LOCUS       NM_001358217            5136 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus F-box protein 40 (Fbxo40), transcript variant 1, mRNA.
ACCESSION   NM_001358217 XM_006521881
VERSION     NM_001358217.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5136)
  AUTHORS   You,L., Yan,K., Zou,J., Zhao,H., Bertos,N.R., Park,M., Wang,E. and
            Yang,X.J.
  TITLE     The chromatin regulator Brpf1 regulates embryo development and cell
            proliferation
  JOURNAL   J Biol Chem 290 (18), 11349-11364 (2015)
   PUBMED   25773539
REFERENCE   2  (bases 1 to 5136)
  AUTHORS   Shi,J., Luo,L., Eash,J., Ibebunjo,C. and Glass,D.J.
  TITLE     The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal
            muscle, limiting IGF1 signaling
  JOURNAL   Dev Cell 21 (5), 835-847 (2011)
   PUBMED   22033112
  REMARK    GeneRIF: The Fbxo40 is muscle specific in expression and is
            upregulated during differentiation.
REFERENCE   3  (bases 1 to 5136)
  AUTHORS   Ye,J., Zhang,Y., Xu,J., Zhang,Q. and Zhu,D.
  TITLE     FBXO40, a gene encoding a novel muscle-specific F-box protein, is
            upregulated in denervation-related muscle atrophy
  JOURNAL   Gene 404 (1-2), 53-60 (2007)
   PUBMED   17928169
  REMARK    GeneRIF: FBXO40 may function as a regulator involved in the
            postnatal myogenesis.
REFERENCE   4  (bases 1 to 5136)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154763.2.
            
            On Nov 23, 2017 this sequence version replaced XM_006521881.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036684.1, AK036385.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-364               AC154763.2         123846-124209       c
            365-394             AC154763.2         112491-112520       c
            395-2311            AC154763.2         102569-104485       c
            2312-5136           AC154763.2         97203-100027        c
FEATURES             Location/Qualifiers
     source          1..5136
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 26.32 cM"
     gene            1..5136
                     /gene="Fbxo40"
                     /gene_synonym="9830003A13Rik; mKIAA1195"
                     /note="F-box protein 40"
                     /db_xref="GeneID:207215"
                     /db_xref="MGI:MGI:2443753"
     exon            1..364
                     /gene="Fbxo40"
                     /gene_synonym="9830003A13Rik; mKIAA1195"
                     /inference="alignment:Splign:2.1.0"
     exon            365..394
                     /gene="Fbxo40"
                     /gene_synonym="9830003A13Rik; mKIAA1195"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..2524
                     /gene="Fbxo40"
                     /gene_synonym="9830003A13Rik; mKIAA1195"
                     /codon_start=1
                     /product="F-box only protein 40"
                     /protein_id="NP_001345146.1"
                     /db_xref="CCDS:CCDS37337.1"
                     /db_xref="GeneID:207215"
                     /db_xref="MGI:MGI:2443753"
                     /translation="MGRARKPPPALHRHCEGCFNRHCHVPVEPSVSCLVISCHLLCGA
                     TFHMCKESEHTLLCPLEQVPCLNSEYGCPLSMARHKLAKHLQVCPASVVCCSMEWIRW
                     PNVDSETFLHENIMKETPSEECLDTALALQDQKVLFRSLKMVELFPETRDATEEEPDM
                     NGDTSWEETGGAVGGVDARLAPNSCLPATSRQMMELSQEERDALAKTKEGMDLDKFGK
                     WESMFSKEHAASVLTGSLGKSEDKNGDVAGKEQCSSNVRIGDAEGSAERRGPQESQKS
                     QELPATMEMTGLAPWQDGVLERLKTAVDAKDYNMYLVHNGRMLIHFGQMPACTPKERD
                     FVYGNLEAQEVKTVYTFKIPVSYCGKRARLGDAMLKCRPSEHKAVDTSDLGISVEDLP
                     KSDLIKTTLQCALERELKGHVISESRSIDGLFMDLATQTYNFEPEQFSSETVLADLLG
                     TAQPGGLHVELHSECVTRRHNKSSSAFTFTCNKFFRRDEFPLHFKNVHTDIQSSLDGW
