LOCUS       NM_001146086            3055 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus F-box protein 34 (Fbxo34), transcript variant 3, mRNA.
ACCESSION   NM_001146086
VERSION     NM_001146086.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3055)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   2  (bases 1 to 3055)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   3  (bases 1 to 3055)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   4  (bases 1 to 3055)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK020018.1, BC049155.1 and BB703607.1.
            
            Transcript Variant: This variant (3) includes an alternate segment
            which results in the use of a downstream start codon, compared to
            variant 1. Variants 2 and 3 encode the same protein (isoform 2)
            which is shorter when it is compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049155.1, SRR1660813.166240.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AK020018.1         2-59
            59-3028             BC049155.1         1-2970
            3029-3055           BB703607.1         382-408
FEATURES             Location/Qualifiers
     source          1..3055
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 24.6 cM"
     gene            1..3055
                     /gene="Fbxo34"
                     /gene_synonym="2900057B08Rik; 5830426G16Rik"
                     /note="F-box protein 34"
                     /db_xref="GeneID:78938"
                     /db_xref="MGI:MGI:1926188"
     exon            1..157
                     /gene="Fbxo34"
                     /gene_synonym="2900057B08Rik; 5830426G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            158..267
                     /gene="Fbxo34"
                     /gene_synonym="2900057B08Rik; 5830426G16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            268..3055
                     /gene="Fbxo34"
                     /gene_synonym="2900057B08Rik; 5830426G16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..2365
                     /gene="Fbxo34"
                     /gene_synonym="2900057B08Rik; 5830426G16Rik"
                     /note="isoform 2 is encoded by transcript variant 3; F-box
                     only protein 34"
                     /codon_start=1
                     /product="F-box only protein 34 isoform 2"
                     /protein_id="NP_001139558.1"
                     /db_xref="CCDS:CCDS49471.1"
                     /db_xref="GeneID:78938"
                     /db_xref="MGI:MGI:1926188"
                     /translation="MHLKLYWKLQKKERPLEVSRDTLRTPMSHGKANGDVKARASYMK
                     PTVLPSASLVKASSRKPFGILSPNVLCSMSGKSPVENSLNVKAKKNVLSAAVHQSEEG
                     LPGTWAIVKPGNTKEKIAFFAAHQYSNRIGSMKIKSSWDIDGRATKRRKKSGDLKKAK
                     LQLEMMREINSQCYQSEPFVCGVEHCSVHYMSDSGDGVCAARPLSVIQMVAFLEQKAT
                     ALLASCTKNCTNSPAIVKISGQSRGIPPAPEPFSAPETCEEPKEQENPETGRSQGEPV
                     RVLDMVARLESECLKHQGQREPGSLSRNNSFRRNVGRVLLTNGSQASDKSEEGSADTA
                     DPQENPLQPVSVGEEPSVTEHHSVGEQAWDGTSQSCPSLPATVSFHMDSTDLEPGQQT
                     AMKSCSRDDVEMVEEFDELPTDAVRRIRRELVTVTKHSPEQRQDPLCISITVCTVEKD
                     RPAALDSLEEPLPGMLFFLSSGQDQQAHPQLREHPAPEASEASQPQDAAEGSSAGEEK
                     DASVEPLLPAASPGGSTSQVLEAATCKKQVSQDFLETRFKIQQLLEPQQYMACLPHHI
                     IVKIFRLLPTLSLAILKCTCRYFKSIIEYYNIRPADSRWVRDPRYREDPCKQCKKKYV
                     KGDVSLCRWHPKPYCQALPYGPGYWMCCHQSQKGFPGCKLGLHDNHWLPACHSFNRAI
                     HKKTRGSETEEEY"
     regulatory      3029..3034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo34"
                     /gene_synonym="2900057B08Rik; 5830426G16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3051
                     /gene="Fbxo34"
