LOCUS       NM_023605               2172 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus f-box protein 9 (Fbxo9), transcript variant 1, mRNA.
ACCESSION   NM_023605
VERSION     NM_023605.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2172)
  AUTHORS   Swenson,S.A., Dobish,K.K., Peters,H.C., Bea Winship,C., Willow
            Hynes-Smith,R., Caplan,M., Wittorf,K.J., Ghosal,G. and Buckley,S.M.
  TITLE     Ubiquitin E3 Ligase FBXO9 Regulates Pluripotency by Targeting DPPA5
            for Ubiquitylation and Degradation
  JOURNAL   Stem Cells 42 (4), 317-328 (2024)
   PUBMED   38227647
  REMARK    GeneRIF: Ubiquitin E3 Ligase FBXO9 Regulates Pluripotency by
            Targeting DPPA5 for Ubiquitylation and Degradation.
REFERENCE   2  (bases 1 to 2172)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2172)
  AUTHORS   Liu,J.A., Tai,A., Hong,J., Cheung,M.P.L., Sham,M.H., Cheah,K.S.E.,
            Cheung,C.W. and Cheung,M.
  TITLE     Fbxo9 functions downstream of Sox10 to determine neuron-glial fate
            choice in the dorsal root ganglia through Neurog2 destabilization
  JOURNAL   Proc Natl Acad Sci U S A 117 (8), 4199-4210 (2020)
   PUBMED   32029586
  REMARK    GeneRIF: Overexpression of Fbxo9 in neural crest progenitors
            down-regulated Neurog2 protein expression through ubiquitination
            and promoted the glial lineage at the expense of neuronal
            differentiation.
REFERENCE   4  (bases 1 to 2172)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 2172)
  AUTHORS   Lee,K.W., Kwak,S.H., Koo,Y.D., Cho,Y.K., Lee,H.M., Jung,H.S.,
            Cho,Y.M., Park,Y.J., Chung,S.S. and Park,K.S.
  TITLE     F-box only protein 9 is an E3 ubiquitin ligase of PPARgamma
  JOURNAL   Exp Mol Med 48 (5), e234 (2016)
   PUBMED   27197753
  REMARK    GeneRIF: FBXO9 directly interacted with PPAR gamma through the
            activation function-1 domain and ligand-binding domain. FBXO9
            decreased the protein stability of PPAR gamma through induction of
            ubiquitination.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2172)
  AUTHORS   Jelcick,A.S., Yuan,Y., Leehy,B.D., Cox,L.C., Silveira,A.C., Qiu,F.,
            Schenk,S., Sachs,A.J., Morrison,M.A., Nystuen,A.M., DeAngelis,M.M.
            and Haider,N.B.
  TITLE     Genetic variations strongly influence phenotypic outcome in the
            mouse retina
  JOURNAL   PLoS One 6 (7), e21858 (2011)
   PUBMED   21779340
  REMARK    Erratum:[PLoS One. 2011;6(10).
            doi:10.1371/annotation/f375292d-9fc7-4e3c-9dc7-af0aee76fa15]
REFERENCE   7  (bases 1 to 2172)
  AUTHORS   Sturgill,T.W., Stoddard,P.B., Cohn,S.M. and Mayo,M.W.
  TITLE     The promoter for intestinal cell kinase is head-to-head with F-Box
            9 and contains functional sites for TCF7L2 and FOXA factors
  JOURNAL   Mol Cancer 9, 104 (2010)
   PUBMED   20459822
  REMARK    GeneRIF: ICK and FBX9 are divergently transcribed from a
            bidirectional promoter that is GC-rich and contains a CpG island.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2172)
  AUTHORS   Yang,I.V., Wade,C.M., Kang,H.M., Alper,S., Rutledge,H.,
            Lackford,B., Eskin,E., Daly,M.J. and Schwartz,D.A.
