LOCUS       NM_173401               1863 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus F-box protein 44 (Fbxo44), transcript variant 1, mRNA.
ACCESSION   NM_173401 XM_905686 XM_919479 XM_919485 XM_919492
VERSION     NM_173401.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1863)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1863)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 1863)
  AUTHORS   West,D.B., Engelhard,E.K., Adkisson,M., Nava,A.J., Kirov,J.V.,
            Cipollone,A., Willis,B., Rapp,J., de Jong,P.J. and Lloyd,K.C.
  TITLE     Transcriptome Analysis of Targeted Mouse Mutations Reveals the
            Topography of Local Changes in Gene Expression
  JOURNAL   PLoS Genet 12 (2), e1005691 (2016)
   PUBMED   26839965
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1863)
  AUTHORS   Sjogren,B., Swaney,S. and Neubig,R.R.
  TITLE     FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a
            Cullin 4B/DDB1 Complex
  JOURNAL   PLoS One 10 (5), e0123581 (2015)
   PUBMED   25970626
  REMARK    GeneRIF: FBXO44-mediated degradation of RGS2 protein uniquely
            depends on a Cul4B/DDB1 complex.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1863)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1863)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   7  (bases 1 to 1863)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   8  (bases 1 to 1863)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY252242.1, BY128919.1, AK077452.1, BQ042735.1 and BP761336.1.
            
            On Oct 26, 2013 this sequence version replaced NM_173401.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Both variants 1 and
            3 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077452.1, SRR1660821.25230.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                BY252242.1         2-53
            53-214              BY128919.1         1-162
            215-994             AK077452.1         1-780
            995-1030            BQ042735.1         653-688
            1031-1840           AK077452.1         817-1626
            1841-1863           BP761336.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..1863
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.67 cM"
     gene            1..1863
                     /gene="Fbxo44"
                     /gene_synonym="5730411K09; FBG3; FBX30; Fbx6a; Fbxo6a"
                     /note="F-box protein 44"
                     /db_xref="GeneID:230903"
                     /db_xref="MGI:MGI:1354744"
     exon            1..352
                     /gene="Fbxo44"
                     /gene_synonym="5730411K09; FBG3; FBX30; Fbx6a; Fbxo6a"
                     /inference="alignment:Splign:2.1.0"
     exon            353..639
                     /gene="Fbxo44"
                     /gene_synonym="5730411K09; FBG3; FBX30; Fbx6a; Fbxo6a"
                     /inference="alignment:Splign:2.1.0"
     CDS             375..1142
                     /gene="Fbxo44"
                     /gene_synonym="5730411K09; FBG3; FBX30; Fbx6a; Fbxo6a"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     only protein 6a; F-box only protein 44"
                     /codon_start=1
                     /product="F-box only protein 44 isoform 1"
                     /protein_id="NP_775577.2"
                     /db_xref="CCDS:CCDS18934.1"
                     /db_xref="GeneID:230903"
                     /db_xref="MGI:MGI:1354744"
                     /translation="MAVGNINELPENILLELFIHIPARQLLLRCRPVCSLWRDLIDLV
                     TLWKRKCLQEGFITEDWDQPVADWKIFYFLRSLQRNLLHNPCAEEGFEFWSLDVNGGD
                     EWKVEDLSKDQRKEFPNDQVKKYFVTSYYTCLKSQVVDLKAEGYWEELMDTTRPDIEV
