LOCUS       NM_027968               4977 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus F-box protein 30 (Fbxo30), transcript variant 1, mRNA.
ACCESSION   NM_027968 XM_125493
VERSION     NM_027968.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4977)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4977)
  AUTHORS   Jin,Y., Yang,M., Gao,C., Yue,W., Liang,X., Xie,B., Zhu,X., Fan,S.,
            Li,R. and Li,M.
  TITLE     Fbxo30 regulates chromosome segregation of oocyte meiosis
  JOURNAL   Cell Mol Life Sci 76 (11), 2217-2229 (2019)
   PUBMED   30980108
  REMARK    GeneRIF: SLBP overexpression caused by Fbxo30 depletion results in
            a remarkable overload of histone H3 on chromosomes that excessively
            condenses chromosomes and inhibits chromosome segregation. The
            finding uncovers an unidentified pathway-controlling chromosome
            segregation and cell progress.
REFERENCE   3  (bases 1 to 4977)
  AUTHORS   Liu,Y., Wang,Y., Du,Z., Yan,X., Zheng,P. and Liu,Y.
  TITLE     Fbxo30 Regulates Mammopoiesis by Targeting the Bipolar Mitotic
            Kinesin Eg5
  JOURNAL   Cell Rep 15 (5), 1111-1122 (2016)
   PUBMED   27117404
  REMARK    GeneRIF: Fbxo30-Eg5 interaction as a critical checkpoint in
            mammopoiesis.
REFERENCE   4  (bases 1 to 4977)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 4977)
  AUTHORS   Sartori,R., Schirwis,E., Blaauw,B., Bortolanza,S., Zhao,J.,
            Enzo,E., Stantzou,A., Mouisel,E., Toniolo,L., Ferry,A.,
            Stricker,S., Goldberg,A.L., Dupont,S., Piccolo,S., Amthor,H. and
            Sandri,M.
  TITLE     BMP signaling controls muscle mass
  JOURNAL   Nat Genet 45 (11), 1309-1318 (2013)
   PUBMED   24076600
  REMARK    GeneRIF: MUSA1 inhibition significantly protected denervated
            muscles from atrophy and the drastic atrophy seen in
            Smad4-deficient muscles was blunted [MUSA1]
REFERENCE   6  (bases 1 to 4977)
  AUTHORS   Combes,A.N., Lesieur,E., Harley,V.R., Sinclair,A.H., Little,M.H.,
            Wilhelm,D. and Koopman,P.
  TITLE     Three-dimensional visualization of testis cord morphogenesis, a
            novel tubulogenic mechanism in development
  JOURNAL   Dev Dyn 238 (5), 1033-1041 (2009)
   PUBMED   19334288
REFERENCE   7  (bases 1 to 4977)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167234.4, AK083479.1, AK135274.1 and AK047174.1.
            
            On Nov 28, 2009 this sequence version replaced NM_027968.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083479.1, AK135274.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AC167234.4         133026-133069
            45-604              AK083479.1         2-561
            605-2224            AK135274.1         564-2183
            2225-3973           AK083479.1         2182-3930
            3974-4977           AK047174.1         1570-2573
FEATURES             Location/Qualifiers
     source          1..4977
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 3.66 cM"
     gene            1..4977
                     /gene="Fbxo30"
                     /gene_synonym="1700026A16Rik; MUSA1"
                     /note="F-box protein 30"
                     /db_xref="GeneID:71865"
                     /db_xref="MGI:MGI:1919115"
     exon            1..171