  TITLE     Identification of novel genes that mediate innate immunity using
            inbred mice
  JOURNAL   Genetics 183 (4), 1535-1544 (2009)
   PUBMED   19805818
REFERENCE   9  (bases 1 to 2172)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   10 (bases 1 to 2172)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159313.3, AK077607.1 and CX567646.1.
            
            On Feb 10, 2007 this sequence version replaced NM_023605.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB041585.1, SRR1660811.148557.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-366               AC159313.3         175552-175917
            367-2148            AK077607.1         28-1809
            2149-2172           CX567646.1         771-794
FEATURES             Location/Qualifiers
     source          1..2172
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 43.53 cM"
     gene            1..2172
                     /gene="Fbxo9"
                     /gene_synonym="9030401P18Rik"
                     /note="f-box protein 9"
                     /db_xref="GeneID:71538"
                     /db_xref="MGI:MGI:1918788"
     exon            1..366
                     /gene="Fbxo9"
                     /gene_synonym="9030401P18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             364..1674
                     /gene="Fbxo9"
                     /gene_synonym="9030401P18Rik"
                     /note="isoform 1 is encoded by transcript variant 1; f-box
                     only protein 9"
                     /codon_start=1
                     /product="F-box only protein 9 isoform 1"
                     /protein_id="NP_076094.2"
                     /db_xref="CCDS:CCDS52863.1"
                     /db_xref="GeneID:71538"
                     /db_xref="MGI:MGI:1918788"
                     /translation="MAEAEEDCHSDADRVGDEGNESPAERDLQAQLQMFRAQWMFELT
                     PGVGSSHGETRPCRAGRSSMLKAAADTKGRQELAKEEKARELFLQAVEEEQNGALYEA
                     IKFYRRAMQLVPDIEFKITYTRSPDGDGVGSGYIEENEDASKMADLLSYFQQQLTLQE
                     SVLKLCQPELETSQTHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSLVCRGFYICARD
                     PEIWRLACLKVWGRSCMKLVPYASWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGF
                     YRAWHQVEYYRYMRFFPDGHVMMLTTPEEPPSIVPRLRTRNTRTDAILLGHYRLSQDA
                     DNQTKVFAVITKKKEEKPLDHKYRYFRRVPVQEADHSFHVGLQLCSSGHQRFNKLIWI
                     HHSCHITYKATGETAVSAFEIDKMYTPLLFARVRSYTAFSERPL"
     exon            367..450
                     /gene="Fbxo9"
                     /gene_synonym="9030401P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            451..609
                     /gene="Fbxo9"
                     /gene_synonym="9030401P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            610..667
                     /gene="Fbxo9"
                     /gene_synonym="9030401P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            668..767
                     /gene="Fbxo9"
                     /gene_synonym="9030401P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            768..898
                     /gene="Fbxo9"
                     /gene_synonym="9030401P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1013
                     /gene="Fbxo9"
                     /gene_synonym="9030401P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1132
                     /gene="Fbxo9"
                     /gene_synonym="9030401P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1223
                     /gene="Fbxo9"
                     /gene_synonym="9030401P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1319
