LOCUS       NM_026346               6936 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus F-box protein 32 (Fbxo32), mRNA.
ACCESSION   NM_026346 XR_105720 XR_106914
VERSION     NM_026346.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6936)
  AUTHORS   Xu,J., Zhang,D., Ma,Y., Du,H., Wang,Y., Luo,W., Wang,R. and Yi,F.
  TITLE     ROS in diabetic atria regulate SK2 degradation by Atrogin-1 through
            the NF-kappaB signaling pathway
  JOURNAL   J Biol Chem 300 (3), 105735 (2024)
   PUBMED   38336298
  REMARK    GeneRIF: ROS in diabetic atria regulate SK2 degradation by
            Atrogin-1 through the NF-kappaB signaling pathway.
REFERENCE   2  (bases 1 to 6936)
  AUTHORS   Ghnaimawi,S., Zhang,S., Baum,J.I. and Huang,Y.
  TITLE     The Effects of Maternal Intake of EPA and DHA Enriched Diet During
            Pregnancy and Lactation on Offspring's Muscle Development and
            Energy Homeostasis
  JOURNAL   Front Physiol 13, 881624 (2022)
   PUBMED   35733999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6936)
  AUTHORS   Liang,R., Shen,X., Wang,F., Wang,X., DesJarlais,A., Syed,A.,
            Saba,R., Tan,Z., Yu,F., Ji,X., Shrestha,S., Ren,Y., Yang,J.,
            Park,Y., Schwartz,R.J., Soibam,B., McConnell,B.K., Stewart,M.D.,
            Kumar,A. and Liu,Y.
  TITLE     H19X-encoded miR-322(424)/miR-503 regulates muscle mass by
            targeting translation initiation factors
  JOURNAL   J Cachexia Sarcopenia Muscle 12 (6), 2174-2186 (2021)
   PUBMED   34704401
REFERENCE   4  (bases 1 to 6936)
  AUTHORS   Matsukawa,S., Kai,S., Seo,H., Suzuki,K. and Fukuda,K.
  TITLE     Activation of the beta-adrenergic receptor exacerbates
            lipopolysaccharide-induced wasting of skeletal muscle cells by
            increasing interleukin-6 production
  JOURNAL   PLoS One 16 (5), e0251921 (2021)
   PUBMED   34003837
  REMARK    GeneRIF: Activation of the beta-adrenergic receptor exacerbates
            lipopolysaccharide-induced wasting of skeletal muscle cells by
            increasing interleukin-6 production.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6936)
  AUTHORS   Perez-Estrada,J.R., Hernandez-Garcia,D., Leyva-Castro,F.,
            Ramos-Leon,J., Cuevas-Benitez,O., Diaz-Munoz,M., Castro-Obregon,S.,
            Ramirez-Solis,R., Garcia,C. and Covarrubias,L.
  TITLE     Reduced lifespan of mice lacking catalase correlates with altered
            lipid metabolism without oxidative damage or premature aging
  JOURNAL   Free Radic Biol Med 135, 102-115 (2019)
   PUBMED   30818059
REFERENCE   6  (bases 1 to 6936)
  AUTHORS   Wang,X., Gargalovic,P., Wong,J., Gu,J.L., Wu,X., Qi,H., Wen,P.,
            Xi,L., Tan,B., Gogliotti,R., Castellani,L.W., Chatterjee,A. and
            Lusis,A.J.
  TITLE     Hyplip2, a new gene for combined hyperlipidemia and increased
            atherosclerosis
  JOURNAL   Arterioscler Thromb Vasc Biol 24 (10), 1928-1934 (2004)
   PUBMED   15331434
REFERENCE   7  (bases 1 to 6936)
  AUTHORS   Sandri,M., Sandri,C., Gilbert,A., Skurk,C., Calabria,E., Picard,A.,
            Walsh,K., Schiaffino,S., Lecker,S.H. and Goldberg,A.L.
  TITLE     Foxo transcription factors induce the atrophy-related ubiquitin
            ligase atrogin-1 and cause skeletal muscle atrophy
  JOURNAL   Cell 117 (3), 399-412 (2004)
   PUBMED   15109499
REFERENCE   8  (bases 1 to 6936)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
REFERENCE   9  (bases 1 to 6936)
  AUTHORS   Gomes,M.D., Lecker,S.H., Jagoe,R.T., Navon,A. and Goldberg,A.L.