                     FQHRCPLAYLGCTFVQNHFRPPGQKAKVIYSQELKTFAIKPEVAPELSEKWKSDHLSG
                     RDGKSLNSLTSLPLEVLQYIAGFLDSISLSQLSQVSVLMRNICATLLQERGMVLSQWK
                     KKRYSHGGTSWKVHNQIWQFSSLFSKINSWEFNDVTSMSEHLKTCPFNIVERKTDPIR
                     LTSMCQPQEKARESLVSTFRARPRGRHF"
     exon            395..2311
                     /gene="Fbxo40"
                     /gene_synonym="9830003A13Rik; mKIAA1195"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..5136
                     /gene="Fbxo40"
                     /gene_synonym="9830003A13Rik; mKIAA1195"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5114..5119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo40"
                     /gene_synonym="9830003A13Rik; mKIAA1195"
                     /note="hexamer: AATAAA"
     polyA_site      5134
                     /gene="Fbxo40"
                     /gene_synonym="9830003A13Rik; mKIAA1195"
                     /note="major polyA site"
ORIGIN      
        1 tgacccttct tgcaaaggct ttcctccctc ctctgtgaaa caaagtccgg ggttgctcta
       61 agcgctactt tcccatgggc tctcctctgc ccctccagca cttagacatt gagtgttgat
      121 aacctacaga gacgaaagag gtcgtaagct gagcccggtc acattgccct gtgatatagt
      181 tttattttta actttgaaac gcttgaacta tgtcagttgg cgttttctcc ctttcgcttg
      241 cctttccaac agaacttggg tgctctgctg cagcggaagc accggcaccc acctcctcca
      301 gacctgcttg atcaacggca aagggctggt agctgcggat gctgagccag cttgtaccgt
      361 ttagagttaa gaagccagaa gcagggaagc catgggtcgg gcacgcaagc ctccacctgc
      421 gctgcacagg cactgtgagg gatgcttcaa ccgccactgc cacgttccgg tggagcccag
      481 cgtctcctgc ctggtgataa gctgccacct gctctgtggc gccaccttcc acatgtgcaa
      541 agagtcagag catacactcc tctgccctct ggagcaggtt ccctgcctca actctgagta
      601 tggctgcccg ctctccatgg cacgccacaa gctggctaag cacctgcagg tatgccccgc
      661 cagcgtggtc tgctgctcca tggaatggat ccgctggcca aacgtggact cagaaacatt
      721 ccttcacgag aacatcatga aagagacccc cagtgaggag tgtttggaca cagccctggc
      781 cctccaggac cagaaggtac tcttcagatc cttgaaaatg gtagagcttt tcccagaaac
      841 cagagacgcc acggaggagg aaccagacat gaatggtgac accagttggg aggagactgg
      901 gggcgcagtg gggggagtgg atgccaggct agcaccaaat tcttgtttgc cggcaaccag
      961 taggcaaatg atggagctca gtcaggagga acgagatgca ctggcaaaaa ccaaagaagg
     1021 gatggacctg gacaagtttg gcaagtggga aagtatgttc agcaaggagc acgcagcctc
     1081 tgttttaaca ggttccttgg ggaagagtga agacaagaat ggggatgtgg ctgggaaaga
     1141 gcagtgctcc agtaatgttc gcatagggga tgcagagggt tctgccgaaa ggagaggacc
     1201 acaggaaagc cagaagtccc aggaacttcc cgctaccatg gagatgacag ggcttgctcc
     1261 ctggcaagat ggtgttctgg aaagactaaa aacagccgtg gatgccaaag actataacat
     1321 gtatctggtg cacaacgggc ggatgctcat ccactttggg cagatgcctg cttgtacgcc
     1381 caaggagagg gactttgttt atggcaacct agaggctcaa gaagtgaaaa cggtttatac
     1441 cttcaagatt cccgtgagct actgcgggaa gcgagctcgc ttgggagatg ccatgttgaa
     1501 atgcagacca agtgaacaca aggctgtgga cacttctgat ctgggcatct ctgtggagga
     1561 cctgcccaaa tctgatctca tcaagaccac cctccagtgt gctttggaaa gagaactcaa
     1621 aggccatgtc atctctgaat ccaggagcat cgatggactc tttatggacc ttgccaccca
     1681 aacatacaac tttgagccag aacagttttc ctcagagaca gtgttggctg atctcctagg
     1741 cactgcccaa cccgggggcc tgcacgtgga gctccacagc gagtgtgtga ctagaagaca
     1801 caacaaaagc agctcagctt ttacgttcac ctgcaacaaa ttcttccgaa gggatgaatt
     1861 tcccctgcac ttcaagaatg tccacactga catccagtcg agtctcgatg gctggttcca
     1921 gcatcgatgc cccctagcct acttgggatg tacatttgtt cagaaccact tccgcccccc
     1981 tggacaaaaa gcaaaagtga tctatagcca ggagctgaag acctttgcca tcaaaccaga
     2041 ggttgctccg gagctgagtg agaaatggaa gagcgaccat ctctctggcc gtgatgggaa
     2101 aagcctgaat tctctaacca gcctgcccct ggaggtgttg caatacattg ctgggtttct
