LOCUS       NM_015791               3507 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus F-box protein 8 (Fbxo8), transcript variant 1, mRNA.
ACCESSION   NM_015791
VERSION     NM_015791.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3507)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3507)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 3507)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   4  (bases 1 to 3507)
  AUTHORS   Yano,H., Kobayashi,I., Onodera,Y., Luton,F., Franco,M., Mazaki,Y.,
            Hashimoto,S., Iwai,K., Ronai,Z. and Sabe,H.
  TITLE     Fbx8 makes Arf6 refractory to function via ubiquitination
  JOURNAL   Mol Biol Cell 19 (3), 822-832 (2008)
   PUBMED   18094045
  REMARK    GeneRIF: Fbx8, an F-box protein bearing the Sec7 domain, mediates
            ubiquitination of Arf6.
REFERENCE   5  (bases 1 to 3507)
  AUTHORS   Kenney-Hunt,J.P., Vaughn,T.T., Pletscher,L.S., Peripato,A.,
            Routman,E., Cothran,K., Durand,D., Norgard,E., Perel,C. and
            Cheverud,J.M.
  TITLE     Quantitative trait loci for body size components in mice
  JOURNAL   Mamm Genome 17 (6), 526-537 (2006)
   PUBMED   16783635
REFERENCE   6  (bases 1 to 3507)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116121.8.
            
            On Feb 7, 2019 this sequence version replaced NM_015791.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029989.1, AK078111.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               AC116121.8         78504-78726
            224-560             AC116121.8         91908-92244
            561-687             AC116121.8         96634-96760
            688-806             AC116121.8         115357-115475
            807-1003            AC116121.8         117408-117604
            1004-3507           AC116121.8         118786-121289
FEATURES             Location/Qualifiers
     source          1..3507
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 29.7 cM"
     gene            1..3507
                     /gene="Fbxo8"
                     /gene_synonym="Fbx8"
                     /note="F-box protein 8"
                     /db_xref="GeneID:50753"
                     /db_xref="MGI:MGI:1354696"
     exon            1..223
                     /gene="Fbxo8"
                     /gene_synonym="Fbx8"
                     /inference="alignment:Splign:2.1.0"
     exon            224..560
                     /gene="Fbxo8"
                     /gene_synonym="Fbx8"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1191
                     /gene="Fbxo8"
                     /gene_synonym="Fbx8"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     only protein 8"
                     /codon_start=1
                     /product="F-box only protein 8 isoform 1"
                     /protein_id="NP_056606.2"
                     /db_xref="CCDS:CCDS22314.1"
                     /db_xref="GeneID:50753"
                     /db_xref="MGI:MGI:1354696"
                     /translation="MGQGLWRVARNHHLQQEAYSETGYLSREQSRRVASSNISHTSHR
                     KQAQGGIDIYHLLKARKSKEQEGFINLEMLPPELSFTILSYLNATDLCLASCVWQDLA
                     NDELLWQGLCKSTWGHCSIYNKNPPLGFSFRKLYMQLDEGSLTFNANPEEGVSYFMSK
                     GILDDSPKEIAKFIFCTRTLNWKKLRIYLDERRDVLDDLVTLHNFRNQFLPNALREFF
                     RHIHAPEERGEYLETLITKFSHRFCACNPDLMRELGLSPDAVYVLCYSLILLSIDLTS
                     PHVKNKMSKREFIRNTRRAAQNISEDFVGHLYDNIYLIGHVAA"
     exon            561..687
                     /gene="Fbxo8"
                     /gene_synonym="Fbx8"
                     /inference="alignment:Splign:2.1.0"
     exon            688..806
                     /gene="Fbxo8"
                     /gene_synonym="Fbx8"
                     /inference="alignment:Splign:2.1.0"
     exon            807..1003
                     /gene="Fbxo8"
                     /gene_synonym="Fbx8"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..3507
                     /gene="Fbxo8"
                     /gene_synonym="Fbx8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1603..1608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo8"
                     /gene_synonym="Fbx8"
                     /note="hexamer: ACTAAA"
     polyA_site      1628
                     /gene="Fbxo8"
                     /gene_synonym="Fbx8"
                     /note="major polyA site"
     regulatory      1832..1837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo8"
                     /gene_synonym="Fbx8"
                     /note="hexamer: AATAAA"
     polyA_site      1857
                     /gene="Fbxo8"
                     /gene_synonym="Fbx8"
                     /note="major polyA site"
     regulatory      1909..1914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo8"
