LOCUS       NM_212433               4659 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus F-box protein 3 (Fbxo3), transcript variant 1, mRNA.
ACCESSION   NM_212433
VERSION     NM_212433.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4659)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4659)
  AUTHORS   Xu,J., Guo,R., Wen,N., Li,L., Yi,Y., Chen,J., He,Z., Yang,J.,
            Xiao,Z.J. and Niu,M.
  TITLE     FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated breast
            cancer metastasis
  JOURNAL   PLoS Biol 21 (12), e3002446 (2023)
   PUBMED   38134227
  REMARK    GeneRIF: FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated
            breast cancer metastasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4659)
  AUTHORS   Gao,Y., Xiao,X., Luo,J., Wang,J., Peng,Q., Zhao,J., Jiang,N. and
            Zhao,Y.
  TITLE     E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate
            Cerebral Ischemia/Reperfusion Injury
  JOURNAL   Int J Mol Sci 23 (21), 13648 (2022)
   PUBMED   36362432
  REMARK    GeneRIF: E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to
            Aggravate Cerebral Ischemia/Reperfusion Injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4659)
  AUTHORS   Shao,W., Zumer,K., Fujinaga,K. and Peterlin,B.M.
  TITLE     FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity
            of AIRE (Autoimmune Regulator)
  JOURNAL   J Biol Chem 291 (34), 17953-17963 (2016)
   PUBMED   27365398
  REMARK    GeneRIF: AIRE, which is phosphorylated on two specific residues
            near its N terminus, then binds to the F-box protein 3 (FBXO3) E3
            ubiquitin ligase. In turn, this SCF(FBXO3) (SKP1-CUL1-F box)
            complex ubiquitylates AIRE, increases its binding to the positive
            transcription elongation factor b (P-TEFb), and potentiates its
            transcriptional activity.
REFERENCE   5  (bases 1 to 4659)
  AUTHORS   Nechiporuk,T., McGann,J., Mullendorff,K., Hsieh,J., Wurst,W.,
            Floss,T. and Mandel,G.
  TITLE     The REST remodeling complex protects genomic integrity during
            embryonic neurogenesis
  JOURNAL   Elife 5, e09584 (2016)
   PUBMED   26745185
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4659)
  AUTHORS   Chen,B.B., Coon,T.A., Glasser,J.R., McVerry,B.J., Zhao,J., Zhao,Y.,
            Zou,C., Ellis,B., Sciurba,F.C., Zhang,Y. and Mallampalli,R.K.
  TITLE     A combinatorial F box protein directed pathway controls TRAF
            adaptor stability to regulate inflammation
  JOURNAL   Nat Immunol 14 (5), 470-479 (2013)
   PUBMED   23542741
REFERENCE   7  (bases 1 to 4659)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   8  (bases 1 to 4659)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   9  (bases 1 to 4659)
  AUTHORS   Ilyin,G.P., Rialland,M., Pigeon,C. and Guguen-Guillouzo,C.
  TITLE     cDNA cloning and expression analysis of new members of the
            mammalian F-box protein family
  JOURNAL   Genomics 67 (1), 40-47 (2000)
   PUBMED   10945468
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY105498.1, AK049870.1, AK029594.1, BB470024.2 and BE980708.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167075.1, BC050758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                BY105498.1         1-43
            44-2428             AK049870.1         2-2386
            2429-3919           AK029594.1         1548-3038
            3920-4392           BB470024.2         187-659
            4393-4659           BE980708.1         19-285              c
FEATURES             Location/Qualifiers
     source          1..4659
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 54.49 cM"