                     /gene="Fbxo30"
                     /gene_synonym="1700026A16Rik; MUSA1"
                     /inference="alignment:Splign:2.1.0"
     exon            172..2224
                     /gene="Fbxo30"
                     /gene_synonym="1700026A16Rik; MUSA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..2428
                     /gene="Fbxo30"
                     /gene_synonym="1700026A16Rik; MUSA1"
                     /note="muscle ubiquitin ligase of SCF complex in
                     atrophy-1"
                     /codon_start=1
                     /product="F-box only protein 30"
                     /protein_id="NP_082244.2"
                     /db_xref="CCDS:CCDS23697.1"
                     /db_xref="GeneID:71865"
                     /db_xref="MGI:MGI:1919115"
                     /translation="MEEEVQQHSHCMNCVSRRCMTRPEPGVSCDLIGCPLVCGAVFHS
                     CKADEHRLLCPFERVACLNRNFGCPFTLARNKVAEHLEMCPASVVCCTMEWNRWPVSY
                     SDRKSYESLSRDVDEVAQLDMALALQDQRMLLESLKVATMMSKATDKISEPREQISVK
                     SSVQEIPRTNGLVSVDEESYGALYQATVETTRSLAAALDILNSATRDIGMLNTSLHAT
                     ANEMDEENNKESFQDKNLKDQDHLDEGEIGAVGGVDYSGTSQNAQAEQNGSSDLLCDL
                     NPSSNGTSALCNGFPLEKMCIQVKGQDQNFHGDSTESNITNGDCVEADGTSEPSSSLV
                     VPEQLREISPFSALPDSTFQQILMPDEDDEKDLCWKKVDLGDLKDVNGSPFSHAPSFK
                     FLSNSWYIPKEDKAVDTSDLEVAEDPMGLQGIDLITAALLFCLGDSPGGRGISDSRMT
                     DVYHVDFGTQTFSLPSAILATNTMVGEIASASACDHANPQLSNPSPFQTLGLDLVLEC
                     VARYQPKQRSMFTFVCGQLFRRKEFSSHFKNVHGDIHAGLNGWMEQRCPLAYYGCTYS
                     QRRFCPSTQGAKIIHDRHLRSFGVQPCVSTVLEEPSRNCVLGLRSDHLSSLPFEVLQH
                     IAGFLDGFSLCQLACVSRLMRDVCGSLLQSRGMVILQWGKKKYPEGNSSWQIKEKVWR
                     FSTAFCSVNDWKFADILSMADHLKNCSYNVIEKREEAIPLPCMCVTRELTKEGRSLRS
                     VLKPVL"
     exon            2225..4977
                     /gene="Fbxo30"
                     /gene_synonym="1700026A16Rik; MUSA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2507..2512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo30"
                     /gene_synonym="1700026A16Rik; MUSA1"
                     /note="hexamer: ATTAAA"
     polyA_site      2529
                     /gene="Fbxo30"
                     /gene_synonym="1700026A16Rik; MUSA1"
                     /note="major polyA site"
     regulatory      3213..3218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo30"
                     /gene_synonym="1700026A16Rik; MUSA1"
                     /note="hexamer: AATAAA"
     polyA_site      3236
                     /gene="Fbxo30"
                     /gene_synonym="1700026A16Rik; MUSA1"
                     /note="major polyA site"
     regulatory      3956..3961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo30"
                     /gene_synonym="1700026A16Rik; MUSA1"
                     /note="hexamer: AGTAAA"
     polyA_site      3973
                     /gene="Fbxo30"
                     /gene_synonym="1700026A16Rik; MUSA1"
     regulatory      4338..4343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo30"
                     /gene_synonym="1700026A16Rik; MUSA1"
                     /note="hexamer: AATAAA"
     polyA_site      4359
                     /gene="Fbxo30"
                     /gene_synonym="1700026A16Rik; MUSA1"
