LOCUS       NM_001081253            4012 bp    mRNA    linear   ROD 03-AUG-2024
DEFINITION  Mus musculus F-box protein 43 (Fbxo43), transcript variant 2, mRNA.
ACCESSION   NM_001081253 XM_619315
VERSION     NM_001081253.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4012)
  AUTHORS   Wang,X., Zhang,Y., Yu,J., Ma,Y., Xu,Y., Shi,J., Qi,Z. and Liu,X.
  TITLE     Identification and analysis of key circRNAs in the mouse embryonic
            ovary provides insight into primordial follicle development
  JOURNAL   BMC Genomics 25 (1), 139 (2024)
   PUBMED   38310234
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4012)
  AUTHORS   Wang,W., Wang,W., Xu,Y., Shi,J., Fu,J., Chen,B., Mu,J., Zhang,Z.,
            Zhao,L., Lin,J., Du,J., Li,Q., He,L., Jin,L., Sun,X., Wang,L. and
            Sang,Q.
  TITLE     FBXO43 variants in patients with female infertility characterized
            by early embryonic arrest
  JOURNAL   Hum Reprod 36 (8), 2392-2402 (2021)
   PUBMED   34052850
  REMARK    GeneRIF: FBXO43 variants in patients with female infertility
            characterized by early embryonic arrest.
REFERENCE   3  (bases 1 to 4012)
  AUTHORS   Guan,Y., Leu,N.A., Ma,J., Chmatal,L., Ruthel,G., Bloom,J.C.,
            Lampson,M.A., Schimenti,J.C., Luo,M. and Wang,P.J.
  TITLE     SKP1 drives the prophase I to metaphase I transition during male
            meiosis
  JOURNAL   Sci Adv 6 (13), eaaz2129 (2020)
   PUBMED   32232159
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4012)
  AUTHORS   Xia,X., Zhou,X., Quan,Y., Hu,Y., Xing,F., Li,Z., Xu,B., Xu,C. and
            Zhang,A.
  TITLE     Germline deletion of Cdyl causes teratozoospermia and progressive
            infertility in male mice
  JOURNAL   Cell Death Dis 10 (3), 229 (2019)
   PUBMED   30850578
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4012)
  AUTHORS   Gopinathan,L., Szmyd,R., Low,D., Diril,M.K., Chang,H.Y.,
            Coppola,V., Liu,K., Tessarollo,L., Guccione,E., van Pelt,A.M.M. and
            Kaldis,P.
  TITLE     Emi2 Is Essential for Mouse Spermatogenesis
  JOURNAL   Cell Rep 20 (3), 697-708 (2017)
   PUBMED   28723571
  REMARK    GeneRIF: besides regulating cell-cycle arrest in mouse eggs, Emi2
            is essential for meiosis I progression in spermatocytes. In the
            absence of Emi2, spermatocytes arrest in early diplotene of
            prophase I.
REFERENCE   6  (bases 1 to 4012)
  AUTHORS   Suzuki,T., Suzuki,E., Yoshida,N., Kubo,A., Li,H., Okuda,E.,
            Amanai,M. and Perry,A.C.
  TITLE     Mouse Emi2 as a distinctive regulatory hub in second meiotic
            metaphase
  JOURNAL   Development 137 (19), 3281-3291 (2010)
   PUBMED   20724447
  REMARK    GeneRIF: separable N- and C-terminal domains of mouse Emi2
            modulated metaphase establishment and maintenance, respectively,
            through indirect and direct mechanisms.
REFERENCE   7  (bases 1 to 4012)
  AUTHORS   Tang,W., Wu,J.Q., Guo,Y., Hansen,D.V., Perry,J.A., Freel,C.D.,
            Nutt,L., Jackson,P.K. and Kornbluth,S.
  TITLE     Cdc2 and Mos regulate Emi2 stability to promote the meiosis
            I-meiosis II transition
  JOURNAL   Mol Biol Cell 19 (8), 3536-3543 (2008)
   PUBMED   18550795
  REMARK    GeneRIF: Cdc2 and Mos regulate Emi2 stability to promote the
            meiosis I-meiosis II transition
REFERENCE   8  (bases 1 to 4012)
  AUTHORS   Madgwick,S., Hansen,D.V., Levasseur,M., Jackson,P.K. and Jones,K.T.
  TITLE     Mouse Emi2 is required to enter meiosis II by reestablishing cyclin
            B1 during interkinesis
  JOURNAL   J Cell Biol 174 (6), 791-801 (2006)
   PUBMED   16966421
REFERENCE   9  (bases 1 to 4012)
  AUTHORS   Shoji,S., Yoshida,N., Amanai,M., Ohgishi,M., Fukui,T., Fujimoto,S.,
            Nakano,Y., Kajikawa,E. and Perry,A.C.
  TITLE     Mammalian Emi2 mediates cytostatic arrest and transduces the signal
            for meiotic exit via Cdc20
  JOURNAL   EMBO J 25 (4), 834-845 (2006)
   PUBMED   16456547
REFERENCE   10 (bases 1 to 4012)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121577.3.
