LOCUS       NM_001081435            5657 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus F-box protein 47 (Fbxo47), transcript variant 1, mRNA.
ACCESSION   NM_001081435 XM_994781
VERSION     NM_001081435.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5657)
  AUTHORS   Shigesawa,I., Nakamura,A., Yamauchi,Y., Kawata,S., Miyazaki,A.,
            Nomoto,H., Kameda,H., Terauchi,Y. and Atsumi,T.
  TITLE     Effects of glucokinase haploinsufficiency on the pancreatic
            beta-cell mass and function of long-term high-fat, high-sucrose
            diet-fed mice
  JOURNAL   J Diabetes Investig 15 (12), 1732-1742 (2024)
   PUBMED   39305123
REFERENCE   2  (bases 1 to 5657)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5657)
  AUTHORS   Tanno,N., Takemoto,K., Takada-Horisawa,Y., Shimada,R., Fujimura,S.,
            Tani,N., Takeda,N., Araki,K. and Ishiguro,K.I.
  TITLE     FBXO47 is essential for preventing the synaptonemal complex from
            premature disassembly in mouse male meiosis
  JOURNAL   iScience 25 (4), 104008 (2022)
   PUBMED   35310947
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5657)
  AUTHORS   Hua,R., Wei,H., Liu,C., Zhang,Y., Liu,S., Guo,Y., Cui,Y., Zhang,X.,
            Guo,X., Li,W. and Liu,M.
  TITLE     FBXO47 regulates telomere-inner nuclear envelope integration by
            stabilizing TRF2 during meiosis
  JOURNAL   Nucleic Acids Res 47 (22), 11755-11770 (2019)
   PUBMED   31724724
  REMARK    GeneRIF: Knockout of Fbxo47 in mice leads to infertility in males.
            The Fbxo47 deficient spermatocytes are unable to form a complete
            synaptonemal complex.
REFERENCE   5  (bases 1 to 5657)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5657)
  AUTHORS   Chen,Y., Zheng,Y., Gao,Y., Lin,Z., Yang,S., Wang,T., Wang,Q.,
            Xie,N., Hua,R., Liu,M., Sha,J., Griswold,M.D., Li,J., Tang,F. and
            Tong,M.H.
  TITLE     Single-cell RNA-seq uncovers dynamic processes and critical
            regulators in mouse spermatogenesis
  JOURNAL   Cell Res 28 (9), 879-896 (2018)
   PUBMED   30061742
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596446.11.
            
            On Mar 15, 2023 this sequence version replaced NM_001081435.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.12162.1, BC158049.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               AL596446.11        162439-162650       c
            213-417             AL596446.11        157900-158104       c
            418-588             AL596446.11        156473-156643       c
            589-665             AL596446.11        151374-151450       c
            666-743             AL596446.11        147108-147185       c
            744-852             AL596446.11        143575-143683       c
            853-1029            AL596446.11        141875-142051       c
            1030-1176           AL596446.11        136184-136330       c
            1177-1319           AL596446.11        134672-134814       c
            1320-1479           AL596446.11        133869-134028       c
            1480-5657           AL596446.11        128827-133004       c
FEATURES             Location/Qualifiers
     source          1..5657
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 61.14 cM"
     gene            1..5657
                     /gene="Fbxo47"