     2161 ggacagcatc agcctgtccc agctgtccca ggtgtcagta ctgatgagga acatctgtgc
     2221 cactttgttg caagagagag ggatggtcct ctcgcaatgg aagaagaaga ggtattctca
     2281 cggaggcacc tcctggaaag tccacaatca gatctggcag ttcagcagcc tcttctcaaa
     2341 aatcaacagc tgggagttta atgacgtcac ctccatgtct gagcacctga aaacctgtcc
     2401 tttcaacatc gtggagcgga agactgaccc gattcgtttg accagcatgt gccagcccca
     2461 agagaaggcc cgggagagct tagtgtccac ctttagggcc cgaccacggg gcagacactt
     2521 ttgaagatat gcacaccact gctcctggct tctcagagta ctcaaagtag gacagtgtgc
     2581 tttgaggaac cactctgaaa cctgcacatc tagaagactt gtggagtcct tcaggcctta
     2641 gcaactacac tagaacacta aggatatttg tttgtttgtt tatttgtttt gtttgagcta
     2701 tggcttatat gaaagcgcca cctttttttg cctttatctt acttctttcc tctcctaaaa
     2761 tagataagtc taggagaaaa ttaatagctt aaggccgttt gataaacgca cccaagttct
     2821 tggttgactg gagagcaaga aaagtctgta accagcatag actggtgctt ctacattgag
     2881 ctgtccagtt tacaaaccac cttcaagttc ttgaggcagg tgacccaggg acagggtctg
     2941 gggtttagtg actacccagg gtatccaggt gaagggagtt caactggaag gttctgaagc
     3001 ttgcttggtc tcgacaactc agggcttttt agtcacccta ctgcatcaaa gcccagatgg
     3061 tttcaaggtg acccaagaga atggaccaca cagcgtaagc acagcagttt cacagacaca
     3121 agccaaagca aaacagtgtg ttgcatatag tcttggcaac accaagagaa aaacaacaac
     3181 tctttacaat gagggaaaga ccaaaaatct ctggaagcaa agtagcagct cctggttgag
     3241 agccactgtc ctaaaggatg ctaccccagc catggtaagt taggaggtgc tcactgttta
     3301 ctgtgacaaa tctgacctta catggccagc ataattcaac gcaactctta ctcgtttact
     3361 aaataagttt taaacatggg acgatgctaa attgagaacc agatggggct gatctaccca
     3421 atatggcttt gggtccttgg gccacatgaa gtaatacatc ttccctgccc tttttaggga
     3481 aactggaaac caggaaagtc attcatctca ggttaagttc ctcctccctt aattggtgcc
     3541 attttccagc aaccctagat gttctcaagc taataataat cataatcata aagaaaaagg
     3601 gaaggcaggc atcacaggga aacagccaag aatccaaata atgaaggact cttgccaatc
     3661 tgtgagctcg ttgtctgggc atctgtctgt ctgaccatag ttcagagctg gtgcagatga
     3721 agaggctggt gcagatgaag aggcttgtgc agatgaagct gctgcctttg caaaggcagc
     3781 agagcaagcc cattctgaga gcgtattcac tctctgctgc attcctcacg tttgttaaca
     3841 caatgctatt atttattcct aatctttaca gtttggtttg gatttcacaa ccactttttt
     3901 ggtgcaagtc atgggttttt ttagaagtgt atctagagtg ttctctaaaa ctttgctccg
     3961 tgaggttgag taactgaaag cagctaaaca atgaggttgg cgagaggaaa gcgagctctt
     4021 tgggtctcga ctctgtgcgt tgggaatctg gttcttccca cacagtggaa tgtggttctc
     4081 ccagcctctc ggggtctatt agagagagag agagagaact atagaccatg gaaacgaacc
     4141 ctggactcaa ttacatgagc caggcgcagc agagaggcag ggaggccaca gggctctgcc
     4201 accttaagct gtactaccct tttctagaca tgggatccag gtgtcctggt atcagagatc
     4261 cttgccctcc taaagccact agacactctt agcccacttg gatctgttct ttggtgttag
     4321 tcttttgcag agaggggcag ggaaccttcc cttcctactt ccaatcctct aatctgtggt
     4381 tcttcctaga gaatcaccac ctgccaggga gtcagagagg tggctcagtt agccaactac
     4441 ttgcctagca agcaggtggg cctaatttgg atctcctgaa cccatgtaaa atggcagatg
     4501 tggcagcttt tgctgataat ctcagtgctg tggaggcaga gacaggagga tccctgagca
     4561 gaaaagccct actgatgagc tccaggtcaa acacaaatcc tgtttaacaa gaggcagatt
     4621 atattcctaa ggactgacag ctaacattgc tctctagcca acacacacac acatcaagta
     4681 tataaaaagt ctggttttcc caggcaggaa gctaacctca tacaactact aaagccagca
     4741 gaggctgaac tgccttaatc tggatgtcac ccaaccctgc tattccacat ttctgccatt
     4801 cccaggtacg ctgcttggtt ttatcaactt gacacaaacc tagacctatc tgggaagaag
     4861 gaatcttagt tgagaaaatg cgtcctaaaa tgccccgtag gcaattctgt aaggcatttt
     4921 taaaattagt ggttgatgtg gagaagctgg cctgctgtgg gtggtaacca tccctgggtg
     4981 agtggttctg gatataagaa agaaggctga gcaagccagt aaccaacact cttccctggc
     5041 tcctgcttca gtttctgcct ctaggttctt gctctgaatc cctgccctgg cttcccttgg
     5101 tgatggagtg tgaaataaac cctttcctct ccgagc
//
