LOCUS       NM_153195               1886 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus F-box protein 7 (Fbxo7), transcript variant 1, mRNA.
ACCESSION   NM_153195
VERSION     NM_153195.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1886)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1886)
  AUTHORS   Wang,J., Joseph,S., Vingill,S., Dere,E., Tatenhorst,L.,
            Ronnenberg,A., Lingor,P., Preisinger,C., Ehrenreich,H., Schulz,J.B.
            and Stegmuller,J.
  TITLE     Loss of the parkinsonism-associated protein FBXO7 in glutamatergic
            forebrain neurons in mice leads to abnormal motor behavior and
            synaptic defects
  JOURNAL   J Neurochem 167 (2), 296-317 (2023)
   PUBMED   37753846
REFERENCE   3  (bases 1 to 1886)
  AUTHORS   Harris,R., Yang,M., Schmidt,C., Royet,C., Singh,S., Natarajan,A.,
            Morris,M., Frezza,C. and Laman,H.
  TITLE     Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T
            cells
  JOURNAL   J Cell Biol 221 (7) (2022)
   PUBMED   35670764
REFERENCE   4  (bases 1 to 1886)
  AUTHORS   Noda,S., Sato,S., Fukuda,T., Ueno,S., Tada,N. and Hattori,N.
  TITLE     Impaired mitochondrial accumulation and Lewy pathology in
            neuron-specific FBXO7-deficient mice
  JOURNAL   Mol Brain 15 (1), 54 (2022)
   PUBMED   35701754
  REMARK    GeneRIF: Impaired mitochondrial accumulation and Lewy pathology in
            neuron-specific FBXO7-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1886)
  AUTHORS   Lee,S.H., Jung,S., Lee,Y.J., Hyun,M. and Chung,K.C.
  TITLE     FBXO7 triggers caspase 8-mediated proteolysis of the transcription
            factor FOXO4 and exacerbates neuronal cytotoxicity
  JOURNAL   J Biol Chem 297 (6), 101426 (2021)
   PUBMED   34800438
  REMARK    GeneRIF: FBXO7 triggers caspase 8-mediated proteolysis of the
            transcription factor FOXO4 and exacerbates neuronal cytotoxicity.
REFERENCE   6  (bases 1 to 1886)
  AUTHORS   Meziane el,K., Randle,S.J., Nelson,D.E., Lomonosov,M. and Laman,H.
  TITLE     Knockdown of Fbxo7 reveals its regulatory role in proliferation and
            differentiation of haematopoietic precursor cells
  JOURNAL   J Cell Sci 124 (Pt 13), 2175-2186 (2011)
   PUBMED   21652635
  REMARK    GeneRIF: The physiological effect of reduced levels of Fbxo7 in
            mice showed significantly increased pro-B cell and pro-erythroblast
            populations, consistent with Fbxo7 having an anti-proliferative
            function and/or a role in promoting maturation of precursor cells.
REFERENCE   7  (bases 1 to 1886)
  AUTHORS   Kenney-Hunt,J.P., Vaughn,T.T., Pletscher,L.S., Peripato,A.,
            Routman,E., Cothran,K., Durand,D., Norgard,E., Perel,C. and
            Cheverud,J.M.
  TITLE     Quantitative trait loci for body size components in mice
  JOURNAL   Mamm Genome 17 (6), 526-537 (2006)
   PUBMED   16783635
REFERENCE   8  (bases 1 to 1886)
  AUTHORS   Laman,H., Funes,J.M., Ye,H., Henderson,S., Galinanes-Garcia,L.,
            Hara,E., Knowles,P., McDonald,N. and Boshoff,C.
  TITLE     Transforming activity of Fbxo7 is mediated specifically through
            regulation of cyclin D/cdk6
  JOURNAL   EMBO J 24 (17), 3104-3116 (2005)
   PUBMED   16096642
  REMARK    GeneRIF: Fbxo7 specifically regulated D cyclin/cdk6 complexes; it
            was highly expressed in epithelial tumors, but not in normal
            tissues, suggesting that it may have a proto-oncogenic role in
            human cancers.
REFERENCE   9  (bases 1 to 1886)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 1886)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD563204.1 and AK151025.1.
