LOCUS       NM_001414923            4430 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus F-box protein 31 (Fbxo31), transcript variant 2, mRNA.
ACCESSION   NM_001414923 XM_006531477
VERSION     NM_001414923.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4430)
  AUTHORS   Zhao,F., Yan,L., Zhao,X., Wu,J., Fang,Y., Xin,Z., Wang,H. and
            Yang,X.
  TITLE     Aberrantly High FBXO31 Impairs Oocyte Quality in Premature Ovarian
            Insufficiency
  JOURNAL   Aging Dis 15 (2), 804-823 (2024)
   PUBMED   37611899
  REMARK    GeneRIF: Aberrantly High FBXO31 Impairs Oocyte Quality in Premature
            Ovarian Insufficiency.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4430)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4430)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   4  (bases 1 to 4430)
  AUTHORS   Mir,A., Sritharan,K., Mittal,K., Vasli,N., Araujo,C., Jamil,T.,
            Rafiq,M.A., Anwar,Z., Mikhailov,A., Rauf,S., Mahmood,H.,
            Shakoor,A., Ali,S., So,J., Naeem,F., Ayub,M. and Vincent,J.B.
  TITLE     Truncation of the E3 ubiquitin ligase component FBXO31 causes
            non-syndromic autosomal recessive intellectual disability in a
            Pakistani family
  JOURNAL   Hum Genet 133 (8), 975-984 (2014)
   PUBMED   24623383
REFERENCE   5  (bases 1 to 4430)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 4430)
  AUTHORS   Tang,F., Barbacioru,C., Nordman,E., Bao,S., Lee,C., Wang,X.,
            Tuch,B.B., Heard,E., Lao,K. and Surani,M.A.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
REFERENCE   7  (bases 1 to 4430)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4430)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC182458.2 and AC122205.6.
            
            On Dec 15, 2022 this sequence version replaced XM_006531477.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14995045.823935.1,
                                           SRR13422598.1515836.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               AC182458.2         172612-172948       c
            338-409             AC182458.2         160429-160500       c
            410-496             AC182458.2         158792-158878       c
            497-573             AC182458.2         154540-154616       c
            574-741             AC182458.2         154077-154244       c
            742-816             AC182458.2         153174-153248       c
            817-926             AC182458.2         150396-150505       c
            927-1080            AC182458.2         149360-149513       c
            1081-1427           AC182458.2         148259-148605       c
            1428-4430           AC122205.6         245302-248304       c
FEATURES             Location/Qualifiers
     source          1..4430
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 70.65 cM"
     gene            1..4430
                     /gene="Fbxo31"
                     /gene_synonym="1110003O08Rik; 2310046N15Rik; Fbx14;
                     Fbxo14"
                     /note="F-box protein 31"
                     /db_xref="GeneID:76454"
                     /db_xref="MGI:MGI:1354708"
     exon            1..337
                     /gene="Fbxo31"
                     /gene_synonym="1110003O08Rik; 2310046N15Rik; Fbx14;
                     Fbxo14"
                     /inference="alignment:Splign:2.1.0"
     exon            338..409
                     /gene="Fbxo31"
                     /gene_synonym="1110003O08Rik; 2310046N15Rik; Fbx14;
                     Fbxo14"
                     /inference="alignment:Splign:2.1.0"
     exon            410..496
                     /gene="Fbxo31"
                     /gene_synonym="1110003O08Rik; 2310046N15Rik; Fbx14;
                     Fbxo14"
                     /inference="alignment:Splign:2.1.0"
     exon            497..573
                     /gene="Fbxo31"
                     /gene_synonym="1110003O08Rik; 2310046N15Rik; Fbx14;