  TITLE     Atrogin-1, a muscle-specific F-box protein highly expressed during
            muscle atrophy
  JOURNAL   Proc Natl Acad Sci U S A 98 (25), 14440-14445 (2001)
   PUBMED   11717410
REFERENCE   10 (bases 1 to 6936)
  AUTHORS   Bodine,S.C., Latres,E., Baumhueter,S., Lai,V.K., Nunez,L.,
            Clarke,B.A., Poueymirou,W.T., Panaro,F.J., Na,E., Dharmarajan,K.,
            Pan,Z.Q., Valenzuela,D.M., DeChiara,T.M., Stitt,T.N.,
            Yancopoulos,G.D. and Glass,D.J.
  TITLE     Identification of ubiquitin ligases required for skeletal muscle
            atrophy
  JOURNAL   Science 294 (5547), 1704-1708 (2001)
   PUBMED   11679633
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU921446.1, AK014793.1 and AC113292.6.
            
            On or before Jul 30, 2011 this sequence version replaced
            XR_105720.1, XR_106914.1, NM_026346.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014793.1, SRR10223970.17521.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BU921446.1         1-18
            19-2678             AK014793.1         1-2660
            2679-6936           AC113292.6         201667-205924       c
FEATURES             Location/Qualifiers
     source          1..6936
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 24.43 cM"
     gene            1..6936
                     /gene="Fbxo32"
                     /gene_synonym="4833442G10Rik; ATROGIN1; Gm20361; MAFbx"
                     /note="F-box protein 32"
                     /db_xref="GeneID:67731"
                     /db_xref="MGI:MGI:1914981"
     exon            1..397
                     /gene="Fbxo32"
                     /gene_synonym="4833442G10Rik; ATROGIN1; Gm20361; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..1349
                     /gene="Fbxo32"
                     /gene_synonym="4833442G10Rik; ATROGIN1; Gm20361; MAFbx"
                     /note="muscle atrophy F-box protein; atrogin 1"
                     /codon_start=1
                     /product="F-box only protein 32"
                     /protein_id="NP_080622.1"
                     /db_xref="CCDS:CCDS27491.1"
                     /db_xref="GeneID:67731"
                     /db_xref="MGI:MGI:1914981"
                     /translation="MPFLGQDWRSPGQSWVKTADGWKRFLDEKSGSFVSDLSSYCNKE
                     VYSKENLFSSLNYDVAAKKRKKDIQNSKTKTQYFHQEKWIYVHKGSTKERHGYCTLGE
                     AFNRLDFSTAILDSRRFNYVVRLLELIAKSQLTSLSGIAQKNFMNILEKVVLKVLEDQ
                     QNIRLIRELLQTLYTSLCTLVQRVGKSVLVGNINMWVYRMETILHWQQQLNSIQISRP
                     AFKGLTITDLPVCLQLNIMQRLSDGRDLVSLGQAAPDLHVLSEDRLLWKRLCQYHFSE
                     RQIRKRLILSDKGQLDWKKMYFKLVRCYPRREQYGVTLQLCKHCHILSWKGTDHPCTA
                     NNPESCSVSLSPQDFINLFKF"
     exon            398..510
                     /gene="Fbxo32"
                     /gene_synonym="4833442G10Rik; ATROGIN1; Gm20361; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     exon            511..560
                     /gene="Fbxo32"
                     /gene_synonym="4833442G10Rik; ATROGIN1; Gm20361; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     exon            561..653
                     /gene="Fbxo32"
                     /gene_synonym="4833442G10Rik; ATROGIN1; Gm20361; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     exon            654..747