                     /gene_synonym="2900052P03Rik; Gm1562"
                     /note="F-box protein 47"
                     /db_xref="GeneID:72973"
                     /db_xref="MGI:MGI:1920223"
     exon            1..212
                     /gene="Fbxo47"
                     /gene_synonym="2900052P03Rik; Gm1562"
                     /inference="alignment:Splign:2.1.0"
     exon            213..417
                     /gene="Fbxo47"
                     /gene_synonym="2900052P03Rik; Gm1562"
                     /inference="alignment:Splign:2.1.0"
     exon            418..588
                     /gene="Fbxo47"
                     /gene_synonym="2900052P03Rik; Gm1562"
                     /inference="alignment:Splign:2.1.0"
     exon            589..665
                     /gene="Fbxo47"
                     /gene_synonym="2900052P03Rik; Gm1562"
                     /inference="alignment:Splign:2.1.0"
     exon            666..743
                     /gene="Fbxo47"
                     /gene_synonym="2900052P03Rik; Gm1562"
                     /inference="alignment:Splign:2.1.0"
     exon            744..852
                     /gene="Fbxo47"
                     /gene_synonym="2900052P03Rik; Gm1562"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1029
                     /gene="Fbxo47"
                     /gene_synonym="2900052P03Rik; Gm1562"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1176
                     /gene="Fbxo47"
                     /gene_synonym="2900052P03Rik; Gm1562"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1319
                     /gene="Fbxo47"
                     /gene_synonym="2900052P03Rik; Gm1562"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1479
                     /gene="Fbxo47"
                     /gene_synonym="2900052P03Rik; Gm1562"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..5657
                     /gene="Fbxo47"
                     /gene_synonym="2900052P03Rik; Gm1562"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1766..1771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo47"
                     /gene_synonym="2900052P03Rik; Gm1562"
                     /note="hexamer: AATATA"
     polyA_site      1793
                     /gene="Fbxo47"
                     /gene_synonym="2900052P03Rik; Gm1562"
     regulatory      2128..2133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo47"
                     /gene_synonym="2900052P03Rik; Gm1562"
                     /note="hexamer: AATAAA"
     polyA_site      2148
                     /gene="Fbxo47"
                     /gene_synonym="2900052P03Rik; Gm1562"
     regulatory      5636..5641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo47"
                     /gene_synonym="2900052P03Rik; Gm1562"
                     /note="hexamer: AATAAA"
     polyA_site      5657
                     /gene="Fbxo47"
                     /gene_synonym="2900052P03Rik; Gm1562"
                     /note="major polyA site"
ORIGIN      
        1 gagagctgag gacgcagctc cggggcggag cggagagagc ggagcaggat ccgcccccat
       61 tatctggcgg gaaaagcctg aggagatttt tttttttaat tttttattta tttttatttt
      121 taagtatttg tgaaatctga ggatggtggg acgagacgac taaatcccac tttcctgtga
      181 tactgtagcc ggaaaaactg tcgaaatctg tggataaatt catgggataa gagaagatgg
      241 cgtctagagt aaataccagt ttcactttga tacccaagca aaaatgtaga cgttctaatc