                     KDWFAARPDCGSKYQLCVQLLSSAHAPLGTFQPDPVMIQQKSDAKWREVSHTFSNYPP
                     GVRYIWFQHGGVDTHYWAGWYGPRVTNSSITIGPPLP"
     exon            640..766
                     /gene="Fbxo44"
                     /gene_synonym="5730411K09; FBG3; FBX30; Fbx6a; Fbxo6a"
                     /inference="alignment:Splign:2.1.0"
     exon            767..862
                     /gene="Fbxo44"
                     /gene_synonym="5730411K09; FBG3; FBX30; Fbx6a; Fbxo6a"
                     /inference="alignment:Splign:2.1.0"
     exon            863..998
                     /gene="Fbxo44"
                     /gene_synonym="5730411K09; FBG3; FBX30; Fbx6a; Fbxo6a"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1844
                     /gene="Fbxo44"
                     /gene_synonym="5730411K09; FBG3; FBX30; Fbx6a; Fbxo6a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1823..1828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo44"
                     /gene_synonym="5730411K09; FBG3; FBX30; Fbx6a; Fbxo6a"
                     /note="hexamer: AATAAA"
     polyA_site      1842
                     /gene="Fbxo44"
                     /gene_synonym="5730411K09; FBG3; FBX30; Fbx6a; Fbxo6a"
                     /note="major polyA site"
ORIGIN      
        1 agtgggcggg tcgcaccccg ggcctccatt ggtccgtaag gctcatcccc aggatccaag
       61 ggtatggcgc agcgcgacca aaagtagttg acaaggagaa tggggaggga gaggggccag
      121 tgttgtggga tggggatggg gcggggtctg atgagtagta ggcggggctg tgtcttgggt
      181 gctgttctcc aacgtaaccc ggctaagagc aggtgacaga aggaggggag cagtgagcgc
      241 cccagcaagg agacgtttgg cgggcagtag gcaggtctgc cttccgggcc acgcaggctc
      301 gggctgtaca gccccacggc ctggcaggat cgctcagcgc gacggatcgc aggagctggc
      361 taggagacgc caccatggca gtaggcaaca tcaacgagct gccagagaac atcctgctgg
      421 aactgttcat ccacatccca gctcgccaac tgctgctgcg ctgccgaccg gtctgcagcc
      481 tctggcgaga cctcattgac ctggttacac tctggaagcg caagtgcctt caagagggct
      541 tcatcaccga ggactgggac cagcctgtgg ctgactggaa gatcttctac ttcctgcgca
      601 gcctccagag gaacctcctt cacaaccctt gtgctgaaga gggatttgag ttctggagcc
      661 tggacgtgaa cggaggcgat gaatggaagg tagaggatct ctctaaagac cagcgaaagg
      721 aattccccaa tgaccaggtc aagaaatact tcgtgacttc ctattacacc tgcctcaagt
      781 cccaggtggt ggacctcaag gctgaagggt attgggagga gctgatggac accacccggc
      841 cggacatcga ggtcaaggac tggtttgcag ccaggccaga ctgcgggtcc aagtaccagc
      901 tgtgcgtcca actcctgtcg tcagcccacg caccactggg aaccttccag ccggacccgg
      961 tgatgattca gcagaaaagc gatgccaagt ggagggaggt ttcacacaca ttctccaact
     1021 atcctcccgg cgtccgctac atctggtttc agcacggagg cgtggacact cactactggg
     1081 ccggctggta cggcccgaga gtcacaaaca gcagcatcac catcgggccc ccgctgccct
     1141 gatgcctcct gagccccagt cctcagagcc ctaattagta aacagtcaga aagggccagg
     1201 cttgggaagg ggaggtggaa actcccagac ctcattgtta gcctttgccc ccagctgcct
     1261 gtgtgtggag tttctaatgt ctgggccacc ctcctctcta gctctccagc aaagctgccc
     1321 ctctaagggt gcagtgcctg aggataggca gatacaacag gtctccatac ttctcatgct
     1381 tgcctagacc tgtttctacc cctgacctct ctccttgttc tcctcaaggg ccctggagag
     1441 cagggacaga caacatatct gacaggcttg gggactgcct ttaatgatgt cataaggcag
     1501 atctaggata gaaggctctg ctggccagtc cttagcctgg tggtcagctg ctgtacgctc
     1561 tctgctttgg ctttaaagtc aggcctggta ccagataggc aggatcagac tatctttgtc
     1621 atcctaccaa tgagtgcagg actccccaga agactccgga tgagaggcca gatgaggggt
     1681 aggatggacc agggttttga gtggaaggac ctggccaagt cctctgtggc ttgaagatgc
     1741 cccagcccca tcggtgggag cgtcaattca cacactaccc ccttgaccct agcaccactc
     1801 catccctcct gttacatagc caaataaaat gtttccagcc tctgaaaaaa aaaaaaaaaa
     1861 aaa
//
