LOCUS       NM_025785               2098 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus F-box protein 25 (Fbxo25), transcript variant 2, mRNA.
ACCESSION   NM_025785 XM_980358 XM_980393
VERSION     NM_025785.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2098)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2098)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2098)
  AUTHORS   Jeong,H.S., Jung,E.S., Sim,Y.J., Kim,S.J., Jang,J.W., Hong,K.S.,
            Lee,W.Y., Chung,H.M., Park,K.T., Jung,Y.S., Kim,C.H. and Kim,K.S.
  TITLE     Fbxo25 controls Tbx5 and Nkx2-5 transcriptional activity to
            regulate cardiomyocyte development
  JOURNAL   Biochim Biophys Acta 1849 (6), 709-721 (2015)
   PUBMED   25725482
  REMARK    GeneRIF: our findings reveal a novel mechanism for regulation of
            SCFFbox25-dependent Nkx2-5 and Tbx5 ubiquitination in cardiac
            development and provide a new insight into the regulatory mechanism
            of Nkx2-5 and Tbx5 transcriptional activity.
REFERENCE   4  (bases 1 to 2098)
  AUTHORS   Xue,W., Kitzing,T., Roessler,S., Zuber,J., Krasnitz,A., Schultz,N.,
            Revill,K., Weissmueller,S., Rappaport,A.R., Simon,J., Zhang,J.,
            Luo,W., Hicks,J., Zender,L., Wang,X.W., Powers,S., Wigler,M. and
            Lowe,S.W.
  TITLE     A cluster of cooperating tumor-suppressor gene candidates in
            chromosomal deletions
  JOURNAL   Proc Natl Acad Sci U S A 109 (21), 8212-8217 (2012)
   PUBMED   22566646
REFERENCE   5  (bases 1 to 2098)
  AUTHORS   Jang,J.W., Lee,W.Y., Lee,J.H., Moon,S.H., Kim,C.H. and Chung,H.M.
  TITLE     A novel Fbxo25 acts as an E3 ligase for destructing cardiac
            specific transcription factors
  JOURNAL   Biochem Biophys Res Commun 410 (2), 183-188 (2011)
   PUBMED   21596019
  REMARK    GeneRIF: Altogether, Fbxo25 acts as an ubiquitin E3 ligase to
            target cardiac transcription factors including Nkx2-5, Isl1, and
            Hand1, indicating that cardiac protein homeostasis through Fbxo25
            has a pivotal impact on cardiac development.
REFERENCE   6  (bases 1 to 2098)
  AUTHORS   Manfiolli,A.O., Maragno,A.L., Baqui,M.M., Yokoo,S., Teixeira,F.R.,
            Oliveira,E.B. and Gomes,M.D.
  TITLE     FBXO25-associated nuclear domains: a novel subnuclear structure
  JOURNAL   Mol Biol Cell 19 (5), 1848-1861 (2008)
   PUBMED   18287534
  REMARK    GeneRIF: The cellular distribution of FBXO25 and its colocalization
            with some nuclear proteins is investigated by using immunochemical
            and biochemical approaches.
REFERENCE   7  (bases 1 to 2098)
  AUTHORS   Maragno,A.L., Baqui,M.M. and Gomes,M.D.
  TITLE     FBXO25, an F-box protein homologue of atrogin-1, is not induced in
            atrophying muscle
  JOURNAL   Biochim Biophys Acta 1760 (6), 966-972 (2006)
   PUBMED   16714087
  REMARK    GeneRIF: FBXO25 is a novel F-box protein analogous to atrogin-1,
            which is not involved in muscle atrophy.
REFERENCE   8  (bases 1 to 2098)
  AUTHORS   Hagens,O., Minina,E., Schweiger,S., Ropers,H.H. and Kalscheuer,V.
  TITLE     Characterization of FBX25, encoding a novel brain-expressed F-box
            protein
  JOURNAL   Biochim Biophys Acta 1760 (1), 110-118 (2006)
   PUBMED   16278047
  REMARK    GeneRIF: mFbx25 shows predominantly neuronal expression and in
            adult mouse brain, expression is confined to the hippocampus, the
            cerebral cortex and the Purkinje cell layer
REFERENCE   9  (bases 1 to 2098)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139186.4.
