LOCUS       NM_134136               4518 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus F-box protein 38 (Fbxo38), transcript variant 5, mRNA.
ACCESSION   NM_134136
VERSION     NM_134136.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4518)
  AUTHORS   Dibus,N., Salyova,E., Kolarova,K., Abdirov,A., Pagano,M.,
            Stepanek,O. and Cermak,L.
  TITLE     FBXO38 is dispensable for PD-1 regulation
  JOURNAL   EMBO Rep 25 (10), 4206-4225 (2024)
   PUBMED   39266770
  REMARK    GeneRIF: FBXO38 is dispensable for PD-1 regulation.
REFERENCE   2  (bases 1 to 4518)
  AUTHORS   Tian,T., Xie,X., Yi,W., Zhou,Y., Xu,Y., Wang,Z., Zhang,J., Lin,M.,
            Zhang,R., Lv,Z., Li,X., Lv,L. and Xu,Y.
  TITLE     FBXO38 mediates FGL1 ubiquitination and degradation to enhance
            cancer immunity and suppress inflammation
  JOURNAL   Cell Rep 42 (11), 113362 (2023)
   PUBMED   37938970
  REMARK    GeneRIF: FBXO38 mediates FGL1 ubiquitination and degradation to
            enhance cancer immunity and suppress inflammation.
REFERENCE   3  (bases 1 to 4518)
  AUTHORS   Dibus,N., Zobalova,E., Monleon,M.A.M., Korinek,V., Filipp,D.,
            Petrusova,J., Sedlacek,R., Kasparek,P. and Cermak,L.
  TITLE     FBXO38 Ubiquitin Ligase Controls Sertoli Cell Maturation
  JOURNAL   Front Cell Dev Biol 10, 914053 (2022)
   PUBMED   35769260
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4518)
  AUTHORS   Meng,X., Liu,X., Guo,X., Jiang,S., Chen,T., Hu,Z., Liu,H., Bai,Y.,
            Xue,M., Hu,R., Sun,S.C., Liu,X., Zhou,P., Huang,X., Wei,L., Yang,W.
            and Xu,C.
  TITLE     FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour
            immunity of T cells
  JOURNAL   Nature 564 (7734), 130-135 (2018)
   PUBMED   30487606
  REMARK    GeneRIF: data indicate that FBXO38 regulates PD-1 expression and
            highlight an alternative method to block the PD-1 pathway
REFERENCE   5  (bases 1 to 4518)
  AUTHORS   Sumner,C.J., d'Ydewalle,C., Wooley,J., Fawcett,K.A., Hernandez,D.,
            Gardiner,A.R., Kalmar,B., Baloh,R.H., Gonzalez,M., Zuchner,S.,
            Stanescu,H.C., Kleta,R., Mankodi,A., Cornblath,D.R., Boylan,K.B.,
            Reilly,M.M., Greensmith,L., Singleton,A.B., Harms,M.B., Rossor,A.M.
            and Houlden,H.
  TITLE     A dominant mutation in FBXO38 causes distal spinal muscular atrophy
            with calf predominance
  JOURNAL   Am J Hum Genet 93 (5), 976-983 (2013)
   PUBMED   24207122
REFERENCE   6  (bases 1 to 4518)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   7  (bases 1 to 4518)
  AUTHORS   Smaldone,S. and Ramirez,F.
  TITLE     Multiple pathways regulate intracellular shuttling of MoKA, a
            co-activator of transcription factor KLF7
  JOURNAL   Nucleic Acids Res 34 (18), 5060-5068 (2006)
   PUBMED   16990251
REFERENCE   8  (bases 1 to 4518)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   9  (bases 1 to 4518)
  AUTHORS   Smaldone,S., Laub,F., Else,C., Dragomir,C. and Ramirez,F.
  TITLE     Identification of MoKA, a novel F-box protein that modulates
            Kruppel-like transcription factor 7 activity
  JOURNAL   Mol Cell Biol 24 (3), 1058-1069 (2004)
   PUBMED   14729953
  REMARK    GeneRIF: MoKA and KLF7 interact functionally to regulate gene
            expression during cell differentiation
REFERENCE   10 (bases 1 to 4518)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165083.2 and AC131714.4.