                     /gene="Fbxo32"
                     /gene_synonym="4833442G10Rik; ATROGIN1; Gm20361; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     exon            748..932
                     /gene="Fbxo32"
                     /gene_synonym="4833442G10Rik; ATROGIN1; Gm20361; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1115
                     /gene="Fbxo32"
                     /gene_synonym="4833442G10Rik; ATROGIN1; Gm20361; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1259
                     /gene="Fbxo32"
                     /gene_synonym="4833442G10Rik; ATROGIN1; Gm20361; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..6936
                     /gene="Fbxo32"
                     /gene_synonym="4833442G10Rik; ATROGIN1; Gm20361; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6913..6918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo32"
                     /gene_synonym="4833442G10Rik; ATROGIN1; Gm20361; MAFbx"
                     /note="hexamer: AATAAA"
     polyA_site      6934
                     /gene="Fbxo32"
                     /gene_synonym="4833442G10Rik; ATROGIN1; Gm20361; MAFbx"
                     /note="major polyA site"
ORIGIN      
        1 gacggggcag cggcccggga taaatactgc gctcgggcag ccgctcagca ttcccagagt
       61 caggaggcga ccttccccaa cgcctgcgcc cctgtgagtg caaggatccc cgcgcccacc
      121 caggatccgc agccctccac actagttgac ccactcttgt cccggtcgcc gcctgcgtcg
      181 ttccccagca tcttcccaac gcgccgcata ccctgggcaa gccaggccgg ttcctggctg
      241 tcaatccgtc ccgtccgtcg gtcgcgtccg cgctctgtac catgccgttc cttgggcagg
      301 actggcggtc cccgggccag agctgggtga agacggcgga cggctggaag cgcttcttgg
      361 atgagaaaag cggcagcttc gtgagcgacc tcagcagtta ctgcaacaag gaggtataca
      421 gtaaggagaa tctgttcagc agcctgaact acgacgtcgc agccaagaag agaaagaaag
      481 acattcagaa cagcaaaacc aaaactcagt acttccatca agaaaagtgg atctatgttc
      541 acaaaggaag tacgaaggag cgccatggat actgtacttt gggggaagct ttcaacagac
      601 tggacttctc gactgccatc ctggattcca gaagattcaa ctacgtagta aggctgttgg
      661 agctgatagc aaagtcacag ctcacatccc tgagtggcat cgcccaaaag aacttcatga
      721 acattttgga aaaagtggta ctgaaagttc ttgaagacca gcaaaacata agacttatac
      781 gggaacttct ccagactctc tacacatcct tatgcacact ggtgcagaga gtcggcaagt
      841 ctgtgctggt gggcaacatt aacatgtggg tgtatcggat ggagaccatt ctacactggc
      901 agcagcagct gaatagcatc cagatcagca ggcctgcctt caaaggcctc acgatcaccg
      961 acctgcctgt gtgcttacaa ctgaacatca tgcagaggct gagtgacggg cgggacctgg
     1021 tcagcctggg ccaggcagcc ccagacctgc atgtgctcag tgaggaccgg ctactgtgga
     1081 agagactctg ccagtaccac ttctcagaga ggcagattcg caagcgtttg atcttgtctg
     1141 acaaagggca gctggattgg aagaagatgt attttaagct tgtacgatgt tacccaagaa
     1201 gagagcagta tggggtcacc ctgcagcttt gcaaacactg ccacattctc tcctggaagg
     1261 gcactgacca tccgtgcacg gccaacaacc cagagagctg ctccgtctca ctttcccctc
     1321 aagactttat caatttgttc aagttctgaa taatcccagc acacgacaac acttcagaag
     1381 gcttctaatt ggatggctgg gagtcgggac acttcatttg taaatagtgt acattttaag
     1441 cattggcttg aaactgcggg ggatacgtca ttgaggagac gttggcgggg aagagatgca
     1501 gttgccgatg gaaatttaca aatgtgaatt ccacatgaga actggtacag aaaagcagaa
     1561 atactgtaaa tagacttttt attttcccta acgatttgca agcaagacta taaaggcaag
     1621 aactctatgt cagccatgga aacggagtcc tcttgagttc cctaggaaga aaaaggcaaa
