LOCUS       NM_173439               4110 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus F-box protein 45 (Fbxo45), mRNA.
ACCESSION   NM_173439 XM_622647
VERSION     NM_173439.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4110)
  AUTHORS   Zhang,J., Lin,X.T., Fang,L. and Xie,C.M.
  TITLE     In vivo analysis of FBXO45-mediated fibrosis and liver
            tumorigenesis in a chemically induced mouse model of hepatocellular
            carcinoma
  JOURNAL   STAR Protoc 4 (1), 102124 (2023)
   PUBMED   36853700
  REMARK    GeneRIF: In vivo analysis of FBXO45-mediated fibrosis and liver
            tumorigenesis in a chemically induced mouse model of hepatocellular
            carcinoma.
REFERENCE   2  (bases 1 to 4110)
  AUTHORS   Wang,Q., Wu,L., Cao,R., Gao,J., Chai,D., Qin,Y., Ma,L., Wu,S.,
            Tao,Y., Ma,J. and Wang,Z.W.
  TITLE     Fbxo45 promotes the malignant development of esophageal squamous
            cell carcinoma by targeting GGNBP2 for ubiquitination and
            degradation
  JOURNAL   Oncogene 41 (43), 4795-4807 (2022)
   PUBMED   36127399
  REMARK    GeneRIF: Fbxo45 promotes the malignant development of esophageal
            squamous cell carcinoma by targeting GGNBP2 for ubiquitination and
            degradation.
REFERENCE   3  (bases 1 to 4110)
  AUTHORS   Lin,X.T., Yu,H.Q., Fang,L., Tan,Y., Liu,Z.Y., Wu,D., Zhang,J.,
            Xiong,H.J. and Xie,C.M.
  TITLE     Elevated FBXO45 promotes liver tumorigenesis through enhancing
            IGF2BP1 ubiquitination and subsequent PLK1 upregulation
  JOURNAL   Elife 10, e70715 (2021)
   PUBMED   34779401
  REMARK    GeneRIF: Elevated FBXO45 promotes liver tumorigenesis through
            enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4110)
  AUTHORS   Rutkowski,T.P., Purcell,R.H., Pollak,R.M., Grewenow,S.M.,
            Gafford,G.M., Malone,T., Khan,U.A., Schroeder,J.P., Epstein,M.P.,
            Bassell,G.J., Warren,S.T., Weinshenker,D., Caspary,T. and
            Mulle,J.G.
  TITLE     Behavioral changes and growth deficits in a CRISPR engineered mouse
            model of the schizophrenia-associated 3q29 deletion
  JOURNAL   Mol Psychiatry 26 (3), 772-783 (2021)
   PUBMED   30976085
REFERENCE   5  (bases 1 to 4110)
  AUTHORS   Na,Y., Calvo-Jimenez,E., Kon,E., Cao,H., Jossin,Y. and Cooper,J.A.
  TITLE     Fbxo45 Binds SPRY Motifs in the Extracellular Domain of N-Cadherin
            and Regulates Neuron Migration during Brain Development
  JOURNAL   Mol Cell Biol 40 (14), e00539-19 (2020)
   PUBMED   32341084
  REMARK    GeneRIF: Fbxo45 Binds SPRY Motifs in the Extracellular Domain of
            N-Cadherin and Regulates Neuron Migration during Brain Development.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4110)
  AUTHORS   Chen,X., Sahasrabuddhe,A.A., Szankasi,P., Chung,F., Basrur,V.,
            Rangnekar,V.M., Pagano,M., Lim,M.S. and Elenitoba-Johnson,K.S.
  TITLE     Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates
            cancer cell survival
  JOURNAL   Cell Death Differ 21 (10), 1535-1545 (2014)
   PUBMED   24992930
REFERENCE   7  (bases 1 to 4110)
  AUTHORS   Han,S., Kim,S., Bahl,S., Li,L., Burande,C.F., Smith,N., James,M.,
            Beauchamp,R.L., Bhide,P., DiAntonio,A. and Ramesh,V.