                     Fbxo14"
                     /inference="alignment:Splign:2.1.0"
     exon            574..741
                     /gene="Fbxo31"
                     /gene_synonym="1110003O08Rik; 2310046N15Rik; Fbx14;
                     Fbxo14"
                     /inference="alignment:Splign:2.1.0"
     exon            742..816
                     /gene="Fbxo31"
                     /gene_synonym="1110003O08Rik; 2310046N15Rik; Fbx14;
                     Fbxo14"
                     /inference="alignment:Splign:2.1.0"
     exon            817..926
                     /gene="Fbxo31"
                     /gene_synonym="1110003O08Rik; 2310046N15Rik; Fbx14;
                     Fbxo14"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1080
                     /gene="Fbxo31"
                     /gene_synonym="1110003O08Rik; 2310046N15Rik; Fbx14;
                     Fbxo14"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1427
                     /gene="Fbxo31"
                     /gene_synonym="1110003O08Rik; 2310046N15Rik; Fbx14;
                     Fbxo14"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..4430
                     /gene="Fbxo31"
                     /gene_synonym="1110003O08Rik; 2310046N15Rik; Fbx14;
                     Fbxo14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1838..1843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo31"
                     /gene_synonym="1110003O08Rik; 2310046N15Rik; Fbx14;
                     Fbxo14"
                     /note="hexamer: AATAAA"
     polyA_site      1869
                     /gene="Fbxo31"
                     /gene_synonym="1110003O08Rik; 2310046N15Rik; Fbx14;
                     Fbxo14"
                     /note="major polyA site"
     polyA_site      1899
                     /gene="Fbxo31"
                     /gene_synonym="1110003O08Rik; 2310046N15Rik; Fbx14;
                     Fbxo14"
     regulatory      4408..4413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo31"
                     /gene_synonym="1110003O08Rik; 2310046N15Rik; Fbx14;
                     Fbxo14"
                     /note="hexamer: AGTAAA"
     polyA_site      4430
                     /gene="Fbxo31"
                     /gene_synonym="1110003O08Rik; 2310046N15Rik; Fbx14;
                     Fbxo14"
ORIGIN      
        1 gtgcgcgtcc gcgtgcgcgc ctccgcggtg gtgacgggca tggcggtgtg tgctcggctc
       61 tgcggcgtgg gccccgcgcg tgggtgccgc cgccgccagc agcgccgcgg cccggccgag
      121 actgcggcgg cggacagtga ggcggacacg gaccccgagg aggagcgcat cgaggcgggg
      181 ccggcgcgtt gctctctgct ggagctcccg cctgagctgc tcgtggagat cttcgcgtcg
      241 ctgcccggca ccgacctgcc cagcctggct caggtctgca gcaggttccg ccgaatcttg
      301 cacacggaca ccatctggag acggcgctgc cgcgaggagt atggcgtttg tgagaacctg
      361 cggaagctgg agatcacagg tgtgtcttgc cgggacgtct atgcaaaacg tataaatcct
      421 cgagtgaagt caggacgctt catgaaaatt ctccccgatt atgagcacat ggagtacaga
      481 gatgtgtaca cctgcctgct tcaccgatac agacacattt tggggctgtg gcagccagat
      541 atcgggccgt acggaggatt gctgaacgtc gtggtggacg gactgttcat cattggctgg
      601 atgtacctgc cacctcatga cccccacgtg ggagacccca tgcggttcaa gccactgttt
      661 agaatccatc tgatggagag gaagtcggct acagtggagt gtatgtacgg ccacaaaggg
      721 ccccacaacg gccacatcca gattgtgaag agggacgagt tctccaccaa gtgtaaccag
      781 acagatcacc acaggatgtc cggtgggagg caggaggagt ttcggacgtg gctgagggag
      841 gagtggggcc gcacgctgga agacatcttc cacgagcaca tgcaggagct gattctgatg
      901 aagttcatct acaccagtca gtacgacaac tgcctgacct accgacggat ctacctcccg
      961 cccagccacc ctgacgacct catcaagccc ggcctcttca agggcaccta tggcagccac
     1021 gggctggaga ttgtgatgct cagcttccac ggctcacgcg ccaggggcac caagatcacg
     1081 ggcgacccca acatccccgc ggggcagcag actgtagaga ttgacctgca gcgccgcatc
     1141 cagctgccgg acgtggagaa cctccgaaac ttcaacgagc tctccaggat tgtcctggag
     1201 gtccgggagc aggtgcggca ggagcaggag gccggcgagg gcgccgcgcc accccgggag