     1681 aagctcaaaa acaagatgga acactctgtt tacaatgtga aaatgttgtt aagacaaaaa
     1741 taaggaagaa ggaagatgaa cgctgtcatt gagaaaccct tgggctttgg gtttggattc
     1801 ggggtttgtt ttcagcaggc caagaagtat atccacctga aatctgcacg ggcttaagtc
     1861 cttatcctat gaagatgcca cacaatggtc tacctctaaa agcatagcgt gttctctggc
     1921 aacatacttt atctgggagg caatgtctgt gtttcatgta agttctatac tctgtgaagt
     1981 gatctaagat gggaaggctg ttaggaaaaa aaaaaaaagc cctctcttgg ttctgacttc
     2041 ctgtcccccc agtccctctc agtccctgca cctcttctcc tttcatgttg tcactcctgt
     2101 agggaaccgg gaggccagct aaagaacagc agaagtcatg aagagagaat taggcacctg
     2161 tgcatgctca gaactttcca tttaactctt ccttcttcta gcctgacttc taggcttgtc
     2221 cgggcttcct tgagtgtctt catggataag tggatgtctg ggaccttagg agagcccaag
     2281 aactgaggct tgagagacac agtttctcac actagccagt taaacattct gccagctgct
     2341 gtttcccctc ggcaggccaa tgagctgagg cactgtctgt tctgtaggcc cagcatccaa
     2401 ctcaagtcac cctgaaccgg gactttttca caagcatgat ttcaaagaaa gcctgataga
     2461 tgtgttcgtc ttaaacttgt ttcaggactg agttagagca aagataaaga gtcccggggg
     2521 ttcttgtgag acagagacat gaacactgtg gaagaaagga gaaggagatc tcagggctta
     2581 aggagttaat tcctggggtg ggggaaatgt ttttatattt tactttttac agattgttgc
     2641 ttttctacaa tgtacatata tttgcaattg tatttgctgt ttttttttta aatctccaaa
     2701 taaaattgcc actatgcatg ctcttggcaa acaagcagaa ataggaattt gttccatgta
     2761 aatgttaagg tgtggtgtga cctgaagcat tgatgcgtgg ggtagtccta ggaggagagg
     2821 aaagatggct gagcgtgaac aagaacaagg ccggggcagt gaacacttct tccttcagtc
     2881 gtagagcacc ctcgggttgg tactgtacag gcggatggag tctgtggggc tccctgattt
     2941 gcagggtctt acatctgtgc ttacaccaga agttctccat gttttcttta tcagcaccat
     3001 ctcctggtgg ccaaattaag ttgaatttaa aggttcgtaa tgagaaaagg gatgtgtaaa
     3061 agaacaagat ttcttttaca tggaaaagtt aaaagtctaa agctgaacct tggagattac
     3121 aaacattgta acagagaaga gtttcctgtt tgctttggga tttttgaaat cttctcccca
     3181 gaaacaattt tacattaaga atgtagggcc ttggggctgg agaggtggct cagcagttaa
     3241 gagcactgac tgctcttctg aaggtcctga gttcaattcc tagcaaccac atggtggctc
     3301 ataaccatcc ataatgagat ctgatggcct cttctggtga gtctgaagac agctacagtg
     3361 tacttacata taataaataa ataaataaat aaataaataa ataaataaat aaataaataa
     3421 atctatcttt aaaagaaaaa gaatgtagga cctaggtgga aggaaggaag gaaggaagga
     3481 aggaagcaag gaaggaagga aagcaggcag gcctgccgcc acagtgattc tgagtgacag
     3541 tgttgaggtt aggggatcgt ggcctttcac atgtcctcag cctgctctgt ggtgcttttc
     3601 agagatggga acttgtaggg accttggggt ttacaggtcc gtcaactttg ccagctttga
     3661 actgccagcg caaaactagt tagccagtct tacagatagg cagcagtacc caaagtcata
     3721 tagcatccat acaccccagg caacaatgta aaatggccct taccccaagc agcaagggca
     3781 cagcttcttg aaatatttag taggtgcttg caggttctcc atgacccttg gtgtcattgg
     3841 atatggtatg tgacacaacc gaagaatcgt ttgacggatg aagaagagga aaggagcatg
     3901 tattggtcgc tgtcactggc tggtagaaaa caggaaggat gtggaaggtg gagagggagt
     3961 gggagaggtg tagaaatgat gtatctttga tgctgtttag ggtgggagca acagagagag
     4021 gagggcaagc aagataccca tattaggtca tggccagagc ctcatattca agtactggga
     4081 gttaaaaaga aaagctctta ggacattaat agtctataga attcttggca aacccatgca
     4141 ggactcccag acttaaaaca caaaacctaa gaattcctga cccagaactg ctagtacaaa
     4201 agcaagaggg gtgtggctat agaagttgct gagagaattg ggactgtgta tctctctact
     4261 ggacctgact cccctccttt gcatgttgaa atgcagaact agagttatac ccactttgaa
