LOCUS       NM_001163706            1205 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus F-box protein 6 (Fbxo6), transcript variant 4, mRNA.
ACCESSION   NM_001163706
VERSION     NM_001163706.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1205)
  AUTHORS   Zhang,T., Wu,S., Xu,R., Zhang,S., Wang,M. and Li,J.
  TITLE     Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and
            chemokine signaling pathway during vascular smooth muscle cell
            phenotypic switch in atherosclerosis
  JOURNAL   Cell Signal 111, 110869 (2023)
   PUBMED   37633478
  REMARK    GeneRIF: Musashi-2 binds with Fbxo6 to induce Rnaset2
            ubiquitination and chemokine signaling pathway during vascular
            smooth muscle cell phenotypic switch in atherosclerosis.
REFERENCE   2  (bases 1 to 1205)
  AUTHORS   Cen,M., Ouyang,W., Lin,X., Du,X., Hu,H., Lu,H., Zhang,W., Xia,J.,
            Qin,X. and Xu,F.
  TITLE     FBXO6 regulates the antiviral immune responses via mediating
            alveolar macrophages survival
  JOURNAL   J Med Virol 95 (1), e28203 (2023)
   PUBMED   36217277
  REMARK    GeneRIF: FBXO6 regulates the antiviral immune responses via
            mediating alveolar macrophages survival.
REFERENCE   3  (bases 1 to 1205)
  AUTHORS   Yoshida,Y., Asahina,M., Murakami,A., Kawawaki,J., Yoshida,M.,
            Fujinawa,R., Iwai,K., Tozawa,R., Matsuda,N., Tanaka,K. and
            Suzuki,T.
  TITLE     Loss of peptide:N-glycanase causes proteasome dysfunction mediated
            by a sugar-recognizing ubiquitin ligase
  JOURNAL   Proc Natl Acad Sci U S A 118 (27) (2021)
   PUBMED   34215698
  REMARK    GeneRIF: Loss of peptide:N-glycanase causes proteasome dysfunction
            mediated by a sugar-recognizing ubiquitin ligase.
REFERENCE   4  (bases 1 to 1205)
  AUTHORS   Shenkman,M., Groisman,B., Ron,E., Avezov,E., Hendershot,L.M. and
            Lederkremer,G.Z.
  TITLE     A shared endoplasmic reticulum-associated degradation pathway
            involving the EDEM1 protein for glycosylated and nonglycosylated
            proteins
  JOURNAL   J Biol Chem 288 (4), 2167-2178 (2013)
   PUBMED   23233672
REFERENCE   5  (bases 1 to 1205)
  AUTHORS   Groisman,B., Shenkman,M., Ron,E. and Lederkremer,G.Z.
  TITLE     Mannose trimming is required for delivery of a glycoprotein from
            EDEM1 to XTP3-B and to late endoplasmic reticulum-associated
            degradation steps
  JOURNAL   J Biol Chem 286 (2), 1292-1300 (2011)
   PUBMED   21062743
REFERENCE   6  (bases 1 to 1205)
  AUTHORS   Yoshida,Y., Adachi,E., Fukiya,K., Iwai,K. and Tanaka,K.
  TITLE     Glycoprotein-specific ubiquitin ligases recognize N-glycans in
            unfolded substrates
  JOURNAL   EMBO Rep 6 (3), 239-244 (2005)
   PUBMED   15723043
REFERENCE   7  (bases 1 to 1205)
  AUTHORS   Bliskovsky,V., Ramsay,E.S., Scott,J., DuBois,W., Shi,W., Zhang,S.,
            Qian,X., Lowy,D.R. and Mock,B.A.
  TITLE     Frap, FKBP12 rapamycin-associated protein, is a candidate gene for
            the plasmacytoma resistance locus Pctr2 and can act as a tumor
            suppressor gene
  JOURNAL   Proc Natl Acad Sci U S A 100 (25), 14982-14987 (2003)
   PUBMED   14634209
REFERENCE   8  (bases 1 to 1205)
  AUTHORS   Yoshida,Y., Tokunaga,F., Chiba,T., Iwai,K., Tanaka,K. and Tai,T.