                     /gene_synonym="2900057B08Rik; 5830426G16Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggtttagcca acaaatgggt ttcggggcga gcgttgggct ccgccgctca gcgctgagct
       61 cctggtccgc ctcagtgtcg gggagcgagt caggcctgcc gccgccgcat cgggctgccg
      121 cagccccggg ccaggccctg gcccggcaga agcacagaac tgctgagtgc ccaccaaggg
      181 aagggggaaa ttgccaccac tcctcccagt cttgagtcag cagcaacaca aacacaggct
      241 tcctaggcct ccctccccag cagtcagggc atctgttatg caccttaagc tgtactggaa
      301 actccagaag aaagagcgcc ctcttgaggt cagcagggac accctgagaa cgcctatgag
      361 ccacggaaag gccaacggtg atgtgaaggc cagagccagc tacatgaaac ccaccgtcct
      421 tccttcagcc tcccttgtca aagcatcgtc tagaaaacct tttgggatcc tttctccaaa
      481 tgttctgtgc agtatgagtg ggaagagccc tgtggagaac agcttgaatg ttaaagccaa
      541 aaagaacgtg ctgtctgcag ccgtgcacca gagtgaggag gggctgcctg ggacctgggc
      601 tattgtcaaa cctgggaaca cgaaggagaa aattgcattc tttgcagccc accagtatag
      661 caataggata ggctctatga aaattaaaag ttcctgggat atcgatggga gagccactaa
      721 aagaaggaaa aaatcaggag atcttaagaa agccaagtta cagctagaaa tgatgagaga
      781 gatcaacagc cagtgctacc agtctgagcc gtttgtgtgt ggcgtggagc actgttctgt
      841 gcactacatg agtgacagcg gggacggtgt ctgtgctgcg aggcctctgt cggtgataca
      901 gatggttgcc ttccttgagc agaaggccac tgctctgcta gctagctgca caaaaaactg
      961 cacaaattcg cctgccattg tgaagatttc tggccagtcc cgaggtatac cgcctgcacc
     1021 tgagcccttc tctgctccgg aaacttgtga agaacccaag gaacaagaaa atcccgagac
     1081 tggcagatcc cagggtgagc cagtccgtgt ccttgacatg gtagccaggt tggagtctga
     1141 gtgcctgaag caccagggcc agcgggaacc cgggagcttg tcacgcaata acagtttccg
     1201 tcgaaatgta ggcagggtgt tgctcactaa tggttctcag gccagcgaca aaagtgaaga
     1261 gggctctgca gacacagccg accctcagga gaatcccttg cagccggtat ctgtgggtga
     1321 agaaccctcc gtaactgagc atcattctgt aggggagcag gcctgggatg gcacttctca
     1381 aagctgtccc tcattgccag ccactgtgag cttccacatg gacagcacag atctagagcc
     1441 gggtcagcaa acagctatga agagctgcag ccgggatgac gtagaaatgg tggaggaatt
     1501 tgatgaattg cctacagatg ctgtccgtcg cataagaaga gagcttgtaa cagtcacaaa
     1561 gcacagtcct gagcagaggc aggacccgct gtgcatcagc atcactgtgt gcacggtaga
     1621 gaaagaccgg ccggcggctt tagactccct tgaggagcct cttcccggga tgctcttctt
     1681 tctgtcatct ggacaggacc agcaagcgca cccccagctg agggaacacc cagcaccaga
     1741 ggcctcagag gccagtcagc ctcaagatgc tgctgagggc agcagtgcag gtgaggagaa
     1801 agatgcctct gtggagccgc tcctcccagc agcctctccg ggagggagca cctcgcaggt
     1861 gcttgaggca gccacgtgca agaagcaggt gtcacaggac tttctggaga ccaggtttaa
     1921 gatccagcag cttctggagc ctcagcagta catggcatgc ctgccccacc acatcatagt
     1981 gaaaatcttc aggttactcc ctaccctgag tttagccatt cttaaatgta cctgtcgcta
     2041 cttcaagtcc atcattgaat actacaacat caggccagca gattctcggt gggttcgaga
     2101 cccacgctat agggaagacc cttgcaagca gtgcaagaaa aagtatgtga aaggggatgt
     2161 gtccctgtgc cggtggcacc ccaaacccta ttgccaggct ttgccatatg ggcctggcta
     2221 ctggatgtgc tgccaccagt ctcagaaggg ctttcctggc tgtaagttag gccttcatga
     2281 caatcactgg ttacctgcct gccatagctt taaccgggca atccataaga agacgagagg
     2341 gagtgagacg gaagaggagt actgaagtcc atgggacagg gaggcaagag gaccgtgaaa
     2401 cacttgggcc aacctccagg gctgcgagct cccccggccc ttcctgatct ctgctcagct
     2461 ctgactgcca ttgctcaggc attttaaact gtttctcagc tgtacaagaa tttagttcca
     2521 tggttttgta tggtggtgcc tcacattaaa cctatccagc tgtgaagaac tcttgcctgt
     2581 tttcctccat caaggacatt cagaggtcac caggcagtct ccacaagggg atcctgaggt
     2641 ggtccaacac tggctctgca cttggagtga gtgaggaggg aagcacacgg ttgagaatta
     2701 tgcctcagaa agaaaaccag gcaccttacc ctaggcctgt atgctcgttc ccgtgagagt
     2761 ggtgactgca gaccgacatg ccctgtgctg tttacagtgt gtataatggt tgtgcttgca
     2821 cagggctgtg aacgtgcaca ttaaacccga gcgcctttac ctgtagatga gtgctttggc
     2881 ccctctgtaa ataacgtgat taaaattcag tattgtatat tatgaacagc tgactaaaca
     2941 taatcaccac agaataagac aatatcatat aatagattaa aatgttgtgc atccttttgt
     3001 ctggttaaaa attttttaaa aaaacttcaa taaaaaaata aacgttttaa atgag
//