                     /gene="Fbxo9"
                     /gene_synonym="9030401P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1413
                     /gene="Fbxo9"
                     /gene_synonym="9030401P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1565
                     /gene="Fbxo9"
                     /gene_synonym="9030401P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..2155
                     /gene="Fbxo9"
                     /gene_synonym="9030401P18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2133..2138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo9"
                     /gene_synonym="9030401P18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2155
                     /gene="Fbxo9"
                     /gene_synonym="9030401P18Rik"
                     /note="major polyA site"
ORIGIN      
        1 atgcgcggcg cggcggcgca gtttccgcag cagagcaggc agctccgccg ctgcgtccag
       61 acgtctcctg ctgggccgac gctcagctct tcgctcggtg ctcggcctcc gctggcgacc
      121 ggcgacccct ccgcagctcg agtccccggc cgccgcagcg cgcctgcctc cggccccctg
      181 tcccgcgaaa atggctgccg tacgccgggc ccgcagttat tgccgctgcc tggtgcgctt
      241 ctccgaccga gaactctgct aagccgcgct gcagcagacg ggcaggagta gacaccgggc
      301 agccgccacc cctccgggag ccgggcgcgg gaagcccctc gactgggccg gccgccggcc
      361 agcatggcag aagcggagga agattgtcat tctgatgctg acagagtagg cgatgaagga
      421 aatgagagtc cggctgagag agacctgcag gcgcagctcc agatgttcag agctcagtgg
      481 atgtttgaac tgaccccagg tgtaggctcc agtcatggag aaactcggcc ttgcagagca
      541 ggaagaagct ctatgctgaa agcagctgca gacaccaaag gacgacagga actggcaaag
      601 gaagaaaagg ctcgagaact cttcctgcag gcagtggagg aagaacaaaa tggagctctc
      661 tatgaagcca tcaagttcta ccgtagggcg atgcagctgg tgccagacat tgagttcaag
      721 atcacttaca cccggtctcc agacggcgac ggcgttggga gcggctacat cgaagagaac
      781 gaggacgcca gcaagatggc cgatctcctg tcgtacttcc agcagcagct cacgttgcag
      841 gagtctgtgc tcaaactctg tcagcctgag cttgagacca gtcagactca catatcagtc
      901 ctgcctatgg aggtgctgat gtacatcttc cgatgggtgg tatcaagtga cttggacctc
      961 agatcgttag agcagttgtc actggtgtgc agaggattct atatctgtgc cagagaccct
     1021 gaaatctggc gtctggcttg cttgaaagtg tggggcagaa gctgcatgaa gctcgttcca
     1081 tacgcgtcct ggagagagat gtttctagaa cggccccgag ttcggtttga tggagtgtac
     1141 atcagtaaaa ccacgtatat tcgccaggga gagcagtcac ttgatggttt ctacagggcg
     1201 tggcaccaag tggaatatta cagatacatg agattctttc ctgatggcca tgtgatgatg
     1261 ttaaccaccc ccgaggagcc tccgtccatc gttccccggt taagaaccag gaacaccaga
     1321 acggatgcaa ttctgctggg tcattaccgc ttgtcacaag atgcagacaa tcagaccaaa
     1381 gtctttgctg taataactaa gaaaaaagaa gaaaagccac ttgaccataa atacaggtat
     1441 tttcgtcgtg ttcctgtcca agaggcagat cacagcttcc atgtgggact gcagctgtgc
     1501 tccagtggcc accagaggtt caacaaactc atctggatcc accactcttg tcacatcact
     1561 tacaaagcaa ctggtgagac tgcagtgagt gcttttgaga ttgacaagat gtacacgccc
     1621 ctgttgttcg ccagagtgag gagctacact gccttctcgg aaaggcctct gtagagccac
     1681 accagcatgt cactgctgca tgagcagaag catagagcgc tgggacacct aagttatatg
     1741 tacatagaca cacgcatgta gatagacatg catatataca tacatggagt tggagcttac
     1801 tttaagttgt tggaattcct ttaagaagag tataaattat tttttttatt taaaaggata
     1861 gttgattcct ggggtacttt gttttgaaat tagaagttgt taaggacact tttgttgtaa
     1921 taaatgttga tgtagagttg aaatcatgtt ttcaagcagg tttctgagca gatctgtcac
     1981 atccactgcc ttgtgcctga gcatcctcaa cacacatagg tcagggagca cactggagag
     2041 ttcttattcc cgcatgactt agtggctttg catcatactc aaaatgtgaa acctgttctg
     2101 gatttgtttg aaactgttca ataaagatca taaataaatg tttctttcaa ggaaaaaaaa
     2161 aaaaaaaaaa aa
//