            
            On Feb 14, 2019 this sequence version replaced NM_001081253.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098484.1, AK030012.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-392               AC121577.3         95624-96015
            393-1875            AC121577.3         97316-98798
            1876-1978           AC121577.3         102448-102550
            1979-2179           AC121577.3         108300-108500
            2180-4012           AC121577.3         108593-110425
FEATURES             Location/Qualifiers
     source          1..4012
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 14.46 cM"
     gene            1..4012
                     /gene="Fbxo43"
                     /gene_synonym="4930533G20Rik; Emi2"
                     /note="F-box protein 43"
                     /db_xref="GeneID:78803"
                     /db_xref="MGI:MGI:1926053"
     exon            1..392
                     /gene="Fbxo43"
                     /gene_synonym="4930533G20Rik; Emi2"
                     /inference="alignment:Splign:2.1.0"
     exon            393..1875
                     /gene="Fbxo43"
                     /gene_synonym="4930533G20Rik; Emi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..1978
                     /gene="Fbxo43"
                     /gene_synonym="4930533G20Rik; Emi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2179
                     /gene="Fbxo43"
                     /gene_synonym="4930533G20Rik; Emi2"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..4012
                     /gene="Fbxo43"
                     /gene_synonym="4930533G20Rik; Emi2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2649..2654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo43"
                     /gene_synonym="4930533G20Rik; Emi2"
                     /note="hexamer: AATAAA"
     polyA_site      2672
                     /gene="Fbxo43"
                     /gene_synonym="4930533G20Rik; Emi2"
                     /note="major polyA site"
     regulatory      2848..2853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo43"
                     /gene_synonym="4930533G20Rik; Emi2"
                     /note="hexamer: AATAAA"
     polyA_site      2871
                     /gene="Fbxo43"
                     /gene_synonym="4930533G20Rik; Emi2"
     regulatory      2950..2955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo43"
                     /gene_synonym="4930533G20Rik; Emi2"
                     /note="hexamer: AATAAA"
     polyA_site      2970
                     /gene="Fbxo43"
                     /gene_synonym="4930533G20Rik; Emi2"
ORIGIN      
        1 agtcccgccc gcagcagacg gctcggcagc tccggtgggg gggcatctct ggtctctagt
       61 cgggagattc ccccaggtcc aagactggct ggagagaggc cggagagtgc ggctgctgcg
      121 gggcggagag attccgagcg acttgacctt cccagccgct gcccctcctg aagccgtccc
      181 ggcgctgctc cgggctccgt taattgttga ggtttttctc ttaagtggtg gtacctcggc
      241 atgaacttta aaggcaaaga tgacagactt tgttgtttgg aagcctacct tactttgaca
      301 tgtcttaaga actcaaggtt gactggtggt aagatattcc actttaatga gagcatcggt
      361 ttaacgaagc agttttctga cttgtatagg gcttgcttgg ctgcacatca caaaggaaga
      421 ataaacttgt atctacttgg taaaaacaga gagcttgaag atatcccaaa ggcactcagc
      481 cagccacaga gcaggaagca atatggactc ctctgctgtc actgtcaagg gtctcagcct
      541 catagacttt tgttccacat cctcctttaa atataggggc catcacgagc tgtcagaatc
      601 ttgcagcctt aataagaaag aagaagagcc tatgctaacc tgtgagcatc ctgaaactcc
      661 aagtttaggt tcccccaatt ctgcagtatc tcccagtcaa ataatgaagt ctgtgtccct
      721 aaggaaggaa aaggataaaa gcccagaact ttgtgagact cctaaactca gaaggaaaaa
      781 atgcacatta cgcaggcggc tagacttttc tttccctctt ctgaaggggg attctgattc
      841 acaaagcaga tctctggaaa gtaacataag ccaaggtgtt agcctagaaa aacatttgcc
      901 aggtagcact tcaggtttcc caaaggaaga caactttagc ccattagtta ccagcacgat