     4321 gtgattcaga atccagagaa ggaaaagagt tctgtccaag caaaccaagg gagatggtca
     4381 ctggtgactt tactttggag caatcagctg agagtctctg aatgagaacc atcgtgtgtg
     4441 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg atacaactga agtttaggaa tgctcctttt
     4501 atagccagaa tcagtaaaag aaaatctcac tgtcactgtc agctagacca tgtcgctact
     4561 accattgctt caagtgggta tctcagttga acgggaggga aaaggtgaca gacagaaagg
     4621 aacagacatt acacagtggg ctctccagcc caccagctga gaggggcttt ctggttagtg
     4681 atgatcaact tcaggtggca ctggtttaga ggagacattt ttaagggaca aagtttccac
     4741 cacaaaagct ttcaacggaa gagccgatct aattgtgacc atgaagccag ctgatgggtg
     4801 accacacaaa cccttccccg ggaggcattt gctgttgaca caggctcctt atttctgccg
     4861 cttcatacgg gagaaaaaaa aagagtggga ctttgatttg tctaagcagt tggtatgatt
     4921 cacagagaga taaatcatca caggagatgg ttagcagtgt atggttctcg gcttcaacgc
     4981 attgtttatt ataaaacatg cacctgggtt tatatttttc tgcctggtta taaagcaata
     5041 acatcttgct atgcaaacac taaatttcat gtgtgaattt tcaactgtga ttttatgtgt
     5101 gcatttttta aactaaactc tatcattttt ctatgttgac atctgttgtt ggtttggttt
     5161 tgttttgttt ttaatctgtt tccaactatc tgagtctgtg aaccatctct cctgactgga
     5221 tgctggcttg aaacctgtta gtgcttaaac agactcagaa acaaccctgg acctctgggg
     5281 caaacgcagg ggtgttactc tttgatatat catgggccct ctgtggcttc aacaaacaaa
     5341 gtcataattc ctctaaattc tgtgttttct gtaaatattt tcttcttctc agctctgcta
     5401 aaatgggggt gggggggggg ggggagagag agaaactcct atcccagact ttagaccaaa
     5461 aggggttgtt agagagtatg gactctggca tttctgcatt tgaagatgag gaagcctttc
     5521 cagaattggg ggtacagagg ctttctctgt gcttcctggg aggtcagcaa gagggttgaa
     5581 cagaaacctg aagcttcctg atgccagagc tcttgagccc acctctcccc cagcaccttg
     5641 tggacgtgtg taaattcatg acacccactg taatgcctcc caagatcttc actgtgggag
     5701 gcatgggagg tgatcccatg atgggctcct gccacaaaat cttccaaacc ttttaagtct
     5761 gattcctgct ggagaagtta gagtccctct ttcattttca taccctctta ctctgctgtg
     5821 agtgccacat tcagctgagc accacctgct tcctaagacg taaccagtgt gctggggaga
     5881 tggctcagtt gataaagtgc ctgcagtgta agtgtgagga cctgaattca ggttccagca
     5941 tctgtgtaag agccaggcag gaacttaagt gcaaggcggg gcaggggtgg ggataggttc
     6001 attgaccaac cagtcttaag aatgaagtgg tacccaggct cattgagaga tcctgtctca
     6061 aaaaataaaa atggacagag atctagggat gcacccaaca tctgccgcaa cctcccaagt
     6121 catatgcgtg tgcacagaaa tccccagatc tttcttctcc cctgaaatgc aaaggtacat
     6181 ttaaactatc catcctcttt cttgcccgtc ttttggcagt gagccctgcc ataacataag
     6241 atccagtgag gagcagttca gccaggttgg acagtgatcc attctgttca tccttgtttg
     6301 taataagcag aatttatcct gtaaggcaag gggtggtgat agccataatt tttgtcggct
     6361 gggctttttt caaagtgtcc ttgaattcag caagcaaacc ttctttgaga aagctctcta
     6421 aacttagtct ctctccattt ggctggaaat aatggatggc cacatccaaa ctccaaattt
     6481 ctggatgtgt catatgcctc agcactacag aatctgactc tctctttgag tatagacatg
     6541 cgtgttaact atgcacaggg ctgtttaaca gatggctcca atccctgctc catacttggg
     6601 agcctttggt tccatcttta taccaaatgc caatcacact ggctacagag agtgtattat
     6661 agtctgtgtc taagcttaga agctttaaat gtatgtttta aagaaaaaat actagagtgg
     6721 gttgaacact ttaactaaac ttggaaggtt ggacagatta tgtgcaaaga tgattgtttg
     6781 tttaataatg aataatctga atcctgtata acttatttgc acacctttct tgcatgatga
     6841 actgacattt ttatagttgt ttgtataaga cagtggcata tttttgtaaa catttttttg
     6901 acactgaact tcaataaatg tttttcctac aacaca
//