     gene            1..4659
                     /gene="Fbxo3"
                     /gene_synonym="1200002G09Rik; 1700026K02Rik; Fba"
                     /note="F-box protein 3"
                     /db_xref="GeneID:57443"
                     /db_xref="MGI:MGI:1929084"
     exon            1..168
                     /gene="Fbxo3"
                     /gene_synonym="1200002G09Rik; 1700026K02Rik; Fba"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1507
                     /gene="Fbxo3"
                     /gene_synonym="1200002G09Rik; 1700026K02Rik; Fba"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     only protein 3; F-box protein FBA"
                     /codon_start=1
                     /product="F-box only protein 3 isoform 1"
                     /protein_id="NP_997598.1"
                     /db_xref="CCDS:CCDS16484.1"
                     /db_xref="GeneID:57443"
                     /db_xref="MGI:MGI:1929084"
                     /translation="MAAVEAETGLLTLESLPTDPLLLILSFVDYRDLINCCYVSRRLS
                     QLSTHDPLWRRHCKKYWLISEEEKAGKSQCWRSLFIETYSDVGRYIDHYAAIKKAWRD
                     LKKYLEPRCPRMVLSLKEGAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVVPGLL
                     GSMALSNHYRSEDLLDVDTAAGGFQQRQGLKYCLPLTFCIHTGLSQYIAVEAAEGRNK
                     NEVFYQCPDQMARNPAAIDMFIIGATFTDWFTSYVNNVVSGGFPIIRDQIFRYIHDPE
                     CVATTGDITVSVSTSFLPELSSVHPPHYFFTYRIRIEMSRDALPEKACQLDSRYWRIT
                     NAKGDVEEVQGPGVVGEFPIISPGRIYEYTSCTTFSTTSGYMEGYYTFHFLYFKDKVF
                     NVAIPRFHMACPTFRVSIARLEMGPDEYEEMEEEAEEEEEEENDDSADMDESDESDAD
                     ENESDEGEGEARRRRVFDVPIRRRRCSRLF"
     exon            169..258
                     /gene="Fbxo3"
                     /gene_synonym="1200002G09Rik; 1700026K02Rik; Fba"
                     /inference="alignment:Splign:2.1.0"
     exon            259..422
                     /gene="Fbxo3"
                     /gene_synonym="1200002G09Rik; 1700026K02Rik; Fba"
                     /inference="alignment:Splign:2.1.0"
     exon            423..537
                     /gene="Fbxo3"
                     /gene_synonym="1200002G09Rik; 1700026K02Rik; Fba"
                     /inference="alignment:Splign:2.1.0"
     exon            538..742
                     /gene="Fbxo3"
                     /gene_synonym="1200002G09Rik; 1700026K02Rik; Fba"
                     /inference="alignment:Splign:2.1.0"
     exon            743..788
                     /gene="Fbxo3"
                     /gene_synonym="1200002G09Rik; 1700026K02Rik; Fba"
                     /inference="alignment:Splign:2.1.0"
     exon            789..873
                     /gene="Fbxo3"
                     /gene_synonym="1200002G09Rik; 1700026K02Rik; Fba"
                     /inference="alignment:Splign:2.1.0"
     exon            874..996
                     /gene="Fbxo3"
                     /gene_synonym="1200002G09Rik; 1700026K02Rik; Fba"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1112
                     /gene="Fbxo3"
                     /gene_synonym="1200002G09Rik; 1700026K02Rik; Fba"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1303
                     /gene="Fbxo3"
                     /gene_synonym="1200002G09Rik; 1700026K02Rik; Fba"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..4659
                     /gene="Fbxo3"
                     /gene_synonym="1200002G09Rik; 1700026K02Rik; Fba"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2393..2398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo3"
                     /gene_synonym="1200002G09Rik; 1700026K02Rik; Fba"
                     /note="hexamer: AATGAA"
     polyA_site      2434
                     /gene="Fbxo3"
