LOCUS       NM_001033156            3446 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus F-box protein 33 (Fbxo33), mRNA.
ACCESSION   NM_001033156 XM_127032 XM_915942
VERSION     NM_001033156.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3446)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3446)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3446)
  AUTHORS   Kweon,S.M., Zhu,B., Chen,Y., Aravind,L., Xu,S.Y. and Feldman,D.E.
  TITLE     Erasure of Tet-Oxidized 5-Methylcytosine by a SRAP Nuclease
  JOURNAL   Cell Rep 21 (2), 482-494 (2017)
   PUBMED   29020633
REFERENCE   4  (bases 1 to 3446)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 3446)
  AUTHORS   Lutz,M., Wempe,F., Bahr,I., Zopf,D. and von Melchner,H.
  TITLE     Proteasomal degradation of the multifunctional regulator YB-1 is
            mediated by an F-Box protein induced during programmed cell death
  JOURNAL   FEBS Lett 580 (16), 3921-3930 (2006)
   PUBMED   16797541
  REMARK    GeneRIF: FBX33 as a component of an SCF E3-ubiquitin ligase that
            targets the multifunctional regulator Y-box binding protein 1
            (YB-1)/dbpB/p50 for polyubiquitination and destruction by the
            proteasome.
REFERENCE   6  (bases 1 to 3446)
  AUTHORS   Flood,W.D., Moyer,R.W., Tsykin,A., Sutherland,G.R. and Koblar,S.A.
  TITLE     Nxf and Fbxo33: novel seizure-responsive genes in mice
  JOURNAL   Eur J Neurosci 20 (7), 1819-1826 (2004)
   PUBMED   15380003
  REMARK    GeneRIF: mRNA expression in the hippocampus 1 h following
            generalized convulsive seizure, in a pattern which is typical for
            other activity-dependant genes expressed in this structure.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC147101.2.
            
            On Feb 2, 2008 this sequence version replaced NM_001033156.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments and ortholog.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.229853.1,
                                           SRR1660815.248838.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-624               AC147101.2         131780-132403
            625-735             AC147101.2         145172-145282
            736-1421            AC147101.2         146267-146952
            1422-3446           AC147101.2         148584-150608
FEATURES             Location/Qualifiers
     source          1..3446
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 26.03 cM"
     gene            1..3446
                     /gene="Fbxo33"
                     /gene_synonym="5730501N20Rik"
                     /note="F-box protein 33"
                     /db_xref="GeneID:70611"
                     /db_xref="MGI:MGI:1917861"
     exon            1..624
                     /gene="Fbxo33"
                     /gene_synonym="5730501N20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..1693
                     /gene="Fbxo33"
                     /gene_synonym="5730501N20Rik"
                     /note="AIG30-12-1"
                     /codon_start=1
                     /product="F-box only protein 33"
                     /protein_id="NP_001028328.2"
                     /db_xref="CCDS:CCDS49072.1"
                     /db_xref="GeneID:70611"
                     /db_xref="MGI:MGI:1917861"
                     /translation="MLLFLSVPQPRPPGARTRAGAARLVRWRRRQRLRLLQLRRLRGL
                     LRGLRRRPGTGGRRPSRMALCGQAAGAASLPSELIVHIFSFLPAPDRLRASASCSHWR
                     ECLFYPALWPQLRICLRVSPAEQPRLEFLMRKCGWFVRELRVEFAAENYLSGGGGPGD
                     GGSGGGTDTGTGGEDGEALQLSSRWLEVLRIYLELVLCVLLSIRNNRNLQKFSLFGDI
                     SVVHQQGSLSSTYLSRVDPDGKKIKQIQQLFEEILSNSRQLKWLSCGFMLEIVTPTSL
                     SSLSNPIANTMEHLSLLDNNIPGNSTLITAVELERFVNLRSLALDFCDFTAEMARVLT
                     DSNHVPLQRLSLLVHNASVMLKSLDNMPNDEHWKALSRKSSSLRVYLMVFDIKSEDML
                     KILKPSIPLERVHFDSYVTCVSGAIVDLISRQYDKFLTHFILMNDMIDTSGFPDLSDN
                     RNEDPLVLLAWRCTKLTLLAIHGYTVWAHNLIAIARLRGSDLKVLQVTEESIDFDQGE
                     LADQDVDPVQNLIEQVSLGLGQSWHAVLDIESLSVFTEPNRHFYREMQSFSEDI"
     exon            625..735
                     /gene="Fbxo33"
                     /gene_synonym="5730501N20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            736..1421
                     /gene="Fbxo33"
                     /gene_synonym="5730501N20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..3446
                     /gene="Fbxo33"
                     /gene_synonym="5730501N20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3427..3432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo33"