  TITLE     The E3 ubiquitin ligase protein associated with Myc (Pam) regulates
            mammalian/mechanistic target of rapamycin complex 1 (mTORC1)
            signaling in vivo through N- and C-terminal domains
  JOURNAL   J Biol Chem 287 (36), 30063-30072 (2012)
   PUBMED   22798074
REFERENCE   8  (bases 1 to 4110)
  AUTHORS   Tada,H., Okano,H.J., Takagi,H., Shibata,S., Yao,I., Matsumoto,M.,
            Saiga,T., Nakayama,K.I., Kashima,H., Takahashi,T., Setou,M. and
            Okano,H.
  TITLE     Fbxo45, a novel ubiquitin ligase, regulates synaptic activity
  JOURNAL   J Biol Chem 285 (6), 3840-3849 (2010)
   PUBMED   19996097
  REMARK    GeneRIF: Data suggest that Fbxo45 plays an important role in the
            regulation of neurotransmission by modulating Munc13-1 at the
            synapse.
REFERENCE   9  (bases 1 to 4110)
  AUTHORS   Saiga,T., Fukuda,T., Matsumoto,M., Tada,H., Okano,H.J., Okano,H.
            and Nakayama,K.I.
  TITLE     Fbxo45 forms a novel ubiquitin ligase complex and is required for
            neuronal development
  JOURNAL   Mol Cell Biol 29 (13), 3529-3543 (2009)
   PUBMED   19398581
  REMARK    GeneRIF: Results suggest that Fbxo45 forms a novel Fbxo45-PAM
            ubiquitin ligase complex that plays an important role in neural
            development.
REFERENCE   10 (bases 1 to 4110)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088738.1.
            
            On or before May 25, 2005 this sequence version replaced
            XM_622647.1, NM_173439.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088738.1, BC026799.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02415122 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4110
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 22.45 cM"
     gene            1..4110
                     /gene="Fbxo45"
                     /gene_synonym="2610017J04Rik"
                     /note="F-box protein 45"
                     /db_xref="GeneID:268882"
                     /db_xref="MGI:MGI:2447775"
     exon            1..532
                     /gene="Fbxo45"
                     /gene_synonym="2610017J04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1075
                     /gene="Fbxo45"
                     /gene_synonym="2610017J04Rik"
                     /note="F-box only protein 45; mFbxo45"
                     /codon_start=1
                     /product="F-box/SPRY domain-containing protein 1"
                     /protein_id="NP_775615.2"
                     /db_xref="CCDS:CCDS28117.1"
                     /db_xref="GeneID:268882"
                     /db_xref="MGI:MGI:2447775"
                     /translation="MAAPGPGAGAASGGASGGGAGAGGGASAGSGSSGVGGRLPSRVL
                     ELVFSYLELSELRSCALVCKHWYRCLHGDENSEVWRSLCARSLAEEALRTDILCNLPS
                     YKAKVRAFQHAFSTNDCSRNVYIKKNGFTLHRNPIAQSTDGARTKIGFSEGRHAWEVW
                     WEGPLGTVAVIGIATKRAPMQCQGYVALLGSDDQSWGWNLVDNNLLHNGEVNGSFPQC
                     NNAPKYQIGERIRVILDMEDKTLAFERGYEFLGVAFRGLPKACLYPAVSAVYGNTEVT
                     LVYLGKPLDG"