     regulatory      4676..4681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo30"
                     /gene_synonym="1700026A16Rik; MUSA1"
                     /note="hexamer: AATAAA"
     polyA_site      4697
                     /gene="Fbxo30"
                     /gene_synonym="1700026A16Rik; MUSA1"
ORIGIN      
        1 ggttggaggc cgaggagaaa aggcggcggt ccgggcaggg cggaggcgca gaggattggg
       61 acgggacggg ccccgtgcgt ggtccggtcc ggtgcgggga cgctgcggag ccgccgggcg
      121 ctaaggccag agaagccagg gtttgagcgg cgcttcggcc cgcgcgggct gagctggact
      181 ggccattatg gaggaagagg tacagcagca ctcacactgt atgaactgtg tcagtagacg
      241 gtgtatgacc agaccagagc ctggggtttc ctgtgacttg attggctgtc cattggtttg
      301 tggagcagtt ttccattctt gtaaagctga cgaacatcgg ctcttgtgtc cctttgaacg
      361 agtagcttgc ttaaatagaa actttggatg tccatttacc ctggcacgaa ataaagttgc
      421 tgaacatcta gaaatgtgtc ctgcaagtgt ggtgtgctgt actatggaat ggaatcgatg
      481 gcccgttagt tattcagacc ggaagtcata tgaaagtcta agcagagatg ttgatgaagt
      541 ggcacaatta gacatggctt tggctcttca agatcaaaga atgcttttgg aatctcttaa
      601 agtagccacc atgatgtcaa aagcaactga taaaatatct gaacctagag aacaaatctc
      661 agtgaaatca agtgttcagg aaataccacg tactaacggg ttggtatccg ttgatgaaga
      721 atcctatggt gcactttatc aagctactgt agaaacaacc agaagtttgg ctgctgcttt
      781 agatatccta aattctgcca caagagacat tggcatgtta aatacaagtc tccatgctac
      841 tgcgaatgaa atggatgagg agaataacaa agaaagcttc caggacaaaa acttgaaaga
      901 ccaggaccac cttgatgagg gtgagatagg ggcagtaggt ggagttgatt atagtggcac
      961 aagtcagaat gctcaggctg aacaaaatgg ctcaagtgat ttgttatgtg acttaaatcc
     1021 aagttctaat ggtacttctg ctctttgcaa tggctttcct ttggaaaaga tgtgtattca
     1081 ggtcaaaggc caggatcaaa attttcatgg tgattccaca gaaagtaata taacaaatgg
     1141 agattgtgtg gaagctgatg gtacttcaga accttccagt tcacttgtag taccagaaca
     1201 actgagggaa ataagtcctt tcagtgcttt gccagatagt acatttcagc aaatcctcat
     1261 gccagatgaa gacgatgaga aggacttgtg ttggaaaaaa gtagacttgg gagacttgaa
     1321 ggatgttaat ggttcacctt tcagtcatgc gccttcattc aagtttcttt ctaattcatg
     1381 gtatatacca aaggaagaca aagcagttga tacatcagat ttagaagttg cagaagatcc
     1441 catgggcctc caaggaatag atctgattac agcagcatta ctgttttgtc tgggagattc
     1501 tccaggtggg agaggtatat ctgatagccg catgactgat gtttatcacg ttgactttgg
     1561 gacacagact ttttcacttc catctgcaat attagctaca aatacaatgg ttggagaaat
     1621 agcttcggct tcagcttgtg atcatgccaa tccacagctt tcaaatccaa gcccttttca
     1681 gacacttggg ctggacttag ttttggaatg tgttgctagg taccagccta agcagcgttc
     1741 aatgtttacc tttgtatgcg gacagctatt tagaagaaaa gaattttctt cccattttaa
     1801 gaatgtgcat ggtgacattc atgctggact caatggatgg atggaacaga ggtgtccttt
     1861 agcttattat ggttgtacct attctcagcg tagattttgc ccatcgacac aaggagcaaa
     1921 gatcatacat gatcgccatt taaggtcatt tggagttcag ccatgtgtat ctacagtatt
     1981 agaagaacct tctagaaact gtgtgttggg attgcgtagt gaccatctaa gtagtctccc
     2041 ttttgaggta ctccaacata ttgcaggctt ccttgacggc ttcagtttat gccagcttgc
     2101 atgtgtatcc cggctaatga gggacgtttg tggcagttta cttcagtctc gtggaatggt
     2161 aatcttgcag tgggggaaga agaagtatcc ggaaggaaat tcatcatggc agataaaaga
     2221 gaaggtatgg cgattcagta ctgcattttg ttctgttaat gactggaaat ttgctgacat
     2281 cctgagcatg gctgaccact tgaagaactg cagttacaac gtgatagaga aacgggagga