            
            On Oct 26, 2006 this sequence version replaced NM_153195.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150626.1, AK147797.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                CD563204.1         1-43
            44-1886             AK151025.1         2-1844
FEATURES             Location/Qualifiers
     source          1..1886
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 41.91 cM"
     gene            1..1886
                     /gene="Fbxo7"
                     /gene_synonym="2410015K21Rik; A230052G17Rik"
                     /note="F-box protein 7"
                     /db_xref="GeneID:69754"
                     /db_xref="MGI:MGI:1917004"
     exon            1..216
                     /gene="Fbxo7"
                     /gene_synonym="2410015K21Rik; A230052G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            217..511
                     /gene="Fbxo7"
                     /gene_synonym="2410015K21Rik; A230052G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            512..739
                     /gene="Fbxo7"
                     /gene_synonym="2410015K21Rik; A230052G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            740..881
                     /gene="Fbxo7"
                     /gene_synonym="2410015K21Rik; A230052G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            882..968
                     /gene="Fbxo7"
                     /gene_synonym="2410015K21Rik; A230052G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1064
                     /gene="Fbxo7"
                     /gene_synonym="2410015K21Rik; A230052G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1241
                     /gene="Fbxo7"
                     /gene_synonym="2410015K21Rik; A230052G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1279
                     /gene="Fbxo7"
                     /gene_synonym="2410015K21Rik; A230052G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1886
                     /gene="Fbxo7"
                     /gene_synonym="2410015K21Rik; A230052G17Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgagcgctgg ggattcctcg ggagcgcagg cccggagctc cttgctttcg gtttcttccc
       61 ggggccgacc gaagcttgcg gtccgactct cgccatgaag ctgcgcgtgc ggcttcagaa
      121 gcggacccag ccgctcgagg tgccggagtc ggagccaacg ctcgggcagc tgcgcgcgca
      181 cctcagccag gtcctgctgc ccacgttggg gttcagttct gatacccgat ttgcaattac
      241 attgaacaac aaggatgccc tcactggaga tgaagagacc ttggcttcat atgggattgt
      301 ttctggggac ttgatatgtt tggttcttga agatgacatg ccggcaccta acttaccttc
      361 atctacagat acagagcatt cctcactcca ggataatgac caaccttctt tggctgccac
      421 cccaagtcag actaacatcc cagatgaaca agggactgat tcatcccaag gacaggccac
      481 cccatttgat gcctggactg atgacagtat ggaagggcct agtcaaaatg ttgaagctga
      541 gtcaattcag gatgccatga gtatggaaga ggtttctggt ttccatccat tggaaccaat
      601 gctctgtaat gaaacagagg atgggcaggt accacattct ctagagaccc tgtaccagtc
      661 agctggctgc tccaacatca gtgatgcctt gatagtgctg gtgcatctcc tgatgctcga
      721 gtcaggctac attcctcagg gaactgaaac caaagcagtg acaatgcctg agaagtggaa
      781 gtcaagtggt gtatacaaac tgcagtacac acatcctctc tgcgagggcg gctttgccgt
      841 gcttacctgt gtgcctttgg gaaacttaat cattataaat gctacaataa aagtcaacgg
      901 tgggattaaa aacgtgaagt cagtgcagct gcagccagga tcctacgttg ctgctggagt
      961 agaaccaggg gaaagcgcag ccaaagtgta caaagatctt aagaagctct ctcgtctctt
     1021 caaagaccag ctggtgtacc ctcttctggc tttcacacgg caagtactga accttccaga
     1081 tgtgtttggg ctggttgtcc ttccactgga gctgaaacta cgcatcttcc gacttttgga
     1141 tgttcattct gtcctggccc tgtctgcagt ctgtcatgac ctcctcattg cgtcaaatga
     1201 cccactgctg tggaggtgtt tgtatctgcg ggattttcga gatggcactg tcagaggtcc
     1261 tgacacagac tggaaagaat tgtatagaaa gaagcacata caaagaaaag aggctcagag
     1321 gatgcggcat gcaatgttcc taccatcagc ccaccctatc ccattttgtc ccattcccgt
     1381 ctaccccagg gcctaccttc ccacctcgct gcttcctcca ggaatcattg gtggtgaata
     1441 tgatgagagg ccgatactgc ctagtgttgg ggacccagtc acctcactta tcccaaggcc
     1501 cggggagctt cctggtcagt tccgtccact cagaccacgt tttgaccctg ttgacccact
     1561 tccaggacct cactccctct tgccaggaag agctatcccc aacaacagat ttcccttcag
     1621 acccggcagg ggtaggtcag ctgacagccg gctgccattc ctgtgaccaa tttggagact
     1681 ttatggaaac tggatgctgt ttccttggat gctgatctct gctgtcggtt tctggttctg
     1741 tgggcaccaa ggacaaggtt gctcaaagag gggtcagctt gggaataggt gactgctggt
     1801 ctctcccctc tggttcacct ctgggatgga gattgtggta ttgataatgt tttgtgttat
     1861 attagtaaaa gtaaaaattg tatggc
//