     exon            533..889
                     /gene="Fbxo45"
                     /gene_synonym="2610017J04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            890..4046
                     /gene="Fbxo45"
                     /gene_synonym="2610017J04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2522..2527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo45"
                     /gene_synonym="2610017J04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2545
                     /gene="Fbxo45"
                     /gene_synonym="2610017J04Rik"
     regulatory      4025..4030
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo45"
                     /gene_synonym="2610017J04Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      4046
                     /gene="Fbxo45"
                     /gene_synonym="2610017J04Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcgggaaccc gagcggctcg cgccatctgc cctcagtgag gcggggcgcg cagcggacgc
       61 cccggggcag gggcgggagc ggtggaggcg cgagcggctg gcgctgaaag gggcggtgag
      121 cgagccgctc gcggctgtag gcgaggcttg gcctcccgcg ccgagacggg gcgaagcggc
      181 ggcggcggcg gccctcgggc cggctggtga ggcgatggcg gcgccgggcc cgggggctgg
      241 ggcagcctcg ggcggcgcta gtggtggcgg cgccggtgcc ggcggcggcg ccagcgcggg
      301 ctcggggtcc tccggggtcg gcggccggtt gcccagccgg gtgctggagt tggtgttctc
      361 ctacctggag ctgtccgagc tgcggagctg cgccctggtt tgcaagcact ggtaccgctg
      421 cctccacggc gacgagaaca gcgaggtgtg gcggagcctg tgcgcccgca gcctagcaga
      481 agaggctctg cgcacggaca tcctctgcaa cctgcccagc tacaaggcca aggtgcgtgc
      541 tttccaacat gccttcagca cgaatgactg ctccaggaat gtctatatca agaagaatgg
      601 ttttacatta catcggaacc ccatcgctca gagcactgat ggtgcaagga ccaagattgg
      661 tttcagtgag ggccgccacg cctgggaagt gtggtgggag ggccctttgg gcacggtggc
      721 agtgattggg attgctacga aacgggcccc catgcagtgc caaggttatg tggccttgct
      781 gggaagtgac gaccagagct ggggctggaa tctggtggac aataatctac tacataacgg
      841 ggaagtcaac ggcagcttcc cacagtgcaa caacgcacca aagtatcaga taggagagag
      901 aatccgagtc atcctggaca tggaggataa gactttagct tttgagcgtg ggtatgagtt
      961 cctgggggtt gcctttcgag gacttccaaa agcctgctta tacccagctg tctctgcagt
     1021 atatggcaac acagaagtga ctttggttta tcttggaaaa cctctggatg gatgacagtg
     1081 actttctgga aagaagaaga gtggagaaga gatctacttg tggaaagtag aaccatgaag
     1141 tgatagtatc atgtgtgcat gcccaagaaa catcctgaag acacgtgaag ttgagaactg
     1201 gagaagcagc tctgccacag agtgatcata gcgtttcctc tttccactgg gccagaaaat
     1261 cctcagggtt gcagttggtt gagtgggcag ttgacatatg catgttgcca cagcgtcttc
     1321 tctaagttag cagtgtgtta cttccagctt aaaggtgagc gtgtagagat gccataggag
     1381 ggaatcgcaa gggtttatgt agtgttgatg gagaaggctc ggtcccatct tacaactgcc
     1441 tgttctttct ccagtccctt tatttctagc cagcttgact tagaaagtat gaaactggct
     1501 gggttttatt taatattttt aatatattga gaagcatggt ctgcctggac tgcacttctc
     1561 tagcaatgag aaataaaatt gtgcagctat tttaaaagtt gtatatataa tgtgtgtaaa
     1621 aactgtataa aaaggggggg gggacaaagg cattgctttg ttctacttca atttcttaaa
     1681 aatcactaca tggtacaaaa ttacagtgac atttggggat agtagggtaa cagagaaaag