                     /gene_synonym="5730501N20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3446
                     /gene="Fbxo33"
                     /gene_synonym="5730501N20Rik"
                     /note="major polyA site"
ORIGIN      
        1 attgatgttg ttgttcttgt cagtgccgca accccgaccg ccgggagcgc gaacccgagc
       61 cggggccgcc cggttggtgc ggtggcggcg gcggcagcgg ctgcggctgc tgcagctgcg
      121 ccggctgcgg gggctgctgc gaggactgcg caggcggccg gggacgggcg gccggcggcc
      181 gagccggatg gctctgtgcg ggcaggcggc cggcgccgcg tcgctgccca gcgagctcat
      241 cgtgcacatc ttctcctttc tgccggcgcc cgaccggctg cgggcctcgg cctcctgctc
      301 gcactggcgg gagtgcctct tctacccagc gctgtggccc cagctccgca tctgcctccg
      361 cgtctcgccc gcggagcagc cgcggctaga gttcctcatg cgcaagtgcg gctggttcgt
      421 gcgggagctg cgggttgagt tcgccgcgga gaattatctg agcggaggcg gcggcccggg
      481 cgacggcggt agcggcggcg gcaccgacac gggcaccgga ggggaagacg gggaggccct
      541 gcagctctcc tcccgctggc tggaagtact gcgcatctac ttggagctgg tgttgtgcgt
      601 gctgctcagc atccggaaca acaggaatct ccagaagttt agtctttttg gagacataag
      661 tgttgtacac cagcaaggaa gtttgtccag cacgtacctc agcagggtag accctgacgg
      721 caagaagatt aagcaaattc aacaactgtt tgaagaaata ctgagcaata gtaggcaact
      781 aaaatggctg tcctgtgggt ttatgctgga aatagtaacc ccaacatcac tgtcgtctct
      841 gtctaaccca attgccaaca ccatggaaca cctgagttta ctggacaaca acattcctgg
      901 caatagcact ctgatcactg cagtggaact agagcggttt gtaaatctac gctcacttgc
      961 cctggatttc tgtgacttta cagctgaaat ggcgagagtc ttgaccgata gcaaccatgt
     1021 gcctttgcag cgactgtctc ttctggtcca caatgcttca gtgatgctca agtcattaga
     1081 caacatgcca aatgatgagc actggaaagc cctgtcacga aagagctcca gccttcgggt
     1141 ctatctaatg gtttttgata ttaaaagtga agacatgcta aagattctga aacccagtat
     1201 accacttgag agggttcact ttgacagcta cgtcacttgt gtctcagggg ctattgttga
     1261 tcttatatcc aggcagtatg acaagttcct tacccatttt atattgatga atgatatgat
     1321 tgacacatct ggttttccag atcttagtga caaccgaaac gaagatccat tggttttgtt
     1381 agcatggagg tgcacaaagc tcaccctttt ggcaattcat ggttacaccg tgtgggcgca
     1441 caacctcatt gccattgctc gtcttcgggg ctctgaccta aaagtgcttc aagtcaccga
     1501 agaaagcatt gattttgacc aaggtgaact agccgaccag gatgtggatc cagtacagaa
     1561 ccttattgag caggtatcac tgggccttgg tcagtcttgg cacgcagtct tggacattga
     1621 atcactcagt gtcttcactg aaccaaatcg tcatttttac agagagatgc aaagcttcag
     1681 cgaagacatt tagctttttt aaaatatata attcctgtgg ctacatatgc aagtagggtc
     1741 ccattatgtt tttttttttc attagtggaa actaatcctt ttgtgctgtg tttaatcagt
     1801 attagcttta tagaattata aatgtatatt ctacttcttg atcaaagaac gtagttgggt
     1861 attggtttta gaagttcaaa gtgacactgt atagggcttt cacggttaat gggattgtta
     1921 gcagacctta aggacataca gccaatgatt atctgaggtt actggctaac tgtttttcac
     1981 tgagttactc tgcctttttg acatttttat tctttgtttg tcagaatcca gagctcagga
     2041 gccaaatatt tttatacata tatatataaa tatccatagc ctggtggatt tgtatgcaat
     2101 gcactgcatc tatgtattct gatagcatct cattgatttt tgtttgaaat agaaggaaag
     2161 atagtatccc aaatgagtta tctttaacag aaagctgagt ttaactttta ttacctatat
     2221 aataattgat attgccaatt accattctga atttcatata gtataagtta gacattgctt
     2281 aatccttttt taaatgtatt tacatagaca cgaacactca aattgttgga tttttaaaac
     2341 tatatctgac ataatttttt tcatctgtta cattaaagtt agcttgttta gcccagattt
     2401 caaaacagta gagaagaaag gagccatatt ccagggaaac ctctgaggct aagtcaaagc
     2461 acagaactgt aaatgcacag gcttgcaaac caacattagt cgtgaaatcc ctaacaagtc
     2521 actggattct ctctgtcagc gcaagtgtca gctgccaaag aatagattta catgaagaag
     2581 tgcccacatg ctggcagggg ctggccagct gtggccagcc agatactgct agattgtaat
     2641 atttaaggtc gaatttcgac ctgtggtaca cagctgtgct gtggctcagt cagcaacctc
     2701 agaactctga aaaaataaaa aataaaaaaa acataaaaaa aaaagaaaaa aaatgcacct
     2761 gtttcactgt gaatagtgaa tgtaaaggag agaaaggaaa accaaaagct tgttccatcc
     2821 aggtatgagc tgctatgata catgaagaac attccatgaa gtatgtttta aaaccttgtt
     2881 atatctgaga ggctttaaaa gccaatttaa ctgtttcagg gcaaccgcgg tacagacgtg
     2941 gtctctgtga gacttccacc tgacccaagt tttaagtggt acgaatgttg tgcatttaat
     3001 gttaaggaca gtctgcaata ataaagtgag tagccaacgt gggtgcccag cagtgctgag
     3061 acctggctgc tctattgtaa gctttggaaa cacaatttat gcaacagatg tccagatatg
     3121 attctattta tggaaaaagt ttatatgttt tacaaatggt tttaccatct tatattaaat
     3181 gaccttttga caggtgtgca ctgttttgtc tccagtgagc acataccatg cggattttat
     3241 atgtacatca gtagtgtgaa tccactggca cagtgtgtgt aaatgccaga tgtggtgaga
     3301 ttttatcttg tatatgtgat cagataaaat aactcctgac agaaactgta aggaaaccag
     3361 ctgaatgttt gacctgatga ctgatgttgt atggtttatg ttaaatgtat attcttttaa
     3421 tcaatgaata aagcattaaa aagtga
//