      301 atcactccag ctatttttgc aacacccttg attcagatcc tcaactctta tctacacttg
      361 gaaattttaa agtcttacca ttggaaatat tacacataat tttaagatac ttgtcagtga
      421 aagatattgg catgttaagt atggtgtcta aaacagtcag ccagcacata attaattata
      481 tctcaacatc atctggaagt aggagacttt tactacagaa ctttcatgac cttgatctgc
      541 ctggcacaaa agaagagact gctctactgg agcactacag agctctaggt ctactattta
      601 aaagatgcac cttgctgctt cccaccaagg aaagactgaa gtacattcac aagatactct
      661 cagaagtatc ctgctttaaa ttcagtggct gttcagttcc tttgcagtgt ttaggattat
      721 catgttacgg catgttttta cagaccttaa cagcaggttg ggatgaactt gaatgccatc
      781 gtgtgtataa cttcttatgt gagctgacta atctctcccg aaagatgcag acagttgtct
      841 gcaacaaacc aggaagtgct cgaaaactag agttaagggt tagactattc tgtcggaatg
      901 tcctacttga tcactggaca catcgaagtg attctgcatt ttggttaact cgaattttaa
      961 agccatggcc aatggtgaat caggcaagat tgctatatat tatctttgga ccaacatctc
     1021 ctcatgatgg gcaggtgatt tggcaggaaa tgatagaagg acctacagat gaatctagtc
     1081 tgaaaggttt ggctaatgcc attaagttac tgtatgacac aggtgccaaa ggctggacag
     1141 cagatgatgt catcagtctt gtagatgaac tatcagtggt tccccgggag tggcttctgg
     1201 agaataatgc acgcctccta atcctgagcg ggaacaacat ctgcttcact ttcatggcca
     1261 gtaaagctgt aaatggacga gccgttgaac tggcaagact tgtagtcttt ttggctttgg
     1321 tgtgtgagaa agagttgtac tgcatggact ggacagtcag aatgatgcag aaagtctgca
     1381 aagtcttcag cactgcagca gagaggaaga gcttcctgca gagcatagca aatgcttttg
     1441 cctgtgtcac gatggaaatg ctgcagcctg ttatgtcggg agatcgcgat gacgatgaca
     1501 gaggcttcct gaatctgttc catcttctcc atgctcaggc gaacttccat aaggaggtgc
     1561 tgtatctgac catgaacgct atctcttcct aagtcaggaa gcttgtgtcc ctctggactg
     1621 gcattcaggg gagtgatgcc ttttcacatc taaggatagc acctatggga ctcttgagaa
     1681 tctaattaac cagaaactca gttgcacaag actttaccta taactgtttc actctgatta
     1741 ttacaaaata gcaggcagac ccaagaatat attgcaactt ttctggaaaa caagttctgg
     1801 ctcttcaggt cttggtaaat gtaacatcaa accaaatcag agtgttaact atccaagagt
     1861 cggcagctgg ctcaccctat ctatctggct ctttgaagca agagctagct ctgccttttt
     1921 aagagcagat ccgcattcag tgactagtgc tctctgttgc tttgcttact ttgagcagat
     1981 acagcccaca tgttctctaa ggatttgtaa tactgacttt tagaatgtac attatgtaag
     2041 tcacattctt taccaccttc ttagcatatg gttacaaaac aatcttatat ttcatttata
     2101 tttgtatgaa ctaatagaaa aattcaaaat aaatatgtat agataatata tatgtatatt
     2161 tatatatgta tagacacatg ttcatatatt tcctgcaaga caatcatcca aaaggtctac
     2221 aaatggagga agatgtgtgt gtgtgtataa actgtagttt tcagataatg gaatcatctt
     2281 gtaacttccc tggggattag agcagaaaat tgcaagcaga agaaaaacat aatagaagta
     2341 agcagctgtc ctgctgccag aacaatcttt ataagtcact tcttttcttg taagactttc
     2401 ctcccaaccc cagaaagtgg ggctgatgac tgtagaatat ccaaagagag agggaacagg
     2461 gcaggaggag agagagagtt tgtggatccc cagaaactct aggcccatat agtcgaccaa
     2521 ccacctccct tcacctccac ttacgtcaaa gtggctataa tgcaggggcc tcctgtagct
     2581 tttcttcttc tccactcaaa cccagggctt tgtgcagcta agcaaggact ttgccactga
     2641 gtttccccaa cccacactca ccttcccact caattctcag aagctgacct tctttctttt
     2701 cctcggcata ctgggagatc aagaaatcac cttcagcagg ggggtataaa gaaaatccat
     2761 gaattttaac aaaaggctca gtgaacattt gatagtactg aggacagtga aaattgtgga
     2821 gaaataaaaa ttgtgatatc aggattttat tatgtctcaa tagcagaaac acacttaata
     2881 tggaaggatc aaaattgcct ttttgttgtc taagtataat tctactagtg ggaagatttt
     2941 gggggctttt cctccagagt ttatttgaag atttagggag ggaaacattc ttgcttttgt