            
            On Mar 1, 2018 this sequence version replaced NM_134136.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056348.1, AK031347.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-252               AC165083.2         173452-173703       c
            253-418             AC165083.2         165721-165886       c
            419-552             AC165083.2         160956-161089       c
            553-716             AC165083.2         158741-158904       c
            717-882             AC165083.2         158349-158514       c
            883-1020            AC165083.2         155529-155666       c
            1021-1158           AC165083.2         154392-154529       c
            1159-1252           AC165083.2         152017-152110       c
            1253-1383           AC165083.2         150972-151102       c
            1384-1554           AC165083.2         147190-147360       c
            1555-1697           AC165083.2         145523-145665       c
            1698-1911           AC165083.2         144594-144807       c
            1912-2031           AC165083.2         143332-143451       c
            2032-2211           AC165083.2         141804-141983       c
            2212-2961           AC165083.2         139635-140384       c
            2962-3062           AC165083.2         135854-135954       c
            3063-3165           AC165083.2         135550-135652       c
            3166-3332           AC131714.4         354-520
            3333-3478           AC131714.4         1605-1750
            3479-3582           AC131714.4         2313-2416
            3583-3696           AC131714.4         2766-2879
            3697-4518           AC131714.4         3474-4295
FEATURES             Location/Qualifiers
     source          1..4518
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 35.11 cM"
     gene            1..4518
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /note="F-box protein 38"
                     /db_xref="GeneID:107035"
                     /db_xref="MGI:MGI:2444639"
     exon            1..252
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            253..418
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..3875
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /note="isoform 4 is encoded by transcript variant 5; F-box
                     only protein 38; F-box protein modulating KLF7 activity;
                     modulator of KLF7 activity"
                     /codon_start=1
                     /product="F-box only protein 38 isoform 4"
                     /protein_id="NP_598897.2"
                     /db_xref="CCDS:CCDS37841.1"
                     /db_xref="GeneID:107035"
                     /db_xref="MGI:MGI:2444639"
                     /translation="MGPRKKSAKVCVMDSEVAEEMTADEEKDYMNQLSHEVLCHIFRY
                     LPLQDIMCMECLSRKLKEAVTLYLRVVRVVDLCAGRWWEYMPSGFTDSSFLTLLKKMP
                     DVEQLYGLHPRYLERRRVRGQEAFSIPGVLEALQACPNLVGVETSHLELVESIWTYMP
                     HVHILGKFRNRNGAFPIPPENKLKIPIGAKIQTLHLVGVNVPEIPCIPMLRHLYMKWV
                     RLTKPQPFKDFLCISLRTFVMRNCAGPTNSLKYVPLVTGLASARNLEHLEMVRVPFLG
                     GLIQHVVEDSWRSGGFRNLHTIVLGACKNALEVDLGYLIITAARRLHEVRIQPSLTKD
                     GVFSALKMAELEFPQFETLHLGYVDEFLLQSRMANADLVKYGLADVVENPGIITDIGM
                     KAVNEVFSCIKYLAIYNCPHLHNPYNWISDHSRWMRLVDINLVRCHALKLDSFGQFVE
                     LLPSLEFISLDQMFREPPKGCARVGLSAGTGIGVSSALVSNQNSNNDNDNNAPNNNAN
                     LHDNNHHHPDDSDDDNDFRPDLQAGEAQFAADALNEMEDMVQEDGELVAESGNGMPAH
                     NREVLPVDADEEQAGPSGLQRVVKPTPIADHDSESDDEEDSLELQEVWAPKNGTRRYS
                     EREEKTGDSGQSRETAVSGKGKTPLRKRCNNSHQTGQAKPFPLEESSCEKGCQVTSEQ
                     IKADMKAARDVSEKKKSKDVYPSCSSSSSSTAASTAGNASSPSTASQSPDFARTVTSS
                     GSSEPSPPEVDVSRQCVCSPGGSEDSEAMEEGDAESSVCPRCCCLRPQESQRRTGRCS
                     DEERPSTSRACVVNGADGTRSAFSFRTLPQGGSSGPAHDERTNGSGCGATGEDRRGSS