  TITLE     Fbs2 is a new member of the E3 ubiquitin ligase family that
            recognizes sugar chains
  JOURNAL   J Biol Chem 278 (44), 43877-43884 (2003)
   PUBMED   12939278
  REMARK    GeneRIF: Fbs2 is a novel member of F-box protein family that
            recognizes N-glycans and plays a role in ERAD
REFERENCE   9  (bases 1 to 1205)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK171483.1 and AK165867.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR,
            compared to variant 1. Variants 1-6 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170743.1, AK171483.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1132              AK171483.1         2-1133
            1133-1205           AK165867.1         1868-1940
FEATURES             Location/Qualifiers
     source          1..1205
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.67 cM"
     gene            1..1205
                     /gene="Fbxo6"
                     /gene_synonym="FBG2; Fbs2; Fbx6b; Fbxo6b"
                     /note="F-box protein 6"
                     /db_xref="GeneID:50762"
                     /db_xref="MGI:MGI:1354743"
     exon            1..88
                     /gene="Fbxo6"
                     /gene_synonym="FBG2; Fbs2; Fbx6b; Fbxo6b"
                     /inference="alignment:Splign:2.1.0"
     exon            89..376
                     /gene="Fbxo6"
                     /gene_synonym="FBG2; Fbs2; Fbx6b; Fbxo6b"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1005
                     /gene="Fbxo6"
                     /gene_synonym="FBG2; Fbs2; Fbx6b; Fbxo6b"
                     /note="F-box only protein 6b; F-box/G-domain protein 2;
                     F-box protein that recognizes sugar chains 2"
                     /codon_start=1
                     /product="F-box only protein 6"
                     /protein_id="NP_001157178.1"
                     /db_xref="CCDS:CCDS18933.1"
                     /db_xref="GeneID:50762"
                     /db_xref="MGI:MGI:1354743"
                     /translation="MVHINELPENILLELFIHIPAPQLLRNCRLVCRLWRDLIDVVSL
                     WKRKSLREGFFTKDRCEPVEDWKVFYILCSLQRNLLRNPCAEENLSSWRIDSNGGDRW
                     KVETLPGSCGTSFPDNKVKKYFVTSFEMCLKSQMVDLKAEGYCEELMDTFRPDIVVKD
                     WVAPRADCGCTYQLRVQLASADYIVLASFEPPPVTFQQWNDAKWQEISHTFSDYPPGV
                     RHILFQHGGQDTQFWKGWYGPRVTNSSIIISHRTAKNPPPARTLPEETVVIGRRRRAS
                     DSNTHEGFFWQGLWQRLRR"
     exon            377..503
                     /gene="Fbxo6"
                     /gene_synonym="FBG2; Fbs2; Fbx6b; Fbxo6b"
                     /inference="alignment:Splign:2.1.0"
     exon            504..599
                     /gene="Fbxo6"
                     /gene_synonym="FBG2; Fbs2; Fbx6b; Fbxo6b"
                     /inference="alignment:Splign:2.1.0"
     exon            600..735
                     /gene="Fbxo6"
                     /gene_synonym="FBG2; Fbs2; Fbx6b; Fbxo6b"
                     /inference="alignment:Splign:2.1.0"
     exon            736..1205
                     /gene="Fbxo6"
                     /gene_synonym="FBG2; Fbs2; Fbx6b; Fbxo6b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1113..1118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo6"
                     /gene_synonym="FBG2; Fbs2; Fbx6b; Fbxo6b"
                     /note="hexamer: AATAAA"
     polyA_site      1134
                     /gene="Fbxo6"
                     /gene_synonym="FBG2; Fbs2; Fbx6b; Fbxo6b"
                     /note="major polyA site"
     polyA_site      1181
                     /gene="Fbxo6"
                     /gene_synonym="FBG2; Fbs2; Fbx6b; Fbxo6b"
ORIGIN      
        1 agtggagcag cagcttggtg aggggggggg gggatcctag agctccgagc tcaccatctt
       61 cgcaccgacg cggaaggccc gctggtcggt ctgggaacgt aattctctgt tgccaccatg
      121 gtccacatca acgagctgcc agagaacatt ctcctggagc tgttcatcca tatcccggcc
      181 ccacagctgc tgcgcaactg ccgcctggtc tgccgcctct ggcgagacct catcgatgtg
      241 gtgtccctat ggaagcgcaa gagtcttcga gagggcttct tcaccaaaga ccggtgcgag
      301 cccgtggaag actggaaggt cttctatatc ctgtgcagcc tgcagaggaa cctccttcgg
      361 aacccgtgtg ctgaagagaa cctgagctca tggcggatag actccaacgg aggggatcgc
      421 tggaaggtgg agacgctccc tgggagctgt ggcacaagct ttcctgacaa caaggtcaag
      481 aagtattttg tcacctcttt tgagatgtgc ctcaaatccc agatggtgga cctcaaagct
      541 gagggctact gcgaggagct gatggacacc tttcggcctg acattgtggt taaggactgg
      601 gttgccccca gagcagactg tggctgcacc tatcaactcc gggtacagct ggcctctgcg
      661 gactacattg tcttggcctc ttttgagcct ccacctgtga cattccaaca gtggaatgat
      721 gccaaatggc aagagatttc ccacaccttc tctgattacc ctccaggtgt ccgtcacatc
      781 ctttttcaac acgggggcca ggacactcag ttctggaaag gctggtacgg cccccgtgtc
      841 accaacagca gcatcattat cagccacagg acagccaaga accctccccc tgccagaact
      901 ctaccggaag aaactgtagt aatcggaagg agacggcgag cttcggactc caacactcat
      961 gagggtttct tctggcaagg gctatggcaa aggctaaggc gttagtgggc agtcaggctc
     1021 ccagtcccat gagcacttgc cctatacaac cttgggcaag cccatcaact cagtagtgat
     1081 agttggcacc cacagctctg acattttgtt gtaataaatg ttttcagtaa cccagcctgg
     1141 tttgagggct tacaggtggg ttgctggcac tctgagaaag agccccttct cagggcagct
     1201 tcgat
//