      961 aaaaacagag gatgtggttt ccaacagtca gaactcaagg ttacattttt ctcagcacaa
     1021 gacttccacc attgaagatt ccaaagacaa ctgtggcttg tttgaagtgg aatgtctgtc
     1081 tccaattgaa ggcaatgatt ttaaagattc tatcacacac tttagtgaca gcagtttaag
     1141 tgttagtgat gagaatacat gtcctgaact tctgggctcc tgtggtagcc aaacaaccta
     1201 tggagcagat gtgactacat ctgtaactcc agtaagtagt ctcatagcaa aaatcaaatt
     1261 taatggaaac caaactcttg attcttcagg agaggtgaga gacagtcttt ttacacctga
     1321 agacagtggc ttttgctcac ttagctggga caaatcagaa gatttcctct ctgaccaaga
     1381 gggctctttt caagaactgc ttcaaaaaca cagggtgact cccaaagttg gggaccaggt
     1441 aaaaaagcca aagcattttg ggaggttgag aagactgtcc actctccagg agcaaggctc
     1501 ccagtcagag gatgaaatgc agacggtcca tcctaactct gattcaggtg tcttggagag
     1561 tctgcaaggc tctgaggaga agcgtgggaa cttggcttta agctttaagg acttatcaaa
     1621 tactccagcc ctgcagttgg tgcaggagct ctttatgaaa agcaaaagga aacgatctca
     1681 gcaggaagat gaccaggaat tctttgagga cagggacgag gggaaaattg ccagactgca
     1741 gcgtgttctc gcaggactga ttggcaagaa gatgggcata gaacagctgg atatcctgac
     1801 cgaattacag tatagaaact tgaagcacat cctagctatg gttttagagt ccttgacttc
     1861 ggagagttta tacagtgctt ggaacgtcag cagaaactgg cgtgaaattg tggctcagga
     1921 taaaaaggca aacaggagga ggaaacttta tatcatacag ctgagagcaa gtgctcaggg
     1981 ggccgctgtg ttacgtgttc aggatgctgc cactcggctc tgccttctga gtcgcttggc
     2041 cttaagatca gtgcaggcac aggcacaggc acccagtggt gagcaggttc caactctgtc
     2101 cccttggggg gatgttctga cacctgtagc aagctcttcc ctcacccacc tacggagtaa
     2161 acaggaacag tatgtgaagg ttgccaggac actgtttact gatgaagctt taaagccttg
     2221 cccgaggtgc caatcccctg ctaagtacca gccgcacaag aaaagggggc tatgcagccg
     2281 cctggcctgc ggctttgact tctgtgtgtt atgtctgtgc gcttatcacg ggtctgaaga
     2341 ctgtagaaga gggtcagcaa aggcgagagg tagcaaagat gttctcccag ggagtgccca
     2401 aagcaagcgg aacttaaaac gcctctgaag agactaagga accactcgcg ctggcccatg
     2461 ttctgtctga cttaaaatta tgactatttt gaacacatgc aaatcttccc attgatgaca
     2521 gacgttgatt tacttcccac tttgtttgtt ataatgcaca ccattgtata ttttctttaa
     2581 agtgatgaat tttgaaagaa ttttatttta ctatgtcata tccccatttt aaatattttg
     2641 atgttttaaa taaagaattt tcagggttgt tatatatgtg tgttttattg ctccatgtaa
     2701 ccttttaaat ttgtgcattt cataacaatg tgttgaaatg ttcttcaatt atttaaaaaa
     2761 taatttccaa ataatttgaa taatttgaat ttgaggtcag tgaactttca ggtttagaaa
     2821 atgagttgat ggctgaaatt aaatataaat aaaatgtttt taaaagttcc atcaaatgta
     2881 atctataatt tcaaccttcc tcttacttga tattttagta gactttttgt ttagtaaaat
     2941 ttacatacta ataaatgtca gttacggtga ctgtgtagtt acttataatg ggaattttat
     3001 ttaataaact cctataagtc acacattttt tttttttttt cgagacaggg tttctctgtt
     3061 tagctctggc tgtcctggaa ctcactttgt agaccaggct ggcctcaaac tcagaaatcc
     3121 gcttgcctct gcctcccaag tgctgggatt aaaggcgtgt gccaccacgc ccggcaagtc
     3181 acacatttct aattaagtac tttaaaaatc tggaattata gtaacagatt ctgatatttt
     3241 aaaagatttg ggctgggcag aaatgatggg ttttgaatgg gaaaaatatg aagttattaa
     3301 taatggccat tataatttgt atgtgtttgt aatgtgcctt tttccaagag ggatttggga
     3361 atgagtgagc tctgttatag atcagtggca aaaagagcta agtttttttt attgctgaaa
     3421 aaagtgtaag agaggactct tgttttgctt ttgggttttt tgttttgttt ttgtcatcat
     3481 ttcgtcattg ttgttactgt tgttttgttt tgaagacagg gtctcactat gtagctctag
     3541 gtctcctgaa gtcactatgt ataccaggct ggccttgaac acacagaagt ccacctgcct
     3601 cctgagctgg ggtcagagtc ctgcaccact acatcaggcc tcaagaagga aacttctaaa
     3661 tgatgattta tttattttta tcttatgcat attggtgttt tgtctgcatt tatgtgtggg
     3721 tattagatcc tttggagctg gagttagaga cagttgtgaa ctgtcatgtg gatgctggga
     3781 actgaacccg agtttttcag accaacagcc agtgctctta accactgagc catctctcca
     3841 gacccatacg agggaaactg acaacacact tgtattttgt atatgtaggt gattgctgta
     3901 tatatgtgtt tttatactat acacacatat ttcaatgtag ctctgaacac attattttaa
     3961 gaaagtggtt aaaattaaaa ctaataatta aatttaaaat ttacatattt tc
//