                     QPESCDVQSNEDYPRRPLTRARSRLSHVPLISESEVAKTKPCHAMKRKRTADKSTSTS
                     DPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLKDCPKMMFIHATRCRVLKHLKVEN
                     APIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYP
                     YHICIIHEFSNPPNVRNKVRIRNWMDTIANINQELIKYEFFLEATRTEEDLKKYPKYP
                     WGREIYTLEGVVDGAPYSMISDFPWLRSLRTAEPNSFARYDFEDDEESTIYAPRRKGQ
                     LSADICMETIGEEISEMRQMKRGIFQRVVAIFIHYCDVNGEPVEDDYI"
     exon            419..552
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            553..716
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            717..882
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1020
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1158
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1252
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1383
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1554
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1697
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1911
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2031
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2211
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2961
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            2962..3062
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            3063..3165
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3332
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            3333..3478
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            3479..3582
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            3583..3696
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            3697..4518
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4402..4407
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /note="hexamer: AATAAA"
     polyA_site      4426
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /note="major polyA site"
     regulatory      4495..4500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /note="hexamer: AATAAA"
     polyA_site      4516
                     /gene="Fbxo38"
                     /gene_synonym="6030410I24Rik; Moka; SP329"
                     /note="major polyA site"
ORIGIN      
        1 gaaataccac gcttatcatg gccgcttcgc taggacggag ccacacctaa catggacgcg
       61 gtgaggcccg cccaggccca tccctcgatg acacttcttc ggaagacgct agaggcggcg
      121 gaagcggaag cgctgcggag gtgggggccg caggaagagt ctgtcgcgat tctcggtccc
      181 tctccaccac aaaaacagac ggagggccgg cgtaagtgag ccgcggcctg ggaggctgtc
      241 gcgacggtgg aggtattttg aactaacttt gacactgagg gagcacagcc atgggaccac
      301 gaaagaaaag tgctaaagtg tgtgtgatgg acagtgaggt cgctgaggaa atgacagccg
      361 atgaagagaa ggactacatg aaccagctgt cacatgaagt gctctgtcat atcttcaggt
      421 acctgccact acaggacatc atgtgcatgg aatgcctctc tcggaagcta aaggaggcag
      481 tcactctgta tctgagagtt gtcagagtgg tggatctctg tgcagggcgc tggtgggaat
      541 atatgccaag tggcttcaca gattccagtt tcctaaccct tttgaagaag atgccagatg
      601 ttgaacagct gtatggcctt caccctagat acctcgagag gcgaagagtg aggggccagg
      661 aggctttcag catcccagga gtcttggaag ctttgcaagc gtgcccaaac ttggtgggtg
      721 tagaaacatc tcatttggag ttggtagaat ccatttggac atatatgccg catgttcata
      781 ttttggggaa atttcgtaat cgtaacggag catttccgat tcctcctgaa aataaactga
      841 aaatccccat aggagccaaa atccaaactt tgcatttagt tggtgtcaat gttcctgaaa
      901 tcccttgtat ccctatgcta aggcacctgt acatgaagtg ggtgagactc actaaaccac
      961 agccgtttaa agatttcctt tgcatcagct tgcgaacttt tgtcatgagg aactgtgcag
     1021 gaccaacaaa ctccttgaaa tacgtgccct tggtaacagg tctggcatct gcccgtaacc
     1081 tggaacactt ggaaatggtt cgagtccctt tcctgggagg tctcatccaa cacgtggttg
     1141 aagacagctg gagatcaggt ggttttagga acttgcacac tattgtctta ggagcttgca
     1201 agaatgccct ggaagtagac cttggctacc tcatcatcac tgctgcgcga aggttacatg
     1261 aagttcgcat ccagccttct ttaaccaaag atggtgtctt ttctgcccta aagatggcag
     1321 aattggagtt tccccagttt gaaacccttc atctgggata tgtagatgag ttcttgctac