                     /gene_synonym="1200002G09Rik; 1700026K02Rik; Fba"
                     /note="major polyA site"
     regulatory      2791..2796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo3"
                     /gene_synonym="1200002G09Rik; 1700026K02Rik; Fba"
                     /note="hexamer: ATTAAA"
     polyA_site      2830
                     /gene="Fbxo3"
                     /gene_synonym="1200002G09Rik; 1700026K02Rik; Fba"
                     /note="major polyA site"
     regulatory      2897..2902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo3"
                     /gene_synonym="1200002G09Rik; 1700026K02Rik; Fba"
                     /note="hexamer: AATGAA"
     polyA_site      2918
                     /gene="Fbxo3"
                     /gene_synonym="1200002G09Rik; 1700026K02Rik; Fba"
                     /note="major polyA site"
     regulatory      3386..3391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo3"
                     /gene_synonym="1200002G09Rik; 1700026K02Rik; Fba"
                     /note="hexamer: GATAAA"
     polyA_site      3411
                     /gene="Fbxo3"
                     /gene_synonym="1200002G09Rik; 1700026K02Rik; Fba"
     regulatory      4377..4382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo3"
                     /gene_synonym="1200002G09Rik; 1700026K02Rik; Fba"
                     /note="hexamer: AATAAA"
     polyA_site      4417
                     /gene="Fbxo3"
                     /gene_synonym="1200002G09Rik; 1700026K02Rik; Fba"
ORIGIN      
        1 ggttcgggcg gcgggggcgg gggcggggcc ggggtggtgc caaggctgca gcgggccggg
       61 caagatggct gccgtagagg ccgagacggg gctgctgacc ctggagtcgc tgcccaccga
      121 ccctctgctg ctcatcttat ccttcgtgga ctacagggac ctaatcaatt gttgctatgt
      181 tagtcgaaga cttagccagc tttcaactca tgatccactg tggagaagac attgcaaaaa
      241 atactggctg atatctgagg aagaaaaagc cgggaagagt cagtgctgga gatccctctt
      301 catagagacc tactcagacg tggggaggta catcgaccat tacgccgcca ttaaaaaggc
      361 ctggcgtgac ctcaagaagt acttggagcc caggtgtcct cggatggttt tatctctgaa
      421 agagggcgca cgtgaggaag acctggatgc tgtcgaagct cagatcggtt gcaagctccc
      481 ggatgattat cgctgttcat accggatcca caacgggcaa aagttagtgg tgccggggtt
      541 gctgggaagt atggcactgt ccaatcacta ccgctctgaa gatctactag atgttgatac
      601 tgctgcagga ggatttcagc agagacaggg actgaaatac tgtctccctt taaccttttg
      661 catacacacc ggcttgagtc agtacatagc tgtggaggct gcagaggggc ggaataagaa
      721 cgaagtgttc taccaatgtc cagaccaaat ggctcggaat cctgctgcta ttgacatgtt
      781 tatcataggt gctactttta ccgactggtt tacatcctat gtcaacaatg ttgtatcagg
      841 tggtttcccc atcatcagag accagatttt cagatatatt catgatccag aatgtgtggc
      901 aacaactgga gatattacag tttcagtgtc cacatcgttt ctgccagaac tcagctctgt
      961 gcatccgcca cactatttct tcacataccg aatcaggatt gaaatgtcaa gggatgctct
     1021 tcctgagaag gcctgtcagt tggacagtcg ctactggagg ataacaaacg ctaaagggga
     1081 tgtggaagaa gtccagggac ctggagtagt cggtgaattt ccaattatta gcccaggtcg
     1141 gatatatgaa tacacaagct gtaccacatt ttctacaaca tcaggctaca tggaagggta
     1201 ttacaccttc cattttctgt actttaagga caaggtcttt aatgttgcca tcccccgatt
     1261 ccacatggca tgtccaacat tcagggtgtc tatagctcga ttggaaatgg gtcctgatga
     1321 atatgaagag atggaggagg aagctgagga ggaggaggag gaagaaaatg atgactctgc
     1381 agacatggat gaatccgatg agtcagatgc ggatgagaat gagtcagatg agggtgaagg
     1441 ggaggcgaga cggaggaggg tctttgatgt tcccattcgc agacgccgct gctctcgtct
     1501 gttttagctg ctgctgaagg aagctctggg atgacactgt tctgttaaac agttttgtca
     1561 ataatgtaaa taattgtgct cagcatatag ccggaagctc gcatgaaatg ttgttccaga
     1621 cctaggcgct acatgacact acattaggcg ttggatcgct ttgcttgact ttgtgcttgt
     1681 aggtagagga acaaatggga attgtttgtt ttctcttcca ggggtcaatg ggagagcagc
