ccactgtacc ccagcccagt cttatccgtc ccaaggtctc tgacagctta aggggtgacg
     2881 agcacttgac cagttcaatt gatgggacaa tgcgccgtgc aggccccctg accagcatgc
     2941 aggtcattaa accaaaccga atgctcgctc ctcgaggcgg cacagccacc ctgtctccca
     3001 agaaagaacg gcctcgtttc tacacaaccc ttgatcctct gagaatgaac actgggttca
     3061 tgctgatgac tgtgaaggag gaaaaagaat ttgctgaagc caagatgaag gaatatgaag
     3121 ccagtgtatc cactaaagag gtcgacccag gaaaagccag caaagctgcg tggatccgta
     3181 agatcaaagg cctccctatt gataatttca tgaaggaagg gaaaacagca gcccccgaac
     3241 ttggacaaaa tgtgtttatc taaaccaggc ttgagaaatt acagcagcat tacaacaaac
     3301 tgaaaactaa
//