     1381 agagcagaat ggcgaatgca gatttggtga agtatggctt ggctgatgtg gtagaaaatc
     1441 ctggtatcat tactgatata gggatgaagg cagtcaatga agttttttcc tgtatcaaat
     1501 atctggcaat ttataactgt cctcatctac acaacccata caattggatc tcagaccact
     1561 cgaggtggat gcgactggtt gatatcaacc tcgtgcggtg ccatgctttg aagctggatt
     1621 cttttggcca gtttgttgaa ttattgccca gcctggaatt tatttctctg gaccagatgt
     1681 tccgtgagcc acccaagggc tgtgctcgag ttggtctgag tgcaggaact ggaattgggg
     1741 tttcctcagc gcttgtcagc aaccagaatt ccaacaatga caatgacaat aatgctccaa
     1801 ataacaacgc caacctccat gataacaatc accatcaccc agatgattcg gatgacgaca
     1861 atgactttcg tccagaccta caagcaggag aggcacaatt tgcagccgat gcgttgaatg
     1921 agatggaaga catggtccag gaagatggag aactggtagc cgagagtgga aatggtatgc
     1981 cagctcacaa tcgggaagtt cttcctgtgg atgctgatga ggaacaagca ggacctagtg
     2041 gtctacaacg cgtggtaaaa cctacaccaa ttgctgatca cgattcagag agcgatgatg
     2101 aagaagatag tttagaactc caagaagtct gggctcctaa gaatggcacc cggcgttact
     2161 cagagcggga agaaaagact ggagactcag gacagtccag ggaaacggca gtaagtggga
     2221 aaggcaagac tccacttcga aagaggtgca acaactccca ccagacgggc caggcgaagc
     2281 cgtttcccct ggaggagagc agctgtgaga aaggctgtca ggtgaccagt gagcagatca
     2341 aagccgatat gaaagcagct agggatgttt ctgaaaagaa aaaatccaag gatgtctatc
     2401 ccagctgcag cagcagcagc agcagcacag ccgccagcac agcgggaaac gccagctcac
     2461 ccagcactgc ttcccagagc ccggactttg caaggacggt gaccagcagc ggctcttccg
     2521 agccgagccc tccagaagta gatgtatcca ggcagtgtgt ctgctcccct ggtgggtcag
     2581 aggactctga ggccatggag gagggagatg cagagagctc tgtctgcccc agatgctgct
     2641 gtctcaggcc ccaggagtct caaaggagaa ctggcaggtg ttctgatgag gagcgtcctt
     2701 caaccagccg agcctgtgtt gtgaatggcg cggatggtac gagatccgcc ttttccttta
     2761 ggactctgcc acaagggggg tcttcaggcc cagcacatga tgagaggact aatgggagtg
     2821 gctgtggggc tacaggtgag gacaggaggg ggagctccca gcctgagagt tgtgacgtgc
     2881 agtctaatga agactatcct cggaggcccc taaccagggc caggagcaga ctgtcccatg
     2941 taccgctgat atctgagtca gaagttgcca aaacaaagcc atgccatgcc atgaaacgaa
     3001 agcgaactgc agataagtct accagcacca gtgaccctgt gattgaagat gaccacgtac
     3061 aggttcttgt attaaaatcc aaaaatcttg ttggagtcac aatgaccaat tgtggaatca
     3121 cagatctagt actgaaagac tgccccaaga tgatgttcat ccatgctacc aggtgcaggg
     3181 tactgaagca tttaaaggta gaaaatgcac caattgtaaa ccgatttgac tatgcacagt
     3241 gcaagaaact aaatatggac caggtactag accaaatact gaggatgcct ccggagagga
     3301 accggatcat ctacctgcgc ccaatgcagc aggtagacac actaactctg gagcagaagc
     3361 tcttcagcgg gccctacccc tatcacatct gcatcatcca cgagttcagc aatcctccca
     3421 acgtgcggaa caaggtgcgc atccgcaatt ggatggacac gatagccaac atcaatcaag
     3481 agctcattaa atacgaattc ttcctggaag ccactcggac tgaagaggat ttaaagaagt
     3541 accctaagta tccctggggg agagaaatct acactttaga gggtgttgta gatggagcgc
     3601 cgtattccat gatttccgac ttcccttggc tgaggtcact gcggaccgca gagcccaaca
     3661 gctttgccag atatgatttt gaagatgatg aagagagcac catctatgct cctcgaagaa
     3721 aagggcagtt gtctgcagac atttgtatgg agacaatagg agaggagatc tcagagatgc
     3781 gccagatgaa gaggggcata tttcagcgag tagtagcgat ttttatccac tactgtgatg
     3841 tcaatggaga gccagttgaa gacgactaca tttaagtaga cttttcctgg ctcttctggc
     3901 ccagagcagc caagagtctc tacacaggaa ccttgggctt ggaattggga ggccctggct
     3961 cagtttgtta tataggaaat atataaggaa catggaaatt gtatacaaag atttatatat
     4021 agaagaaata tacaaagata cttccaaatg taacatcttt atatcctatg tttatacatc
     4081 ttaatttaaa gacgtcattt gaaggcaggc aaatcgttta gcagtggtcg tgttcttttc
     4141 ctgacttagt tctcagtgtc aggcgactga gcctattgcc tctgctcctc accacgtcct
     4201 tcagtctgtg cctttttctt ctccagcaga gctgtttgag tcaccctcct aaagagtgtt
     4261 gtatcttgtg tgtttttgtt accatgatgc caactaaacc cttagtcaga gaagattatg
     4321 tttctgcact aagatgtggc tcttcttttt tgtgtgttta tatttggcat attcatttac
     4381 atgaaaagat tgacgaactt aaataaattt gaagggcaaa tagagagttt ccagagcatt
     4441 tctagttatt tatttccaca tgcagttgtg tacatgcttt atcttgaaca taaaaataaa
     4501 cacttagtaa aaactatt
//