            
            On Feb 2, 2018 this sequence version replaced NM_025785.2.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            3' coding region, compared to variant 3. The encoded isoform (2) is
            shorter than isoform 3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014749.1, AK018626.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AC139186.4         135732-135856
            126-266             AC139186.4         142937-143077
            267-367             AC139186.4         148941-149041
            368-417             AC139186.4         149878-149927
            418-510             AC139186.4         151918-152010
            511-604             AC139186.4         154941-155034
            605-789             AC139186.4         157249-157433
            790-972             AC139186.4         159175-159357
            973-1116            AC139186.4         163139-163282
            1117-2098           AC139186.4         167556-168537
FEATURES             Location/Qualifiers
     source          1..2098
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 6.42 cM"
     gene            1..2098
                     /gene="Fbxo25"
                     /gene_synonym="9130015I06Rik; Fbx25"
                     /note="F-box protein 25"
                     /db_xref="GeneID:66822"
                     /db_xref="MGI:MGI:1914072"
     exon            1..125
                     /gene="Fbxo25"
                     /gene_synonym="9130015I06Rik; Fbx25"
                     /inference="alignment:Splign:2.1.0"
     exon            126..266
                     /gene="Fbxo25"
                     /gene_synonym="9130015I06Rik; Fbx25"
                     /inference="alignment:Splign:2.1.0"
     exon            267..367
                     /gene="Fbxo25"
                     /gene_synonym="9130015I06Rik; Fbx25"
                     /inference="alignment:Splign:2.1.0"
     exon            368..417
                     /gene="Fbxo25"
                     /gene_synonym="9130015I06Rik; Fbx25"
                     /inference="alignment:Splign:2.1.0"
     exon            418..510
                     /gene="Fbxo25"
                     /gene_synonym="9130015I06Rik; Fbx25"
                     /inference="alignment:Splign:2.1.0"
     exon            511..604
                     /gene="Fbxo25"
                     /gene_synonym="9130015I06Rik; Fbx25"
                     /inference="alignment:Splign:2.1.0"
     exon            605..789
                     /gene="Fbxo25"
                     /gene_synonym="9130015I06Rik; Fbx25"
                     /inference="alignment:Splign:2.1.0"
     exon            790..972
                     /gene="Fbxo25"
                     /gene_synonym="9130015I06Rik; Fbx25"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1116
                     /gene="Fbxo25"
                     /gene_synonym="9130015I06Rik; Fbx25"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..2098
                     /gene="Fbxo25"
                     /gene_synonym="9130015I06Rik; Fbx25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2052..2057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo25"
                     /gene_synonym="9130015I06Rik; Fbx25"
                     /note="hexamer: AATAAA"
     regulatory      2067..2072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo25"
                     /gene_synonym="9130015I06Rik; Fbx25"
                     /note="hexamer: AAGAAA"
     polyA_site      2076
                     /gene="Fbxo25"
                     /gene_synonym="9130015I06Rik; Fbx25"
                     /note="major polyA site"
     polyA_site      2098
                     /gene="Fbxo25"
                     /gene_synonym="9130015I06Rik; Fbx25"
ORIGIN      
        1 tcagcgggac gccaaggcgg ggcgtccagc ggtggccctc ggcgggaggc ggacggcttc
       61 cggcaataat tggacgctgc ggctcggtgt ggttggtggc tgtctcgtct ggaagggacc
      121 cgcaggagca cgatgccgtt tctgggtcag gactggaggt cccctggatg gagctggatt
      181 aaaaccgagg atgggtggaa aaggtgtgac ccctgtagcc acgagctcag gagcgaggat
      241 agccagtaca ccatcaacca cagcattatc ttaaatagtg gtgaagaaga aatattcaac
      301 aatgagtgtg aatacgcagc caaaaagagg aagaaggaac attttggaaa tgacacagct
      361 gctcacagtt tttatcgtga aaaatggatc tacgtccata aggaaagcac aaaggaaagg
      421 catggctact gcaccctggg agaagccttc aaccggctag acttctcaag tgccattcag
      481 gacatcagga ggttcactta cgtggtcaaa ctactgcagc taattgcgaa gtcccagtta
      541 acctcactga gtggagtggc acagaagaac tacttcaaca ttttggataa aatcgtccaa
      601 aaggttcttg atgaccatca gaaccctcgc ctgatcaaag gcctcctcca ggacctgagc
      661 tccacccttg gcatcctggt gagaggggtg gggaagtcag tgctagtcgg gaacatcaac
      721 atctggatct gccgcctgga gaccgtcctc agctggcagc agcagctgca gaacctccag
      781 gtgacaaagc aggtaaacac tggcctcaca ctcagtgacc tgcccctgca catgctgaac
      841 aacatcctgt accgtttctc agatggctgg gacattgtca ccctgggcca ggtaacacca
      901 accctgtaca tgctcagtga agacaggcgg ctgtggaagc gactgtgtca gtaccacttt
      961 gctgagcagc agttttgtag acatttgatc ctttcagaaa aaggtcatat cgagtggaag
     1021 ctgatgtatt tcacgcttca gaagtattac ccgaccaaag agcagtacgg ggacacgcta
     1081 cacttctgcc gccactgcag catcctcttc tggaaggact cgggacaccc ctgcaccgca
     1141 gctgaccccg acagctgctt cactcctgtg tctccggagc acttcattga cctcttcaag
     1201 ttctgatggt gcactcagcc ccgtgccctt gtctacagct gtcccttgtg ctttctgtgt
     1261 cgtgtagttg gtgtgagtat tctgtgacac aagtgacgac aggctcagtg actgcctgta
     1321 cctgtgcaac cctcgcttgc tccttggaga acctgacagg acgctgaaga tgtgcgggca
     1381 gttgtgcacc gtcagtgagg gagagagacc ccgactccat ttgtacttct ttcttgacac
     1441 tcttctcagc ttataaaatt tgccgttttg tatattttta aatatggatc aaaaagagtc
     1501 ttggatactc agccccatat tttgtgctga actgacatga acaaccgaga atgtccttct
     1561 tggttgtcaa aagacagttt tccatcctac agtaattggg atgaagaaca aaacagttga
     1621 tccttgtaaa tacattatgc agaatattta tttttcttaa aatgtatttt cacaacccca
     1681 gtggctgtgg ccaaatgagt cctcattgaa cacgagatgg agctaggaat gcacgtgggg
     1741 ctgtgaactg gatgcactgg ccatagctag catcaatgtc cccgtgtttc caggaacccc
     1801 tgccatgagg ccatcataga tccagactcg ggatgtgggc tccaaaccag aatagagcct
     1861 ctgccaagga gctggaaaca gcccagtgag gctgaagttc tcttgtagaa attcctttcc
     1921 tgggtaaagt gatgagccat gtttatctac tgatcagctt catcaaattc gcatctaact
     1981 gaatggtagt gtctttaaaa tgtgctgttt tattttaaaa ataatgcatg tgcactttag
     2041 aaatttttga aaataaagat acatgaaaga aagttatata atttttctgc aacaataa
//