                     /gene_synonym="Fbx8"
                     /note="hexamer: AATAAA"
     polyA_site      1931
                     /gene="Fbxo8"
                     /gene_synonym="Fbx8"
     polyA_site      1959
                     /gene="Fbxo8"
                     /gene_synonym="Fbx8"
ORIGIN      
        1 actcgggctt ctgcaggcag aggtgctgtg acttcgcggg agtctggggc ggcttctggt
       61 tccctcgcag ccatcgtgtt ctccagcgcg aacacgtgcg ctctggacag gcctctccat
      121 ggcttgggca ccagttcccg gctgagccat tttcttctcg gctgacagcc cccgcccaca
      181 ggccgagtcg tcgcggcggc ggtggagatc ccaggtcgct caggcttgca gatgggtcaa
      241 ggactctgga gagtggccag aaaccatcat ctccaacagg aagcctacag tgagacaggc
      301 tacctcagca gagaacagag caggagagtg gcttcaagca acatttctca caccagccac
      361 cggaaacaag cccaaggagg cattgatatc tatcatcttc tgaaggcaag gaagtctaaa
      421 gaacaggagg ggttcataaa cttggaaatg ctgcctcctg agctgagctt caccatctta
      481 tcctacctga atgcaactga cctttgctta gcttcctgtg tttggcaaga cctcgctaat
      541 gatgaacttc tctggcaagg gttgtgtaaa tctacatggg gtcactgctc tatatacaat
      601 aagaacccac ctttaggatt ttcttttaga aaattgtata tgcagctaga tgagggaagc
      661 ctcaccttta atgccaaccc agaggaggga gtgagctact ttatgtccaa gggtatccta
      721 gatgattcgc caaaggaaat agcaaaattt atcttctgta ccagaacact aaattggaaa
      781 aaactgagaa tctatcttga tgaaaggaga gatgtcttgg atgaccttgt aaccttgcat
      841 aattttagaa atcagttctt gccgaatgca ctgagagaat tttttcgtca tattcatgcc
      901 cctgaagagc gtggggagta ccttgaaact cttataacca agttctcaca taggttctgt
      961 gcttgcaatc ctgacctcat gcgagaactt ggccttagtc ctgatgctgt ctatgtactg
     1021 tgctactctt tgattctact ttccattgac ctcactagtc ctcatgtgaa gaataaaatg
     1081 tcaaaaagag agtttattcg aaatacgcgc cgtgctgctc agaacattag tgaagatttt
     1141 gtaggacacc tttatgacaa catctacctt attggccatg tggctgcata aaagcacaag
     1201 tgttcgaact tcaacttttt actccagact gaggctaccc agggacagac ttagtggcag
     1261 cagggttgca tcagcactgg tcactccagt ccagcctgtg tgtaaaatcc agcttgactg
     1321 caccccccct tttttgtttc actgttttct agtttagaaa tctcagaact aactaatttt
     1381 acagaacttt tcttaatttg ctcatcatgt ttgcacaaaa cagccactgt ctaacacaac
     1441 tgttagagaa tgttaaactg acatatgctc tataaatgga gtgtttgtgc attagattgg
     1501 tctgggaact atccatttcc atccttttac aaataccatg taatgtatgc atatttaact
     1561 gaagagattt ataatcataa ttattttatt gtaaagattt taactaaagg ttttcctttt
     1621 ctcttgaact gagtttggaa atttatttga ctttgaacta agaatattgt tggctttgtc
     1681 aaagttggat ctgaccctag aaaccaatac cagcttccca tttctctgaa ctttgaaaag
     1741 aatgttgatt tgttactata ttaatatact atgcaaaact ggccttattt gtataacata
     1801 tcatttgatt catttttaaa acttctgggt taataaagtt tcagtatatc acttaaacat
     1861 tgagaatata aaaatgtgtc agaatttaga agtcacattt ataaacagaa taaaatgtga
     1921 ttagaactca aggaggtatt tacttccttg tttctgaaat actcagtgtt aactattttc
     1981 ctaatcttga tctcttgatt agttaactaa taatgggata ctatgctgtg aatcacattc
     2041 ttcaaatatt tatcaagggc tttctctgtg ctgtatccta tgctccacta cagtactggt
     2101 acctggacat gagttctgca ttcagagatg gcacatgctt gtgtaataag ggggaaactg
     2161 ctgaattttt tttctcttgt tattttttgg agtgtgattc actgatctct ccctctgtct
     2221 actcccgacc tcttttctgt agctatctgt gttaccacct gaaatctccc tccctctcta
     2281 tctcctctcg ttctcaattt gactgtcatt ttaaaaaaaa gtttaatttc cacactctac
     2341 atcctttttt aaatataatt ttccaatgga attattcaga tagaaaatat aagcatttta
     2401 cagagaaagc ctgaacactc tacctagatc ctacaatcag agttccactc tgttcagcat
     2461 atatgaaccc attcctccac ccgtcaactc atctgaatga ttttaaacat agaaaaatta
     2521 atttcaaaaa tctatattct ctgttgctaa gcacatacat ttatatagca ttgatgaaag
     2581 gtctacattt ttaccatctt tcacttccag gtataattta catttaagaa aatgtaaaaa
     2641 tatgtgaatc tttacaaatg cctatcccat gaaaattaaa ttgatatgtc agttatatga
     2701 agtttcttcc acaattttag agttgttaag ttacaaaatc caaagtcttt ttttaacaag
     2761 cattattaat tgaggaaaaa aaatattctt tcatgtttgc caataataca attttaaata
     2821 cttattttgt attcaagccc tttttacaat aattttcttt tcaaaatgag aacatctatt
     2881 caagttggag tcacctagaa accatcatag ttttatttga tttttttttg ttgttttact
     2941 tttattgaaa tagatttgtc tctcacacac tgcatcccaa acacagtttc cccttcgtca
     3001 ctcctcccag ctccccacac tttcttgtcc cccagggcca ctccccacat tgatcagaaa
     3061 agatcaggcc tccaagagtc cacagccaaa taggacaaaa caaaagatat aaaagaagac
     3121 aaagcactat gtgagagaac caagtatgac ttggggaaga aaaacaaaat caatgagatg
     3181 attcctaatg gcactctggt tatactcaga tcagggcctt ccttgtccag ttatcatcag
     3241 aggcttcctc tggcagcata agggagtggt gctaagcccc acagctgggt gttatacaca
     3301 gagagagtct tacttggagt tctccatcca ggtcctatca gaagagtgac accaagagaa
     3361 catggtccac agaatcaacg aagcagggtt cctatgggca agcaaggagc ttgcatggag
     3421 ctgagccaat cctctgcata tatacatgga tgttagcttg tattgtggga ctcattgtta
     3481 tatttgaaaa taacattctt tttgaag
//