     2341 agccatccca ttgccgtgta tgtgtgtgac tcgagagctt acaaaagaag gacgttccct
     2401 gcgctcagtt ttaaagcctg tgctttaagg ctgtaacttc ttcacttgca cacacatgca
     2461 agcacctggt atcagttctt tgtatgatgt gatactttat taatgcatta aagactacaa
     2521 ctagccaaat tgattgtcac tatgtatata ctgttttgca gtgacatata tttttataat
     2581 gtactattag ttagaaaaat gttgccttaa tatttgaaat gtgtgaaatt gttgggacat
     2641 gctagacagg gtgatctttt ctgcataatg ttagtattaa tggtgtgcac atttaaattc
     2701 tgaaatcttt gctcctcaaa ctaaaacgat cttgaccaaa acaattcttt atattttcta
     2761 tggattgaag cccatgttat caaaaaggaa aactttgatt cgaaattttt gttgcataga
     2821 tttttcacat aatacatttg atgttgaaac actgccataa gattataatc aagttttcct
     2881 ggtactttca taattattga tcacaagtgt aatacagtat tcacataagg cacaatagtg
     2941 acttcatgtc tttaaaacaa catacaaaga tattttatct tctgttctta aaactcttat
     3001 gcaaaaaatg gtcatatgca ggtctttttt tttcgttaaa taccgtatct gaagagttgt
     3061 ggcacaatgt attatatgac agattaaagt gaaaacaaag gaagcctgtg aatttaactt
     3121 gaaaattttc atggtatttc atattttcta ggtatccaat gtttgaaaag aaaatatacc
     3181 tcactaaaag tttgagtttg gaatattgtt cgaataaact tcaaatattc agaatacaaa
     3241 gggtttgact ttttgagggg ccttaaaaat gttctgcttt tgatatttgt aagacttttt
     3301 tttttttttt tgtcccgaga cagggtttct ctatgtagct gtggctgtcc tggaactcac
     3361 tctgtacaca aggctggcct caaactcaga aatcctcctg tctctgcctc ccaagtgctg
     3421 ggataagaca ttattttaag acctttaaaa atgtgaaaat tcaaagtgtt tgtaaaataa
     3481 cgttaagcag aaatctgtct tggttgataa tatttgtgaa acatttccag ttttgcttca
     3541 catatttctc agaaagtaag aattgtctct tttttgtaaa catcaagtgt ggtaatgaaa
     3601 tagtcaaaaa acctataggc ttccatgttc acataatgtg cttattaaag aaatgaacat
     3661 acattgtcag catttagaag taagttgtga agacagggac attaagtgat ttgtccagtt
     3721 aaattctggc attggtaagc ggaaatggtt attaatgtga aacctcaagt gtatattttc
     3781 tttctccgtt gttttgagag tactctgtgg gtagattcat atgtcccata tattagtcag
     3841 agtgggaagc tgattcatat gtcccatata tagtagttag ggtgggaaga gggtcttccc
     3901 tgggcattac tgatgaattc tcaattgctt gtgatttgtt ttgacaaaat gtagcagtaa
     3961 agattaatca cttgttttgc ctcacctgtc atttaactta caaggattcg tcatttcagt
     4021 gcttaaattt ctttttcaac tgtgagactg aattgcattt aaataacacc accaccacct
     4081 ccatctttat ttctgccaaa aggtagaaat aagaatcaaa tatgacagaa tataactttt
     4141 ctgaagattg tttctatagt taggcaacac aagcaattaa ccttttgttt tatgtttgta
     4201 ctttttaaag ttcatggttt gtaagtttaa atctatttcc agacagttaa catttttttt
     4261 acctttcttg aatgagatgg atattttaat aatagcatat gtacaatgaa aactatttct
     4321 actttttatt ctgttcaaat aaatattttt ttcaattaat tttgggtcaa aaaaacaata
     4381 gttaggtact agacatgtat ctccaggcga ggcaagcata gtctagctgc tttctttagc
     4441 ctgttattca tgcagtcagt tttagataac cagaagtgtg gatgcttact gagacaatta
     4501 gacatgggaa caagtgtgga attttacatg agtttctgga tcagaaaaca taactcgttc
     4561 ttcagggtag ttagtattta aatgctgctg atatcactgc cattttagcc atcaatcctt
     4621 catgtgaaag caacttaggg agacatagga actaaaaagt tgaatgtatt tgcttaataa
     4681 aacagtttta atcctaatac ataaaatctt aaaaaataca ataactatag tttacaaaaa
     4741 ttgagatcaa ccatgtggta agtaaagtaa ttcttattta agaaaatgtc aaatttaagt
     4801 taaaacagaa gttgaacatg atgggtgttt acaagtttat tagcatcata aaaagtattc
     4861 ctctttgttt tttgaacatc tgtatgcgat caggtgtttg gatggcaaac ctgggatgtt
     4921 gcatgagtac tctaaagtac tgtgaactgc agccaaaata aaagccactt agaagct
//