     1741 aagaggagac atgttgtact ggttcatttg atagtgtttt gggcttatag tccatggcta
     1801 taacaggatt atgataaagg ttcctcaatg gttaacgcct ggggaagcag atctacttag
     1861 cattgtgcac atgccagcaa ggctgactca gaagtgatag ataggaacgt gcctcttggc
     1921 atctggctta gtttttggcc ttctgagaaa actggtctcc acacagaaca gtctcagctg
     1981 atcttacaga actcagtgtg agcgctgtta gtataaaccc taggaaaaca catggtcagc
     2041 cattctctca tttcttaact ttataatgct gtagctgtta tgaagaattt ttaatttcat
     2101 attgtttaca ttatacaaca atcgaagcct caaagtctcc actggggctg tcatcaaatg
     2161 tttactcacc cacctgagac agtgccagcc tgagcccagg ttaggagtgt tcttagtcac
     2221 ctaggtgttg ccccatggga cttaaggctg aaaccttcag gttggcagca ccatgaaagc
     2281 ttccttggca agagtgaacg tcagctccta ttctgacccg taaccttctc actaatactc
     2341 tctggagtga ctcaacacat gggctgaggt ggttgttggt tgttttcctt ttgttagaac
     2401 agaaacgtct ttctgtataa aagtataatt aatatggttt agatacataa gaattgatga
     2461 aggcaagtaa aatctttgta ctttttacat gattgctgta tgtatatttt gttttaaatc
     2521 taataaaatt agggacagag agtgactcgc tggggttctt ggggtccttg agaattaaat
     2581 ttgtcaaaac tgctatgaaa caggagactg gccacaggac ggtctgtagt tgcctcctga
     2641 aagggttaca tgtatttatt gtatatttgc tatgttgctt gaaaaagaaa tttgttaaag
     2701 attctttttg ataatctgta tcaagaagaa accttgtaca aagtggaatt atatgttaaa
     2761 cgttttaggg aagatagctg gcccaggaat tgttttgttt ttcttgtttt ttgtgggttt
     2821 tttgtttgtt tttctgctct agaacaactc aatttggtgg cacttaaaaa ttgattaaag
     2881 acctgggtaa ggatgaagac tgactagtta aaaggtgcgg gtggtcctta ctcgctgcat
     2941 cttcagggta ttacagttcc tcaagttctc atgagtttga ctcagaactt ctgtttttgt
     3001 cttgttgttg gtaaatgttc atttgcaaca agtttttgaa ggtggtgact ggaaaacaaa
     3061 atcacatggt tattcattcc tcattgaact tagagtcgga taattgtcta acaatttaac
     3121 accaacccac tctttctgtg tcttgttttg attttggttt ttttaaaagc tgaactcaca
     3181 gcgatctccc tgcgtcaacc tccccaaaac tgggattaga gggaatgcta ccattcccag
     3241 aacaacaagc cattttagct caacgatttg agtgttccta gtcaggacag gcctctagag
     3301 aacagagaac cttcatttat agcctgatct atttactaga aatcttgtta gtgagataag
     3361 tagtggctgc ccagatcatt aaggtaaact gctgagtgtt aaaggaggtc gtgctcttgg
     3421 tggtgcgtaa agagcacatg gaagacacag ttgtacctga gctgagtatg agtcacctga
     3481 gtcagtgctg ttcaaacatg gccagatctc agagtggctt aaaagtactg tggatgggtc
     3541 cgtatcctga tcctggtgtc agaactggga tatgttccga ccataaggat ttaaaaatgc
     3601 cctggtttca gaatgctacc aaaggttgag agcagttgtg tcgaatttga cctagaagtt
     3661 tctcacctac aaagtaggaa gttcttgccc cactcattgc ctcacgggga tgcagagggc
     3721 gcaagagaac actgggagtg gtggcggtat ggatgaacaa tggtgcagaa gtgtagcatc
     3781 tgtcacattc cagctgcagc caccgtgacc agggaaacgt gtcgttgaat ttgttgttgc
     3841 tgtaggaatc tcttacgtca tgcataagga agcatgcagg ggtggaacaa aatgttaatt
     3901 aatattactc ttattcacta tggccttctg tcctacttga gacaggcggt tatattacct
     3961 aagttttcat aggaaagaag aaatattaag gcttaattct gtaatgttca ttggctcata
     4021 attcattaaa aacttcatac aaggaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     4081 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