     1741 tctctagcta aagaacagga gttcctttgt ttaaaaatat tttctactta aaaacaaaac
     1801 agaggtgaag gggaaattgt tttggatgag gattttatat gtaacaaaaa cacccaccca
     1861 agggcagaaa gagactgcag gaaggactga ctgtgcaaag acccctctca gttgtttaga
     1921 cactaacaaa atttatactt agcttaatcc acttcatggt tgttaacatt ttatactcat
     1981 tgggcaacta aatggctaag ttcaataggg atagtttgcc cttacttaga caatctctcc
     2041 ttgcattagt ctttgtcaca ccgacctgag ttgcaaattt ttatcattac ttttaattta
     2101 aagtcttcaa cataactttg ggctttaaaa gttaaagttc ttacgctatg accgttctca
     2161 cattatttat agattcatca ttttaaatgt agtttgtgaa agtacgtagg gtgttgctaa
     2221 agattcttca tgatgtctca tgtagtctaa atttgtaaat atgctttctg ttttgtttct
     2281 ttatacattt gtctaacttt gtggtaagtg atctgaattt tatgttaggg ttaggatatt
     2341 tttgtgaaac atggatattt tttttttggt aattatataa ttgagagttt ggaatgaaat
     2401 ccttcaagtg tcaaaaactc ctattttgaa aacatttttg tgtaagtgcc tatttcccat
     2461 agatagtatt gagcttttgt tcttaagctg gaagatggcc atggtgcttg ctggcttaca
     2521 gcctgagtat agctggtcca ttcagagctg actgctggct ttgcttacac ctggagaaaa
     2581 tgagagcgcc atattcaggt ctaagtgcct gctctcgggt accgtgagca aacttgccct
     2641 tttatgaaga cagatcagaa tattccaagt cattttccta cttatttttc ataaaagagt
     2701 acaatcgcat ggtgtttcaa cagaagcccg cggcagcctc atcttctgta taccacatct
     2761 gttgaatgta tcatttttct cttgtgcttg attaaatctc atgtgttttt gtttgttatg
     2821 gcccaaagca tacacagtct actgctaaag ttgacagtaa gttgtcatca agtgattgtc
     2881 ctagaaatga aattaaaatg aaggactttg aagcggaagc atcaccatgg ctactgctta
     2941 ttaagtcagc cgcttcacca tagctgcacc cgcagaggac aagaacaggt aggacgtaag
     3001 ttactggagc atctgcttca ttgaaggcag tacgactatt tcaagagagg tcaatatcag
     3061 atctggagac ccttgtttgt aatcacctga cgtgacaaaa atgtgtcctc aacagcatga
     3121 tgaccactgc caaagcaggg tttgcctaca gcgttgaaag agaagactag acctgtcaga
     3181 gttcctgaga actctgggtg gtctaaaatg attgaagatc attagagaat ttgaaaggaa
     3241 gtgataaacc tgcaaacttg tgggtaaagg ccgctaactt ttaaaagcta gaaaagtggg
     3301 tgtggagagc ggttactcgc cagagcaagc cctcctctat tccatctagg tttgtataaa
     3361 atacattttg tggtctttgc acagtgataa aattacctgg caacacagtc acctaatgac
     3421 tcatttctta aactatattc ccactgttaa gtgagaacat ggctgttatc agacttgaaa
     3481 tactattcag gctacccttg ttaaaaaata gtcaaccctt ttaatttagg ctgccataat
     3541 aaaataccct tgattataat ataaatagaa aatatagcca ggccatggtg gcacatacct
     3601 gtaatcccaa cttgagaggc agattgaggc agaaggatta tagtgagttt gaaattagcc
     3661 caggctacaa agtaaaatct tgtctttaaa aaaaaaaatg tagctataca aacaagtcgt
     3721 taataacaac ctaatgtcct acattttcat aaagatgctt tgttgattag tcagtataag
     3781 gaaggagaca ggatgtagac aacaaacatt cagaccctag tatcaacccc ctttaaaagg
     3841 actttcccag taaagtagca attaagaaac catgacaaag ctggccccac acttccttgt
     3901 cattccttgt atcttttttc tagtacattg atggcccaac tgtgcctgag cccagcctaa
     3961 tgtttgttat agtacttcat gattgcttag cctcccttca aaatttgcct tttggtatat
     4021 tcaacagact tttattttct gggacagagg acaataacag accaaagaaa tccatccaag
     4081 ctcagcctgg tgggccaaca aattatcagg attactaaca ggaacatgga tgattgacag
     4141 ctgcaactga ggaacaacat agcagcctgg gggaggactc acaagcattg gggttcctgg
     4201 gaaactcaag gcagctgcat gtttgaagaa tctcttctag caagtttgca ctgcttatat
     4261 aaccactggg agaggtgttt ggtcataaat ctcagaatct tgaatcctct gaggagtttc
     4321 atgagccttc ctactcccat caggaggctg tttctatgaa taggaattag ctgtacaata
     4381 aacctccaca tcacacaaag gtgtggttag ttgacaagcc tctgtaaact acattgcaaa
     4441 aattcttatt catgaaagtg tttagcatgt atgggtgctt tgccctctgt gtatatctgt
     4501 gcaccacttg ggtgcccagt gcccatggag gccactagca ttattggatg ccctaggttc
     4561 tgagagttga aactgaatgg tctggatctg gaactgaagt cagtgctatt aactgctgag
     4621 ccatccctct agcccctcaa taaacggagt ttaaccatt
//