     1261 ccttcagcca aggccgctga tgggccacct gctaaggacg gcaaagagcc tggaggtgga
     1321 gccgaggcag ctgagcagtc ggcctcgtct gggcaggggc agccgtttgt gcttcctgtg
     1381 ggtgtcagct cgaggaacga ggattacccc cgcacttgcc gcctatgttt ctatggcaca
     1441 ggcctcatcg ctggccacgg ctttaccagc cctgagcgca cccccggagt cttcgtcctg
     1501 tttgatgagg accgctttgg atttctgtgg ctggaattga agtccttcag cttgtacagc
     1561 cgagtccagg ccaccttcca gaacgccgcc gcgccgtcgc cgcaggcctt tgacgagatg
     1621 ctcaggaaca tccagtctct cacctcctga cctccgcatc gtgggcggag aggctgcacc
     1681 ggggcccggg tgggggaagc atgcacttta gaaatgaacg cacacctcct cactggggtc
     1741 ccggtcgccc cgggacgctt cttgtatagt gtgtaacata ctcttgtaca tttgacttgt
     1801 tggtagctat gaaggagaac gctaagcatg gtgagaaaat aaacggagtt gagccaggat
     1861 cgagctgaat gaccggtgcc tgtggcatgg agaattaaat ggatgcctgc tggttttctg
     1921 aagcaagcaa atctgcccct aggaagggtt atatatcacc cagccaccgt gagtcgtagg
     1981 gggcagggtt ctgtgcacct gttcccttcc aatgacctaa acggtcactg cttggatgtg
     2041 gccgctgtgg gatggccgag tgtcaggctc agggataggt ttccatttcc tcactggctt
     2101 gcttagatct tggacagggc attccaccat ggcctctgtc ctggttgcta ggagccacca
     2161 aagattgcca gggagtcgcc actctggccc ctggtgacct ctgggccaca cccactctcg
     2221 aagtagagcc gagttgtcag gccagccacc tgcttgtccc cagcagccga atgccctccc
     2281 ttggtcctcc acacgtttat ctggagggcc cgcctgccga caccacatcg ctggtgctct
     2341 catttcacgg ctgtgcagat gcctctccaa gtgttgacac cgacgacctt gtcagcagcg
     2401 agcactgtca agccctttgt aggtgaaggc agtcttctag atacttctct gtggccatgt
     2461 gcccgggagc attgctaatt gagggcttac ctgctcagag atcagtgtgc cgggcctgct
     2521 agtgtttgtg tttgaggacc ctgtctgagc ccagcctttg ggagcgtctg cctgagcttc
     2581 cagtgttagc atgcctctag gccgcccttc ccccatggct gttcatcccc tggggctttg
     2641 gcaagccctc atgctgagaa ctcatcccgc tggcgaggga ccttaggaag atggcagcca
     2701 ctcgaggctg ggcctgtaga ctcaggagag gtagtgtggt gaaggaagga cccttgcttg
     2761 caagctgcct ttagggcttt aggatgctgg ctttgtcagg agcagtaaca gaacctgcgg
     2821 cgagctctgt tagtcctgag aagctttgga cagtggcgga tgtgaccagg aagccgcaga
     2881 gtcagtggag agcaggtagc tgggcacgcg ggtagctctt gtcaggtttc cctggagaaa
     2941 agcagaagtg tgcatttccc agaacctttc cctgagtgtc ttcggccgct tctggttcag
     3001 tgggggcgct cacgccatat tagcccacca cacaccggct tccctaaacg cacgccctgc
     3061 ttgctgcaga cgaggcttgt tgggggctga taccattgtt gcatgtagtg tggcctcatg
     3121 tagagaacag caaggccctg gaagtccgct caacaaggca ggtggacatc cttgtccccg
     3181 ggcctcacca ggccagtgcc attggctgct cttgtaattt tgctgctgca ggctgcacag
     3241 cccatggatt ttggagaaaa ggcgccttgt gggtttgcac acttggcctg ccccgctgtg
     3301 tgtggagatg gtatgggtaa ggtcaggggc aagcctcggg aagtttatag cggggactgg
     3361 actctttcga gtgaggatat tgccggtgtc tgtttatgtc ccgatttctt caggcctgcc
     3421 agtgtcagga cattaccgcc atcactcaga cctcagacat caacagtgtg tctgtggggg
     3481 gggagctcta gactccatgc cttggtcctg actcaccttg tgtccctttg acatcagctg
     3541 tctggctcct tgtaacatga gtttagactc tgggcccctc tgctctgggc tgtcagctct
     3601 gcacacttcc tgtccctgca tgtctaccta tagagtgggt acttgacagt ggcttctggc
     3661 caactgctgc gccagccagg ccttcttcac atcaagcaat gaggcactcg cctgctaacc
     3721 gccttccttc cccaagaacc tggagctgaa cacgctgatc tggccatctg gggcacctcc
     3781 ccggctgctg gctgcctccc ccagccctca gcagctctct gccaggctcg ctgtgaacag
     3841 tataccgccc agggtataat tgttcgttca cctttcagga cctatgggca ttagagcaga
     3901 gggcccatcc tgctcagctg tcaggacttt gcgaacctca ggacacctgc atcgcctagt
     3961 gtgggactgt cttctcaaga cagtggggca cagaggacat caagcgcctg acctgtacca
     4021 acctccggcc cacatgaccc actttccaag aagggtttca ctgtgggtcg tgacactgaa
     4081 ggaacctgcc gggtgctttt ctgtggtgga gtcctctgtg tttgcacaga gaccagcaca
     4141 aagtgctagc atgtgcgttc tcagcccgtt tcttgtgctc accgagcctg tttggagcat
     4201 ggggtttgtc tggagcacac acagacacac acacaacaca cacacacaca cctggttctg
     4261 gacagagggt ggctcttaaa agctctcagg tcagctccgc tttgcctagg gtcagggaag
     4321 gaccctgaaa cagtagctgc tgtgtacctg gtgcctgata tcacctgtgt cactcgccta
     4381 ggatgtgtgg ttctcctttc ggttctcagt aaacctgttt ttgaagcctt
//