     3001 tcttcattta attttcttct gttcagctga agaattgatc tgtaaccaac agcctgggca
     3061 gcctgcagta acagaaagtg gtagagtaca aagtaacacc tcagagtggt tcattttttc
     3121 ctctatctat gatagtccca tacctacttt ggaaagatga ctaaatttac ttatcaaaac
     3181 actagtgttt ttaggttgac attttcttgg aaagaaaggg agaaaaaagg aaatgttatt
     3241 gggaaaggta ttttactatt tattttaggt ttcttgaatt acggtttctc tacatatccc
     3301 tggctgtctt gaaacactat gcagaccaag ttggctttga actcacagag atctacctgc
     3361 ttctgcctcc tgagtgctgg gattaaaatt gtgtgccacc acatctaggt ctaaagatct
     3421 tgataagtag ataatttcat tttaggaggc taagagtact acaggctgct cttacagaga
     3481 acccagttca gtctctagca cccacatggc aacttaacac catctgtaac tccagttcca
     3541 ggggaaacct tggccctctt ctggcctgta caggcatttt atacattgtg cacatccatt
     3601 cactcatcca gtcaaaatac ccatacacat agaataaata taaacctttt aaaagataat
     3661 tttcttagag aaagaaatgt atcagtatga agtttgcttt gaataatgta agtctccaca
     3721 attcagataa cttaccaaag aagcatgttt taattaagac aatttattgt ctgtactggg
     3781 aattgaactc agagcctcac acctgctaga taactactcc actactgagc tatcattctg
     3841 atcatttaaa ttttcttaat tttttattgg gatttgactg catctttgtt gacataactc
     3901 attgctataa attattttaa attcatgtaa ttttgttaat cttggttact ttccccactt
     3961 ctgagtttaa atctgaaaga aaattaagcc atgaaaacag taatggcctt tcttcttcct
     4021 gagacagggt ttttctgtgt agccctggct gtcctagaac ttgctctgta gaccaggctg
     4081 gcctcgaact catgagcttc acctgctttt gcctcccaag tgctgggact aaaggtgtgc
     4141 gccacaattg tctggctcct tttttctgtc tctaaaaact aaattggcaa attcttcatc
     4201 tattaataga taaagtaaat ttgggaacaa atttgaaatt tccacaattc agtgatctag
     4261 ttattgattt tgctaagtac atttgtcatt aaaaaaaaaa gtgattttga gttttaaaga
     4321 gagacattaa ggggctgaag ggctggagag atggctcagt tgttaagagc actcactgct
     4381 ctgggtcctg agttcaattc ccattcaatt cctagcaacc acatgatagt tcacaaccat
     4441 ctgcaatggg atccaatgcc ttcttctggt ctgtcagaag acagttacag tgtactcaca
     4501 tacagaaaat aaatctttaa aaagaaaaag agagagacat taacttgaaa aagacatttg
     4561 tatagcaaat gtttaagtaa caggcagtct aatcacacac acatacacac acacaaacac
     4621 acaaagtgga acttttgaaa atgagtagac tgtcagggca gtggtggcgc atgcctttaa
     4681 tcccagcact cgggaggcag aggcagctgg atttctgagt ttgaggccag cctggtctac
     4741 agagtgagtt ccaggacagt caagactaca cagagaaacc ctgccttgag agagagagag
     4801 aaagaatgag aatgaatgag tagactgaaa tgctagaact ggctagactg gagttaacta
     4861 gaatagtcac aaaaacacgg taagctttcc aataaacaga taatttttcc tgtctttttc
     4921 caaatcttct caagttactg tgatcactgg agacccaggc tcccagaatg tcttttcctc
     4981 tgtgtgtgga tctcctttta ctagaaggga aagccaatga catcactgca ctgctgttat
     5041 tgttatttct gtacacacaa cataccatgt tgccactcat tttaggaact gaagtttata
     5101 tcttgtgatg actatgttaa ctgtgaaatg atgcacttgt agcagcacac tgttgtggtg
     5161 atgccatctg tcctcttagt ccctaagtgg tggcgtgtgt gttccagtgg caaagttcag
     5221 cactgttcat ccggcaccag cttagaagtt ccttatcctg tgcgcctggt cgactctgtt
     5281 tgcactccta ggtctttgtt aataacagtt tattgctagg ggaactgttc acctttggag
     5341 aacagagcaa gcaggaggtg cccagtagaa ggtgtaatga cagaaccagt tcatgtctga
     5401 aaagtaaaca ctaccctctg tgtgtggtta gcttcaaggt caacaacctc ctgggaatag
     5461 tactcagtca cgtgattgca gatttgtact tgcccttgac agcctccttt cgtactggaa
     5521 actgcattag caccccacta gctgtgggca gtgttatctc aagcgcattg tgttgtgcta
     5581 aacatctttg aaaactaata ttgtatttgt tcaactttaa tatcttattc attctaataa
     5641 aattaagtta aaattaa
//
